Protective effects of curcumin on ischemic reperfusion of rat retina
Conclusions:This study concluded that a high dose of curcumin confers a more preventive effect on retinal injury by ischemic reperfusion than a low dose. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - January 8, 2019 Category: Pathology Source Type: research

Epidemiology of cattle amphistomiasis in Gilan province, north of Iran
AbstractAmphistomiasis is a widespread disease of ruminants in many parts of the world including Iran. The aim of this study was to determine the prevalence and intensity of amphistomiasis in cattle from Gilan province, north of Iran in association with sex, age, breed, and season. This investigation was carried out over a 12-month period in Gilan. Through seasonal sampling and visual examination for amphistomiasis, the rumens and reticulum of 406 cattle, slaughtered in Rasht abattoir, Gilan province, were collected and relevant data on sex, age, and breed were recorded. The total number of harvested amphistomes, which was...
Source: Comparative Clinical Pathology - January 8, 2019 Category: Pathology Source Type: research

Short-term effect of low-, moderate-, and high-intensity exercise training on cerebral dopamine neurotrophic factor (CDNF) and oxidative stress biomarkers in brain male Wistar rats
AbstractNeurotrophic factors and exercise training are effective in the growth and survival of neuronal cells. These factors play a protective role against oxidative stress damage and have the same function as antioxidants. The purpose of this study was to investigate the effect of a session of endurance training with three different intensities on CDNF, SOD, and MDA levels of cerebral cortex in male rats. Thirty-two male Wistar rats (aged 20  weeks) were divided randomly into two control and training groups. The training group consisted of low-, moderate-, and high-intensity trainings. The training groups, after gett...
Source: Comparative Clinical Pathology - January 5, 2019 Category: Pathology Source Type: research

Pathological and hematological studies on the effect of curcumin on manganese chloride-induced neurotoxicity in rats
In conclusion, curcumin therapy has a powerful neuroprotective effect in Mncl2 toxicity. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - January 5, 2019 Category: Pathology Source Type: research

Haematological parameters of a monitor lizard
AbstractThe aims of this study were to collect blood samples using the lateral caudal vein and to determine the haematological parameters of monitor lizard. Apparently, healthy monitor lizard was used for the purpose of this study. Blood sample was collected into sterile sample bottle containing ethylenediaminetetraacetic acid (EDTA) as anticoagulant over a period of 15  days at 3-day intervals. The lizard was screened for haemoparasites. Microhaematocrit and thin blood smear techniques were used for the haematological analyses. Haemoglobin concentration (Hb) was determined using the cyanmethaemoglobin method. Mean co...
Source: Comparative Clinical Pathology - January 5, 2019 Category: Pathology Source Type: research

Pathology and immunohistochemical evaluation of Vibrio alginolyticus infection in Macrobrachium rosenbergii
This study investigated the histological alterations in groups ofMacrobrachium rosenbergii experimentally injected intramuscularly between the second and third abdominal segment with 50  μL of 107 CFU ofV. alginolyticus. Twenty-four hours post inoculation, the organism was isolated and molecularly characterized while infected giant freshwater prawns were observed for histological alterations and immunoreactivity in different tissues due to the experimental challenge.The lesions observed in the organs include incipient haemocytic infiltration into the interstitial space of the tubules of the hepatopancreas and loss ...
Source: Comparative Clinical Pathology - January 4, 2019 Category: Pathology Source Type: research

SURGICEL compared with simple gauze packing in grade IV liver injury: an experimental study
This study aims to compare stereological findings in using SURGICEL vs. gauze packing in grade 4 liver lacerations in Wistar rats. In this experimental study, 20 male Wistar-albino rats weighing 250 –300 g were purchased from Shiraz University of Medical Sciences animal laboratory. At the beginning of the study, a 1-cm length and 0.5-cm depth linear laceration was made on the large lobe of the liver in all rats through laparotomy. At least one or more liver tissue samples were obtained from live rats to compare the efficacy of SURGICEL vs. gauze packing. According to our stereological results, normal liver tissu...
Source: Comparative Clinical Pathology - January 4, 2019 Category: Pathology Source Type: research

Chicken infectious anemia: emerging viral disease of poultry —an overview
AbstractDue to the emerging status of chicken infectious anemia in Africa and its similarity to infectious bursal disease, it was necessary to review this disease. Chicken infectious anemia (CIA) is an immunosuppressive pathogen and thus, causes great economic losses to the poultry industry. It is caused by chicken infectious anemia virus (CIAV), a member of the genusGyrovirus, and it primarily affects progenitor cells of erythroid and myeloid series. The disease is characterized by aplastic anemia, atrophy of the thymus, and immunosuppression. It is transmitted horizontally and vertically, and chicken is considered to be ...
Source: Comparative Clinical Pathology - January 2, 2019 Category: Pathology Source Type: research

The central role of ATP in controlling broiler ’s food intake
AbstractPurine nucleotides play different roles in many physiological functions of the central nervous system. The aim of this study was to investigate the effect of the central purine molecule ATP, an agonist of P2 receptors, for the first time, in the regulation of feeding behavior in broilers. Different doses of ATP (2.5, 25, and 50  μg) and its antagonist pyridoxal-phosphate-6-azophenyl-2′, 4′-disulphonic acid (PPADS) (50 μg), ATP (50 μg) plus PPADS (50 μg), and the solvent were injected intracerebroventricularly (ICV) to broilers. ATP increased food intake. PPADS reduced foo...
Source: Comparative Clinical Pathology - January 2, 2019 Category: Pathology Source Type: research

Pathological and immunohistochemical evaluation of wound healing potential of Nigerian bee propolis in albino rats
This study evaluated the efficacy of the Nigerian bee propolis as a wound healing agent, on full thickness skin wounds of healthy adult male (150.0  ± 0.5 g) albino rats randomly divided into three treated groups (propolis extract (PE), propylene glycol (PG), silver sulfadiazine) and an untreated group. Each rat had three circular full thickness skin wounds created on the cranial, middle, and caudal surface of the rat’s dorsum. The woun ds in each group were topically treated with bee propolis extract (PE, 0.1 ml), propylene glycol (PG, 0.1 ml) and silver sulfadiazine (SS, 0.1 ...
Source: Comparative Clinical Pathology - December 19, 2018 Category: Pathology Source Type: research

Correction to: Subclinical nodular goiter associated with Hurthle cell, papillary, and adenomatoid hyperplasic nodules in the dromedary camel in the Sultanate of Oman
The original published version of this article contained a mistake in the name of Remya R. Nair. It was incorrectly presented as Remya R. Nir. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - December 15, 2018 Category: Pathology Source Type: research

Pathogenicity of Cryptococcus neoformans VNI (ST 32) recovered from environmental and clinical isolates in Nigeria
We present the comparative pathogenicity of Nigeria environmental and clinicalCryptococcus neoformans VNI (ST32) strains in an animal model. Isolates previously identified and confirmed in a different study, using matrix-assisted laser desorption ionization –time-of-flight mass spectrometry (MALDI–TOF MS) and multi-locus sequence typing (MLST) techniques, were inoculated into male mice weighing 26 ± 4.0 g. Postinfection survival time, tissue fungal burden, and histopathological changes were observed. Log–rank survival curve comparisons show ed that there is a significant differen...
Source: Comparative Clinical Pathology - December 12, 2018 Category: Pathology Source Type: research

Mathematical determination of some oncological parameters and their therapeutic implications in dogs
AbstractCancer is a serious life-threatening disease with increased morbidity and mortality in dogs. A number of cancers are diagnosed after metastasis has taken place when therapeutic intervention would have been useless. In view of this, mammary gland tumors and adenocarcinoma of the lungs were calculated using some established and revised formulas. The reported fundamental parameters were calculated using macroscopy. But the mathematical oncological analysis revealed that tumor doubling time (82.1 –123.1 days) of adenocarcinoma of the lung was lower than that of complex mammary adenoma (101.3–151.9 ...
Source: Comparative Clinical Pathology - December 12, 2018 Category: Pathology Source Type: research

Atherosclerosis plaque area reduction: working hypothesis to prevent cardiovascular event
AbstractCardiovascular events are the leading cause of death worldwide. In this sense, cardiovascular diseases (CVD) are the main products of atherosclerosis (ATR), whose origin is multifactorial. The measurable identification of the so-called cardiovascular risk factors (CRF) was a great advance for its prevention. Scientific evidences have shown that the reduction of mortality due to cardiovascular disease is an important achievement of the optimal control of CRF. However, a large proportion of patients have cardiovascular events when CRF is controlled. It is therefore imperative to stratify the patient ’s risk in ...
Source: Comparative Clinical Pathology - December 12, 2018 Category: Pathology Source Type: research

The first Entamoeba moshkovskii molecular detection in Egypt
AbstractAmebiasis infection is caused byEntamoeba histolytica. The nonpathogenicEntamoeba species,E.moshkovskii andE.dispar, are distinct but morphologically indifferentiable fromE.histolytica, which led us to use of multiplex PCR to detect and molecularly differentiateEntamoeba species in fecal samples of a cohort of 504 diarrheic/dysenteric Egyptians attending outpatient clinics of the Beni-Suef University Hospital.E.moshkovskii was detected for the first time in Egypt, added to already reportedE.histolytica andE.dispar. Molecular prevalence of allEntamoeba species was 10%.E.histolytica (1.4%) was the least prevalentEnta...
Source: Comparative Clinical Pathology - December 11, 2018 Category: Pathology Source Type: research

Epidemiological profile and drug abuse: fatal occupational injuries in Espirito Santo, Brazil
AbstractTo evaluate the profile and frequency of drug abuse before fatal occupational injuries from cases registered in Vitoria, ES, Brazil. From 2008 to 2012, 302 fatal work accidents were registered in the analyzed area. Epidemiological variables like age, sex, type of drug detected, occupation, cause of death, and location of the accident were studied. Drugs that were routinely searched for and considered in the analysis are alcohol, cocaine, marijuana, barbiturates, benzodiazepines, and amphetamines. Male workers, with a mean age of 40  years old, were affected more frequently than females. In the 302 analyzed cas...
Source: Comparative Clinical Pathology - December 11, 2018 Category: Pathology Source Type: research

Nimesulide effects on the blood pro-oxidant –antioxidant status in lipopolysaccharide-challenged mice
AbstractThe maintenance of the pro-oxidant –antioxidant equilibrium between ROS production and antioxidant protection systems is an important element of systemic defence and requires efficient control. The aim of the study was to monitor the dynamics of antioxidants and lipid peroxidation in mice challenged intraperitoneally withEscherichia coli (O111:B4) lipopolysaccharide (LPS) and to evaluate the antioxidant potential of the non-steroidal anti-inflammatory drug nimesulide. Albino mice were divided into three groups (n = 36). Group I received a single intraperitoneal (i.p.) injection with 25 μ...
Source: Comparative Clinical Pathology - December 7, 2018 Category: Pathology Source Type: research

Phylogenetic evaluation of Macrorhabdus ornithogaster isolated from a case of canary ( Serinus canaria )
AbstractTwo dead birds from a flock of domestic canaries (Serinus canaria) were referred with a history of anorexia, weight loss, abdominal distension, and occasional mortality. A slightly enlarged liver and proventriculus were seen on the examination of the abdominal cavity. A large number of yeast resemblingMacrorhabdus ornithogaster were observed on gram staining of the proventriculus mucosa.Pseudomonas aeruginosa was isolated on the microbial culture of the liver. The complete genomic sequence of the internal transcribed spacer 1 (ITS1) was determined inMacrorhabdus ornithogaster using panfungal primers. The alignment ...
Source: Comparative Clinical Pathology - December 6, 2018 Category: Pathology Source Type: research

Biochemical and physiological responses of Nile tilapia ( Oreochromis niloticus Linn.) subjected to rapid increases of water temperature
AbstractThis research evaluated the general stress response, serum biochemistry, hematology, cortisol level, and ventilation rates of the commercial fresh water fishOreochromis nilotichus, which was subjected to acute heat shock treatment. The consequences of heat shock were evaluated using five different water temperature levels (25  °C used as the control group, then 27 °C, 29 °C, 33 °C, and 37 °C, the rate was increased 3 °C per hour). All serum indices showed significant changes (p 
Source: Comparative Clinical Pathology - December 4, 2018 Category: Pathology Source Type: research

Dietary flaxseed oil inhibits kidney NF-kappa B activation and pro-inflammatory cytokine expression in cisplatin-treated rats
AbstractThe current study explores the anti-inflammatory effect of flaxseed oil (FXO) on cisplatin (CP)-induced renal damage. Rats prefed with normal experimental diets (normal/FXO diet) for 10  days were administered 30 mg kg−1 and 50  mg kg−1 i.p. CP in a single dose, while still on the experimental diets. Significant improvement in kidney function test and antioxidant enzyme activities in rats treated with combination therapy (FXO + CP) was detected. Interestingly, treatment by FXO resulted in significant downregulation (P
Source: Comparative Clinical Pathology - November 29, 2018 Category: Pathology Source Type: research

The effect of lipotropic agents on the nutritional induction of fatty liver syndrome in broilers
This study hypothesized that the application of lipotropic agents may help broiler chicks to efficiently utilize the high-energy diets. A total of 100-day-old broiler chicks were randomly divided into five equal groups; negative control, positive control (fed on high-energy diet), and three groups fed on high-energy diet with supplemental lipotropic agents (100  mg/kg b.wt. carnitine asl-carnitine or 1000  mg/kg b.wt. choline as choline chloride or combination of both). Average body weight (BW) and daily weight gain (BWG) were recorded during the 42-day experimental period. Alanine aminotransferase (ALT) and alka...
Source: Comparative Clinical Pathology - November 27, 2018 Category: Pathology Source Type: research

Co-administration of nicotine ameliorates cannabis-induced behavioral deficits in normal rats: role of oxidative stress and inflammation
In conclusion, the co-administration of Nic reduced THC-induced depressive-like behavior and memory impairment as well as hypo-locomotion associated with THC20. Such effects could be linked to Nic-mediated inhibition of brain oxidative stress, inflammation, and decreased serum BChE deactivity. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - November 23, 2018 Category: Pathology Source Type: research

Effects of different doses of curcumin on testicular histopathology, apoptosis, and reproductive organs weight index in mice d -galactose-induced aging model
AbstractDue to the value of aging and its effect on body organs, it is necessary to study the factors that can have protective effects on this process. Curcumin is the active ingredient ofCurcuma longa Turmeric, which has a strong antioxidant effect. We evaluated the curcumin treatment on testicular histopathology, apoptosis, and reproductive organs index in a mouse model of aging. Forty-eight mice divided into control, sham,d-galactose, and curcumin 1 to 3 groups. Thed-galactose group was administered intraperitoneally 300  mg/kgd-galactose for 6  weeks. The curcumin 1 to 3 groups receivedd-galactose plus 25, 50...
Source: Comparative Clinical Pathology - November 23, 2018 Category: Pathology Source Type: research

Hematological alterations in fish exposed at agricultural fair
The objective of this study was to evaluate if there were alterations in hematological variables of fish after transportation and exhibition at an agricultural fair. We first collected blood samples from 12 fish of the speciesProchilodus lineatus (curimbat á) at the Goio-En research institute; then, these animals were transported (60 km) to the agricultural fair, where they stayed for 3 days in glass aquariums exposed to the visitors of the event. On the return of the fish to the institute, we collected blood again. We performed hematological analy ses, measuring hematocrit, hemoglobin concentration, and t...
Source: Comparative Clinical Pathology - November 20, 2018 Category: Pathology Source Type: research

An epidemiological survey of bovine viral diarrhea infection in calves in Egypt with identification of high prevalence of persistent infected animals
AbstractIn the present study, we identified the persistent infection by bovine viral diarrhea virus (BVDV) in 45 clinically suspected persistent infected (PI) calves and 260 apparently healthy calves from Damietta governorate (North) in Egypt during 2016 using enzyme-linked immunosorbent assay (ELISA), serum neutralization test (SNT), immunohistochemistry (IHC), and reverse transcription polymerase chain reaction (RT-PCR). The identification of PI calves was performed after vaccination by CattleMaster ® 4. The age of PI calves in the current study was ranged from 2 to 4 months (n = 7) and from 5 to 8&n...
Source: Comparative Clinical Pathology - November 17, 2018 Category: Pathology Source Type: research

Saccharomyces cerevisiae inhibits growth and metastasis and stimulates apoptosis in HT-29 colorectal cancer cell line
AbstractColorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide. Accumulating evidence has suggested that probiotics affect cellular pathways and specific genes involved in slow growth. Probiotics reduce the impact or stop the growth of cancer cells and tumors in animal models and human cell lines. The aim of this study was to investigate the effect ofSaccharomyces cerevisiae (S. cerevisiae) on cell growth, metastasis, and apoptosis of the HT-29 colon cancer cell line. The HT-29 cells andS.cerevisiae were co-cultured in order to study the effects ofS.cerevisiae on cell apoptosis, growth, and ...
Source: Comparative Clinical Pathology - November 16, 2018 Category: Pathology Source Type: research

Effects of dietary supplementation of bentonite and yeast cell wall on serum blood urea nitrogen, triglyceride, alkaline phosphatase, and calcium in high-producing dairy cattle during the transition period
In conclusion, lower BUN concentration could be a result of better stimulation of ruminal microbial protein synthesis in the treatment groups and also due to lower triglyceride in control group, which might be result of lower pH in the rumen, we suggest that endotoxins binders (especially combined feeding of endotoxin binders) can modulate rumen function by optimizing the rumen pH. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - November 15, 2018 Category: Pathology Source Type: research

Detection of peste des petits ruminants and concurrent secondary diseases in sheep and goats in Ngorongoro district, Tanzania
This study was initiated because of a massive outbreak of a respiratory disease in sheep and goats in Loliondo area in Ngorongoro district of Arusha region in Tanzania in 2016. During flock examination, a total of 240 serum samples and 61 nasal swabs were collected. Antibodies to small ruminant morbillivirus, causative agent of peste des petits ruminants (PPR), were detected from sera using a competitive enzyme-linked immunosorbent assay. A multiplex reverse transcription real-time polymerase chain reaction assay was used to detect four pathogens: small ruminant morbillivirus,Mycoplasma capricolum subspeciescapripneumoniae...
Source: Comparative Clinical Pathology - November 15, 2018 Category: Pathology Source Type: research

An immunoturbidimetric assay for bovine haptoglobin
AbstractIn cattle, the serum protein haptoglobin (Hp) is a major acute phase protein (APP) that rises in concentration over a thousand fold following stimulation by pro-inflammatory cytokines. As such, this APP is a valuable biomarker for infection, inflammation and trauma in cattle. The assay for bovine Hp is becoming more commonplace in clinical pathology and in experimental studies when a biomarker of innate immunity is required. The most widely used assay for Hp utilises its binding to haemoglobin (Hp-Hb binding assay), which at low pH enables the preservation of the native peroxidase activity in the haemoglobin. This ...
Source: Comparative Clinical Pathology - November 14, 2018 Category: Pathology Source Type: research

Sero-prevalence and associated risk factors of Mycoplasma hyopneumoniae infection in Kailali and Kanchanpur District of Far Western, Nepal
AbstractRespiratory diseases cause severe distress leading to serious effects on production characteristics of pigs.Mycoplasma hyopneumoniae (Mh) is one of the primary contributors of porcine respiratory disease complex (PRDC). A cross-sectional study was conducted to determine the sero-prevalence and associated risk factors of enzootic pneumonia (EP) caused by Mh in Kailali and Kanchanpur Districts of Nepal. The herd level information of the site was gathered using standardized questionnaire survey. A total of 184 porcine serum samples were collected randomly and tested by using competitive ELISA targeting anti-Mh antibod...
Source: Comparative Clinical Pathology - November 14, 2018 Category: Pathology Source Type: research

Assessment of antioxidant and cutaneous wound healing effects of Falcaria vulgaris aqueous extract in Wistar male rats
AbstractTreatment of wounds by ethnomedicinal plants which have fewer side effects than chemical drugs has been on the rise. In this experiment, we evaluated cutaneous wound healing potential of aqueous extract ofFalcaria vulgaris in Wistar male rats. DPPH free radical scavenging test was used to examine the antioxidant effect ofF. vulgaris aqueous extract, which indicated high antioxidant activity compared to butylated hydroxy toluene (BHT) as the positive control. In our study, after creating the cutaneous wound on the back of the rats, the animals were randomly divided into four groups; untreated control, treatment with...
Source: Comparative Clinical Pathology - November 13, 2018 Category: Pathology Source Type: research

Detection of VanA type vancomycin resistance among MRSA isolates from an emergency hospital in Egypt
AbstractResistance of methicillin-resistantStaphylococcus aureus (MRSA) strains to vancomycin is increasing and represents a major threat in the therapeutic fields. To assess susceptibility ofS. aureus to vancomycin and determine the occurrence ofVanA gene amongMRSA isolates. Agar diffusion method using cefoxitin disc (30  μg) was used to identifyMRSA among 100 isolates ofS. aureus. AmongMRSA, vancomycin resistance was determined by broth macrodilution andVanA gene was detected by PCR. Frequency ofMRSA was 92%. Phenotypically,MRSA isolates were vancomycin-susceptibleS. aureus (VSSA) (67.4%), vancomycin-intermediate...
Source: Comparative Clinical Pathology - November 12, 2018 Category: Pathology Source Type: research

Comparative study on mineral status of lymphoid organs of broiler chicken in commonly encountered immunosuppressive disease outbreaks
AbstractThe present study was conceded to evaluate the mineral concentration of lymphoid organs of broiler chicken in commonly encountered immunosuppressive diseases like an infectious bursal disease, Newcastle disease, colibacillosis, and concurrent infections of IBD-ND and IBD-coccidiosis. A total of 500 broiler chickens from each outbreak were examined, which included the diseased and dead broiler chicken. The birds examined belonged to different age groups and were assigned the group number as per age. The outbreaks which occurred in the age groups of 18, 21, 23, 25, and 27 were selected and a total of five outbreaks f...
Source: Comparative Clinical Pathology - November 12, 2018 Category: Pathology Source Type: research

Serum biochemical reference values of Kyrgyz donkeys ( Equus asinus )
AbstractThe aim of the study was to determine the some serum biochemical values of Kyrgyz donkeys and present the reference values. Fifty (50) healthy donkeys in different ages (6 –24 months, 2–15 years, and>  15 years old) and gender (male and female) were clinically examined and blood samples were taken. Serum triglycerides (TG), creatine phosphokinase (CPK), aspartate aminotransferase (AST), gamma glutamyl transferase (GGT), alkaline phosphatase (ALP), total bilirubin (TBil), total protein (TP), al bumin (Alb), creatinine (Creat), urea (Urea), amylase (Amy), lipase (Lip), calcium (Ca...
Source: Comparative Clinical Pathology - November 11, 2018 Category: Pathology Source Type: research

Erysipelas, the opportunistic zoonotic disease: history, epidemiology, pathology, and diagnosis —a review
AbstractDue to the recent multidisciplinary collaborations towards ‘One Health’, it was necessary to review this important zoonotic disease, erysipelas. Swine erysipelas also referred to as diamond skin disease has since become one of the most serious hazards of swine production worldwide.Erysipelothrix rhusiopathiae, the aetiology of erysipelas could affect pigs, turkeys, sheep, chickens, ducks, and emus. The most important animal reservoir ofE. rhusiopathiae is the domestic swine. The organism is shed by diseased animals in faeces, urine, saliva, and nasal secretions, which can contaminate food, water, and so...
Source: Comparative Clinical Pathology - November 10, 2018 Category: Pathology Source Type: research

Yeast ( Saccharomyces cerevisiae ) and its effect on production indices of livestock and poultry —a review
AbstractImproved feed efficiency is the current drive of today ’s livestock enterprise and this may be actualized using feed supplementation. The use of natural growth promoting products in livestock feed is on the increase because of the ban on the use of antibiotics in feed by the European Union (EU). The use of antibiotics in animal feed has been reported to increase antimicrobial resistance and this has made animal nutritionist search for natural alternatives to antibiotics. Yeast, one of such natural alternatives in animal production, has received great attention in the last couple of decades. Research has shown...
Source: Comparative Clinical Pathology - November 9, 2018 Category: Pathology Source Type: research

Rumex alveollatus hydroalcoholic extract protects CCL4-induced hepatotoxicity in mice
This study was carried out to explore the protective effects ofRumex alveollatus L. on the liver damage induced by CCl4 in mice. In this experimental study, 30 male mice (35  ± 4) were divided into five groups, each with six mice. The negative control group was administered 0.5-ml olive oil; positive control group was administered 2-ml/kg CCl4 plus olive oil at 1:1 ratio for 4  days, and the experimental groups were administered 2 ml/kg CCl4 andRumex alveollatus L. extract at 150, 300, and 450  mg/kg for 4 days. All administrations were done intraperitoneally. Twenty days later, blo...
Source: Comparative Clinical Pathology - November 9, 2018 Category: Pathology Source Type: research

Morphological and molecular identification of Acanthocheilonema reconditum in a canine
This report alerts veterinarians to the presence ofA.reconditum in the region of Santa Maria, Rio Grande do Sul, Brazil, and highlights the importance of performing the differentiation of microfilaria species. In addition, it demonstrates the importance of fine needle aspiration cytology as a diagnostic tool. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - November 8, 2018 Category: Pathology Source Type: research

The protective effect of coenzyme Q10 and berberine on sperm parameters, with and without varicocelectomy in rats with surgically induced varicoceles
AbstractThe current study aimed to investigate the protective effects of coenzyme Q10 (Co Q10) and berberine (BB) with and without varicocelectomy on sperm parameters in postoperative varicocele rats. For the current purpose, a total of 60 mature male Wistar rats were randomly divided into control (n = 6 rats), control-sham (n = 6 rats), and experimental (n = 6 rats) groups. The animals in the experimental groups were undergone experimental varicocele, and simple laparotomy was performed in control-sham group. The experimental group was subdivided into the following groups 60 ...
Source: Comparative Clinical Pathology - November 8, 2018 Category: Pathology Source Type: research

The aqueous extract of Glycyrrhiza glabra effectively prevents induced gastroduodenal ulcers: experimental study on Wistar rats
In conclusion, the obtained results indicated the hepatoprotective, nephroprotective, hematoprotective, immunoprotective, and gastroduodenal protective properties ofG. glabra aqueous extract. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - November 7, 2018 Category: Pathology Source Type: research

Hepatoprotective potential of aqueous extract of Allium eriophyllum Boiss in high-fat diet-induced fatty liver diseases
AbstractIn recent years, Iranian traditional medicine has been used to control, prevent, and treat various diseases such as fatty liver. One of these plants isAllium eriophyllum Boiss. In this research, we assessed the potential of aqueous extract ofA. eriophyllum in the treatment of fatty liver disease in Wistar male rats. At beginning of the study, a total of 10 rats were selected as the negative control, and 50 rats were treated with a high-fat diet for 4  months. Then, the animals were randomly divided into six subgroups, including negative healthy control, untreated negative control, and four groups receiving the...
Source: Comparative Clinical Pathology - November 6, 2018 Category: Pathology Source Type: research

Assessment of the anti-anemic effect of aqueous extract of Allium eriophyllum Boiss leaf in phenylhydrazine-treated Wistar male rats
In this study, 60 rats were used. Induction of hemolytic anemia was done by three injections of phenylhydrazine in 50 animals. After 1  day, the rats were divided into six subgroups, including negative healthy control, untreated negative control, and four groups receiving theA. eriophyllum at 20, 40, 80, and 160  mg/kg concentrations. At the end of day 15 of treatment, the animals of all groups were sacrificed, and blood samples were drawn immediately from the animals’ hearts to analyze the biochemical and hematological parameters. The data were analyzed by SPSS-21 software. Different doses ofA. eriophyllum...
Source: Comparative Clinical Pathology - November 5, 2018 Category: Pathology Source Type: research

The therapeutic potential of aqueous extract of Falcaria vulgaris in the treatment of fatty liver disease: a histopathological and biochemical approach
In this study, we assessed the potential of aqueous extract ofFalcaria vulgaris in treatment of fatty liver disease by investigating the histopathological and biochemical approaches. In beginning of the research, a total of 10 Wistar male rats were selected as the negative healthy control, and 50 rats were treated with a high-fat diet for 4  months. Then, the animals were randomly divided into six subgroups, including negative healthy control group, untreated group, and four groups receiving the aqueous extract ofF. vulgaris at 25, 50, 100, and 200-mg/kg concentrations. After 2  months, the rats were sacrificed, ...
Source: Comparative Clinical Pathology - November 5, 2018 Category: Pathology Source Type: research

A preliminary study for building a reference serum bank to identify freshwater snails in Lorestan Province
AbstractSnails transfer certain parasites that are important in medicine and veterinary medicine. There is a wide range of trematodes that are particularly important. One of the main issues in trematode parasitology is the diagnosis of the intermediate host snail. The present study was conducted to build a reference serum bank for identifying freshwater snails in Lorestan Province. After sampling and identifying the snails, the soft body of each species was separately extracted. After injecting soft body with adjuvant into rabbits and preparing their serum, counterimmunoelectrophoresis was performed to ensure the appearanc...
Source: Comparative Clinical Pathology - October 22, 2018 Category: Pathology Source Type: research

Characterization of pennyroyal ( Mentha pulegium ) essential oil as an herbal, antibacterial, and antioxidant substance
In conclusion, pennyroyal essential oil can be a good substitution for some synthetic antibiotics and antioxidants. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - October 22, 2018 Category: Pathology Source Type: research

Evaluation of antimalarial and biochemical profiles of Abaleria ® in Plasmodium berghei -infected mice
AbstractThe rate of increasing resistance to most antimalarial drugs suggests a need for better alternatives. Hence, the present study evaluates the in vivo antimalarial and biochemical profiles of a locally formulated herbal antimalarial therapy, Abaleria ® on mice infected withPlasmodium berghei. Eight groups of five mice each were used. The control groups include uninfected, infected with 1.0  × 107P. berghei parasites but not treated, infected, and treated 3  days after inoculation with 25 mg kg−1 chloroquine diphosphate (CDP). Other groups were infected and treated with 50,...
Source: Comparative Clinical Pathology - October 22, 2018 Category: Pathology Source Type: research

Endocrine and oxidative stress characteristics in different anesthetic methods during pneumoperitoneum in dogs
AbstractGeneral anesthesia and pneumoperitoneum are two main components of laparoscopic surgery. The aim of this study was to evaluate the effects of anesthesia on endocrine and oxidative variables during pneumoperitoneum including as follows: triiodothyronine (T3), thyroxin (T4), cortisol, malondialdehyde (MDA), and total antioxidant capacity (TAC). Twenty mixed-breed adult dogs were randomly divided into four groups: propofol and mechanical ventilation (group P-M), propofol and spontaneous ventilation (group P-S), isoflurane and mechanical ventilation (group I-M), isoflurane and spontaneous ventilation (group I-S). The d...
Source: Comparative Clinical Pathology - October 22, 2018 Category: Pathology Source Type: research

Protective effect of royal jelly on the DNA integrity of sperms and early in vitro embryonic development in ofloxacin treated rats
This study was designed to determine the protective effects of royal jelly on the DNA integrity of sperms and early in vitro embryonic development in ofloxacin treated rats. In this study, 32 adult male rats were used and randomly allocated into 4 groups, each consisted of eight rats and dosed daily for 28  days by oral gavage: control—distilled water (216 mg/kg BW); ofloxacin group—ofloxacin (216 mg/kg BW); royal jelly group—royal jelly (100 mg/kg BW); royal jelly with ofloxacin group—216 mg/kg BW ofloxacin and 100 mg/kg BW royal jelly. The results showed that sperm vi...
Source: Comparative Clinical Pathology - October 17, 2018 Category: Pathology Source Type: research

Comparative diagnosis of Mycobacterium avium subspecies paratuberculosis in the tissues of clinical and subclinical sheep of paratuberculosis endemic farm
AbstractParatuberculosis (Johne ’s disease) is the chronic infectious granulomatous enteritis of ruminants caused byMycobacterium avium subspeciesparatuberculosis. Due to the lack of definite diagnostic tests, the early detection of the disease is difficult. The present study was undertaken to assess comparative efficacy of diagnostic methods routinely used in the identification and confirmation ofMycobacterium avium subspeciesparatuberculosis (MAP) in the tissue samples of naturally infected clinical and subclinical sheep. The ileum and mesenteric lymph node (MLN) tissues were collected from 20 paratuberculous sheep...
Source: Comparative Clinical Pathology - October 16, 2018 Category: Pathology Source Type: research

Function indices of liver and kidney and haematological parameters of male Wistar rats after oral administration of aqueous extract of Terminalia avicennioides root barks
This study aims to investigate the effects of aqueous extract ofT.avicennioides root barks on biochemical and haematological parameters of Wistar rats. Male rats were distributed randomly into four groups (A –D) and orally administered aqueous root bark extract ofT.avicennioides (250, 500 and 1000  mg/kg body weight) for 7 days. Liver, kidney and serum enzymes, function indices and malondialdehyde, as well as haematological parameters were monitored. The extract significantly (p 
Source: Comparative Clinical Pathology - October 9, 2018 Category: Pathology Source Type: research