Medical management of phimosis associated with generalized Sticker ’s sarcoma in an intact mongrel dog
AbstractA 3-year-old intact male mongrel dog was presented to the Referral Veterinary Polyclinic, ICAR-Indian Veterinary Research Institute, Izatnagar, with the history of inappetence, multiple subcutaneous swellings, and haematuria for the past 15  days. The dog had a history of mating with stray dogs, a few months ago. Physical examination revealed normal vital signs and generalized lymphadenopathy along with multiple subcutaneous hard masses of approximately 1–5 cm size was observed all over the body including the eyelids, inner canthus , and prepuce; and swelling on the shaft of the penis was also palpa...
Source: Comparative Clinical Pathology - October 29, 2019 Category: Pathology Source Type: research

Analysis of comments and questions in letters to the editor about nocardiosis
AbstractNocardia spp. are causing various infections in human and animals.Nocardia isolation and identification are hard and need of professional experts and equipped laboratory. Sometimes there are various bugs in the isolation, identification, antibiogram, etc. according to some articles. The purpose of this study is to survey comments and questions in letters to the editor that have been published in the journals about nocardial infections (nocardiosis) in human, and we discussed them in this article. We searched and found fifteen letters to the editor about nocardiosis. Comments and questions were about isolation, iden...
Source: Comparative Clinical Pathology - October 29, 2019 Category: Pathology Source Type: research

Methylene blue protects against pentylenetetrazole-induced seizures, oxidative stress, and neuronal injury
In this study, the effect of acute administration of MethyB on epileptic seizures, brain oxidative stress, and neuronal injury induced in rats by pentylenetetrazole (PTZ) was studied. Rats received repeated intraperitoneal (i.p.) injections of PTZ until the development of status epilepticus and were i.p. treated once with MethyB at doses of 50 or 100  mg/kg, 30 min prior to the first PTZ injection. Results indicated that compared with the PTZ control group, the administration of MethyB at 50 and 100 mg/kg decreased the mean seizure score over the study period by 48.8% and 55.1%, respectively. The development...
Source: Comparative Clinical Pathology - October 25, 2019 Category: Pathology Source Type: research

Protective roles of crude and fractions of A . senegalensise carpel against alloxan-induced hyperglycemia and hyperlipidemia in rats
AbstractMedicinal plants are increasingly been investigated for potentials to provides active, safe and cost-effective alternative to synthetic antidiabetics. In the present study, hypoglycemic and hypolipidemic activities of crude methanol, hexane and ethylacetate fractions ofAnnona senegalensis (A.senegalensis) in alloxan-induced diabetic rats were evaluated. The extract and fractions ofA.senegalensis were administered to alloxan (120  mg/kg bw) induced diabetic rats at doses of 100, 300 and 600 mg/kg bw. Glibenclamide (5 mg/kg bw) was used as the reference drug. All treatments were administered daily for ...
Source: Comparative Clinical Pathology - October 23, 2019 Category: Pathology Source Type: research

Comparative evaluation of xylazine, detomidine, and medetomidine on cardiovascular biomarkers in dromedary camels
This study was performed to comparatively evaluate cardiovascular effects of xylazine, detomidine, and medetomidine after intravenous (IV) administration in dromedary camels. Ten clinically and paraclinically healthy immature male dromedary camels aged 24  ± 2 months and weighing 200 ± 20 kg were used in this study. Camels were sedated with each of three treatments in a randomized, crossover design, with a minimum washout period of 8 days between treatments. Treatments were xylazine (0.4 mg kg−1), detomidine (50  μg kg−1), and medet...
Source: Comparative Clinical Pathology - October 23, 2019 Category: Pathology Source Type: research

Ziziphus jujube protects against cisplatin-induced nephrotoxicity in rats
AbstractAll components ofZiziphus jujube (ZJ) were used in medicine and food in ancient Iran and China. Cisplatin is one of the most important drugs in the treatment of solid tumors. Taking this drug can result in nephrotoxicity through several mechanisms. The purpose of this study was to evaluate the effects of ZJ on the nephrotoxicity induced by cisplatin in rats. Thirty-five experimental rats were randomly divided into the following five groups (n = 7 per group) for an 8-day study: (Wafaa et al. Aust J Basic Appl Sci 5:652-659,2011) group C1 was the control group and received distilled water (1  ml/da...
Source: Comparative Clinical Pathology - October 22, 2019 Category: Pathology Source Type: research

Erythrocyte osmotic fragility and erythrocyte sizes for captive African rock pythons ( Python sebae )
AbstractThe aim of the experiment was to determine the erythrocyte sizes and osmotic fragility index of the African rock python in a transitional zone. Ten African rock pythons (ARPs) were used as experimental animals. Blood samples were obtained from captive ARP by venepuncture of the ventral coccygeal vein. Erythrocyte counts, packed cell volume, mean corpuscular volume and erythrocyte sizes were determined. Erythrocytes obtained from each snake were added into saline solution of different NaCl concentrations of 0.1, 0.3, 0.5, 0.7 and 0.9  g/100 mL, respectively. Erythrocyte osmotic fragility index was determin...
Source: Comparative Clinical Pathology - October 21, 2019 Category: Pathology Source Type: research

Effects of acute experimental Trypanosoma brucei brucei infections on serum super oxide dismutase activities in relations to development of parasitaemia, anaemia and leucopenia in Wistar rats
AbstractThe alterations in serum super oxide dismutase (SOD) enzymes activities in relation to sequential haematological changes were determined to assess the impacts of oxidative stress in Wistar rats experimentally infected withTrypanosoma brucei brucei. Forty adult male rats allocated into infected and control groups, of 20 rats each based on their mean body weight were used. Rats in infected group were administered 1 ml of reconstituted infected blood containing 1 × 106 trypanosomes/ml obtained fromT. b. brucei–infected donor rat. Blood sample in EDTA sample tubes was collected for haematological parameters...
Source: Comparative Clinical Pathology - October 19, 2019 Category: Pathology Source Type: research

Plasma proteins and leukocyte kinetics of turtles ( Podocnemis unifilis (Troschel, 1848)) inoculated with inactivated Escherichia coli
AbstractThe plasma protein fractions and leukocyte response induced by an experimental subcutaneous inoculation ofEscherichia coli isolated and inactivated in turtlesin captivity (Podocnemis unifilis—“tracajá”), were evaluated. The animals were divided into two groups (test group and control) with 10 turtles each. Blood samples from all animals were collected the day before the inoculation and at days 15, 28, 42 and 125 days in both groups. The inoculation ofE. coli did not significantly alter the red blood cell count, but the serial collection of blood led to a mild normochromic macrocytic anemia....
Source: Comparative Clinical Pathology - October 17, 2019 Category: Pathology Source Type: research

Effects of administration of probiotic on body growth and hematobiochemical profile in growing Barki lambs
AbstractThe purpose of this study was to investigate the potential effect of probiotic supplementation on body growth and selected hematobiochemical parameters of growing Barki lambs. For this reason, twenty apparently healthy weaning lambs were randomly allotted into two equal groups (6 each): the first group (control) received a basal diet without any supplement, whereas the 2nd group (supplemented group) received the basal diet supplemented with probiotic (Bacillus subtilis, sorbitol sodium, vitamin B1, and glucose) which was given via drinking water at a dose of 1 g/L/day for 30 consecutive days. A blood sample was col...
Source: Comparative Clinical Pathology - October 16, 2019 Category: Pathology Source Type: research

Optimization of the effectiveness and cytocompatibility of Nigella sativa as a co-treatment for reducing methotrexate-related adverse effects
In this study, in vitro evaluation of anti-tumor and anti-angiogenic activities of NS, MTX, or their mixture in different concentrations using liver hepatocellular carcinoma and endothelial cells were performed. The protective effects of NS on normal hepatic and kidney cells against the risks of MTX treatment was also tested in vitro. Moreover, for in vivo evaluation, male Wistar rats were treated with MTX or a combination of MTX and NS. Hematological and serological, biochemical, functional, and histopathological studies were performed. The results showed that the low concentration of NS enhanced the anti-tumor and anti-a...
Source: Comparative Clinical Pathology - October 14, 2019 Category: Pathology Source Type: research

Effect of aqueous extract of Allium saralicum R.M. Fritsch on fatty liver induced by high-fat diet in Wistar rats
In conclusion, the acquired results showed the hepatoprotective potential of aqueous extract ofA. saralicum, so that it can use for the treatment of fatty liver disease. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - October 1, 2019 Category: Pathology Source Type: research

Histopathological and biochemical effects of aqueous extract of Tragopogon graminifolius on the liver tissues of Wistar rats fed with high-fat diet
In conclusion, the obtained results demonstrated the hepatoprotective effect ofT. graminifolius aqueous extract. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - October 1, 2019 Category: Pathology Source Type: research

Correction to: Impaired epididymal function in Trypanosoma brucei brucei and Trypanosoma congolense infected and treated albino rats
The publisher rephrases the article title of this article to ‘Impaired epididymal function of albino rats infected and treated withTrypanosoma brucei brucei andTrypanosoma congolense’ but the authors prefer the above article title. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - October 1, 2019 Category: Pathology Source Type: research

Comparison of sodium tetradecyl sulfate, bleomycin, and talc powder for rat pleurodesis induction
This study demonstrates the efficacy of STS for induction of pleurodesis in rat; however, further studies should be done for evaluation of its safety and efficacy in human subjects. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - September 4, 2019 Category: Pathology Source Type: research

Haemoprofile of yellow-bellied house gecko, Hemidactylus flaviviridis Ruppell, 1835
AbstractThe study is carried out to investigate the haemogram of yellow-bellied house gecko in Odisha, India. Fifteen adult lizards of each sex were collected from the coastal area of Rajnagar block of Kendrapara, 754 225, Odisha, located in 20 ° 20′ N to 20° 37′ N latitude and 86° 14′ E to 87° 01′ E longitude. One millilitre of blood was collected from the ventral tail vein and transferred into vials containing ethylenediaminetetraacetic acid (EDTA) and then transported in icebox to laboratory. The morphology of blood cells al ong with haematological parameters like haemoglobin (Hb)...
Source: Comparative Clinical Pathology - September 2, 2019 Category: Pathology Source Type: research

Phytochemical screening and toxicity study of aqueous-methanol extract of Ziziphus spina-christi seeds in Wistar albino rats
This study investigated the phytochemical content and toxicity of aqueous-methanol extract ofZ. spina-christi seeds on hepatic and renal tissues of Wistar rats. The extract was screened for the presence of phytochemicals and orally administered to rats at 200, 600 and 1000  mg/kg bwt for 2 weeks. Haematological parameters and markers of the liver and kidney functions were evaluated as well as histoarchitecture. Tannins, saponins, alkaloids, flavonoids, phenols and glycosides were detected in the extract which significantly (P 
Source: Comparative Clinical Pathology - August 29, 2019 Category: Pathology Source Type: research

Resveratrol ameliorates pathophysiological changes associated with Brucella melitensis infection in dexamethasone-treated does
This study aimed at evaluating serological responses, oxidative status, and pathological derangements associated withBrucella melitensis infection in does treated with dexamethasone. Twelve does were divided into 4 groups designated A, B, C, and D with 3 animals each. Groups A and B were ocularly inoculated with 107 CFU ofB. melitensis. From day 21 postinoculation (pi), dexamethasone was administered for 7  days at 2 mg/kg intramuscularly. Group A was further treated with resveratrol for 5 days from day 31 post-B. melitensis inoculation. Group C was inoculated with similar dose ofB. melitensis ocularly ...
Source: Comparative Clinical Pathology - August 29, 2019 Category: Pathology Source Type: research

Anatomo-pathological study of lung lesions in slaughtered sheep at Batna municipal Slaughterhouse (Eastern Algeria)
This study focused on the research of lung lesions in sheep slaughtered in the slaughterhouse of Batna city (Eastern Algeria). The objective of this study was to determine the frequency of lung lesions during the period from March to September 2013. Macroscopic examination was performed at the slaughterhouse to determine lung lesions and to take samples from injured lung areas for microscopic examination of anatomo-pathological lesions. Among 7420 inspected sheep, 2722 had pulmonary lesions (alone or in combination). The overall prevalence of lung affection was 36.68% (2722/7420), which is statistically significant (P 
Source: Comparative Clinical Pathology - August 27, 2019 Category: Pathology Source Type: research

Sex variation in hematological and serum biochemical parameters of cultured Chinese silver carp, Hypophthalmichthys molitrix
AbstractHematological parameters are essential for the evaluation of both physiological and pathological changes developed in fishes due to the involvement of endogenous and exogenous factors. Among the endogenous factors, sex plays a significant role in determining the hematological and serum biochemical parameters of fish. The aim of the present study was to obtain a basic knowledge about the variation in hematological and serum biochemical parameters of cultured silver carp,Hypophthalmichthys molitrix with respect to sex. In order to establish the information, a blood sample was collected from the fishes from March to J...
Source: Comparative Clinical Pathology - August 23, 2019 Category: Pathology Source Type: research

Ameliorative effect of Parinari curatellifolia seed extracts on sodium nitroprusside –induced cardiovascular toxicity in rats
AbstractThe pharmacological potential ofParinari curatellifolia has remained largely unexplored by the scientific community and little information is available to support the folkloric and ethnobotanical uses of the plant. This present study was carried out to investigate the ameliorative effect ofP. curatellifolia seed extracts on sodium nitroprusside (SNP) toxicity on the heart and artery in rats.P. curatellifolia seed crude aqueous-methanolic extract (CMPC) as well as n-hexane (HFPC), dichloromethane (DFPC), ethyl acetate (EFPC), and n-butanolic (BFPC) fractions was prepared and screened for phytoconstituents. In the in...
Source: Comparative Clinical Pathology - August 22, 2019 Category: Pathology Source Type: research

Haematology of southern bent-winged bats ( Miniopterus orianae bassanii ) from the Naracoorte Caves National Park, South Australia
This study highlights the importance of generating species-specific reference ranges as extrapolating from even closely related species can lead to errors in interpretation. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - August 21, 2019 Category: Pathology Source Type: research

Brachial plexus block as a part of balanced anesthesia in a jungle cat ( Felis chaus ) undergoing forelimb orthopedic surgery
AbstractAn adult male jungle cat (Felis chaus) weighing 6  kg with the history of inability to bearing weight on its left forelimb was presented. Physical examination and radiography revealed transverse radio-ulna fracture and carpal subluxation. Internal fixation with plate was chosen for treatment. On the day of surgery, anesthesia was induced with intr amuscular ketamine (10 mg/kg) and midazolam (0.3 mg/kg). Brachial plexus block (BPB) was performed using lidocaine (3 mg/kg) and bupivacaine (0.75 mg/kg) mixture guided by an electrical nerve stimulator. During the surgery, anesthesia was maintain...
Source: Comparative Clinical Pathology - August 19, 2019 Category: Pathology Source Type: research

Hyperhomocysteinemia and increased risk of coronary artery disease in Iranian patients with diabetes mellitus type II: a cross-sectional study
This study investigated the relationship between hyperhomocysteinemia and coronary heart disease in patients with type 2 diabetes. This study was a hospital-based cross-sectional study performed on 100 diabetic patients with indications of coronary artery angiography. After the measurement of serum HbA1c and homocysteine, the patients went through coronary angiography and, based on the results, were divided into two groups of normal and obstructed coronary arteries. Serum homocysteine and other related risk factors were further compared between the two groups. The mean serum homocysteine of patients was 13.18  &plus...
Source: Comparative Clinical Pathology - August 17, 2019 Category: Pathology Source Type: research

The protective role of l -carnitine against 1st- and 2nd-generation antihistamine-induced liver injury in mice
In conclusion, oxidative stress can be a possible explanation of hepatic damage induced by chronic therapy with chlorpheniramine maleate and cetirizine hydrochloride.l-Carnitine has prominent hepatoprotective effects on chlorpheniramine maleate – and cetirizine hydrochloride–induced hepatic damage possibly through improvement of hepatic function and decreasing oxidative stress. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - August 14, 2019 Category: Pathology Source Type: research

Effect of sex on biochemical, cytomorphometrical and haematological parameters of mallard duck, Anas platyrhynchos (Linnaeus, 1758)
This study was based upon biochemical, cytomorphometrical and haematological analysis of different blood cells of the duck with respect to sex. Blood of the bird was collected from its metatarsal vein, kept in EDTA for haematological test and the smear was prepared immediately after the blood was obtained for morphometrical analysis. For biochemical test, blood was kept in EDTA containing fluoride and left it for 2 –3 h and centrifuged. Plasma chemistry for the glucose, cholesterol, TPP, albumin and globulin was determined. The result of biochemical test differs significantly atP ≤ 0.05. The cel...
Source: Comparative Clinical Pathology - August 13, 2019 Category: Pathology Source Type: research

Ameliorative effects of Mentha aquatica on diabetic and nephroprotective potential activities in STZ-induced renal injury
This study was hypothesized to evaluate the antidiabetic and nephroprotective activities ofMentha aquatica in streptozotocin (STZ)-induced diabetic rats. Diabetes was induced by a single intraperitoneal injection of STZ at a dosage of 40  mg/kg bw. At the end of the study, overnight-fasted rats were dissected, and the blood and kidney samples were analyzed for biochemical and histopathological analysis. Oral administration of aqueous extract of leaves ofMentha aquatica (AELMA) at a dose of 100  mg/kg bw/day for 90 days significantly decreased the level of fasting blood glucose, HbA1c, TC, TG, plasm...
Source: Comparative Clinical Pathology - August 13, 2019 Category: Pathology Source Type: research

Immunohematological parameters of rainbow trout ( Oncorhynchus mykiss ) fed supplemented diet with different forms of barberry root ( Berberis vulgaris )
AbstractIn this experiment, the effect of barberry root powder and methanol extract on the growth and immunohematological parameters of rainbow trout (Oncorhynchus mykiss) was studied. A total of 306 rainbow trout fingerlings (15.55  ± 0.76 g) were fed for 8 weeks with six experimental diets: control (C), BRP10 (10 g kg−1 of barberry root powder), BRP20 (20  g kg−1 of barberry root powder), BRE250 (250  mg kg−1 of barberry root extract), BRE500 (500  mg kg−1 of barberry root extract), and oxytetracycline OTC30 (30  g kg...
Source: Comparative Clinical Pathology - August 13, 2019 Category: Pathology Source Type: research

Anaplasma ovis infection in goat flocks around Gaborone, Botswana
AbstractAnaplasma is a genus of gram-negative, intracellular bacteria infecting different blood cells in animals.A.ovis infects erythrocytes of sheep and goats, inducing clinical signs that include haemolytic anaemia, icterus and loss of production. Aim of this study was to evaluate the prevalence ofAnaplasma spp. in goats in smallholder flocks around Gaborone, Botswana. Whole blood and serum samples were collected from 100 goats coming from 10 smallholder goat flocks from three villages around Gaborone, Botswana. Body condition and FAMACHA © scores were estimated. Blood was used for packed cell volume (PCV), blood sm...
Source: Comparative Clinical Pathology - August 13, 2019 Category: Pathology Source Type: research

Report on antemortem diagnosis of sarcocystosis in a buffalo
AbstractSarcocystosis is one of the zoonotic parasitic diseases noticed in different species of animals. The diagnosis is difficult because of the long latency between infection and manifestation of a disease. Fourteen years old buffalo was referred to the hospital with a history of anorexia, diarrhea, cough, and chronic emaciation. Clinical examination revealed mild tympany and enlarged lymph nodes. Ultrasonography of the thorax revealed anechoic structures surrounding the heart along with the hyper echoic structures. Thoracic fluid was collected by the thoracocentesis and microscopic examination of the fluid revealed pre...
Source: Comparative Clinical Pathology - August 13, 2019 Category: Pathology Source Type: research

Evaluation of time and temperature storage in platelet counts in blood samples of dogs
AbstractThe reliability of platelet counts obtained by different methods following different storage times/conditions is not well defined. The aim was to evaluate temporal changes in platelet count of canine blood samples submitted to two thermal storage conditions using three techniques of platelet counting. Blood samples were obtained from 40 dogs aged between 6  months and 12 years. Blood samples were collected by jugular venipuncture, separated into two aliquots, and stored in EDTA tubes: one kept at room temperature (RT group) and the other kept under refrigeration (RE group). The platelet count was performe...
Source: Comparative Clinical Pathology - August 10, 2019 Category: Pathology Source Type: research

Melatonin synergistically enhances protective effect of atorvastatin against busulfan-induced spermatogenesis injuries in a rat model
In conclusion, the results of the present study indicated that co-administration of melatonin and atorvastatin an d monotherapy can attenuate busulfan-induced spermatogenesis injuries in rats via reducing oxidative stress. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - August 10, 2019 Category: Pathology Source Type: research

Hematology, plasma biochemistry, and hormonal analysis of captive Louisiana pine snakes ( Pituophis ruthveni ): effects of intrinsic factors and analytical methodology
This study is the first to provide baseline information on blood analytes in endangered LPS, which will be useful for individual animals in managed care and as baseline for future population-level assessments. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - August 9, 2019 Category: Pathology Source Type: research

Verapamil caused biochemical alteration, DNA damage, and expression of hepatic stress-related gene biomarkers in Nile tilapia, Oreochromis niloticus
AbstractImpacts of long-term exposure to sub-lethal verapamil (VRP) at 0.14, 0.28, and 0.57  mg L−1 were examined for 60  days to find the effects on activities of metabolic catalysts as well as molecular reactions in Nile tilapia. Alanine aminotransferase, aspartate aminotransferase, and lactate dehydrogenase activities in the liver increased significantly (p 
Source: Comparative Clinical Pathology - August 7, 2019 Category: Pathology Source Type: research

Clinical management of cutaneous hemangiosarcoma in canines: a review of five cases
AbstractHemangiosarcoma is a type of malignant vascular tumour that commonly affects the canines and has a very poor prognosis. Five dogs affected with cutaneous hemangiosarcoma were presented to Referral Veterinary Polyclinic, Indian Veterinary Research Institute, Izatnagar, over a 6-month period. All of the cases were subjected to thoracic radiography and intra-abdominal ultrasonography to rule out metastasis. The tumour mass was surgically excised in all the five animals. The cases were diagnosed as hemangiosarcoma on the basis of histopathology and immunohistochemistry. Two of the animals received chemotherapy using ei...
Source: Comparative Clinical Pathology - August 6, 2019 Category: Pathology Source Type: research

In silico molecular modeling and docking studies on the Leishmania mitochondrial iron transporter-1 (LMIT1)
AbstractLeishmania mitochondrial iron transporter-1 (LMIT1) is a transmembrane protein required for normal mitochondrial structure and function. This protein is essential for the replication, survival, virulence, and the differentiation of promastigotes into infective amastigotes. Regarding the important role of LMIT1 in the iron-regulated process inLeishmania parasites, it can be considered as a promising target for structure-based drug design against leishmaniasis. In the present study, the three-dimensional (3D) structure of LMIT1 was determined by various in silico modeling approaches. The quality of the built models w...
Source: Comparative Clinical Pathology - August 6, 2019 Category: Pathology Source Type: research

Evaluation of induced spawning on oocyte characteristics and serum biochemistry of African catfish ( Clarias gariepinus )
AbstractThe effects of induced spawning using salmon gonadotropin-releasing hormone analogue (GnRHa) and domperidone proprietary drug (ovaprim) injected (0.4  ml/kg) intramuscularly on oocyte characteristics, sex hormones, thyroid hormones, and serum biochemical response were evaluated at 0, 12, 24, and 36 h post-induction. Twenty-eight 8 months old femaleClarias gariepinus were used. At the designated hour, 7 of these fish were randomly selected for sampling. The response to the induction of spawning using ovaprim was time-dependent. The onset of response was observed from 12  h for increase in GSI, oocyte ...
Source: Comparative Clinical Pathology - August 6, 2019 Category: Pathology Source Type: research

Morphometric study of red blood cells in non-descriptive cattle with respect to age and sex
AbstractThe present study was conducted to investigate the influence of age (calf, young and adult) and sex (female and castrated male) on the morphometry (mean length and mean breadth) of red blood cells (RBCs) of non-descriptive cattle. Blood samples were collected from each non-descriptive cattle with respect to age and sex by jugular venipuncture and collected in EDTA vials. Then, blood smears were prepared on grease-free microscopic slides then air-dried, fixed on methanol, and stained with Giemsa stain for morphometric study. The morphometric study was done with the help of the ocular micrometer and stage micrometer ...
Source: Comparative Clinical Pathology - August 6, 2019 Category: Pathology Source Type: research

Diagnostic accuracy of milk oxidation markers for detection of subclinical mastitis in early lactation dairy cows
The objective of the present study was to evaluate the diagnostic value of milk oxidative stress variables in early lactation of dairy cow with subclinical mastitis. A total of 925 milk samples from quarters of cows during (7  ± 3) days post-calving from two dairy herds were included in the present study. Bacterial culture, somatic cell count (SCC), DTNB (dithiobis nitrobenzoic acid for oxidative capacity), and FRAP (ferric reducing antioxidant power for antioxidatant capacity) have been assayed. Receiver-operating characteristic (ROC) analysis was used to assess the accuracy diagnostic value of e...
Source: Comparative Clinical Pathology - August 5, 2019 Category: Pathology Source Type: research

Inorganic nanoparticles restrict viability of metastatic breast cancer cells in vitro
In this study, we comparatively determined the in vitro anti-cancer potential of inorganic nanoparticles (NPs) in MDA-MB-231 cancer cells. Flow cytometry, confocal microscopy, and reactive oxygen species (ROS) assays were employed to probe likely mechanism of anti-cancer action of NPs. Study demonstrated dose-dependent toxicity of NPs to MDA-MB-231 cells. The NPs promoted production of ROS and might have caused early apoptotic clearance of MDA-MB-231 cells. Considered together, the findings support anti-cancer potential of inorganic NPs. Furthermore, preliminary evidence suggests that the anti-cancer potential of these NPs...
Source: Comparative Clinical Pathology - July 11, 2019 Category: Pathology Source Type: research

Prevalence of diabetes mellitus and reference values for the fasting blood glucose levels of locally available breeds of dogs in Warri, Nigeria
This study evaluated the FBGL of dogs presented for veterinary care in Warri, Nigeria, determined the prevalence of DM in the dog population, and also established reference values for the FBGL of dog breeds. A cross-sectional survey of FBGL of dogs presented for veterinary care in Warri, Nigeria, from January to December 2015 was done in five veterinary hospitals/clinics. The FBGL was measured using a glucometer, and diagnosis of DM was based on the WHO criteria as modified for dogs. A total of 2750 dogs were evaluated, and 6 (0.22%) of them were diabetic. The prevalence of DM in the dogs was significantly (p 
Source: Comparative Clinical Pathology - July 11, 2019 Category: Pathology Source Type: research

Use of the turbidimetric method for determining hemoglobin (A1C) in diabetic and nondiabetic dogs
AbstractCanine diabetes mellitus is a multifactorial disease with a worldwide prevalence of 0.005 to 1.5%, affecting dogs between 4 and 14  years of age, males and females. Persistent fasting hyperglycemia and glycosuria confirm the diagnosis, and glycated hemoglobin (A1C) is an efficient biomarker for the risk of complications and monitoring. The scarcity of unvalidated reference values and commercial kits justifies its low applicati on in veterinary medicine. The aim of this study was to identify A1C as a diagnostic biomarker of diabetes mellitus in dogs through immunoturbidimetry assay and to propose an A1C referen...
Source: Comparative Clinical Pathology - July 11, 2019 Category: Pathology Source Type: research

Evaluation of cutaneous wound healing activity of Ocimum basilicum aqueous extract ointment in rats
In conclusion, the acquired findings showed the cut aneous wound healing property ofO. basilicum aqueous extract ointment. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - July 4, 2019 Category: Pathology Source Type: research

Biochemical, histopathological, and pharmacological evaluations of cutaneous wound healing properties of Quercus brantii ethanolic extract ointment in male rats
In conclusion, the acquired findings showed the cutaneous wound healing potential ofQ. brantii ethanolic extract ointment. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - June 29, 2019 Category: Pathology Source Type: research

Ameliorative property of Kigelia africana crude and flavonoid leaf extracts on aluminum-induced hepatotoxicity in albino rats
This study investigated the protective property ofKigelia africana crude leaf extract (KAE) and its flavonoid-rich fraction (FKAE) on AlCl3-induced hepatotoxicity in rats. Forty-two adult male Sprague Dawley rats were divided into seven groups (n = 6). Animals in the negative control group received tap water orally. The hepatotoxic group received 17 mg/kg AlCl3 daily, for four consecutive weeks. Positive control group received rivastigmine (0.3  mg/kg/day), while groups 4 and 5 received 50 and 100 mg/kg KAE, respectively, daily for 2 weeks followed by combination of KAE treatment with AlCl...
Source: Comparative Clinical Pathology - June 28, 2019 Category: Pathology Source Type: research

Healing and cytotoxicity potentials of ointment containing aqueous extract of Anethum graveolens on cutaneous wounds in male rats
In conclusion, the present study showed that the application ofA. graveolens extract on wounds induces considerable wound contraction and accelerates healing, and it may be suggested for treating different types of wounds in animals and human beings. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - June 28, 2019 Category: Pathology Source Type: research

Diminazene aceturate experimental repeat treatments in albino rats: efficacy and clinico-pathologic considerations
AbstractTo determine the clinico-pathologic effects, safety and efficacy of diminazene aceturate repeat treatments, thirty adult albino rats were randomly assigned into six groups (A –F) of five rats each. Groups A–D were infected with 1.0 × 106 trypanosomes, while groups E and F served as uninfected controls. Groups A –E were treated once with 7 mg/kg Dinazene® on day 11 post-infection. Treatments were repeated once, twice and thrice in groups B–D respectively at 7 days interval. The serum levels of alanine aminotransferase, aspartate aminotransferase, alkaline pho...
Source: Comparative Clinical Pathology - June 28, 2019 Category: Pathology Source Type: research

Correction to: Comparative hypolipidaemic effects of crude seed powder, aqueous and methanolic seed extracts of Buchholzia coriacea in carbon tetrachloride-induced toxicity in albino rats ( Rattus norvegicus )
The given name and family name of the authors of the original publication of this article were inversed. Correct presentation of the author names are presented here. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - June 25, 2019 Category: Pathology Source Type: research

The effect of crocin on apoptotic, inflammatory, BDNF, Pt, and A β40 indicators and neuronal density of CA1, CA2, and CA3 regions of hippocampus in the model of Alzheimer suffering rats induced with trimethyltin chloride
AbstractAlzheimer disease (AD) is one of the most prevalent progressive neurodegenerative diseases of the central nervous system. Regarding the anti-oxidant and neuroprotective effects of crocin, this research was conducted to determine the effect of crocin on apoptotic, inflammatory, brain-derived neurotrophic factor (BDNF), phospho tau protein (Pt), and A β40 (Amyloid beta40) indicators and neuronal density in CA1, CA2, and CA3 regions in hippocampus in the model of Alzheimer suffering rats. In this experimental study, 56 male rats were divided into 4 equal groups (14 rats in each group). Control group: model of Alz...
Source: Comparative Clinical Pathology - June 25, 2019 Category: Pathology Source Type: research

Effect of storage time on transforming growth factor beta 1 and vascular endothelial growth factor subunit A concentration in canine platelet-rich fibrin
AbstractPlatelet-rich fibrin (PRF) has gained more interests as an alternative modality for periodontal therapy due to its anti-inflammatory effect from platelet cytokines embedded in fibrin network. One of the factors that affect efficacy of PRF is the concentration of the incorporated cytokines. However, there is inadequate information regarding PRF preservation. Thus, this study was conducted to build on the knowledge in canine study regarding cytokine concentration and also the effect of storage condition. Transforming growth factor beta 1 (TGF- β1) and vascular endothelial growth factor subunit A (VEGF-A) in cani...
Source: Comparative Clinical Pathology - June 24, 2019 Category: Pathology Source Type: research