Clinical evaluation of the anti-inflammatory effects of Heracleum persicum fruits
This study aimed to evaluate the anti-inflammatory effects of H. persicum extract in patients with minimal coronary artery disease. Subjects with  0.05). Comparison of the magnitude of changes between the study groups did not indicate any significant difference between H. persicum extract and placebo (p > 0.05). The present results did not indicate any superior effect of H. persicum to placebo in terms of changing serum levels of inflammatory biomarkers. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - February 25, 2015 Category: Pathology Source Type: research

Pyothorax associated with Salmonella and Pseudomonas spp. infection in a FIV-positive cat
Abstract Pyothorax associated with Salmonella and Pseudomonas spp. infection in a 2-year-old female domestic shorthair cat is described in this clinical report. The cat had cachexia with a past history of diarrhea and severe dyspnea. Retrovirus testing by using rapid polymerase chain reaction (PCR) showed that the animal was infected with feline immunodeficiency virus (FIV). Radiography showed severe pleural effusion. On postmortem examination, pyothorax with extensive deposition of fibrin on pleural membranes and tracheobronchial tree and pulmonary congestion were seen. Salmonella and Pseudomonas spp. was isolate...
Source: Comparative Clinical Pathology - February 25, 2015 Category: Pathology Source Type: research

Comparative analysis of phylogenetic group and antimicrobial resistance pattern of fecal Escherichia coli isolates between healthy dogs and their owners
Abstract To compare the phylogenetic group and antimicrobial resistance pattern of fecal Escherichia coli from dogs and their owners in Shiraz, Iran, a total of 385 E. coli was isolated from 32 dog–owner pairs and 17 control humans. All isolates were subjected to Clermont PCR phylotyping and standard disk diffusion susceptibility testing to 13 antibiotics. Phylogenetic group distribution was significantly different among dogs, owners, and controls. Highest resistance was found to ampicillin (100 %) followed by amoxicillin (96.6 %) and trimethoprim–sulfamethoxazole (57.1 %) and lowest to ...
Source: Comparative Clinical Pathology - February 21, 2015 Category: Pathology Source Type: research

Bilateral corneal lipidosis secondary to hypothyroidism in a terrier
Abstract A 6-year-old, female terrier dog was presented with a history of excessive lacrimation, photophobia, decreased appetite, weight gain, hair loss, lethargy, and mental dullness. Clinical examinations revealed comedones, seborrhea, thickening, and hyperpigmentation of the skin. Conjunctival congestion, hyperemia, and a white central corneal deposit on both eyes were observed during eye examination. Hematological investigations showed hypercholesterolemia and hypertriglyceridemia. The Hormone profile revealed low serum levels of total and free thyroxin and an increased serum level of TSH. The appearance of oc...
Source: Comparative Clinical Pathology - February 20, 2015 Category: Pathology Source Type: research

Histopathologic and biochemical study of the effect of saffron extract on gentamicin-induced nephrotoxicity in rats
Abstract Aminoglycoside antibiotic, gentamicin, is widely used against gram-negative bacteria; however, its clinical use is limited due to its nephrotoxicity. Saffron extract has been previously used to decrease oxidative stress induced by ischemia-reperfusion. Here, we studied the effect of aqueous saffron extract on gentamicin toxicity. Twenty-eight male Wister rats were divided randomly into 4 equal groups and were injected with gentamicin (100 mg/kg I.M.), aqueous saffron extract (5 mg/kg I.P.), combination of thereof, and saline (1 ml I.M.). All treatments were done for ten consecutive days. Ge...
Source: Comparative Clinical Pathology - February 14, 2015 Category: Pathology Source Type: research

Monocytes in Icelandic horses: comparison between automatic gating by the ADVIA 2120i, a manual gating method and microscopic differentiation
Abstract Inspection of the ADVIA 2120i PEROX cytograms from healthy Icelandic horses revealed a mismatch of the automatic gating (A) for monocytes, resulting in a lower percentage. The raw data of 40 Icelandic horses were transformed to FCS files. Data were imported to WinMDI 2.9 (Purdue Cytometry Laboratories) and gated manually (M). In addition, a manual 200-cell differential (D) was performed. ANOVA was used to test for significant differences. RefVal 2.1 (Toulouse Veterinary School) was used to calculate the reference values by different methods. Significance level was set at P 
Source: Comparative Clinical Pathology - February 7, 2015 Category: Pathology Source Type: research

Association between serum copper concentration and the risk of bovine leptospirosis
Abstract Leptospirosis is a zoonotic disease found in nearly all parts of the world. This disease is exacerbated by a weakened immune system. Copper is an important component of the immune system. The aim of this study was to investigate the effect of copper deficiency on leptospirosis occurrence. A total of 260 serum samples were randomly collected from eight industrial and semi-industrial dairy farms from center and southeast of Iran. Microscopic agglutination test to check leptospirosis was performed. Serum copper level was analyzed using an atomic absorption spectrometer. Fifty-eight serum samples had detectab...
Source: Comparative Clinical Pathology - February 2, 2015 Category: Pathology Source Type: research

Serum bile acids concentration in captive American flamingos ( Phoenicopterus ruber )
This study was conducted in order to determine serum bile acids concentration in captive American flamingos (Phoenicopterus ruber). Seventeen healthy flamingos of both sexes were evaluated as part of an overall clinical health assessment. Each bird underwent a complete physical examination, complete blood count, and serum biochemistry testing. Blood samples were collected from the medial metatarsal vein and submitted for a serum bile acids analysis. The median serum bile acids concentration for the American flamingo was 30 μmol/L (min = 20 μmol/L, max = 58 μmol/L), with n...
Source: Comparative Clinical Pathology - February 2, 2015 Category: Pathology Source Type: research

The mechanistic role of epigenetic in multiple myeloma
This article reviews recent findings on the role of epigenetic alterations in MM pathogenesis, which affect the expression of cell cycle regulatory molecules, apoptosis, DNA repair system, CD markers, cell signaling pathways as well as tumor suppressor miRNAs. Given these results, it can be stated that these epigenetic changes play an important role in the initiation and progression of MM. Therefore, understanding the impact of epigenetics in MM pathogenesis in each stage of disease progression can help develop therapeutic targets to increase survival and reduce drug resistance. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - February 1, 2015 Category: Pathology Source Type: research

Lipid peroxidation and decrease on the activities of antioxidant enzymes in experimental infection by Babesia bovis in cattle
Abstract Babesia bovis is one of the causative agents of bovine babesiosis, a disease with high morbidity and mortality in susceptible populations. The aim of this study was to evaluate the occurrence of oxidative stress in cattle experimentally infected with attenuated B. bovis. For that, eight healthy cattle were used and divided into two groups: animals infected with B. bovis (n = 4; group A) and non-infected animals (n = 4; group B). Blood samples of all animals were collected at 0, 7, 11, and 15 days post-infection (DPI) for red blood cells (RBCs) count, and measure...
Source: Comparative Clinical Pathology - February 1, 2015 Category: Pathology Source Type: research

Effects of diazinon on some immunological components of common carp, Cyprinus carpio juveniles
In conclusion, our results showed that diazinon can suppress the immunity of common carp juveniles through decreasing IgM levels as well as stimulates lysozyme activity. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - January 30, 2015 Category: Pathology Source Type: research

A hematologic and biochemical profile on 3-month-old hatchlings of Lepidochelys olivacea
Abstract The olive ridley turtle (Lepidochelys olivacea) is globally distributed. However, the species is considered vulnerable. Additionally, hematological and biochemical data for this species are seldom published in the scientific literature. The aim of this study was to gather hematological and biochemical data on young L. olivacea, drawing comparisons with hematological and biochemical data already published for sea turtles. Blood samples from 23 olive ridley sea turtles were collected, and hematological and biochemical parameters were determined. Mean and standard deviation values were determined for the hem...
Source: Comparative Clinical Pathology - January 29, 2015 Category: Pathology Source Type: research

Hereditary xanthinuria and urolithiasis in a domestic shorthair cat
Abstract A 2-year-old domestic shorthair cat was presented with a history of hematuria, stranguria, and intermittent urethral obstruction. Urine sedimentation showed hematuria, pyuria, and yellow-brown, amorphous, and spherical crystals. Upon surgical correction of the obstructed urethra by perineal urethrostomy, many dark yellow to grey, irregular, gravel-like to millet grain-sized uroliths were found. These uroliths were shown to consist of 100 % xanthine by crystallography. The urinary xanthine concentration was high. The cat subsequently developed bilateral nephroliths, recurrent urinary tract infections,...
Source: Comparative Clinical Pathology - January 29, 2015 Category: Pathology Source Type: research

The relationship between bovine adenomyosis and endometritis
In conclusion, the present study showed a numerically higher prevalence of adenomyosis in cows with endometritis. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - January 28, 2015 Category: Pathology Source Type: research

Antidiabetic effect of Pistacia atlantica and Amygdalus scoparia in streptozotocin-induced diabetic mice
Abstract Diabetes mellitus (DM) is a growing health concern worldwide. Many traditional treatments have been recommended in the alternative system of medicine for treatment of DM. Pistacia atlantica and Amygdalus scoparia have a long history as a medicinal plant since the ancient times. The present study evaluated the differential effects of N-hexane extraction of these plants on the blood glucose concentration and the pathology of the pancreas in diabetic mice. DM was induced in 40 out of 50 adult female mice, using intraperitoneal injection of 60 mg/kg BW streptozotocin. The diabetic mice were assigned into...
Source: Comparative Clinical Pathology - January 26, 2015 Category: Pathology Source Type: research

Effects of synbiotic (Biomin IMBO) on haematological and immunological components of Russian sturgeon, Acipenser guldenstadti
Abstract The present study was carried out to evaluate the effects of synbiotic (Biomin IMBO) on haematological (white blood cell (WBC) and red blood cell (RBC) counts, haemoglobin (Hb) concentration, haematocrit (Hct), mean corpuscular haemoglobin (MCH), mean corpuscular volume (MCV) and mean corpuscular haemoglobin concentration (MCHC)) and immunological (immunoglobulin (IgM) and lysozyme activity) components of Russian sturgeon, Acipenser guldenstadti. Five experimental treatments and one control group with three replicates were considered. In treatment groups, fish were fed with diet containing 1 (T1), 1.5 (T2...
Source: Comparative Clinical Pathology - January 26, 2015 Category: Pathology Source Type: research

Effects of dietary Thymus vulgaris extract alone or with atorvastatin on the liver, kidney, heart, and brain histopathological features in diabetic and hyperlipidemic male rats
Abstract Thymus vulgaris (thyme) is commonly used in folk medicine for several therapeutic purposes. The aim of the present study was to evaluate the histopathological changes in the four vital organs, liver, kidney, heart, and brain, of diabetic and hyperlipidemic male rats after consumption of different doses of hydroalcoholic extract of thyme alone or in 11 combinations with atorvastatin. In a double-blind animal-based controlled randomized clinical trial, 90 male rats were randomly allocated into nine equal independent groups, according to consumption of atorvastatine and/or T. vulgaris extract, and...
Source: Comparative Clinical Pathology - January 23, 2015 Category: Pathology Source Type: research

Role of skin biopsy in papulosquamous lesions—a comparative study
This study was done to assess the correlation between the clinical diagnoses of papulosquamous lesions made at dermatological clinics and the diagnosis of these lesions at biopsy. Our study lends insight into the list of most common to least common lesions of papulosquamous lesions. This is a cross-sectional study conducted at a dermatological clinic, on those patients who consulted to a dermatologist. This presumptive investigation on papulosquamous lesion was implied on 83 patients as lichen planus, lichen nitidus, lichen striata, lichenoides dermatitis, psoriasis, pityriasis rubra pilaris, pityriasis rosea, pityriasis l...
Source: Comparative Clinical Pathology - January 23, 2015 Category: Pathology Source Type: research

Studies on the protective effects of ascorbic acid and thiamine on lead-induced lipid and protein oxidation as well as enzymatic alterations in some tissues of Cyprinus carpi o
Abstract The present study has been undertaken to evaluate the possible protective effects of ascorbic acid and thiamine on modulating lead-induced lipid and protein oxidation as well as metabolic enzyme alterations in some tissues of common carp. Fish were divided into 4 groups, as follows: group A served as control; group B received lead acetate (5 mg L−1, 15 days); and group C and D received ascorbic acid (500 mg kg−1 feed) and thiamine (50 mg kg−1 feed) respectively, in addition to lead acetate. Lead acetate exposure caused significant increase in MDA conten...
Source: Comparative Clinical Pathology - January 20, 2015 Category: Pathology Source Type: research

Bovine generalized lipofuscinosis and sarcoplasmic inclusions: histopathological and histochemical features in three cases
Abstract Three adult Holstein-Friesian dairy cows (4 to 6 years old) which had been raised at three different farms were culled with a long history of locomotor dysfunction attributed to dislocation or subluxation of the hip joint (two cows) or foot rot (one cow). They revealed dark brown discoloration of multiple sites of the carcasses at postmortem examination. On histopathological and histochemical investigations, lipofuscin pigments showing autofluorescence, sudanophilia, argyrophilia, periodic acid-Schiff (PAS) positiveness, and acid fastness were stored within otherwise normal cells of various sites in ...
Source: Comparative Clinical Pathology - January 19, 2015 Category: Pathology Source Type: research

The expression of IL-7RA in Egyptian patients with multiple sclerosis
Abstract Multiple sclerosis has a clinically significant heritable component. The interleukin 7 receptor alpha (IL-7RA) has been recognized as a susceptibility gene for multiple sclerosis (MS). It is known that demographic, environmental factors, as well as population genetic background have a substantial role in multiple sclerosis development. The aim of the present study was to assess the relevance of IL-7RA messenger RNA (mRNA) gene expression level in peripheral blood mononuclear cells (PBMC) on MS phenotype (including clinical and magnetic resonance imaging (MRI) parameters). A total of 31 unrelated Egyptian ...
Source: Comparative Clinical Pathology - January 18, 2015 Category: Pathology Source Type: research

Cutaneous lesions due to babesiosis in a dog
Abstract A 5-year-old dog was identified suffering with recurrent skin lesions, fever, and progressive weight loss. Peripheral blood smear revealed presence of Babesia organisms. Dog had anemia, leucopenia, thrombocytopenia and it was treated with diminazene aceturate along with supportive therapy. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - January 15, 2015 Category: Pathology Source Type: research

Outbreak of leptospirosis: reproductive losses in sheep
Abstract Sheep are considered less susceptible to leptospirosis than other livestock species, and reports of reproductive problems are scarce in scientific literature. Thus, our objective was to report an epidemic outbreak of leptospirosis in a flock in southern Brazil, causing economic impact represented by several numbers of abortions and barren ewes. From a flock of 602 sheep, 79 ewes had problems during gestational period. Blood samples were collected from 25 of these 79 ewes, 10 with confirmed abortion, 10 barren, and 5 ewes that delivered normally. Serum was separated and subjected to serological evaluation....
Source: Comparative Clinical Pathology - January 15, 2015 Category: Pathology Source Type: research

Comparative evaluation of clinicopathological, immunohistochemical, and immunofluorescent techniques for diagnosis of rabies in animals
Abstract Rabies is one of the most feared zoonotic diseases in the world. The present study was envisaged to compare the sensitivity of detection of rabies virus antigen by histopathological and immunohistochemical approaches in the brain tissues of 100 rabies-suspected animals. In dogs, anorexia, difficulty in standing/paralysis, and hypersalivation were the common clinical signs, whereas in cattle and buffaloes, important clinical signs of rabies were anorexia, circling/head pressing, behavioral change, and bellowing. Percentage of neurons positive for Negri bodies by hematoxylin and eosin (H&E) and immunohi...
Source: Comparative Clinical Pathology - January 7, 2015 Category: Pathology Source Type: research

The effect of caraway ( Carum carvi L.) on the blood antioxidant enzymes and lipid peroxidation in streptozotocin-induced diabetic rats
Abstract Different studies have shown that oxidative stress has an important role in both types of diabetes mellitus. The aim of this study was to evaluate the effect of different doses of Carum carvi oil on antioxidant enzymes of streptozotocin-induced diabetic rats. Fifty-six Wistar male rats weighing between 250 ± 50 g were divided into seven equal groups. Diabetes was induced in the experimental rats with streptozotocin (60 mg kg−1 body weight). Rats in group I served as the normal control animals; group II served as the caraway control, whereas group III served as the...
Source: Comparative Clinical Pathology - January 7, 2015 Category: Pathology Source Type: research

Evaluating the gene expression level of IL-12 in the fibrous layer of hepatic hydatid cysts isolated from slaughtered animals
This study aimed at evaluating the gene expression level of IL-12 in the fibrous layer of hepatic hydatid cysts in bovine and ovine samples. For each one of the bovine or ovine groups, 12 samples were considered (6 = control and 6 = experimental). The test samples were collected from the fibrous layer of the bovine and ovine hepatic hydatid cysts and the control ones from the normal liver tissues. Thus, the total number of samples was 24. The total RNA was extracted from the samples and then converted to cDNA. Subsequently, the gene expression level of IL-12 in both test and control groups of th...
Source: Comparative Clinical Pathology - January 7, 2015 Category: Pathology Source Type: research

Hematological reference values of the snakes Oxyrhopus guibei and Xenodon neuwiedii (Serpentes: Dipsadidae)
Abstract The aim of this study was to establish the reference range of hematological values for two species of Brazilian nonpoisonous snakes recently wild-caught and sent to the Butantan Institute. Blood samples were collected from the ventral caudal vein of 26 Oxyrhopus guibei (18 females and 8 males) and 19 Xenodon neuwiedii (nine females and ten males) snakes. Hematologic analyses were performed using manual standard methods and mean values (X ± SD) for O. guibei and X. neuwiedii were, respectively, red blood count ×109/L (476.6 ± 138.8 and 455.3 ± 125.9);...
Source: Comparative Clinical Pathology - January 1, 2015 Category: Pathology Source Type: research

The first report of Neospora caninum prevalence in aborted and healthy sheep from west of Iran
Abstract Serum samples from 586 sheep were collected from eight flocks within Aleshtar-Kahman region, in the west area of Iran. The samples were examined by enzyme-linked immunosorbent assay (ELISA) for the detection of antibody against Neospora caninum. The observed prevalence of N. caninum infection was 1.13 % for aborted sheep and 1.70 % for healthy sheep, and the titers ranged from 1/160 to 1/2,560. There was no significant difference between aborted and healthy sheep for N. caninum infection (overall χ 2 = 1.04, p value = 0.516, d.f. = 1). Th...
Source: Comparative Clinical Pathology - January 1, 2015 Category: Pathology Source Type: research

Aetiology of skeletal deformity in a Barbus grypus (Heckel, 1843) fish: clinical and radiological studies
This study characterized bone deformities in adult Barbus grypus fish and investigated potential associations between some agent(s) and these deformities by using a series of clinical examinations. Radiological findings included lordosis and scoliosis in trunco-caudal spines. Vertebral numbers and intervertebral spaces were normal, but the vertebrae were shorter compared to healthy fish. Alkaline phosphatase and inorganic phosphorus levels in serum of deformed fish also showed marked changes compared to healthy fish. Ca:Pi ratio was reduced in deformed fish compared with healthy cases. Histopathological investigation of bo...
Source: Comparative Clinical Pathology - January 1, 2015 Category: Pathology Source Type: research

Case report of adult Setaria digitata in sheep, Hamedan province, Iran
Abstract In October 2011, a 1.5-year old ram was anatomized, abdominal and thoracic cavities of the sheep were checked carefully. The liver, lung, and lymph nodes were collected in PBS and transferred to a parasitology laboratory of the Para Veterinary School, University of Hamedan. During this study, five nematode worms were detected in the abdominal cavity of a 1.5-year old ram. After fixation and morphological examination, the worms were identified as Setaria digitata. The worms were observed and identified by light microscopy on the basis of features at the anterior and posterior parts of the worms. The worms...
Source: Comparative Clinical Pathology - January 1, 2015 Category: Pathology Source Type: research

Giant cell-rich osteosarcoma of tibia in a dog: a pathological and immunohistochemical study
This report describes a GCRO in the tibia of a six and half-year-old, spayed, 41 kg, female, Scottish deerhound dog with a history of a mass on the tibia and severe lameness being observed by the owner. Histologically, the tumor was characterized by numerous multinucleated giant cell nests separated by small bundles of pleomorphic to polygonal cells. Between the spindle cells, osteoid was rare and organized in thin strands. Immunohistochemical stains for vimentin were positive, with no detectable cellular staining for cytokeratin. A GCRO was concluded in this case. The dog died 1 week after the biopsy. (Source: C...
Source: Comparative Clinical Pathology - January 1, 2015 Category: Pathology Source Type: research

The anesthetic effects of MS-222 (tricaine methanesulfonate) on some hematological parameters of sterlet, Acipenser ruthenus
In this study, we investigated the effects of MS-222 as an anesthetic on hematological parameters including hemoglobin (Hb), erythrocyte number (RBCs), hematocrit (Hct), and white blood cells (WBCs) in sterlet, Acipenser ruthenus. For this purpose, the hematological parameters were assessed immediately and 24 h after anesthesia. The results showed that despite no mortality occurred after anesthesia in 5 mg/l MS-222, this chemical substance influenced some hematological parameters. The values of Hb, Hct, and RBCs decreased. Immediately after anesthesia, these values increased significantly 24 h after anesthes...
Source: Comparative Clinical Pathology - January 1, 2015 Category: Pathology Source Type: research

Helicobacter pylori -induced chronic active gastritis in Saudi patients with special reference to the ultrastructural pathology
In conclusions, most of the presented patients showed histopathological features of chronic active gastritis. Ultrastructurally, bacillary form represents the main extracellular form of Helicobacter pylori and coccoid form might be formed in the gastric epithelial cells as a kind of bacillary transformation. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - January 1, 2015 Category: Pathology Source Type: research

Hematological parameters and nuclear abnormalities in peripheral erythrocytes of Achirus lineatus ( Pleuronectiformes: Achiridae )
Abstract Hematological parameter of demersal fish constitutes important measures of biological effects of seasonality and contaminants in sediments. We aimed to assess the hematological parameters and nuclear abnormalities, including micronuclei levels, in peripheral erythrocytes of flatfish Achirus lineatus collected in São Vicente Estuary in summer and winter. The number of lymphocytes was significantly higher in summer, whereas the number of neutrophils was significantly higher in winter. For other measured parameters, no significant differences were observed in spite of the levels of erythroblasts, leu...
Source: Comparative Clinical Pathology - January 1, 2015 Category: Pathology Source Type: research

The first detection of Cytauxzoon felis in a wild cat ( Felis silvestris ) in Iran
Abstract A free-ranging, adult, male Arabian wild cat (Felis silvestris) was found in a protected zone at the province of Khorasan, Iran and transported to the Ferdowsi University of Mashhad Veterinary Teaching Hospital. The cat had normal temperature and respiratory and cardiac frequency, but was significantly dehydrated and had hindlimb lameness. The animal also was cachectic, with pale mucus membranes, third eyelid protrusion, and bilaterally enlarged submandibular lymph nodes. The cat was stabilized by intensive fluid and electrolyte therapy and hospitalized. In radiographic evaluations, comminuted and multip...
Source: Comparative Clinical Pathology - January 1, 2015 Category: Pathology Source Type: research

Prevalence of Cysticercus tenuicollis in slaughtered sheep and goats by season, sex, age, and infected organ at Amol abattoir, Mazandaran province, Iran
Abstract Sheep and goats are the major sources of meat in Iran. The carcasses of 1,200 sheep and also 1,200 goats with their internal organs including the liver, diaphragm, and omentum from Amol abattoir were randomly inspected to estimate the prevalence rate of Cysticercus tenuicollis and asses its relationship with season, sex, age, and infected organs in slaughtered animals. A total of 2,400 animals (goats and sheep) was examined and 4.21 % was positive for C. tenuicollis. About 4.33 and 4.08 % of goats and sheep, respectively, were infected according to this survey; the difference of the prevalence ...
Source: Comparative Clinical Pathology - January 1, 2015 Category: Pathology Source Type: research

Oxidative stress in lymphoma: similarities and differences between dog and human
Abstract In the last 20 years, an increasing interest toward oxidative stress has been documented in order to investigate their direct or indirect involvement in several mechanisms regarding oncogenesis and lymphomas in particular. The aim of this paper was to evaluate oxidative stress in dogs affected by malignant lymphoma in comparison to a control group, to investigate what factors can affect this status, and to point out similarities and differences with human. Forty-eight samples from four subjects, affected by high-grade centroblastic polymorphic lymphoma and receiving a standard chemotherapy, have bee...
Source: Comparative Clinical Pathology - January 1, 2015 Category: Pathology Source Type: research

Erratum to: MRI and CT evaluations of an invented bioglue in experimentally induced articular cartilage defects in rabbits
(Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - January 1, 2015 Category: Pathology Source Type: research

Erratum to: Major metacestodes in small ruminants slaughtered at Dessie municipal abattoir, Eastern Ethiopia: prevalence, cyst viability, organ distribution and economic implications
(Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - January 1, 2015 Category: Pathology Source Type: research

Effect of ketamine on oxidative stress following lipopolysaccharide administration
Abstract The aim of this study was to determine the effect of ketamine on oxidative stress and inflammation in the brain and liver in basal state and during systemic inflammation induced by intraperitoneal (i.p.) lipopolysaccharide (LPS) administration. Rats were treated with subcutaneous ketamine (15 or 30 mg/kg) alone, LPS (300 μg/kg, i.p.) or with ketamine (30 mg/kg) and LPS (300 μg/kg, i.p.) and euthanized 4 h later. Lipid peroxidation (malondialdehyde: MDA), reduced glutathione (GSH), nitric oxide (nitrite) concentrations and paraoxonase 1 (PON1) activity were measured in the b...
Source: Comparative Clinical Pathology - January 1, 2015 Category: Pathology Source Type: research

Morphological development of ovaries in ostrich ( Struthio camelus ) embryo
Abstract The aim of this study was to investigate the histological development of right and left ovaries in ostrich embryo. The research was carried out on the ovaries of 20-, 26-, 30-, and36-day-old embryos. At first, anatomical observation was done, and then 5 μm sections of ovaries were stained by hematoxylin and eosin, periodic acid Schiff, and Masson’s trichrome staining methods. Some ovaries embedded in Epon and 1 μm thickness sections were stained with toluidine blue and examined using regular optical microscopy. The results showed ovaries had an unequal growth resulting into a larger ...
Source: Comparative Clinical Pathology - December 30, 2014 Category: Pathology Source Type: research

Isolation, culture, characterization, and adipogenic differentiation of heifer endometrial mesenchymal stem cells
Abstract Mesenchymal stem cells (MSCs) have been isolated from various tissues of different species. The mammalian endometrium has morphological and functional modifications throughout the estrous cycle undergoing periodic proliferation and degeneration. The aim of this study was to isolate, culture, and characterize and to determine adipogenic differentiation of endometrial mesenchymal stem cells (En-MSCs) in heifers. Uteri of healthy heifers were collected from Shiraz Slaughterhouse, Iran and transferred to Stem Cell Laboratory of Stem Cell and Transgenic Technology Research Center to isolate En-MSCs from endome...
Source: Comparative Clinical Pathology - December 25, 2014 Category: Pathology Source Type: research

Protective effect of Lithium Chloride against Trimethyltin-induced hippocampal degeneration and comorbid depression in rats
Abstract Pathophysiology of depression is a controversial issue. The present study aimed at investigating the pathophysiology of depression in trimethyltin (TMT) intoxication as a hippocampal degeneration inducer. The effect of Lithium Chloride (LiCl) chronic administration on the amelioration of depression symptoms was also investigated. The rats were injected with single dose of TMT (8 mg/kg intra-peritoneal). The three test groups received 20, 40 and 80 mg/kg of LiCl respectively. Likewise, the vehicle treated group received saline for fourteen day. In order to assess the depression level, the immobil...
Source: Comparative Clinical Pathology - December 20, 2014 Category: Pathology Source Type: research

Incidental findings of pathological significance in pneumonic lungs of sheep in Al Qassim Area, Kingdom of Saudi Arabia: an abattoir survey
Abstract A total of 1425 ovine lungs were grossly examined at the local abattoir during a 6-month survey on the aetiology and pathology of pneumonia in slaughtered sheep at the Al-Qassim region, Kingdom of Saudi Arabia. The results of the survey demonstrated the occurrence of several types of pneumonic and related lesions in 140 specimens of condemned lungs. However, more detailed microscopic examination of the pneumonic lungs incidentally revealed the coexistence of some other significant pathological alterations indicative of sheep pulmonary adenomatosis (Jaagziekte), ovine syncytial virus infection, ovine progr...
Source: Comparative Clinical Pathology - December 20, 2014 Category: Pathology Source Type: research

Effect of Persian sage ( Salvia Rhytidia ) extract on histomorphometric changes of cerebellum following ischemia reperfusion injuries in rat
This study showed that SR extract can protect the forebrain from IR injuries due to anti-oxidative effect of drug which is similar to silymarin. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - December 20, 2014 Category: Pathology Source Type: research

The relationship between blood lead level with iron status and hemopoietic parameters in smoker and non-smoker workers at lead battery factory
Abstract The present study aimed at evaluating the effect of lead exposure on hemopoietic system (through the index delta-aminolevulinic acid dehydratase [δ-ALAD] activity, hemoglobin concentration [Hb], hematocrit concentration [Hct]) and on iron status (levels of serum iron [Fe], ferritin [Fr], total iron binding capacity [TIBC], percentage of transferrin saturation [TS%]) in Iranian workers at lead batteries factory. Forty-four workers were divided into two groups: smokers (n = 21) and non-smokers (n = 23). Also, 45 healthy subjects were studied as control group. δ-ALAD, ...
Source: Comparative Clinical Pathology - December 19, 2014 Category: Pathology Source Type: research

Antioxidant activity and mineral element contents of Calotropis procera from Iran: a traditional medicinal plant in Middle East
Abstract Calotropis procera is a medicinal plant used traditionally in animal and human medicine for its digestive and anti-asthmatic effects. In the present study, antioxidant activity and mineral element contents of the leaves and flowers of C. procera were determined. Different extraction methods that include ethanol, chloroform, and water extraction were used to prepare extracts from the leaves and flowers of this plant. Diphenyl picrylhydrazyl (DPPH) method for antioxidant activities and flame atomic absorption spectrometry (FAAS) with microwave digestion for mineral element contents were performed...
Source: Comparative Clinical Pathology - December 18, 2014 Category: Pathology Source Type: research

Observed variation in the heterophil to lymphocyte ratio values of birds undergoing investigation of health status
Abstract Analysis of blood has been commonly used in the clinical assessment of the health status of birds and typically encompasses a suite of haematological assays. Determination of the heterophil to lymphocyte (H/L) ratio has been commonly reported as an alternative measure of leukocyte values, particularly in studies of naturally occurring physiological influences on birds. Relatively few studies have assessed the H/L ratio values of birds undergoing haematological assessment as part of an investigation of health status. In the current study, the H/L ratio was retrospectively determined for birds that had unde...
Source: Comparative Clinical Pathology - December 15, 2014 Category: Pathology Source Type: research

Erratum to: Studying histopathological effects of barley grain (Hordeum vulgare L.) on the evolution of the cortical portion of the adrenal glands in foetuses of diabetic albino rats
(Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - December 15, 2014 Category: Pathology Source Type: research

Introduce Indian gray mongoose ( Herpestes edwardsii ): as a successful animal model for influenza virus infection (a preliminary study)
Abstract Indian gray mongoose (Herpestes edwardsii) is native to a large geographic area, but there is a lack of data about the biology of this animal. In the present investigation, the possibility of experimental infection with influenza (H1N1) virus in mongoose was studied. Ten H. edwardsii were gathered. Two animals were maintained without inoculation, and others were inoculated by nasal route and then euthanized in different situations. The inoculated group showed clinical signs of pulmonary disorder. Necropsy findings and histopathologic investigation revealed a severe interstitial pneumonia. In the next step...
Source: Comparative Clinical Pathology - December 14, 2014 Category: Pathology Source Type: research