Fasting hyperglycaemia, glucose intolerance and pancreatic islet necrosis in albino rats associated with subchronic oral aluminium chloride exposure
AbstractExposure to aluminium is associated with altered glycaemia, but this effect in relation to glucose tolerance and pancreatic islet pathology requires validation. The study was aimed at assessing the glycaemic changes, glucose tolerance and islet morphology of albino rats during oral aluminium chloride exposure. Twenty male albino rats weighing 189 –270 g were randomly divided into two equal groups. The control group was sham-treated with normal saline and the treated group was administered aluminium chloride solution (100 g/L) by gavage at 12.5% of LD50 (50  mg/kg) daily for 28 days. Fastin...
Source: Comparative Clinical Pathology - January 9, 2020 Category: Pathology Source Type: research

Clinical blood gas indices and histopathological effects of intrathecal injection of tolfenamic acid and lidocaine Hcl in donkeys
AbstractThe present study aimed to investigate the clinical blood gas indices and histopathological consequences after intrathecal injection of tolfenamic acid and lidocaine Hcl and moreover, to elucidate the spinal safety of tolfenamic acid as a cyclooxygenase inhibitor in donkeys. Ten clinically healthy donkeys were divided into two groups, 5 animals each. The first group received lidocaine Hcl 2% and the second one received tolfenamic acid 4% intrathecally. The physical parameters and ataxia, analgesia, and motor blockade scores were recorded. Blood gases and acid base balance indices and histopathological examination w...
Source: Comparative Clinical Pathology - January 9, 2020 Category: Pathology Source Type: research

Haematology, plasma biochemistry and serum of table size African catfish, Clarias gariepinus , naturally infected with Listeria species in Oyo State
This study evaluated the haematology, plasma biochemistry and blood enzymes of farm-raised African catfish,Clarias gariepinus, naturally infected with listeriosis in Oyo State. Fish were collected from 36 farms using stratified method. A total of 108 fish were collected where 37 were positive for listeriosis. The blood of the affected fish was used for this study. Haematology, plasma biochemistry and blood enzyme analysis were determined. Fish from Oyo zone had the highest PCV, Hb, RBC and MCHC with 29.33  ± 2.96%, 10.04 ± 1.04 dL, 3.55 ± 0.09 &time...
Source: Comparative Clinical Pathology - January 9, 2020 Category: Pathology Source Type: research

Bovine dilated cardiomyopathy with overlapping myocarditis in an adult Holstein-Friesian dairy cow
AbstractIn humans, it is acknowledged that dilated cardiomyopathy is also caused by infection-induced myocarditis. To evaluate whether the occurrence of lesions of dilated cardiomyopathy in cattle may be triggered by myocarditis, an adult Holstein-Friesian dairy cow which showed dilated cardiomyopathy associated with myocarditis was examined by histopathology. Traumatic pericarditis or idiopathic congestive heart failure was clinically suspected, and the animal was culled because of unfavorable prognosis. Histopathological examination revealed an intrinsic cardiomyopathic lesion that overlapped with myocarditis. Cardiomyoc...
Source: Comparative Clinical Pathology - January 9, 2020 Category: Pathology Source Type: research

Oxidative stress in liver of grass carp Ctenopharyngodon idella naturally infected with Saprolegnia parasitica and its influence on disease pathogenesis
AbstractFungal diseases are one of the major problems in freshwater fish culture and have been linked to significant losses and high mortality rate, and saprolegniosis caused bySaprolegnia parasitica is the most important oomycete affecting freshwater fish worldwide. The hepatic pathophysiology of infection remains poorly understood and is limited only to histopathological alterations. Thus, the aim of this study was to evaluate whether tissue oxidative damage can be considered a pathway linked to liver damage duringS.parasitica infection in grass carp (Ctenopharyngodon idella). Grass carp was divided into two groups (n&th...
Source: Comparative Clinical Pathology - January 5, 2020 Category: Pathology Source Type: research

Alterations in hematological and biochemical parameters and DNA status in mice bearing Ehrlich ascites carcinoma cells and treated with cisplatin and cyclophosphamide
AbstractChemotherapy medicates cancer via killing cells. It may destroy both cancer and normal cells. This research was performed to investigate the  influences of cisplatin and cyclophosphamide on Ehrlich ascites carcinoma (EAC) bearing mice through some hematological, biochemical, molecular, and pathological studies. A total of 80 healthy female Swiss mice were equally divided into four groups. Group 1 was kept as the negative control. Grou ps 2 to 4 were injected intraperitoneally (IP) with 2.5 × 106 EAC where mice in group 2 were kept as the positive control without treatment. Groups ...
Source: Comparative Clinical Pathology - January 2, 2020 Category: Pathology Source Type: research

Pathogenicity, haematology and pathology of Listeria monocytogenes in rat
AbstractListeria monocytogenes is a gram positive bacterium of public health concern with low morbidity but high mortality rate. Listeriosis in human is usually caused by the consumption of infected animal and food. It is noteworthy that an infected animal such as rat could be potential carrier and vector. Therefore, this study examined the clinic pathological changes associated withListeria monocytogenes infection in rat. Six (6) Winstar laboratory rats divided into 2 groups. Group 1 was challenged with 0.1-mL saline water as control while the second group was challenged intraperitoneally with 0.1  mL molecularly cha...
Source: Comparative Clinical Pathology - January 1, 2020 Category: Pathology Source Type: research

Determination of histopathological and biomedical parameters in protective effects of Petroselinum crispum on hepatotoxicity induced by dichlorvos in male Wistar rats
This study examines the detoxification feature of PC on Dich-induced hepatotoxicity in male Wistar rats. Sixty-four male Wistar rats were grouped into eight including sham (normal saline), Dich (4  mg/kg/day), PC 1, 2, 3 (100, 150, 200 mg/kg/day, respectively) and Dich+PC 1, 2, 3 (100, 150, 200 mg/kg/day, respectively). All treatments were applied intraperitoneally (i.p) at 10 A.M. daily for 4 weeks. A day after the last treatment, the animals were sacrificed by cervical dislocation. The histopathological changes and apoptosis processes were assessed by light and fluorescent microscopy methods. The...
Source: Comparative Clinical Pathology - January 1, 2020 Category: Pathology Source Type: research

Health performance and blood profile changes in commercial broilers supplemented with dietary monocalcium phosphate
AbstractFast-growing broilers faced with various leg health problems are in crucial need of an adequate nutritional supply of both calcium and phosphorus. The aim of the current work was to study the effect of different level of monocalcium phosphate supplementation on the health performance, haematology, and biochemistry changes of commercial broiler chickens. A total of 108 broiler birds (Cobb 500) were randomly divided into three treatment groups with six replicates consisting of six birds per replicates. Treatment 1 (control) was fed with available commercial starter and finisher diets containing dicalcium phosphate. T...
Source: Comparative Clinical Pathology - December 23, 2019 Category: Pathology Source Type: research

Impact of dietary bee honey during first weeks of life in dairy lambs on growth and metabolism
The objective of this study was to determine whether a daily dose of honey would improve productive performance as well as energy, protein, and lipid metabolisms in lactating lambs. Bee honey (fromApis mellifera) was offered orally for the first 7  days of the animals’ lives. Twenty Lacaune lambs were used, allocated to two groups: group C, lambs not supplemented with honey, and group T, consisting of lambs fed daily doses of 10 mL of honey. The experimental period lasted 45 days. Body weight measurements and blood sample collections wer e performed at five time points (days 1, 7, 15, 30, and 45 of lif...
Source: Comparative Clinical Pathology - December 20, 2019 Category: Pathology Source Type: research

Rare case presentation: DLBCL and plasma cell myeloma coexisting together
AbstractThe synchronous presence of dual hematological malignancy is an uncommon finding. In the present case, an 82-year-old male, presented with lymph nodal mass which was diagnosed as diffuse large B cell lymphoma (DLBCL) on histopathology and plasma cell myeloma (PCM), was diagnosed with identification of clonal plasma cells in the bone marrow. Interestingly, both clonal plasma cells and lymphoma cells showed lambda light chain restriction. The patient also developed spontaneous tumor lysis syndrome which can be seen in aggressive hematopoietic malignancies. The present case is a rare presentation of synchronous dual h...
Source: Comparative Clinical Pathology - December 20, 2019 Category: Pathology Source Type: research

Experimental hypothyroidism in adult male rats: the effects of Artemisia dracunculus aqueous extract on serum thyroid hormones, lipid profile, leptin, adiponectin, and antioxidant factors
This study lasted for 90 days. The animals were divided into six experimental groups (eight rats per each group): (1) normal control; (2) hypothyroid rats + levothyroxine, as positive control (4 μg/100 g/day); (3) hypothyroid rats, as negative control; (4) hypothyroid rats + tarragon aqu eous extract (100 mg/kg); (5) hypothyroid rats + tarragon aqueous extract (200 mg/kg); and (6) hypothyroid rats + tarragon aqueous extract (300 mg/kg). Blood samples were obtained using cardiac puncture. In blood samples, thyroid hormones (triiodothyronine (T3), free triiodothyronine (fT3), thyro xine (T4),...
Source: Comparative Clinical Pathology - December 13, 2019 Category: Pathology Source Type: research

Apoptosis and regeneration of hepatocytes in rats orally exposed to caffeinated energy drinks
AbstractCaffeinated energy drinks (CEDs) have become extremely popular over the last decade. In recent years, many researchers have raised a concern about the safety of CEDs. The aim of our study was to evaluate the morphology of the liver, as well as the features of hepatocyte apoptosis/regeneration, in rats orally exposed to CEDs for 2  weeks. Sixteen WAG rats formed two equal groups. Rats from the experimental group were orally exposed to a CED at a dose of 12 ml/kg of body weight for 2 weeks. The control group consisted of intact animals with the provided access to drinking water instead. The content of ...
Source: Comparative Clinical Pathology - December 13, 2019 Category: Pathology Source Type: research

The effect of methadone, buprenorphine, and shift of methadone to buprenorphine on sperm parameters and antioxidant activity in a male rat model
In conclusion, methadone and buprenorphine enhanced testicular oxidative stress, suppressed blood levels of sexual hormone, including LH, FSH, TT, and FT, and resulted in suppressed sperm parameters. There wer e no significant differences between methadone and buprenorphine treatments in terms of their adverse effects on sperm parameters and antioxidant activity. However, shift of methadone to buprenorphine resulted in the worst adverse effect in the male reproductive system in the rat model. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - December 11, 2019 Category: Pathology Source Type: research

FSH and estradiol benzoate administration recover spermatogenesis and sexual hormone levels in a busulfan-injured rat model
AbstractBusulfan induces azoospermia and testicular atrophy, while follicle stimulating hormone (FSH) and estradiol benzoate (EB) may improve spermatogenesis. Our objective was to determine the effects of FSH and EB on the recovery of spermatogenesis, histology, sexual hormones, and testicular gene expression in the testis of a busulfan-injured rat model. Forty adult rats were assigned into eight groups. Half received a single intraperitoneal saline or 30  mg/kg busulfan injection, and 42 days after, the animals received intramuscular injections for 10 days: 1 ml saline, 7.5 IU FSH, and 12 &mu...
Source: Comparative Clinical Pathology - December 2, 2019 Category: Pathology Source Type: research

Report and abstracts for 20th ACCP conference with training workshops, and technology exhibits
AbstractA report is made on the 2-day, 20th annual conference held by the Association for Comparative Clinical Pathology (ACCP). This included two workshops that were given by veterans of the toxicologic clinical pathology community including on haematotoxicity and on the interpretation of clinical pathology data of pre-clinical toxicology studies in support of pharmaceuticals in development. Also, included was a series of scientific and technology presentations on the latest developments in toxicologic and veterinary clinical pathology. Key developments presented on were the invention of a rapid and simple diagnostic test...
Source: Comparative Clinical Pathology - December 2, 2019 Category: Pathology Source Type: research

Clinical pathology and health reference values for loggerhead sea turtles ( Caretta caretta ) and olive ridley turtles ( Lepidochelys olivacea ) in the Gulf of Ulloa, Baja California Sur, Mexico
AbstractAnthropogenic impact and environmental threats can cause diseases to marine turtles and in severe cases death, contributing to population decline worldwide. The Gulf of Ulloa (GU) represents an important foraging habitat for loggerhead sea turtles and olive ridley turtles; it is also considered a highly productive area for fisheries and is known for the mortality of marine turtles, which has been associated to bycatch. However, there is little information in the area regarding the health status of marine turtles; thus, the aims of this study were to (1) assess the health of marine turtles via physical examination, ...
Source: Comparative Clinical Pathology - October 29, 2019 Category: Pathology Source Type: research

Antifungal activity of ethanolic extracts of Ocimum gratissimum and Vernonia amygdalina leaves against dermatomycotic agents isolated from domestic animals in South Eastern Nigeria
This study aims to isolate dermatomycotic agents from domestic animals and evaluate, using ethanolic leaf extracts ofOcimum gratissimum andVernonia amygdalina, the in vitro antifungal profile of these extracts against these isolates. A total of 698 domestic animals (dogs, sheep, goats, and pigs) were examined for skin lesions suggestive of dermatomycosis and skin scrapings collected. The agar well diffusion assay was used to evaluate the in vitro activity of both leaf extracts using voriconazole and their solvent, dimethyl sulfoxide (DMSO), as control positive and negative respectively. Results showed that among the fungal...
Source: Comparative Clinical Pathology - October 29, 2019 Category: Pathology Source Type: research

Haematological reference values of dromedary camels in northern Nigeria
AbstractThe aim of this study was to determine the haematological reference values of a population of dromedary camels (Camelus dromedarius) in northern Nigeria to provide data required during laboratory investigation of health. The haematological variables were determined with EDTA anti-coagulated blood samples collected from the jugular veins of 121 camels during antemortem sessions at the abattoir in Maiduguri (Borno State). Serum total protein, albumin and globulin concentrations were estimated with serum samples harvested from clotted blood samples collected from the same animals. The haematological data were normally...
Source: Comparative Clinical Pathology - October 29, 2019 Category: Pathology Source Type: research

Evaluation of anti-inflammatory and analgesic activities of selected antibiotics in Wistar Albino rats
AbstractAnti-inflammatory, analgesic, and leukocyte mobilization activities of ciprofloxacin, lincomycin, and erythromycin were evaluated in this study. The study involved two sets of thirty-three adult female Wistar rats assigned into five treatments, grouped into eleven of three rats per group. For agar-induced paw edema, the first three groups were treated 10  mg/kg, 20 mg/kg, and 40 mg/kg of ciprofloxacin, next three groups same doses of lincomycin, next three groups same doses of erythromycin, the tenth group received the reference drug, indomethacin 5 mg/kg while the last group 5 mg/kg normal...
Source: Comparative Clinical Pathology - October 29, 2019 Category: Pathology Source Type: research

A survey of leukocyte profiles of red-backed salamanders from Mountain Lake, Virginia, and associations with host parasite types
AbstractIn this project, red-backed salamanders,Plethodon cinereus, were collected from the heart of their range (Mountain Lake, Virginia, USA), in an effort to document the typical, or baseline, leukocyte profile of this species in its natural state. From microscopic examination of thin blood films, we determined relative proportions of all leukocyte types and determined the ratio of neutrophils to lymphocytes, which is a useful index of stress levels. In addition, individuals were examined for three naturally occurring endoparasites: two gastro-intestinal (trematodes and a ciliated protozoan in the genusCepedietta) and o...
Source: Comparative Clinical Pathology - October 29, 2019 Category: Pathology Source Type: research

Medical management of phimosis associated with generalized Sticker ’s sarcoma in an intact mongrel dog
AbstractA 3-year-old intact male mongrel dog was presented to the Referral Veterinary Polyclinic, ICAR-Indian Veterinary Research Institute, Izatnagar, with the history of inappetence, multiple subcutaneous swellings, and haematuria for the past 15  days. The dog had a history of mating with stray dogs, a few months ago. Physical examination revealed normal vital signs and generalized lymphadenopathy along with multiple subcutaneous hard masses of approximately 1–5 cm size was observed all over the body including the eyelids, inner canthus , and prepuce; and swelling on the shaft of the penis was also palpa...
Source: Comparative Clinical Pathology - October 29, 2019 Category: Pathology Source Type: research

Analysis of comments and questions in letters to the editor about nocardiosis
AbstractNocardia spp. are causing various infections in human and animals.Nocardia isolation and identification are hard and need of professional experts and equipped laboratory. Sometimes there are various bugs in the isolation, identification, antibiogram, etc. according to some articles. The purpose of this study is to survey comments and questions in letters to the editor that have been published in the journals about nocardial infections (nocardiosis) in human, and we discussed them in this article. We searched and found fifteen letters to the editor about nocardiosis. Comments and questions were about isolation, iden...
Source: Comparative Clinical Pathology - October 29, 2019 Category: Pathology Source Type: research

Methylene blue protects against pentylenetetrazole-induced seizures, oxidative stress, and neuronal injury
In this study, the effect of acute administration of MethyB on epileptic seizures, brain oxidative stress, and neuronal injury induced in rats by pentylenetetrazole (PTZ) was studied. Rats received repeated intraperitoneal (i.p.) injections of PTZ until the development of status epilepticus and were i.p. treated once with MethyB at doses of 50 or 100  mg/kg, 30 min prior to the first PTZ injection. Results indicated that compared with the PTZ control group, the administration of MethyB at 50 and 100 mg/kg decreased the mean seizure score over the study period by 48.8% and 55.1%, respectively. The development...
Source: Comparative Clinical Pathology - October 24, 2019 Category: Pathology Source Type: research

Protective roles of crude and fractions of A . senegalensise carpel against alloxan-induced hyperglycemia and hyperlipidemia in rats
AbstractMedicinal plants are increasingly been investigated for potentials to provides active, safe and cost-effective alternative to synthetic antidiabetics. In the present study, hypoglycemic and hypolipidemic activities of crude methanol, hexane and ethylacetate fractions ofAnnona senegalensis (A.senegalensis) in alloxan-induced diabetic rats were evaluated. The extract and fractions ofA.senegalensis were administered to alloxan (120  mg/kg bw) induced diabetic rats at doses of 100, 300 and 600 mg/kg bw. Glibenclamide (5 mg/kg bw) was used as the reference drug. All treatments were administered daily for ...
Source: Comparative Clinical Pathology - October 22, 2019 Category: Pathology Source Type: research

Comparative evaluation of xylazine, detomidine, and medetomidine on cardiovascular biomarkers in dromedary camels
This study was performed to comparatively evaluate cardiovascular effects of xylazine, detomidine, and medetomidine after intravenous (IV) administration in dromedary camels. Ten clinically and paraclinically healthy immature male dromedary camels aged 24  ± 2 months and weighing 200 ± 20 kg were used in this study. Camels were sedated with each of three treatments in a randomized, crossover design, with a minimum washout period of 8 days between treatments. Treatments were xylazine (0.4 mg kg−1), detomidine (50  μg kg−1), and medet...
Source: Comparative Clinical Pathology - October 22, 2019 Category: Pathology Source Type: research

Ziziphus jujube protects against cisplatin-induced nephrotoxicity in rats
AbstractAll components ofZiziphus jujube (ZJ) were used in medicine and food in ancient Iran and China. Cisplatin is one of the most important drugs in the treatment of solid tumors. Taking this drug can result in nephrotoxicity through several mechanisms. The purpose of this study was to evaluate the effects of ZJ on the nephrotoxicity induced by cisplatin in rats. Thirty-five experimental rats were randomly divided into the following five groups (n = 7 per group) for an 8-day study: (Wafaa et al. Aust J Basic Appl Sci 5:652-659,2011) group C1 was the control group and received distilled water (1  ml/da...
Source: Comparative Clinical Pathology - October 21, 2019 Category: Pathology Source Type: research

Erythrocyte osmotic fragility and erythrocyte sizes for captive African rock pythons ( Python sebae )
AbstractThe aim of the experiment was to determine the erythrocyte sizes and osmotic fragility index of the African rock python in a transitional zone. Ten African rock pythons (ARPs) were used as experimental animals. Blood samples were obtained from captive ARP by venepuncture of the ventral coccygeal vein. Erythrocyte counts, packed cell volume, mean corpuscular volume and erythrocyte sizes were determined. Erythrocytes obtained from each snake were added into saline solution of different NaCl concentrations of 0.1, 0.3, 0.5, 0.7 and 0.9  g/100 mL, respectively. Erythrocyte osmotic fragility index was determin...
Source: Comparative Clinical Pathology - October 20, 2019 Category: Pathology Source Type: research

Effects of acute experimental Trypanosoma brucei brucei infections on serum super oxide dismutase activities in relations to development of parasitaemia, anaemia and leucopenia in Wistar rats
AbstractThe alterations in serum super oxide dismutase (SOD) enzymes activities in relation to sequential haematological changes were determined to assess the impacts of oxidative stress in Wistar rats experimentally infected withTrypanosoma brucei brucei. Forty adult male rats allocated into infected and control groups, of 20 rats each based on their mean body weight were used. Rats in infected group were administered 1 ml of reconstituted infected blood containing 1 × 106 trypanosomes/ml obtained fromT. b. brucei–infected donor rat. Blood sample in EDTA sample tubes was collected for haematological parameters...
Source: Comparative Clinical Pathology - October 18, 2019 Category: Pathology Source Type: research

Plasma proteins and leukocyte kinetics of turtles ( Podocnemis unifilis (Troschel, 1848)) inoculated with inactivated Escherichia coli
AbstractThe plasma protein fractions and leukocyte response induced by an experimental subcutaneous inoculation ofEscherichia coli isolated and inactivated in turtlesin captivity (Podocnemis unifilis—“tracajá”), were evaluated. The animals were divided into two groups (test group and control) with 10 turtles each. Blood samples from all animals were collected the day before the inoculation and at days 15, 28, 42 and 125 days in both groups. The inoculation ofE. coli did not significantly alter the red blood cell count, but the serial collection of blood led to a mild normochromic macrocytic anemia....
Source: Comparative Clinical Pathology - October 16, 2019 Category: Pathology Source Type: research

Effects of administration of probiotic on body growth and hematobiochemical profile in growing Barki lambs
AbstractThe purpose of this study was to investigate the potential effect of probiotic supplementation on body growth and selected hematobiochemical parameters of growing Barki lambs. For this reason, twenty apparently healthy weaning lambs were randomly allotted into two equal groups (6 each): the first group (control) received a basal diet without any supplement, whereas the 2nd group (supplemented group) received the basal diet supplemented with probiotic (Bacillus subtilis, sorbitol sodium, vitamin B1, and glucose) which was given via drinking water at a dose of 1 g/L/day for 30 consecutive days. A blood sample was col...
Source: Comparative Clinical Pathology - October 15, 2019 Category: Pathology Source Type: research

Optimization of the effectiveness and cytocompatibility of Nigella sativa as a co-treatment for reducing methotrexate-related adverse effects
In this study, in vitro evaluation of anti-tumor and anti-angiogenic activities of NS, MTX, or their mixture in different concentrations using liver hepatocellular carcinoma and endothelial cells were performed. The protective effects of NS on normal hepatic and kidney cells against the risks of MTX treatment was also tested in vitro. Moreover, for in vivo evaluation, male Wistar rats were treated with MTX or a combination of MTX and NS. Hematological and serological, biochemical, functional, and histopathological studies were performed. The results showed that the low concentration of NS enhanced the anti-tumor and anti-a...
Source: Comparative Clinical Pathology - October 13, 2019 Category: Pathology Source Type: research

Effect of aqueous extract of Allium saralicum R.M. Fritsch on fatty liver induced by high-fat diet in Wistar rats
In conclusion, the acquired results showed the hepatoprotective potential of aqueous extract ofA. saralicum, so that it can use for the treatment of fatty liver disease. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - September 30, 2019 Category: Pathology Source Type: research

Histopathological and biochemical effects of aqueous extract of Tragopogon graminifolius on the liver tissues of Wistar rats fed with high-fat diet
In conclusion, the obtained results demonstrated the hepatoprotective effect ofT. graminifolius aqueous extract. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - September 30, 2019 Category: Pathology Source Type: research

Correction to: Impaired epididymal function in Trypanosoma brucei brucei and Trypanosoma congolense infected and treated albino rats
The publisher rephrases the article title of this article to ‘Impaired epididymal function of albino rats infected and treated withTrypanosoma brucei brucei andTrypanosoma congolense’ but the authors prefer the above article title. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - September 30, 2019 Category: Pathology Source Type: research

Comparison of sodium tetradecyl sulfate, bleomycin, and talc powder for rat pleurodesis induction
This study demonstrates the efficacy of STS for induction of pleurodesis in rat; however, further studies should be done for evaluation of its safety and efficacy in human subjects. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - September 3, 2019 Category: Pathology Source Type: research

Haemoprofile of yellow-bellied house gecko, Hemidactylus flaviviridis Ruppell, 1835
AbstractThe study is carried out to investigate the haemogram of yellow-bellied house gecko in Odisha, India. Fifteen adult lizards of each sex were collected from the coastal area of Rajnagar block of Kendrapara, 754 225, Odisha, located in 20 ° 20′ N to 20° 37′ N latitude and 86° 14′ E to 87° 01′ E longitude. One millilitre of blood was collected from the ventral tail vein and transferred into vials containing ethylenediaminetetraacetic acid (EDTA) and then transported in icebox to laboratory. The morphology of blood cells al ong with haematological parameters like haemoglobin (Hb)...
Source: Comparative Clinical Pathology - September 1, 2019 Category: Pathology Source Type: research

Phytochemical screening and toxicity study of aqueous-methanol extract of Ziziphus spina-christi seeds in Wistar albino rats
This study investigated the phytochemical content and toxicity of aqueous-methanol extract ofZ. spina-christi seeds on hepatic and renal tissues of Wistar rats. The extract was screened for the presence of phytochemicals and orally administered to rats at 200, 600 and 1000  mg/kg bwt for 2 weeks. Haematological parameters and markers of the liver and kidney functions were evaluated as well as histoarchitecture. Tannins, saponins, alkaloids, flavonoids, phenols and glycosides were detected in the extract which significantly (P 
Source: Comparative Clinical Pathology - August 28, 2019 Category: Pathology Source Type: research

Resveratrol ameliorates pathophysiological changes associated with Brucella melitensis infection in dexamethasone-treated does
This study aimed at evaluating serological responses, oxidative status, and pathological derangements associated withBrucella melitensis infection in does treated with dexamethasone. Twelve does were divided into 4 groups designated A, B, C, and D with 3 animals each. Groups A and B were ocularly inoculated with 107 CFU ofB. melitensis. From day 21 postinoculation (pi), dexamethasone was administered for 7  days at 2 mg/kg intramuscularly. Group A was further treated with resveratrol for 5 days from day 31 post-B. melitensis inoculation. Group C was inoculated with similar dose ofB. melitensis ocularly ...
Source: Comparative Clinical Pathology - August 28, 2019 Category: Pathology Source Type: research

Anatomo-pathological study of lung lesions in slaughtered sheep at Batna municipal Slaughterhouse (Eastern Algeria)
This study focused on the research of lung lesions in sheep slaughtered in the slaughterhouse of Batna city (Eastern Algeria). The objective of this study was to determine the frequency of lung lesions during the period from March to September 2013. Macroscopic examination was performed at the slaughterhouse to determine lung lesions and to take samples from injured lung areas for microscopic examination of anatomo-pathological lesions. Among 7420 inspected sheep, 2722 had pulmonary lesions (alone or in combination). The overall prevalence of lung affection was 36.68% (2722/7420), which is statistically significant (P 
Source: Comparative Clinical Pathology - August 26, 2019 Category: Pathology Source Type: research

Sex variation in hematological and serum biochemical parameters of cultured Chinese silver carp, Hypophthalmichthys molitrix
AbstractHematological parameters are essential for the evaluation of both physiological and pathological changes developed in fishes due to the involvement of endogenous and exogenous factors. Among the endogenous factors, sex plays a significant role in determining the hematological and serum biochemical parameters of fish. The aim of the present study was to obtain a basic knowledge about the variation in hematological and serum biochemical parameters of cultured silver carp,Hypophthalmichthys molitrix with respect to sex. In order to establish the information, a blood sample was collected from the fishes from March to J...
Source: Comparative Clinical Pathology - August 22, 2019 Category: Pathology Source Type: research

Ameliorative effect of Parinari curatellifolia seed extracts on sodium nitroprusside –induced cardiovascular toxicity in rats
AbstractThe pharmacological potential ofParinari curatellifolia has remained largely unexplored by the scientific community and little information is available to support the folkloric and ethnobotanical uses of the plant. This present study was carried out to investigate the ameliorative effect ofP. curatellifolia seed extracts on sodium nitroprusside (SNP) toxicity on the heart and artery in rats.P. curatellifolia seed crude aqueous-methanolic extract (CMPC) as well as n-hexane (HFPC), dichloromethane (DFPC), ethyl acetate (EFPC), and n-butanolic (BFPC) fractions was prepared and screened for phytoconstituents. In the in...
Source: Comparative Clinical Pathology - August 21, 2019 Category: Pathology Source Type: research

Haematology of southern bent-winged bats ( Miniopterus orianae bassanii ) from the Naracoorte Caves National Park, South Australia
This study highlights the importance of generating species-specific reference ranges as extrapolating from even closely related species can lead to errors in interpretation. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - August 20, 2019 Category: Pathology Source Type: research

Brachial plexus block as a part of balanced anesthesia in a jungle cat ( Felis chaus ) undergoing forelimb orthopedic surgery
AbstractAn adult male jungle cat (Felis chaus) weighing 6  kg with the history of inability to bearing weight on its left forelimb was presented. Physical examination and radiography revealed transverse radio-ulna fracture and carpal subluxation. Internal fixation with plate was chosen for treatment. On the day of surgery, anesthesia was induced with intr amuscular ketamine (10 mg/kg) and midazolam (0.3 mg/kg). Brachial plexus block (BPB) was performed using lidocaine (3 mg/kg) and bupivacaine (0.75 mg/kg) mixture guided by an electrical nerve stimulator. During the surgery, anesthesia was maintain...
Source: Comparative Clinical Pathology - August 18, 2019 Category: Pathology Source Type: research

Hyperhomocysteinemia and increased risk of coronary artery disease in Iranian patients with diabetes mellitus type II: a cross-sectional study
This study investigated the relationship between hyperhomocysteinemia and coronary heart disease in patients with type 2 diabetes. This study was a hospital-based cross-sectional study performed on 100 diabetic patients with indications of coronary artery angiography. After the measurement of serum HbA1c and homocysteine, the patients went through coronary angiography and, based on the results, were divided into two groups of normal and obstructed coronary arteries. Serum homocysteine and other related risk factors were further compared between the two groups. The mean serum homocysteine of patients was 13.18  &plus...
Source: Comparative Clinical Pathology - August 16, 2019 Category: Pathology Source Type: research

The protective role of l -carnitine against 1st- and 2nd-generation antihistamine-induced liver injury in mice
In conclusion, oxidative stress can be a possible explanation of hepatic damage induced by chronic therapy with chlorpheniramine maleate and cetirizine hydrochloride.l-Carnitine has prominent hepatoprotective effects on chlorpheniramine maleate – and cetirizine hydrochloride–induced hepatic damage possibly through improvement of hepatic function and decreasing oxidative stress. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - August 13, 2019 Category: Pathology Source Type: research

Effect of sex on biochemical, cytomorphometrical and haematological parameters of mallard duck, Anas platyrhynchos (Linnaeus, 1758)
This study was based upon biochemical, cytomorphometrical and haematological analysis of different blood cells of the duck with respect to sex. Blood of the bird was collected from its metatarsal vein, kept in EDTA for haematological test and the smear was prepared immediately after the blood was obtained for morphometrical analysis. For biochemical test, blood was kept in EDTA containing fluoride and left it for 2 –3 h and centrifuged. Plasma chemistry for the glucose, cholesterol, TPP, albumin and globulin was determined. The result of biochemical test differs significantly atP ≤ 0.05. The cel...
Source: Comparative Clinical Pathology - August 12, 2019 Category: Pathology Source Type: research

Ameliorative effects of Mentha aquatica on diabetic and nephroprotective potential activities in STZ-induced renal injury
This study was hypothesized to evaluate the antidiabetic and nephroprotective activities ofMentha aquatica in streptozotocin (STZ)-induced diabetic rats. Diabetes was induced by a single intraperitoneal injection of STZ at a dosage of 40  mg/kg bw. At the end of the study, overnight-fasted rats were dissected, and the blood and kidney samples were analyzed for biochemical and histopathological analysis. Oral administration of aqueous extract of leaves ofMentha aquatica (AELMA) at a dose of 100  mg/kg bw/day for 90 days significantly decreased the level of fasting blood glucose, HbA1c, TC, TG, plasm...
Source: Comparative Clinical Pathology - August 12, 2019 Category: Pathology Source Type: research

Immunohematological parameters of rainbow trout ( Oncorhynchus mykiss ) fed supplemented diet with different forms of barberry root ( Berberis vulgaris )
AbstractIn this experiment, the effect of barberry root powder and methanol extract on the growth and immunohematological parameters of rainbow trout (Oncorhynchus mykiss) was studied. A total of 306 rainbow trout fingerlings (15.55  ± 0.76 g) were fed for 8 weeks with six experimental diets: control (C), BRP10 (10 g kg−1 of barberry root powder), BRP20 (20  g kg−1 of barberry root powder), BRE250 (250  mg kg−1 of barberry root extract), BRE500 (500  mg kg−1 of barberry root extract), and oxytetracycline OTC30 (30  g kg...
Source: Comparative Clinical Pathology - August 12, 2019 Category: Pathology Source Type: research

Anaplasma ovis infection in goat flocks around Gaborone, Botswana
AbstractAnaplasma is a genus of gram-negative, intracellular bacteria infecting different blood cells in animals.A.ovis infects erythrocytes of sheep and goats, inducing clinical signs that include haemolytic anaemia, icterus and loss of production. Aim of this study was to evaluate the prevalence ofAnaplasma spp. in goats in smallholder flocks around Gaborone, Botswana. Whole blood and serum samples were collected from 100 goats coming from 10 smallholder goat flocks from three villages around Gaborone, Botswana. Body condition and FAMACHA © scores were estimated. Blood was used for packed cell volume (PCV), blood sm...
Source: Comparative Clinical Pathology - August 12, 2019 Category: Pathology Source Type: research