Nano-chitosan/bovine lactoperoxidase and lactoferrin formulation modulates the hepatic deterioration induced by 7,12-dimethylbenz[a]anthracene
This study aimed to evaluate the therapeutic potential of a prepared nano-combination composed of LPO and LF loaded on chitosan nanoparticles (LPO  + LF/CNPs) against oxidative damage in the liver of rats exposed to 7,12-dimethylbenz[a]anthracene (DMBA). Twenty-four male Wistar albino rats (4 months old) were divided into three equal groups and treated orally as follow: (1) rats were given saline and served as control, (2) rats received a single dose (20 mg/kg) of DMBA dissolved in soy oil, and (3) rats intoxicated with a single dose (20 mg/kg) of DMBA, 56 days prior to their oral treatment with the nano-combinatio...
Source: Comparative Clinical Pathology - August 18, 2023 Category: Pathology Source Type: research
Investigation of some acute phase protein levels in cattle infected with Brucella abortus
AbstractBrucellosis is a chronic zoonotic disease caused by brucella strains that adversely affects human and animal health. Increases or decreases in acute phase protein (APP) levels are observed in various infective diseases in cattle. In our study, it was aimed to investigate how the change in APP levels in cattle infected withBrucella abortus and which ones can be used as a marker. In the study, blood serum and plasma of 28 brucella and 10 healthy cattle collected from various cattle farm in Samsun were used. Rose bengal plate test and complement fixation test were applied to the serums. While serum amyloid A (SAA), ha...
Source: Comparative Clinical Pathology - August 12, 2023 Category: Pathology Source Type: research
Bisphenol A toxicity induced hepatotoxicity and altered biochemical, histopathology, and immunohistochemical parameters: the metal chelating and antioxidant roles of naringin
This study was carried out to assess the potential ameliorative effect of naringin on BPA-induced hepatotoxicity in cockerel chicks. Thirty-one-day-old cockerel chicks were used for this study and randomly divided into 6 groups of five chicks per group as follows: Group 1 (control), Group 2 (BPA 100  ppm), Group 3 (BPA + 100 mg/kg naringin), Groups 4 (BPA + 200 mg/kg naringin), Group 5 (100 mg/kg naringin), and Group 6 (200 mg/kg naringin), respectively. The administration of BPA was via drinking water and naringin through oral gavage. BPA intoxication caused significant (p <  0.05) increases in ALT, AL...
Source: Comparative Clinical Pathology - August 11, 2023 Category: Pathology Source Type: research
Light exposure impairs hematological characteristics and oxidative stress markers in male African giant pouched rat (Cricetomys gambianus) reared in captivity
In conclusion, photoperiod affects the most hematological characteristics measured and has stressful effects in AGPR. This new knowledge provides a relevant information for the rearing environment of African giant pouched rat. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - August 3, 2023 Category: Pathology Source Type: research
Prevalence and hematological criteria of piroplasmosis in horses of different ages, sex, and breed in Accra Metropolis, Ghana
AbstractEquine piroplasmosis is reported to be mostly endemic in tropical and subtropical regions of the world including Africa. The disease is of major negative economic significance by affecting the trade of horses as well as leading to poor performance of horses and death. The study was aimed at ascertaining the prevalence of equine piroplasmosis and its associated hematological changes in horses in the Accra Metropolis. Simple random sampling technique was used to sample a total of 101 horses from the Shangrilla, Osu, and the Burma Camp. Whole blood samples were obtained from the jugular vein of all sampled horses and ...
Source: Comparative Clinical Pathology - July 28, 2023 Category: Pathology Source Type: research
Improves immunological and histological alterations associated with Polycystic ovarian syndrome in DHEA -induced mice by Licorice extract
This study investigated the anti-inflammatory effect of licorice extract on PCOS. After induction of PCOS by subcutaneous injection (SC) of dehydroepiandrosterone (DHEA) (60  mg/kg) in BALB/C mice for 21 days, the mice were treated with licorice extract (50 mg/kg) for 21 days. At the end of experimental procedures, ovarian morphology, blood antioxidant capacity, nitric oxide (NO), the abundance of Treg cells, and expression of matrix metalloproteinase-9 (MMP-9), tra nsforming growth factor-ß (TGF-ß), cyclooxygenase-2 genes (COX-2), and tumor necrosis factor-alpha (TNF-α) were measured. The estrus cycle returned to n...
Source: Comparative Clinical Pathology - July 26, 2023 Category: Pathology Source Type: research
Influence of two defaunating agents and defaunation intervals on milk profile and selected serum parameters in lactating dairy goats in Egypt
This study quantified the effects of defaunation intervals using two defaunating agents; sodium lauryl sulfate (SLS) and dioctyl sodium sulfosuccinate (DSS), on serum and milk profiles in lactating goats. Ten apparently healthy female Egyptian native breed lactating goats were assigned into two e xperimental groups. The administration of both defaunating agents was carried out daily for the first three days of the experiment then once weekly for three consecutive weeks. The research samples were collected before defaunation, 7, 14, and 21 days post defaunation. Milk parameters were determi ned using milk lactometer and ...
Source: Comparative Clinical Pathology - July 26, 2023 Category: Pathology Source Type: research
Effects of berberine on pentylenetetrazole-induced seizures during estrus cycle in rats
This study aimed to determine the effects of berberine on pentylenetetrazole-induced seizures during the estrus cycle in rats. A total of 30 adult female Wistar rats were randomly allocated into 5 groups control (saline), valproic acid (75  mg/kg), berberine (10 mg/kg), berberine (20 mg/kg), and berberine (30 mg/kg). Each contains proestrus, estrus, metestrus, and diestrus. Then, each group followed the i.p. administration of saline or vehicle intraperitoneal administration of PTZ (80 mg/kg). Then, initiation time of myoclonic se izures (ITMS), initiation time of tonic–clonic seizures (ITTS), and seizure duration (S...
Source: Comparative Clinical Pathology - July 17, 2023 Category: Pathology Source Type: research
Effect of resistance training on pathological cardiac hypertrophy and FGF23-Klotho axis-induced adverse cardiovascular outcomes in rats with CKD
AbstractPatients with chronic kidney disease (CKD) confront with cardiovascular disease (CVD) complications which can be ameliorated with exercise. The purpose of the current study was to determine the effect of resistance training on pathological cardiac hypertrophy and FGF23-Klotho axis-induced adverse cardiovascular outcomes in rat model of CKD. Thirty male Wistar rats (7 –8 weeks old) were randomly divided into three groups of the 5/6 nephrectomy (5/6NX) with and without resistance training and control group. The resistance training protocol consisted of 3 sessions per week. The proposed blood factors (Klotho, FGF23...
Source: Comparative Clinical Pathology - July 15, 2023 Category: Pathology Source Type: research
Investigation of antilipidemic efficacy of condensed tannins from three varieties of Sorghum bicolor seeds on high-fat diet-induced obese rats
AbstractHigh levels of lipids in the system are a significant illness condition that raises the risk of coronary artery disease as well as a rise in blood pressure; all of which might finally lead to death. Tannins, which are obtained naturally from plants, are widely utilized in the management of diseases related to lipid metabolism and have proven to be safer and potent, while also having less harmful and adverse effects. In the meanwhile, there has been a surge in the acknowledgment of the relevance of dietary tannins in the prevention as well as management of diseases related to lipid metabolism. The aim of this study ...
Source: Comparative Clinical Pathology - July 15, 2023 Category: Pathology Source Type: research
Investigations of biological activities of aqueous extracts of Prosopis africana in rats with chemical-induced oxidative stress
This study conducted phytochemical screening of the plant extract and investigated its antioxidative and hepatoprotective effects in rats with acetaminophen-induced oxidative stress and liver injury. Aqueous extracts ofP. africana extracts were prepared. Phytochemical analysis of the extract was conducted. Wistar rats were pre-treated with or withoutP. africana extracts (50 –200 mg/kg bw) for 10 days prior to acetaminophen intoxication. Levels of thiobarbituric reactive substances, reduced ascorbic acid, catalase activities, enzyme markers of liver function, and erythrocyte levels of cholesterol and phospholipid were m...
Source: Comparative Clinical Pathology - July 5, 2023 Category: Pathology Source Type: research
Correction to: Effects of melatonin on interleukins and heat stress protein responses in donkeys subjected to packing during the hot ‑dry season in the Northern Guinea Savanna zone of Nigeria
(Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - July 5, 2023 Category: Pathology Source Type: research
Ashwagandha root extract ’s phenolic compound counteracts alloxan’s effects on oxidative stress, inflammatory cytokines, and peripheral neuropathy in rats
AbstractDespite advances in understanding the intricate pathophysiological mechanisms underlying peripheral nerve injury, there are still few proven cures. Finding potential alternative therapies is necessary because conventional therapies have associated side effects and poor efficacy. In this regard, a study was conducted that offered substitute therapeutic agents in place of the alloxan injection. The target study pathway after alloxan injection is oxidative stress and inflammatory pathways, according to the study point. It argues that multitarget therapies must be developed to combat inflammation brought on by diabetic...
Source: Comparative Clinical Pathology - June 30, 2023 Category: Pathology Source Type: research
Effects of melatonin on interleukins and heat stress protein responses in donkeys subjected to packing during the hot-dry season in the Northern Guinea Savanna zone of Nigeria
AbstractMelatonin is a hormone secreted from the pineal gland in the suprachiasmatic nuclei of the hypothalamus. Hypothermic effect of melatonin has been reported in working donkeys. It may, thus, exert positive effects on the responses of donkeys exposed to strenuous physical activity. The study was aimed at evaluating the effects of melatonin administration on changes in tumour necrosis factor-alpha (TNF- α), interleukin-10 (IL-10), heat shock protein 70 (HSP70), and sestrin-2 (Sesn2) concentrations in donkeys subjected to packing (load-carrying) during the hot-dry season. Ten male pack donkeys (2–3 years old; 93 Â...
Source: Comparative Clinical Pathology - June 27, 2023 Category: Pathology Source Type: research
High-intensity interval training protects the heart against acute myocardial infarction through SDF-1a, CXCR4 receptors, and c-kit levels
AbstractOne of the best and most effective applied and tolerable approaches for cardioprotection is the regular exercise. In the situation of exercise activity and even cardiac ischemic injury, the activity of the myocardial stem cells and their recruiting factors are changed so that contribute to the adaptation and repairment of the myocardium. The aim of this study was to investigate the effect of myocardial preconditioning with HIIT on SDF-1a myocardial levels, CXCR4 receptors, and c-kit after acute myocardial infarction in male rats. Twenty male Wistar were randomly divided into 4 groups: control (C), training (T), myo...
Source: Comparative Clinical Pathology - June 26, 2023 Category: Pathology Source Type: research
