Ultrastructural changes on fertile and infertile hydatid cysts induced by conventional and solid lipid nanoparticles of albendazole and albendazole sulfoxide
AbstractCystic echinococcosis (CE), a serious public health problem worldwide, is caused by the larval stage ofEchinococcus granulosus (E. granulosus). Despite recent progress in the CE medical treatment, this subject still remains as a priority of research. Albendazole (ABZ) is a drug of choice for the treatment of hydatidosis. Its use as an antiparasitic agent with the most efficacy is limited by the lack of water solubility. Therefore, the aim of the present study was to compare in vitro efficacy of free and solid lipid nanoparticles (SLNs) of ABZ and albendazole sulfoxide (ABZSO) against fertile and infertile hydatid c...
Source: Comparative Clinical Pathology - February 21, 2019 Category: Pathology Source Type: research

Hematological and serum biochemical parameters of five freshwater snow trout fish species from river Jhelum of Kashmir Himalaya, India
AbstractFish blood is a pathophysiological indicator of the whole body function and is thus considered as an important tool in diagnosing the structural and functional status of fish. However, the blood parameters vary between species to species and it mainly depends upon the favorable environmental conditions where the species live. The purpose of the current study is to evaluate the hematological and serum biochemical indices of fiveSchizothorax species:Schizothorax labiatus,S. plagiostomus, S. esocinus,S. curvifrons andS. niger in order to establish the resemblances and variations between theseSchizothorax species which...
Source: Comparative Clinical Pathology - February 19, 2019 Category: Pathology Source Type: research

BOX-PCR fingerprinting for molecular typing of Salmonella enterica subsp. enterica serovar Enteritidis strains originated from humans, dairy cattle, and broiler chickens
AbstractSalmonellosis is a global zoonotic infection of domestic animals and poultry with serious consequences on public health. Globally one of the most prevalent and commonSalmonella enterica serotypes is serovar Enteritidis. Our goal in this research was a molecular characterization and evaluation of biodiversity and relatedness of different Salmonella isolates. Sixty-four Salmonella Enteritidis isolates which were gathered and cultured from various hosts and locations including dairy cows, broiler chicken, and patients with diarrhea of Tehran and Kerman provinces were typed by BOX-PCR assay. Dendrograms were produced b...
Source: Comparative Clinical Pathology - February 18, 2019 Category: Pathology Source Type: research

Influence of stanozolol administration together with resistance training on thyroid and some steroid hormones in male rats
AbstractAbuse of anabolic –androgenic steroids (AASs) can lead to numerous detrimental health effects on body systems. With the increased self-administration of these steroids during the last decades, endocrine modifications and hormonal alterations associated with them have become an important clinical issue. The purpose of this research was to study the influence of 8-week injections of different doses of stanozolol (ST) along with resistance training (RT) on the levels of thyroid and some steroid hormones. Twenty-four male Wistar rats were divided into four groups, equally: group 1, untrained + norma...
Source: Comparative Clinical Pathology - February 15, 2019 Category: Pathology Source Type: research

Gallic acid reduces inflammatory cytokines and markers of oxidative damage in a rat model of estradiol-induced polycystic ovary
AbstractHormonal disorders, oxidative stress, and inflammation in ovarian tissue cause ovulation failure in women with polycystic ovary syndrome. Considering the antioxidant properties of gallic acid (GA), the aim of this study was to investigate the effect of GA on pro-inflammatory cytokines, antioxidant enzyme activity, and DNA oxidative damage of ovarian tissue in a rat model of estradiol-induced polycystic ovary (PCO). In this experimental study, 32 female Wistar rats were divided into four groups. These included control (saline solution, orally), PCO+saline (estradiol valerate + saline solution, orally), PCO+GA50, and...
Source: Comparative Clinical Pathology - February 15, 2019 Category: Pathology Source Type: research

Pathology, isolation and characterisation of virulent and diverse Mannheimia haemolytica and Pasteurella multocida associated with fatal pneumonia in sheep, Rajasthan, India
AbstractPneumonia, a major sheep disease, causes high mortality among affected animals predominantly the lambs. It is caused by a number of microbes includingMannheimia haemolytica/Pasteurella multocida. It was aimed to explore the pathology in the lungs due to pneumonia, and to isolate and characterise the virulentM. haemolytica/P. multocida strains. The lung tissues and heart blood specimens were collected by necropsy of sheep (n = 96). These samples were used for isolation and characterisation ofM. haemolytica/P. multocida. Moreover, the fresh and square-shaped lung pieces were also taken to perform the hi...
Source: Comparative Clinical Pathology - February 15, 2019 Category: Pathology Source Type: research

Comparison of the diagnostic accuracy of markers of the acute phase of inflammation in cats. A preliminary evaluation
AbstractMarkers of acute inflammation are gaining broader acceptance in feline veterinary practice but the criteria of their diagnostic accuracy have mostly not been determined. The goal of this study was to compare the diagnostic accuracy of a variety of markers of inflammation that can be rapidly measured in everyday veterinary practice settings. White blood cell, as well as neutrophil and band cell count, degree of toxic neutrophilia, total proteins, albumin, albumin-to-globulin ratio, fibrinogen, and serum amyloid A protein were measured in 35 cats with acute inflammatory diseases and 16 control cats. The sensitivity, ...
Source: Comparative Clinical Pathology - February 9, 2019 Category: Pathology Source Type: research

Phylogenetic typing and virulence gene profile of pathogenic and commensal avian Escherichia coli in Iran: a notable finding
AbstractThe aim of this study was to compare phylogenic groups and virulence genes profiles ofEscherichia coli isolated from poultry suffering from Colibacillosis withE.coli in the intestinal flora of healthy poultry. For this purpose,var,tsh,iucd,papc,irp2, andiss virulence genes ofE. coli were investigated by multiplex PCR in 70 isolates (35 obtained from healthy samples and the other 35 isolated were attained form those with Colibacillosis) in Ardabil province, northwest of Iran. The phylogenic groups were also determined through use of PCR multiplex. Among them, 32 isolates (91%) of samples taken from poultry with Coli...
Source: Comparative Clinical Pathology - February 8, 2019 Category: Pathology Source Type: research

Multicentric intrahepatic cholangiocellular carcinoma in a budgerigar ( Melopsittacus undulatus ): a case report
AbstractCholangiocarcinoma or intrahepatic bile duct carcinoma is a malignant neoplasm of biliary epithelium which occurs mainly in wild animals rather than domestic ones. An adult 4-year-old male budgerigar was referred with symptoms of lethargy, decreased activity, and vomiting with undigested food in feces. Supportive care was tried for 3  months, but the bird did not show any signs of recovery and was finally euthanized. Necropsy revealed hepatomegaly in one lobe of the liver while the other lobe was dwindled. The remaining large lobe had a multinodular appearance with white to gray, non-umbilicated foci ranging f...
Source: Comparative Clinical Pathology - February 7, 2019 Category: Pathology Source Type: research

Histomorphogenesis on hindbrain in Huso huso ( Beluga sturgeon ) larvae
This study has been done on evolution and morphology of hindbrain structure, during larvae life from 1 to 54 dph onHuso huso. It was concentrated on significant cerebellum and medulla oblongata. The cerebellum occupied the rostral part of dorsal wall of fourth ventricle. The fourth ventricle was visible on 1  day old and by aging was majorly. The fourth ventricle lied on the caudally and continued into central canal (cc) in spinal cord. Cortex of cerebellum had three layers, which were visible from 6 days old. Granular layer of corpus cerebelli, eminentia granularis, and less valvula cerebelli contain ed Golgi ty...
Source: Comparative Clinical Pathology - February 7, 2019 Category: Pathology Source Type: research

Antidiabetic efficacies of methanolic and ethyl acetate extracts of Aristolochia ringens (Vahl) roots: in vivo comparative studies
AbstractAntidiabetic effects of methanol and ethyl acetate extracts of roots ofAristolochia ringens (Vahl) were comparatively assessed in streptozotocin (STZ)-induced rats. Pulverized root ofA. ringens was soaked with methanol, filtered, and concentrated to dryness. The resulting residue was subsequently dissolved in ethyl acetate, filtered, and concentrated to dryness to obtain ethyl acetate extract. Methanol and ethyl acetate extracts ofA. ringens root yielded 20.50  g (10.25%) and 16.4 g (8.2%) respectively. Both extracts (150 mg/kg bw) and metformin (14.2 mg/kg bw) used as reference were administere...
Source: Comparative Clinical Pathology - February 5, 2019 Category: Pathology Source Type: research

Evaluation of the serum fructosamine concentrations in transition period and its relationship with serum proteins and energy characteristics in dairy cows
AbstractThe relationship between fructosamine (FRUC) and glucose (GLU) amounts in dog was previously reported. On the other hand, no correlations were reported in transition dairy cow and late-pregnant sheep. Similar controversy also existed concerning the relationship between FRUC, albumin (ALB), and total protein (TP) concentrations. Thirty-three healthy Holstein cows were enrolled in to the study. Blood samples were obtained by jugular venipuncture at 3 and 1  weeks before and 1 and 3 weeks after calving. The concentrations of FRUC, GLU, ALB, TP, β hydroxybutyrate (BHBA), and non-esterified fatty acids (N...
Source: Comparative Clinical Pathology - February 4, 2019 Category: Pathology Source Type: research

Clinicopathological and mineral changes associated with dogs infested with Sarcoptes scabiei var. canis
AbstractThe clinicopathological features including mineral level of dogs infested withSarcoptes scabiei var.canis were evaluated to understand the pathogenesis of infestation in order to propose an effective treatment plan. Twenty healthy dogs were recruited for the study and were divided into two groups after environmental adjustments. Group A dogs were scabies free while group B dogs were housed with scabies infested dogs. The PCV, HB, RBC, WBC, platelets, lymphocytes, neutrophils, monocytes, eosinophils, TP, albumin, globulin, ALT, AST, ALP, creatinine, BUN, and glucose levels were examined for 6  weeks following e...
Source: Comparative Clinical Pathology - February 4, 2019 Category: Pathology Source Type: research

Oxidative stress and toxicity effect of Echium amoenum on mice brain
In this study, 40 mice were chosen and divided into four groups. Group (1) as control group (without injection), group (2) received 12.5  mg/kg, group (3) received 25 mg/kg, and group (4) received 50 mg/kg body weight plant.Boraginaceae was injected into mice for a month by intraperitoneal injection (i.p). Then, the mice were decapitated and brains were collected to evaluate oxidative stress. The level of lipid oxidation was significant in all groups except among high dose in comparison with control groups, and low with the intermediate dose. Changes in ion-reducing antioxidant capacity assay (CUPRAC) were n...
Source: Comparative Clinical Pathology - February 4, 2019 Category: Pathology Source Type: research

Effect of zinc on erythrocyte osmotic fragility and hemogram following chronic exposure to glyphosate-based herbicide in Wistar rats
AbstractThe study was conducted to assess the effect of zinc on erythrocyte osmotic fragility and hemogram of rats following chronic oral exposure to glyphosate-based herbicide (BUSHFIRE ®) at daily doses of 14.4–750 mg/kg of glyphosate. The erythrocyte osmotic fragility, estimated as percentage hemolysis in hypotonic saline, was significantly (p 
Source: Comparative Clinical Pathology - February 4, 2019 Category: Pathology Source Type: research

Trichostatin A (TSA) levels in response to treatment of rainbow trout with gamma-irradiated trophonts against Ichthyophthirius multifiliis
In this study, TSA levels induced by gamma-irradiated trophonts and alginate/calcium phosphate nanoparticles were measured after 30  days following treatment againstI.multifiliis in spleen, kidney, and liver tissues of rainbow trout. This sounds like TSA is an anti-parasitic enzyme that can increase in spleen, kidney, and liver tissues following treatment of rainbow trout againstI.multifiliis (P 
Source: Comparative Clinical Pathology - February 2, 2019 Category: Pathology Source Type: research

Combined effects of dietary bovine lactoferrin, Lactobacillus plantarum , and xylooligosaccharide on hemato-immunological and digestive enzymes of silvery-black porgy ( Sparidentex hasta ) fingerlings
AbstractA 6-week study was conducted to evaluate the effects of the following eight experimental diets, which varied in bovine lactoferrin (LF), xylooligosacharide (XOS), andLactobacillus plantarum (LP) as probiotic silvery-black porgy (Sparidentex hasta) juveniles including control (diet 1), 400  mg kg−1 LF + 5  g kg−1 XOS (diet 2), 400  mg kg−1 LF + 10  g kg−1 XOS (diet 3), 400  mg kg−1 LF + 1  × 106 CFU g−1 LP (diet 4), 800  mg kg−1 LF + 5  g kg−1 XOS (diet 5), 800  mg&...
Source: Comparative Clinical Pathology - February 2, 2019 Category: Pathology Source Type: research

Idiopathic nodular panniculitis of an exceptionally large size in a German Shepherd dog: a case report
AbstractAn unusual occurrence of idiopathic nodular panniculitis of an extremely large size was recognised in a German Shepherd dog. The dog was presented with a large subcutaneous nodule at the latero-ventral aspect of the abdomen on the left side of the animal. The lesion grossly appeared as a large tissue mass resembling some kind of adipose tissue tumour such as lipoma or liposarcoma. However, the histologic appearance of the tissue mass was indicative of nodular panniculitis as reflected by diffuse cellular inflammatory reaction on a wide area of adipose tissue. The cellular infiltrate was mainly dominated by lymphocy...
Source: Comparative Clinical Pathology - February 1, 2019 Category: Pathology Source Type: research

Adenosine deaminase behavior in experimental infection by Brucella ovis and its participation in the modulation of the inflammatory response
The objective of this study was to evaluate the activity of adenosine deaminase (ADA) and its participation in the modulation of the inflammatory responses of mice experimentally infected withB. ovis. We used 48 animals, divided in two groups: group A (control) and group B (infected). We evaluated ADA activity and C-reactive protein (CRP) concentrations at four time points (days 7, 15, 30, and 60) post-infection (PI). There was a reduction in ADA activity in the acute phase (day 15 PI), followed by elevation when the infection became chronic (days 30 and 60 PI). Serum C-reactive protein levels were higher in infected anima...
Source: Comparative Clinical Pathology - February 1, 2019 Category: Pathology Source Type: research

Trans-scrotal ultrasonography evaluation of the cross-bred Ongole bulls
In conclusion, trans-scrotal ultrasonography is helpful in the differential diagnosis of the scrotal swells in large animals. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - February 1, 2019 Category: Pathology Source Type: research

Diabetes upregulates the expression of HSP90 and downregulates HSP70 in the liver of diabetic rats
The objectives of the present study were to investigate the expression of Hsp90 and Hsp70 in the liver of diabetic rats and to compare it with the liver of control rats. A diabetic model was conducted using alloxan monohydrate (150  mg/kg). Immuno-histochemical staining for HSP70 and HSP90 was carried out using indirect immune-peroxidase protocol. Results showed that the expression of HSP90 in diabetic group was significantly upregulated compared with control group (p = 0.008), while the expression of HSP70 was downregulated in diabetic liver compared with control group (p = 0.000). Further...
Source: Comparative Clinical Pathology - February 1, 2019 Category: Pathology Source Type: research

Effect of Crotalaria lachnosema Stapf . (Fabaceae) extract on biomarkers of hepatic and renal function and oxidative stress in male Wistar rats
AbstractThe aim of this study was to determine the subchronic effect ofCrotalaria lachnosema Stapf. (Fabaceae) extract (MLECL) on biochemical and oxidative stress biomarkers in male Wistar rats. The rats were assigned into four groups designated as groups 1(control), 2, 3, and 4, of ten rats each, and were exposed to dose levels of 0, 40, 200, and 1000  mg of MLECL extract per kilogram in feed, respectively, for a period of 6 weeks. At the end of the study period, the surviving rats were sacrificed and blood was collected from each rat via jugular venesection and used for biochemical analysis. Postmortem examinat...
Source: Comparative Clinical Pathology - February 1, 2019 Category: Pathology Source Type: research

The effects of different doses of onion ( Allium cepa. L) extract on leptin, ghrelin, total antioxidant capacity, and performance of suckling lambs
In conclusion, it could be said that onion extract has a promising effect as a feed additive in ruminant nutrition and has the ability to improve feed intake in these animals. Moreover, onion extract has a positive effect on concentrations of leptin, ghr elin, TAC, and the performance in lambs. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - February 1, 2019 Category: Pathology Source Type: research

Light and scanning electron microscopic study of the tongue in the guinea fowl ( Numida meleagris )
AbstractConsidering that, in birds, the tongue has an important role in taking food, so its shape and morphology are affected by the nutrition method and the environment of the animal. For this study, six adult female guinea fowl were prepared and, after slaughtering them humanely, their tongues were completely removed from the oral cavity and were completely washed with distilled water. After examining the morphology and measuring the tongue area, the tissue preparation stages were used for light and electron microscopes on each case. Morphological results showed that the tongue of the guinea fowl was triangular-shaped an...
Source: Comparative Clinical Pathology - January 28, 2019 Category: Pathology Source Type: research

Medical management of conjunctivitis and shell rot in a red-eared slider ( Trachemys scripta elegans )
AbstractConjunctivitis and shell rot in a red-eared slider and its successful clinical management are described. The red-eared slider was presented to Veterinary Polyclinic Mannarkkad with swollen eyes and white patches on the carapace. The turtle was treated with enrofloxacin bath for 7  days. Superficial lesions on the carapace were treated by application of chlorhexidine gel. Three percent boric acid was used for washing the eye. Vitamin A was administered orally. Several managemental changes ware also made to hasten the recovery. After 1 week of treatment, improvement in the c ondition of eye was observed. Wi...
Source: Comparative Clinical Pathology - January 26, 2019 Category: Pathology Source Type: research

Vitamin D supplementation enhanced oral glucose tolerance in normoglycemic rats and insulin sensitivity in rats fed high fat emulsion
AbstractSeveral reports have suggested possible role of vitamin D deficiency in the pathogenesis of both type 1 and 2 diabetes. However, there is no agreement on the level of vitamin D requirement for optimum glycemic control. This work evaluated the effect of vitamin D supplementation on oral glucose tolerance (OGT) and insulin sensitivity, with the aim of determining the possible supplementation rate of vitamin D required for optimum glycemic control. Oral glucose tolerance was evaluated in normoglycemic rats, with vitamin D supplementation (VDS) at the rate of 0.07, 0.14, and 0.35  μg/kg orally for 28 days....
Source: Comparative Clinical Pathology - January 25, 2019 Category: Pathology Source Type: research

Antioxidant effects of Allium cepa and cinnamon on biochemical parameters and ultrastructure of ovarian tissue in extremely low frequency electromagnetic field exposed rats
AbstractWe investigated whether 50  Hz wave (3 mT) extremely low frequency electromagnetic field (ELF-EMF) had effect on ovarian tissue biochemical parameters and whetherAllium cepa and cinnamon can reduce potential adverse effects of electromagnetic exposure. Forty female Wistar rats were subdivided into four groups; (1) a control group received 3  cc normal saline (0.9%) daily and was treated for 6 weeks, (2) a group exposed to ELF-EMF of 3 mT for 4 h/day 7 days/week for 6 weeks, (3) a group receivedAllium cepa and cinnamon (75  mg/kg body weight) daily for 6 weeks, (4) a...
Source: Comparative Clinical Pathology - January 21, 2019 Category: Pathology Source Type: research

Health status of indigenous and exotic chickens sold in live bird markets
AbstractLive bird markets (LBMs) contain pool of various birds of different breeds, species, types, and ages, and from different sources and have been identified as impending cores of diseases ’ incubation and transmission. From the point of food safety concern, it is highly empirical to document the health status and possible disease invasion in such markets to control the market for disease-free chicken so as to ensure supply of safe food for the consumers. One hundred twenty birds co mprising of exotic and indigenous breeds of cockerels and layers were surveyed in three LBMs within Abeokuta Metropolis, Ogun State,...
Source: Comparative Clinical Pathology - January 16, 2019 Category: Pathology Source Type: research

Impairment of neuro-renal cells on exposure to cosmopolitan polluted river water followed by differential protection of Launea taraxacifolia in male rats
AbstractNeuron-nephron toxicity (NNT) has been associated with the development of Alzheimer ’s disease and mental disorders. We hypothesized that increased neuronal cholinesterase activities and oxidative stress play significant roles in kidney injury and that methanolic fraction fromLaunea taraxacifolia (LTME) could differentially promote brain-kidney wellness after sub-chronic exposure to metropolitan Surulere polluted river water (SPRW). The animals were divided into six groups (n = 8). Group I was orally given 1 ml of distilled water only; group II received 1 ml of SPRW only; group III (pr...
Source: Comparative Clinical Pathology - January 16, 2019 Category: Pathology Source Type: research

Editorial
(Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - January 15, 2019 Category: Pathology Source Type: research

Moringa leaf meal improves haemato-biochemical and production indices in broiler chickens: a review
AbstractThe high cost of feed materials and feed additives in developing nations has elicited interest in the search for sustainable alternatives having in mind the human food security. Moringa (Moringa oleifera), one of such sustainable alternatives, is a tropical plant with excellent nutritive and phytochemical content. It is one of the species in the family of Moringaceae and thrives well in the tropics. The excellent nutritional quality ofM. oleifera has positioned it as a choice feed ingredient/additive for broiler production. Furthermore, the high carotenoid content of moringa leaves offers great potential for its us...
Source: Comparative Clinical Pathology - January 13, 2019 Category: Pathology Source Type: research

Spilt bile and gallstones effect during laparoscopic cholecystectomy: an experimental study for adhesion formation
AbstractLaparoscopic cholecystectomy (LC) is recognized as the standard treatment for symptomatic gallstone disease. In comparison with open techniques, LC results in a higher rate of iatrogenic biliary tract damage and spillage of bile and stones. The present study was designed to compare intraperitoneal adhesion formation following LC due to the bile and stone spillage. In this randomized experimental study, 15 dogs were randomly allocated to three groups. Each group contained five dogs. The control group underwent LC, while in the group of bile and stone spillage (BS), 5  cc of a mixture of dog bile and a sterile g...
Source: Comparative Clinical Pathology - January 12, 2019 Category: Pathology Source Type: research

Glucose and urea levels in suckling piglets
AbstractA description of physiological and biochemical parameters in suckling piglets is important for identifying suitable management methods according to current realities of commercial swine management. Therefore, the aim of this study was to measure plasma glucose and urea levels in suckling piglets on the first days of life. To accomplish this, 30 male newborn piglets born to 10 sows were used as the experimental model. The animals were weighed on days of life 1 (newborn), 7, 14, and 21, and blood samples were collected to measure plasma levels of glucose and urea. Plasma glucose levels increased over time, while plas...
Source: Comparative Clinical Pathology - January 11, 2019 Category: Pathology Source Type: research

Prevalence and hematological parameters of Fasciola gigantica -infected cattle in Nsukka, Southeastern Nigeria
AbstractA cross-sectional study to determine the prevalence and hematological parameters ofFasciola gigantica-infected cattle in Nsukka, Southeastern Nigeria, was carried out between March and May, 2008. Blood samples were collected immediately after slaughter into labeled sample bottles containing EDTA. Characteristics of each slaughtered cattle such as sex and breed were noted. Postmortem examination of the liver, bile ducts, and gall bladder were carried out. Standard techniques were used to determine the packed cell volume (PCV), red blood cell count (RBC), white blood cell count (WBC), and hemoglobin concentration (Hb...
Source: Comparative Clinical Pathology - January 11, 2019 Category: Pathology Source Type: research

Association between beta defensin gene polymorphism and clinical endometritis in dairy cows
In conclusion, our study suggested that the C to T transition within the intronic region ofβ4-defensin gene (position 2239) might be useful for increasing the resistance of reproductive system in Holstein dairy cows. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - January 11, 2019 Category: Pathology Source Type: research

Hematologic reference intervals for the Italian Heavy Draft horse
AbstractEstablished breed-specific reference intervals (RIs) are important for monitoring the health status of horses. Breed-specific RIs have been evaluated in horses and other animal breeds, but there are no studies on breed-specific RIs for Italian Heavy Draft horse (IHDH). The aim of this study was to determine hematologic RIs for the IHDH living in central Italy. The comparison between different physiological status (pregnancy) and age (foals and adults) have been executed. Inclusion criteria were established for selection of subjects and for blood collection and handling. Blood samples were collected from 309 apparen...
Source: Comparative Clinical Pathology - January 9, 2019 Category: Pathology Source Type: research

Cross-sectional sero-prevalence of tularemia among murine rodents of Nepal
This study was designed to identify the disease status of tularemia in different species of murine rodents of Chitwan District of Nepal. Once the rodents were recovered from metal traps, they were euthanized by injectable anesthesia overdose followed by cervical dislocation. Blood was collected from the heart, and serum was isolated. Presence of tularemia antibodies in the serum was tested by using immunochromatographic test kit containing bacterial lipopolysaccharides. Of the total 80 serum samples tested, 1 sample was found tularemia positive, i.e., apparent prevalence 1.25% (95% CI, i.e., normal approx. CL, −&thin...
Source: Comparative Clinical Pathology - January 9, 2019 Category: Pathology Source Type: research

Protective effects of curcumin on ischemic reperfusion of rat retina
Conclusions:This study concluded that a high dose of curcumin confers a more preventive effect on retinal injury by ischemic reperfusion than a low dose. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - January 8, 2019 Category: Pathology Source Type: research

Epidemiology of cattle amphistomiasis in Gilan province, north of Iran
AbstractAmphistomiasis is a widespread disease of ruminants in many parts of the world including Iran. The aim of this study was to determine the prevalence and intensity of amphistomiasis in cattle from Gilan province, north of Iran in association with sex, age, breed, and season. This investigation was carried out over a 12-month period in Gilan. Through seasonal sampling and visual examination for amphistomiasis, the rumens and reticulum of 406 cattle, slaughtered in Rasht abattoir, Gilan province, were collected and relevant data on sex, age, and breed were recorded. The total number of harvested amphistomes, which was...
Source: Comparative Clinical Pathology - January 8, 2019 Category: Pathology Source Type: research

Short-term effect of low-, moderate-, and high-intensity exercise training on cerebral dopamine neurotrophic factor (CDNF) and oxidative stress biomarkers in brain male Wistar rats
AbstractNeurotrophic factors and exercise training are effective in the growth and survival of neuronal cells. These factors play a protective role against oxidative stress damage and have the same function as antioxidants. The purpose of this study was to investigate the effect of a session of endurance training with three different intensities on CDNF, SOD, and MDA levels of cerebral cortex in male rats. Thirty-two male Wistar rats (aged 20  weeks) were divided randomly into two control and training groups. The training group consisted of low-, moderate-, and high-intensity trainings. The training groups, after gett...
Source: Comparative Clinical Pathology - January 5, 2019 Category: Pathology Source Type: research

Pathological and hematological studies on the effect of curcumin on manganese chloride-induced neurotoxicity in rats
In conclusion, curcumin therapy has a powerful neuroprotective effect in Mncl2 toxicity. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - January 5, 2019 Category: Pathology Source Type: research

Haematological parameters of a monitor lizard
AbstractThe aims of this study were to collect blood samples using the lateral caudal vein and to determine the haematological parameters of monitor lizard. Apparently, healthy monitor lizard was used for the purpose of this study. Blood sample was collected into sterile sample bottle containing ethylenediaminetetraacetic acid (EDTA) as anticoagulant over a period of 15  days at 3-day intervals. The lizard was screened for haemoparasites. Microhaematocrit and thin blood smear techniques were used for the haematological analyses. Haemoglobin concentration (Hb) was determined using the cyanmethaemoglobin method. Mean co...
Source: Comparative Clinical Pathology - January 5, 2019 Category: Pathology Source Type: research

Pathology and immunohistochemical evaluation of Vibrio alginolyticus infection in Macrobrachium rosenbergii
This study investigated the histological alterations in groups ofMacrobrachium rosenbergii experimentally injected intramuscularly between the second and third abdominal segment with 50  μL of 107 CFU ofV. alginolyticus. Twenty-four hours post inoculation, the organism was isolated and molecularly characterized while infected giant freshwater prawns were observed for histological alterations and immunoreactivity in different tissues due to the experimental challenge.The lesions observed in the organs include incipient haemocytic infiltration into the interstitial space of the tubules of the hepatopancreas and loss ...
Source: Comparative Clinical Pathology - January 4, 2019 Category: Pathology Source Type: research

SURGICEL compared with simple gauze packing in grade IV liver injury: an experimental study
This study aims to compare stereological findings in using SURGICEL vs. gauze packing in grade 4 liver lacerations in Wistar rats. In this experimental study, 20 male Wistar-albino rats weighing 250 –300 g were purchased from Shiraz University of Medical Sciences animal laboratory. At the beginning of the study, a 1-cm length and 0.5-cm depth linear laceration was made on the large lobe of the liver in all rats through laparotomy. At least one or more liver tissue samples were obtained from live rats to compare the efficacy of SURGICEL vs. gauze packing. According to our stereological results, normal liver tissu...
Source: Comparative Clinical Pathology - January 4, 2019 Category: Pathology Source Type: research

Chicken infectious anemia: emerging viral disease of poultry —an overview
AbstractDue to the emerging status of chicken infectious anemia in Africa and its similarity to infectious bursal disease, it was necessary to review this disease. Chicken infectious anemia (CIA) is an immunosuppressive pathogen and thus, causes great economic losses to the poultry industry. It is caused by chicken infectious anemia virus (CIAV), a member of the genusGyrovirus, and it primarily affects progenitor cells of erythroid and myeloid series. The disease is characterized by aplastic anemia, atrophy of the thymus, and immunosuppression. It is transmitted horizontally and vertically, and chicken is considered to be ...
Source: Comparative Clinical Pathology - January 2, 2019 Category: Pathology Source Type: research

The central role of ATP in controlling broiler ’s food intake
AbstractPurine nucleotides play different roles in many physiological functions of the central nervous system. The aim of this study was to investigate the effect of the central purine molecule ATP, an agonist of P2 receptors, for the first time, in the regulation of feeding behavior in broilers. Different doses of ATP (2.5, 25, and 50  μg) and its antagonist pyridoxal-phosphate-6-azophenyl-2′, 4′-disulphonic acid (PPADS) (50 μg), ATP (50 μg) plus PPADS (50 μg), and the solvent were injected intracerebroventricularly (ICV) to broilers. ATP increased food intake. PPADS reduced foo...
Source: Comparative Clinical Pathology - January 2, 2019 Category: Pathology Source Type: research

Pathological and immunohistochemical evaluation of wound healing potential of Nigerian bee propolis in albino rats
This study evaluated the efficacy of the Nigerian bee propolis as a wound healing agent, on full thickness skin wounds of healthy adult male (150.0  ± 0.5 g) albino rats randomly divided into three treated groups (propolis extract (PE), propylene glycol (PG), silver sulfadiazine) and an untreated group. Each rat had three circular full thickness skin wounds created on the cranial, middle, and caudal surface of the rat’s dorsum. The woun ds in each group were topically treated with bee propolis extract (PE, 0.1 ml), propylene glycol (PG, 0.1 ml) and silver sulfadiazine (SS, 0.1 ...
Source: Comparative Clinical Pathology - December 19, 2018 Category: Pathology Source Type: research

Correction to: Subclinical nodular goiter associated with Hurthle cell, papillary, and adenomatoid hyperplasic nodules in the dromedary camel in the Sultanate of Oman
The original published version of this article contained a mistake in the name of Remya R. Nair. It was incorrectly presented as Remya R. Nir. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - December 15, 2018 Category: Pathology Source Type: research

Pathogenicity of Cryptococcus neoformans VNI (ST 32) recovered from environmental and clinical isolates in Nigeria
We present the comparative pathogenicity of Nigeria environmental and clinicalCryptococcus neoformans VNI (ST32) strains in an animal model. Isolates previously identified and confirmed in a different study, using matrix-assisted laser desorption ionization –time-of-flight mass spectrometry (MALDI–TOF MS) and multi-locus sequence typing (MLST) techniques, were inoculated into male mice weighing 26 ± 4.0 g. Postinfection survival time, tissue fungal burden, and histopathological changes were observed. Log–rank survival curve comparisons show ed that there is a significant differen...
Source: Comparative Clinical Pathology - December 12, 2018 Category: Pathology Source Type: research

Mathematical determination of some oncological parameters and their therapeutic implications in dogs
AbstractCancer is a serious life-threatening disease with increased morbidity and mortality in dogs. A number of cancers are diagnosed after metastasis has taken place when therapeutic intervention would have been useless. In view of this, mammary gland tumors and adenocarcinoma of the lungs were calculated using some established and revised formulas. The reported fundamental parameters were calculated using macroscopy. But the mathematical oncological analysis revealed that tumor doubling time (82.1 –123.1 days) of adenocarcinoma of the lung was lower than that of complex mammary adenoma (101.3–151.9 ...
Source: Comparative Clinical Pathology - December 12, 2018 Category: Pathology Source Type: research