The hypoglycemic and anti-hyperlipidemic activity of vitamin C in di(2-ethylhexyl) phthalate-induced toxicity in female mice, Mus musculus
AbstractDi(2-ethylhexyl) phthalate (DEHP) is the most extensively useful plasticizer, a common cosmopolitan contaminant, and known for its endocrine-disrupting nature. Human exposure level surpasses hazardous limit due to its diverse application. This has been discovered to cause reproductive abnormalities in male rodents. Its anti-androgenic characteristic focuses attention on its toxicity to the endocrine and reproductive systems. The role of vitamin C on DEHP-induced toxicity with reference to female reproductive disruptions is very scarce. So, in this study, we have mainly focused on the beneficial role of vitamin C in...
Source: Comparative Clinical Pathology - March 9, 2023 Category: Pathology Source Type: research
RIPC and HIIT affect inflammatory and cardiac injury biomarkers in middle-aged rats
This study demonstrated that 3 weeks of HIIT did not significantly alter cTnI and CRP and caused a reduction in CK-MB as a myocardial injury biomarkers in middle-aged male Wistar rats. On the other hand, applying RIPC caused a significant elevation in cTnI. Therefore, these physiological adaptations can improve ischemic tolerance and inhibit myocardial infarction. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - March 3, 2023 Category: Pathology Source Type: research
Blood metal levels linked with hematological, oxidative, and hepatic-renal function disruption in Swiss albino mice exposed to multi-metal mixture
AbstractThis
study evaluates the toxic effect of various doses of multi-metal mixtures leading to metal accumulation in the blood of exposed mice and alterations in the blood biomarkers. To explore the health consequence of multiple metal exposures,Swiss Albino mice were orally given different doses of metal mixtures via drinking water for 8 weeks. The mice were randomly divided into fourteen groups. Besides the control animals, each mouse received a corresponding dose of heavy metal mixture [MPL (maximum permissible limit), 1 × , 5 × , 10 × , 50 × or 100 ×]. The mice were sacrificed, and blood...
Source: Comparative Clinical Pathology - March 1, 2023 Category: Pathology Source Type: research
New record of gill hemorrhagic parasite Myxobolus richardsonii n. sp. (Cnidaria: Myxozoa) infecting Schizothorax richardsonii in Kashmir Himalayas
AbstractMyxozoans are highly specialized metazoan parasites with a very diverse host range that live on aquatic hosts. In both wild and farm-raised fish, myxozoans are the most frequent parasites. The aim of the current study was to evaluate any myxozoan parasite found in different organs ofSchizothorax richardsonii. Live fish were transported with artificial aeration to the University of Kashmir. Thirty-five fish specimens were examined during the study period, and only gills of 6 fish were determined to be infected. Taxonomic study was carried out with the help of different keys, and histopathologcal study w as assay...
Source: Comparative Clinical Pathology - March 1, 2023 Category: Pathology Source Type: research
Repeated dose 13-week oral toxicity evaluation of Chlorophytum alismifolium Baker methanol extract in Wistar rats
This study was performed to evaluate the effect of sub-chronic (13 weeks) administration ofC. alismifolium in Wistar rats. The tubers ofC. alismifolium were obtained, processed and extracted with methanol to get the methanol extract ofC. alismifolium (MECA). MECA (150, 300, and 600 mg/kg) was administered orally and daily to rats for 13 weeks. Thereafter, toxicological parameters were evaluated. Administration of MECA for 13 weeks did not significantly alter the feed intake, water consumption and body weights of the animals. Hematological analysis showed a significant (p < 0.05) rise in granulocyte levels in ...
Source: Comparative Clinical Pathology - February 27, 2023 Category: Pathology Source Type: research
Oxidative stress biomarkers status in selected equine sports
AbstractOxidative stress is an imbalance between oxidants and antioxidants. Chronic exercise can lead to an increase in the production of oxidants and the up-regulation of antioxidant defense mechanisms. In horses, there are several potential exercise-related mechanisms for oxidant production. Athletic horses are exposed to different amounts of stress according to the type of sport and physical exertion. The present study aimed to investigate the effect of type of sport, gender, and age on oxidant/antioxidant and enzymatic status in active athletic horses. Thirty-nine healthy athletic show-jumping, polo, tent-pegging, and ...
Source: Comparative Clinical Pathology - February 23, 2023 Category: Pathology Source Type: research
Evaluation of haematological and biochemical changes following xylazine, tramadol and lignocaine premedicated propofol anaesthesia in West African dwarf goat
This study was conducted to evaluate the haematological and biochemical changes during propofol anaesthesia in West African dwarf goat. Four groups A, B, C and D of five (5) goats in each group received normal saline (2 ml, IV), xylazine (0.05 mg/kg body weight, IV), tramadol (2 mg/kg, IV) and lignocaine (2.5 mg/kg, SC) respectively as premedicants. Each goat in all the groups was anaesthesized with propofol at 9 mg/kg body weight (b/w). The biochemical and haematological parameters were determined pre-induct ion and post-induction of the anaesthesia. Blood was collected through the jugular vein using a 5-ml syringe ...
Source: Comparative Clinical Pathology - February 23, 2023 Category: Pathology Source Type: research
Piperine abates cognitive dysfunction via modulation of key enzymes relevant to neurodegeneration in scopolamine-induced rats
This study assessed the effects of piperine (PIP) on spatial memory, thiobarbituric acid reactive substances (TBARS) production, and key enzymes [acetylcholinesterase (AChE), butyrylcholinesterase (BChE), monoamine oxidase (MAO)] linked to neurodegeneration. Scopolamine was used to induce an Alzheimer ’s disease (AD)–like model in rats. Forty male Wistar rats were randomly divided into eight groups of five rats: normal control rats (NC), scopolamine-induced amnesia (SCO), scopolamine-induced amnesia plus piperine 5 mg/kg, scopolamine-induced amnesia plus piperine 10 mg/kg, scopolamine-induc ed amnesia plus prostigmin...
Source: Comparative Clinical Pathology - February 22, 2023 Category: Pathology Source Type: research
The effects of gallic acid on inflammation and oxidative stress in valproic acid-induced hepatotoxicity in rats
AbstractValproic acid (VPA) is one of the most broadly used drugs for epilepsy disorders worldwide. Despite its great effectiveness, this drug causes liver toxicity. In this work, the effects of gallic acid (GA) on hepatic injury caused by VPA were investigated. We randomly divided 48 Wistar rats into 6 groups. Group 1 was considered as control. The second group received only valproic acid. The third group was a positive control group which was administrated with VPA and then Silymarin. The fourth, fifth, and sixth groups also received GA after taking valproic acid. Then serum lipid profile, alkaline phosphatase (ALP), asp...
Source: Comparative Clinical Pathology - February 21, 2023 Category: Pathology Source Type: research
Editorial review
(Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - February 21, 2023 Category: Pathology Source Type: research
Ameliorative role of thymoquinone against reprotoxic effect caused by potassium bromate in female mice
In this study, we investigated the effects of potassium bromate (KBrO3) and thymoquinone (TQ), on reproductive hormone levels and histomorphological variations in the ovaries and uteri of female mice. In the current study, all experimental animals were orally administered KBrO3 (100 mg/kg body weight) and TQ (20 mg/kg body weight) for 60 days. Alterations in hormone and antioxidative parameters along with histomorphological variations were assessed in mice. The findings demonstrated that the oral administration of KBrO3 had a significant effect on body weight, uterine weight, and gonadosomatic index (GSI), along with c...
Source: Comparative Clinical Pathology - February 16, 2023 Category: Pathology Source Type: research
A clinical case of enzootic bovine leukosis diagnosed by using clonal analysis of peripheral B lymphocytes in a Japanese Black cow
AbstractA 7-year-old Japanese Black cow with anorexia was presented at a local veterinarian. As rectal palpation revealed an enlarged induration of the uterus, lymphoma was suspected, and the patient was introduced to the Veterinary Teaching Hospital of Obihiro University of Agriculture and Veterinary Medicine. Although lymphadenopathy and lymphocytosis were not found, a high proviral load of bovine leukemia virus (BLV) with 464 copies/10 ng DNA was recorded, and lymphocytes with constricted or flower-like nuclei were found occasionally in the peripheral blood; accordingly, enzootic bovine leukosis (EBL) was suspected. Acc...
Source: Comparative Clinical Pathology - February 16, 2023 Category: Pathology Source Type: research
Reviewer thank you
(Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - February 16, 2023 Category: Pathology Source Type: research
The role of HDL-related myeloperoxidase (MPO) and paraoxonase 1 (PON1) in terms of coronary artery disease in Hashimoto ’s thyroiditis
AbstractHashimoto ’s thyroiditis (HT) is an autoimmune disease of the thyroid gland. Free radicals have been reported to be responsible for the complications observed in the pathogenesis of thyroid diseases and the later stages of the disease. Myeloperoxidase (MPO), which is released from neutrophils during inflamm ation and oxidative stress and causes cell destruction, is a marker that plays a role in the development of cardiovascular disease associated with oxidative damage in the arterial wall. Paraoxonase-1(PON-1), which is one of the molecules that play a role in oxidant balance, is an enzyme that inhibit s lipoprot...
Source: Comparative Clinical Pathology - February 13, 2023 Category: Pathology Source Type: research
Effect of melatonin implant on some dog ’s reproductive factors, kidney, and liver function
This study aimed to investigate the effect of melatonin implants on some dogs ’ reproductive factors, kidney, and liver function. Ten male mixed-breed adult dogs in two groups, 5 dogs receiving subcutaneous melatonin implant (18 mg), and 5 dogs in the control group were involved in this study for 9 weeks. Blood sampling and ultrasonographic examinations of the testes were performed weekly. There was no significant difference in the mean concentration of testosterone between the two groups during the study. Mean testicular diameter changes, blood urea nitrogen (BUN), creatinine, alkaline phosphatase (ALP), and alanine t...
Source: Comparative Clinical Pathology - February 11, 2023 Category: Pathology Source Type: research
