Central neurocytoma exhibits radial glial cell signatures with FGFR3 hypomethylation and overexpression
This study used advanced technology to analyze the genetic makeup of CN. The researchers found that CNs don't have any major repeated changes in their genes, gene combinations, or gene copies that could cause the tumor. Instead, they found that the increase in activity of the PI3K-AKT pathway (a pathway involved in cell growth) and changes in several pathways involved in nerve cell development are controlled by an increase in FGFR3 (a protein that helps cells grow and divide) in CNs. This research provides important information about the genetics of CN and could help guide future research and treatments.This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author.Introduction
Source: Experimental and Molecular Medicine - Category: Molecular Biology Authors: Yeajina Lee Tamrin Chowdhury Sojin Kim Hyeon Jong Yu Kyung-Min Kim Ho Kang Min-Sung Kim Jin Wook Kim Yong-Hwy Kim So Young Ji Kihwan Hwang Jung Ho Han Jinha Hwang Seong-Keun Yoo Kyu Sang Lee Gheeyoung Choe Jae-Kyung Won Sung-Hye Park Yong Kyu Lee Joo Heon Source Type: research