Recent advances in CRISPR-based functional genomics for the study of disease-associated genetic variants

Experimental & Molecular Medicine, Published online: 01 April 2024; doi:10.1038/s12276-024-01212-3Genetic mutations, changes in our DNA, can cause many human diseases, but it’s hard to understand how they affect our cells. Traditionally, researchers have studied mutations that occur naturally, but this method has its limits. Genome editing methods, like the CRISPR-Cas system, allow for the study of disease-related genetic changes. In this review, Kim et al. outlined the integration of CRISPR-Cas tools with advanced sequencing technologies to explore how genetics influence disease. They comprehensively described both small-scale tests for individual changes and large-scale tests for the simultaneous analysis of many genetic changes. This review could help improve translational precision medicine (tailored treatments based on individual’s genetics), offering more personalized and effective treatments for various diseases. The study also shows the potential for future research in this field.This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author.
Source: Experimental and Molecular Medicine - Category: Molecular Biology Authors: Source Type: research