Effects of fine particulate matter on bone marrow-conserved hematopoietic and mesenchymal stem cells: a systematic review

Experimental & Molecular Medicine, Published online: 10 January 2024; doi:10.1038/s12276-023-01149-zAir pollution, particularly fine particulate matter (tiny particles in the air, PM2.5), poses major health dangers, including diseases linked to the breathing and heart systems, and cancer. This research by Bhattarai, Shrestha, Sim, Lee, and Kook examines how PM2.5 impacts bone marrow stem cells and hematopoietic stem cells, which are vital for blood creation and immune system operation. The scientists discovered that prolonged exposure to PM2.5 can disturb the bone marrow environment, causing oxidative stress (damage caused by free radicals) and inflammation in HSCs. This can result in irregular blood development and a weakened immune system. The research also showed that PM2.5 can adversely affect BMSCs, which are crucial for preserving the bone marrow environment and assisting tissue repair. The study emphasizes the necessity for tactics to decrease PM2.5 pollution to safeguard human health.This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author.
Source: Experimental and Molecular Medicine - Category: Molecular Biology Authors: Source Type: research