Investigation of antilipidemic efficacy of condensed tannins from three varieties of Sorghum bicolor seeds on high-fat diet-induced obese rats

AbstractHigh levels of lipids in the system are a significant illness condition that raises the risk of coronary artery disease as well as a rise in blood pressure; all of which might finally lead to death. Tannins, which are obtained naturally from plants, are widely utilized in the management of diseases related to lipid metabolism and have proven to be safer and potent, while also having less harmful and adverse effects. In the meanwhile, there has been a surge in the acknowledgment of the relevance of dietary tannins in the prevention as well as management of diseases related to lipid metabolism. The aim of this study is to understand the antilipidemic effect of sorghum condensed tannins (SCT) from three different varieties in high-fat diet (HFD)-induced obese male Wistar rats. Seventy-eight male Wistar rats divided into 7 groups containing 6 rats each for each variety of sorghum were used for the study. However, the orlistat and non-treated groups (I, II, III, and VII) consist of only one group containing 6 rats which equals 24 rats in groups I, II, III, and VII while 54 rats were used in SCT-treated groups IV, V, and VI with each group containing 6 rats across the three sorghum varieties. Following feeding with a high-fat diet, the treated groups were administered with SCT at different concentrations (50, 100, and 200  mg/kg body weight) for a period of 14 days; after which they were sacrificed and the serum, heart, liver, and kidney were harvested for biochemical ass...
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research