First record of hematologic values in free-living silky anteaters (Cyclopes didactylus: Xenarthra: Cyclopedidae)
This article is the first to present the hematological profile of free-living silky anteaters, also known as pygmy anteaters (Cyclopes didactylus) – the smallest tamandua. Researchers captured five animals from Delta do Parnaíba, one of the best-preserved coastal areas located in northeastern Brazil between the states of Maranhão and Piauí. After capture, researchers anesthetized the animals with a combination of ketamine chloride and mid azolam for blood collection. The following hematological parameters were determined: hematocrit count and total and differential leukocyte count. The hematocrit count in silky anteat...
Source: Comparative Clinical Pathology - November 16, 2021 Category: Pathology Source Type: research
Hepatoprotective and anti-inflammatory potential of chebulagic acid on carbon tetrachloride –induced hepatic fibrosis by antioxidative activities in rats
AbstractThe aim of the present study was to evaluate the hepatoprotective, antioxidant, and anti-inflammatory potential of chebulagic acid on carbon tetrachloride –induced hepatic fibrosis in rats. The liver was damaged in the rats using CCL4 (2 ml/kg b.w dissolved in 20% corn oil) intragastrically twice/week for 8 weeks. After 8 weeks, activities of serum aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and lactate dehydrogenas e, lipid peroxidation markers, and enzymic and non-enzymic antioxidant enzymes, inflammatory and anti-inflammatory cytokines were analyzed and all these parameters we...
Source: Comparative Clinical Pathology - November 8, 2021 Category: Pathology Source Type: research
Haematology of Calotes versicolor Daudin (1802) in different seasons
AbstractThe study is aimed to investigate the haemoprofile of common garden lizard in Odisha, India. Ten adult lizards of each sex in different seasons were collected from the coastal area of Rajnagar block of Kendrapara, 754 225, Odisha, located in 20 ° 20′ N to 20° 37’ N latitude and 86° 14′ E to 87° 01′ E longitude. One millilitre of blood was collected from the ventral tail vein and transferred into vials containing ethylenediaminetetraacetic acid (EDTA) and then transported to the laboratory. The haematological parameters such as Hb, PCV, TEC and TLC were determined while erythrocyte indices such as MCV, M...
Source: Comparative Clinical Pathology - November 7, 2021 Category: Pathology Source Type: research
Picralima nitida protects against hepatotoxicity and oxidative stress in alloxan-induced diabetic rats
AbstractPicralima nitida is widely used in herbal medicine due to its numerous health benefits. We investigated the effects of extracts ofP. nitida in alloxan-induced diabetic rats. Thirty Wistar rats were randomized into 6 groups of 5 rats each and treated as follows; Group I — normal control rats, Group II — diabetic rats treated with glibenclamide, Group III — diabetic rats not treated, Group IV — diabetic rats treated with methanol extract ofP. nitida leaf, Group V — diabetic rats treated with methanol extract ofP. nitida seed, Group VI — diabetic rats treated with methanol extract ofP. nitida root. Phytoch...
Source: Comparative Clinical Pathology - November 3, 2021 Category: Pathology Source Type: research
Urtica dioica extract —suitable dietary supplement influencing the growth body characteristics, antioxidant status, and serum biochemical parameters of broiler chickens
In conclusion, it can be summarized that using NE affected growth performance, carcass characteristics, serum biochemistry, and antioxidant status of broiler chickens. The optimal dose in the present study of NE in broiler diets was 0.25 ml/l. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - November 2, 2021 Category: Pathology Source Type: research
Influence of dietary basil (Ocimum basilicum) supplementation on growth performance, oxidative status biomarkers, and plasma biochemistry in common carp
AbstractBecause the cumulative effect of chemical components has a deterrent effect on consumer health, the use of natural food additives instead of traditional chemical food additives is becoming more and more useful for fish feed. The present research was conducted in common carp with the mean initial weight of 63.16 ± 0.72 g to assess the effect of dietary basil (Ocimum basilicum) powder (DBP) on some oxidative biomarkers in tissues and plasma biochemical parameters. Four formulations of experimental diets were prepared; group 1: control diet (in the absence of DBP), groups 2 (2% DBP), groups 3 (4% DBP), and grou...
Source: Comparative Clinical Pathology - November 1, 2021 Category: Pathology Source Type: research
Effects of apple cider vinegar on haemato-biochemical parameters of gestating rats and morphometric indices of their pups at delivery
This study investigated the effect of consuming ACV during pregnancy on the haematological and biochemical profile of adult female albino rats in correlation with morphometric of the litters. Graded concentrations of ACV were administered to gestating albino rats to evaluate their effects on haematological and biochemical parameters of gestating rats and morphology of their pups at delivery. Ninety-six rats comprising 48 females (12 to 13 weeks old) and 48 males (15 weeks old) were used. The impregnated rats were randomly assigned to four groups (A, B, C and D) of 12 rats each. Each group was further sub-assigned into t...
Source: Comparative Clinical Pathology - October 29, 2021 Category: Pathology Source Type: research
Potential antioxidant properties and anti-diabetic and hepatic/pancreatic protective effects of dietary Boswellia serrata gum resin powder against oxidative damage in streptozotocin ‐induced diabetic rats
AbstractThe present study was designed to explore the potential antidiabetic and antioxidant capacity and hepatic/pancreatic protective effects ofBoswellia serrata gum resin (BSGR) powder against streptozotocin-induced oxidative stress in diabetic rats. Diabetes was induced by a single intraperitoneal injection of 60 mg/kg of streptozotocin (STZ). Forty rats were randomly allocated into four groups of ten each: group 1 served as a control and received a normal rat diet (ND-0); group 2 received diet containing 2% ofBoswellia serrata gum resin powder (ND-BSGR); group 3 diabetic control received a diet containing 2% of BSGR...
Source: Comparative Clinical Pathology - October 21, 2021 Category: Pathology Source Type: research
Antiviral activity of Phoenix dactylifera extracts against herpes simplex virus type 1: an animal study
AbstractHerbal medicines have recently been developed for the treatment of infectious diseases. The aim of this study was to investigate the therapeutic potential ofPhoenix dactylifera fruit and kernel extracts against herpes simplex virus type 1 (HSV-1) in an animal model. Five, 10, and 15% (w/w) concentrations of aqueous, ethanol, and acetone extracts of kernel and fruit ofPhoenix dactylifera were used for the formulation of cream-based drugs for the treatment of HSV-1-infected mice. The clinical improvement was evaluated using lesion scoring and histopathological assessments. Our results demonstrated that there is a pot...
Source: Comparative Clinical Pathology - October 20, 2021 Category: Pathology Source Type: research
Efficacy of combined therapy of Diminaveto ® and Intromidium® in albino rats experimentally infected with Trypanosoma brucei brucei
AbstractThe chemotherapeutic effect of Diaminaveto ® (diminazene aceturate) and Intromidium® (isomethamidium chloride) combination in rats infected withTrypanosoma brucei was evaluated. Forty albino rats used for this study were grouped into 8 groups of 5 rats each. Rats in group 1 were not infected while group 2 –8 rats were inoculated intraperitoneally (i.p.) with 1 × 106 trypanosomes. Rats in group 2 were left untreated while group 3 and 4 rats were treated with 3.5 mg/kg Diaminaveto (DM) and 0.5 mg/kg Intromidium (IM) intramuscularly (i.m.) respectively at day 19 post infection (PI). Also, 7.0 mg/kg DM an...
Source: Comparative Clinical Pathology - October 8, 2021 Category: Pathology Source Type: research
Soothing effect of dietary Allium sativum supplementation on immuno-biochemical alterations, and oxidative stress parameters in E. coli–experimentally infected broiler chickens
In conclusion,A. sativum mitigates hematological, biochemical, and antioxidant alterations induced by experimentally E. coli infection in broiler chickens. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - October 6, 2021 Category: Pathology Source Type: research
Azadirachta indica (A. Juss.) and Curcuma longa (L.) modulate immunoglobulin and cytokine levels in Plasmodium berghei-infected mice
AbstractPlasmodium infection causes inflammation in the host. A combination of herbs likeAzadirachta indica andCurcuma longa may have beneficial effect in remediating inflammation in malaria disease. The aim of this study is to investigate the immunomodulatory and synergistic effects of the association ofAzadirachta indica andCurcuma longa in experimentalPlasmodium berghei infection. Fifty male Swiss mice were infected with chloroquine susceptible (NK 65) strain ofPlasmodium berghei intraperitoneally. Parasitemia was confirmed using microscopy and the animals were grouped (n = 5), treated once daily and orally for 7 d...
Source: Comparative Clinical Pathology - September 20, 2021 Category: Pathology Source Type: research
Protective effect of betaine against gentamicin-induced renal toxicity in mice: a biochemical and histopathological study
AbstractConsidering the role of oxidative stress as a molecular mechanism underlying the deleterious side effects of gentamicin, applying antioxidants is likely to have ameliorative effects against GNT-induced tissue damages. This work was aimed to investigate the protective effect of betaine or trimethylglycine upon gentamicin-induced toxicity in mice. Thirty male mice were randomly divided into five groups: group 1 (control; i.p. injection of isotonic saline), group 2 received gentamicin (GNT; 80 mg/kg, i.p.) for 10 days, group 3 received GNT (80 mg/kg, i.p.) for 10 days and betaine (2% in the diet) for 18 days sta...
Source: Comparative Clinical Pathology - September 18, 2021 Category: Pathology Source Type: research
Oxidant-antioxidants and trace mineral status in Coccidiosis affecting buffalo calves
This study aimed to investigate the biochemical, and oxidative stress parameters in diarrhetic buffalo calves. A total number of 16 buffalo calves enrolled in this study. Calves aged between 3 and 6 months and divided into diarrhetic calves (N = 10) and healthy calves (n = 6). Clinical signs were recorded, and fecal samples were taken and examined for the presence ofEimeria oocytes. A total of 10 ml of blood was withdrawn from the jugular vein to estimate superoxide dismutase (SOD) and glutathione peroxidase (GPx), catalase (CAT), malondialdehyde (MDA), total antioxidant capacity (TAC), total protein, albumin, ...
Source: Comparative Clinical Pathology - September 17, 2021 Category: Pathology Source Type: research
Revealed pathophysiological mechanisms of crosslinking interaction of affected vital organs in COVID-19
AbstractSARS-CoV-2 is one of the main serious challenges of human societies, which emerged in December 2019 from China and quickly extends to all parts of the world. The virus was previously believed to only affect the lungs and respiratory system, but subsequent research has revealed that it affects a variety of organs. For this reason, this disease is known as a multiorgan disease. Current article aimed to highlight latest information and updates about molecular studies regarding pathogenesis of SARS-CoV-2 in kidney, liver, and cardiovascular and respiratory systems, as well as the mechanisms of interaction of these orga...
Source: Comparative Clinical Pathology - September 10, 2021 Category: Pathology Source Type: research
