Age-dependent loss of Crls1 causes myopathy and skeletal muscle regeneration failure

Experimental & Molecular Medicine, Published online: 01 April 2024; doi:10.1038/s12276-024-01199-xAging often results in a decrease in muscle mass and function, a condition called sarcopenia. This research examines the role of a protein found in mitochondria (the energy factories of cells), cardiolipin synthase 1 (CRLS1), in muscle health and aging. The scientists discovered that levels of CRLS1 and cardiolipin, a fat it produces, decrease in the muscles of older mice. When CRLS1 levels were artificially lowered in young mice, their muscle mass and strength reduced. On the other hand, increasing CRLS1 levels in older mice improved muscle mass and strength. The research also found that CRLS1 is essential for muscle cell development and mitochondrial function. These results suggest that CRLS1 could be a potential treatment target for sarcopenia. More research is needed to further understand the metabolic changes caused by CRLS1 regulation.This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author.
Source: Experimental and Molecular Medicine - Category: Molecular Biology Authors: Source Type: research