Transcriptome-based deep learning analysis identifies drug candidates targeting protein synthesis and autophagy for the treatment of muscle wasting disorder

Experimental & Molecular Medicine, Published online: 01 April 2024; doi:10.1038/s12276-024-01189-zScientists used artificial intelligence to find a possible cure for sarcopenia, a disease marked by muscle loss and decreased function. The group, headed by Dr. Jin Woo Choi, used AI to study gene expression patterns in muscle tissues from healthy people and sarcopenia patients. They found a medicine named dimenhydrinate (DH) as a possible cure. The group then experimented with DH on lab-grown muscle cells and mice, discovering that it encouraged muscle cell growth and repair. The scientists concluded that DH could be a hopeful cure for sarcopenia. However, more studies are required to validate these results and to comprehend how DH functions at a molecular level.This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author.
Source: Experimental and Molecular Medicine - Category: Molecular Biology Authors: Source Type: research