Regulation of cargo selection in exosome biogenesis and its biomedical applications in cancer

Experimental & Molecular Medicine, Published online: 05 April 2024; doi:10.1038/s12276-024-01209-yExtracellular vesicles (EVs)—tiny structures produced by cells that are important for cell-to-cell communication—contain various molecules, a process known as cargo sorting. However, how these molecules are selected and packaged into EVs is not fully understood. This research by Lee, Shin, and Chae provides a detailed analysis of our current knowledge of cargo sorting in exosome biogenesis. They reviewed the literature on the types of molecules in exosome cargo, the factors and machinery controlling cargo selection and packaging, and the role of cargo sorting in diseases. They found that understanding exosome cargo sorting is vital for managing diseases and developing exosome-based treatments. This could help design exosomes that can more effectively deliver therapeutic substances to specific cells or tissues, improving the effectiveness and accuracy of these treatments in clinical use.This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author.
Source: Experimental and Molecular Medicine - Category: Molecular Biology Authors: Source Type: research