Effect of oral berberine administration on the renal profiles of adenosine deaminase, arginase, and nitric oxide in streptozotocin-induced diabetic nephropathy of rats
In conclusion, oral administration of BBR decreased FBG, ADA and arginase activities, and MDA level, and increased NO and antioxidant in diabetic rats. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - February 19, 2022 Category: Pathology Source Type: research
Clinical and hematological changes of canine tick-borne diseases in Thailand
This study revealed the need to be aware of the subclinical sign cases and also that the association of clinical sign and hematology value can be used as a direction for diagnosing canine tick-borne disease. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - February 19, 2022 Category: Pathology Source Type: research
Hematopoietic toxicity in Wistar rats experimentally exposed to cement dust
This study investigates the pattern of CD hematopoietic effect using a controlled model of exposure. Thirty (30 ) 3-month-old male Wistar rats weighing between 150 and 180g were randomized into three (3) groups (n = 10); control, 14-day and 28-day exposed. We assessed hematological differentials and indices, osmotic fragility test, erythrocyte morphology, and morphometry. Gross osteological variables and indices, osteohistopathology, and bone marrow cytology were also investigated. Results show that CD a lters hematological variables with significant increase in packed cell volume (PCV), erythrocyte count (RBC), hemogl...
Source: Comparative Clinical Pathology - February 15, 2022 Category: Pathology Source Type: research
Hematological approaches of canines naturally infected by Babesia spp. and Hepatozoon spp.
This study highlights the importance of epidemiological care, especially with the puppies, keeping them free from disease vectors and reinforces the importance of the blood count in the diagnosis, treatment, and prognosis of these diseases. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - February 15, 2022 Category: Pathology Source Type: research
Reference intervals for hematological and serum biochemical analytes in snow trout, Schizothorax esocinus inhabiting Dal Lake of Kashmir Himalaya
AbstractHematological and serum biochemical analytes are the main aspects of studying fish health. The primary objective of the present study was to establish hematological and serum biochemical reference intervals of a commercially important food fish,Schizothorax esocinus inhabiting Dal Lake. Data from a total of 432 adult fish specimens (length = 33.76 ± 2.26 cm; weight = 402.85 ± 84.24 g) was recorded over 2 years of study period from April 2017 to March 2019. Various parameters such as hemoglobin (Hb), red blood cell (RBC) and white blood cell (WBC) counts, packed cell volume (PCV), erythrocyte s...
Source: Comparative Clinical Pathology - February 9, 2022 Category: Pathology Source Type: research
Oral transmission of Trypanosoma evansi infection in a German Shepherd dog —a rare case report
AbstractA three-year-old male German Shepherd dog was presented to Referral Veterinary Polyclinic, Indian Veterinary Research Institute (RVP, IVRI), with a history of anorexia, progressive weight loss and relapsing fever for 15 days. Anamnesis revealed that the dog often attacked Nilgai and other wild animals in the forest and consumed wild rabbit regularly. Clinical examination revealed pale oral and conjunctival mucous membranes, pyrexia (104.3 F) and popliteal lymphadenopathy. Haemato-biochemical examination revealed anaemia, increased alkaline phosphatase (ALP), serum glutamic pyruvic transaminase (SGPT), blood urea ...
Source: Comparative Clinical Pathology - February 9, 2022 Category: Pathology Source Type: research
Zingiberene attenuates high fat diet –induced non-alcoholic fatty liver disease through suppression of lipogenesis and oxidative stress in rats
In conclusion, this study suggests that ZB supplementation might ameli orate the obesity-associated NAFLD via attenuation of elevated lipogenesis and oxidative stress in liver. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - February 1, 2022 Category: Pathology Source Type: research
Exercise increases the expression of glucose transport and lipid metabolism genes at optimum level time point 6 h post-exercise in rat skeletal muscle
In this study, we accessed NRF-1 and its target gene expression crucial in glucose transport and lipid oxidation during exercise. Five- to 6-week-old male Wistar rats were exercised to identify the time-point for an optimum increase in the levels of NRF-1 and target genes. Gastrocnemius muscles were harvested after 0, 2, 4, 6, 8, 10, 12, and 15 h post-exercise and non-exercise rats. Primers were used to amplify the region of the genes; Nrf-1, glut 4, carnitine palmitoyltransferase, peroxisome proliferator-activated receptor gamma co-activator 1, mef2a, and acetyl-CoA carboxylase-1. Relative mRNA expression was normalized...
Source: Comparative Clinical Pathology - January 27, 2022 Category: Pathology Source Type: research
Clinicopathological and immunological features of pleomorphic rhabdomyosarcoma in the subcutis of a 9-year-old Lolo dog
AbstractA 9-year-old female Lolo dog presented with a subcutaneous, large mass protruding from the right-side of her flank region with intact covering skin. Surgical excision of the mass revealed a well demarcated, large firm mass without invading the underlying muscle of the flank. The gross examination revealed a fish-flesh colored, large firm mass, histologically neoplastic cells exhibiting pleomorphism, multinucleated giant cells, and bizarre mitosis. Using immunohistochemical staining, the tumor cell was expressed with vimentin, desmin, and myogenin. Based on histological and immunohistochemical staining, it was confi...
Source: Comparative Clinical Pathology - January 25, 2022 Category: Pathology Source Type: research
Effects of adding corn silage to the diet of dairy calves on the weight gain, dry matter intake, and chemical blood parameters before weaning
The objective of this study is to survey the effect of primary ration forage type on weight gain, dry matter intake, and blood parameters before weaning. For this purpose, 20 Holstein calves were individually housed and randomly assigned to one of two groups, control (diet 1) and treatment (diet 2). The control group was given solid feed ad libitum including 80% concentrate (CON), and the 20% chopped hay (CH), and the treatment group was fed 80% CON, 10% CH, and 10% corn silage. All calves received milk 4 L per day from day 45 until day 75. Feed intakes were recorded on a daily basis and calves were weighed every 2 weeks...
Source: Comparative Clinical Pathology - January 20, 2022 Category: Pathology Source Type: research
Effects of 3-O-[6-deoxy-3-O-methyl- β-D-allopyranosyl-(1 4)-β-D-canaropyranosyl]-17β-marsdenin on selected indices of cardiovascular diseases in mouse
AbstractSome anticancer pregnane glycosides, e.g., 3-O-[6-deoxy-3-O-methyl- β-d-allopyranosyl-(1 → 4)-β-d-canaropyranosyl]-17β-marsdenin (3DMACM), have been isolated fromGongronema latifolium leaves which have not been evaluated for their effects on the cardiovascular system. Thus, this study was carried out to evaluate the effects of 3DMACM on selected indices of cardiovascular diseases in albino mice. Forty mice were randomly divided into four groups (ten mice each). Group A mice were orally administered 5% DMSO while mice in groups B, C, and D were orally administered 0.25, 0.5, and 1 mg/kg body weight of the c...
Source: Comparative Clinical Pathology - January 20, 2022 Category: Pathology Source Type: research
Prevalence, risk factors and metabolic predictors associated with subclinical ketosis on dairy cattle in Batna, Eastern of Algeria
AbstractEconomic impact of subclinical ketosis (SCK) in dairy herds resulted from a decreased productivity, reproductive performances, and health condition. In Algeria, data availability regarding the prevalence of SCK in dairy cows were limited. The present study is a contribution in that direction and aimed to determine the prevalence of SCK between 2 and 50 days postpartum whereas investigating herd- and cow-level risk factors and the metabolic profile associated, on two bovine populations imported and native. The study was conducted with 16 typical representative local dairy cow herds (n = 100; 2–12 years old;...
Source: Comparative Clinical Pathology - January 18, 2022 Category: Pathology Source Type: research
Alterations in serum activity of hepatocellular enzymes, levels of liver function markers, and liver histology of dogs given high (nephrotoxic) doses of gentamicin
This study evaluated the effects of nephrotoxic doses of gentamicin on serum activity of hepatocellular enzymes, levels of liver function markers, and liver histology of dogs. Nine dogs, randomly assigned to two groups (A and B) of five and four dogs each, were used for the study. Baseline values for kidney function, hepatocellular, hepatobiliary, and liver function parameters were assayed initially. Gentamicin injections (100 mg/kg) were given intravenously daily for 10 days to the dogs in Group A, while the Group B dogs served as the untreated control. After the 10 days of injections, blood was collected from the dog...
Source: Comparative Clinical Pathology - January 18, 2022 Category: Pathology Source Type: research
Dietary implications of toasted Jatropha curcas seed: Insight on zootechnical and hematological parameters of Clarias gariepinus
AbstractJatropha curcas seeds (JCS) have high crude protein and excellent amino acid profile. However, JCS contain antinutrients which affect the health of animals fed with it negatively. Therefore, this study evaluated toasting at varying durations (0, 10, 20, and 30 min) as a means of detoxifying the JCS, and evaluated the health implication and nutritional characteristics ofClarias gariepinus fed diets included with the seeds (35% CP; 315 kcal/g). The nutritional profile of the JCS was substantially improved by decreasing antinutrients with prolonged duration of processing by toasting (i.e., between 10 and 30 min)....
Source: Comparative Clinical Pathology - January 17, 2022 Category: Pathology Source Type: research
Evaluation of mice testosterone and sperm parameters affected with Crocin
In conclusion, higher doses (100 mg/kg) of Crocin administration may negatively affect the repro ductive system by reducing sperm count, sperm motility, and testicular damage. However, a relatively safe dose of Crocin (20 mg/kg) is required in clinical trials. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - January 14, 2022 Category: Pathology Source Type: research
