Reducing Severe Maternal Morbidity for Birthing Persons with Severe Hypertension through a Statewide Quality Improvement Initiative
Hypertensive disorders of pregnancy are a leading preventable cause of severe maternal morbidity and maternal mortality worldwide. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - April 30, 2024 Category: OBGYN Authors: Ann BORDERS, Lauren KEENAN-DEVLIN, Elissa H. OH, Danielle YOUNG, William GROBMAN, Patricia LEE KING Tags: Original Research: Obstetrics Source Type: research
Blood pressure cut-offs at 11-13 weeks ’ gestation and risk of preeclampsia
A parallel has been drawn between first trimester placental vascular maturation and maternal cardiovascular adaptations, including blood pressure. Although 140/90 mmHg is well-accepted as the threshold for chronic hypertension in the general obstetric population in early pregnancy, a different threshold could apply to stratify risk of adverse outcomes, such as preeclampsia. This could have implications for interventions, such as the threshold for initiation of antihypertensive therapy and the target blood pressure level. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - April 30, 2024 Category: OBGYN Authors: Laura J. SLADE, Argyro SYNGELAKI, Milly WILSON, Hiten D. MISTRY, Ranjit AKOLEKAR, Peter VON DADELSZEN, Kypros H. NICOLAIDES, Laura A. MAGEE Tags: Original Research: Obstetrics Source Type: research
No Association Between AGT Gene Polymorphisms with Hypertension in a South African Population
(Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - April 29, 2024 Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity Source Type: research
Guidelines-based therapeutic strategies for controlling hypertension in non-controlled hypertensive patients followed by family physicians in primary health care in Portugal: the GPHT-PT study
CONCLUSION: In patients with uncontrolled HTN, therapeutic measures in accordance with guidelines, with a fixed combination candesartan/amlodipine, allowed to overall achieve HTN control at 12 weeks in 82% of previously uncontrolled HTN patients, reinforcing the advantages of these strategies in primary clinical practice.PMID:38680045 | DOI:10.1080/08037051.2024.2345887 (Source: Blood Pressure)
Source: Blood Pressure - April 29, 2024 Category: Hematology Authors: Jorge Pol ónia Raul Marques Pereira Source Type: research
Outcomes of endoscopic sclerotherapy for jejunal varices at the site of choledochojejunostomy (with video): Three case reports
CONCLUSION: We conclude that endoscopic sclerotherapy with lauromacrogol/α-butyl cyanoacrylate injection can be an easy, effective, safe and low-cost treatment option for jejunal varicose bleeding at the site of choledochojejunostomy.PMID:38681128 | PMC:PMC11045488 | DOI:10.3748/wjg.v30.i14.2059 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 29, 2024 Category: Gastroenterology Authors: Jun Liu Peng Wang Li-Mei Wang Jing Guo Ning Zhong Source Type: research
Exploring the Risk Factors for Deep Vein Thrombosis after Percutaneous Nephrolithotomy
CONCLUSIONS: D-dimer on the first day after PCNL, postoperative bed rest time and Caprini RAM scores were independent risk factors for DVT after PCNL.PMID:38684495 | DOI:10.62713/aic.3308 (Source: Annali Italiani di Chirurgia)
Source: Annali Italiani di Chirurgia - April 29, 2024 Category: Surgery Authors: Jia Wei He Zhan Peng Zhu Xiao Yan Cai Yan Feng Su Pei Zhen Li Source Type: research
Prevalence and predictive features of metabolic dysfunction-associated steatotic liver disease in type 1 diabetes
CONCLUSION: Individuals with type 1 diabetes and high blood pressure, older age, BMI and duration of disease could be considered at high-risk for developing MASLD.PMID:38679966 | DOI:10.1093/ejendo/lvae043 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - April 29, 2024 Category: Endocrinology Authors: Coco M Fuhri Snethlage Abraham S Meijnikman Anne Linde Mak Elena Rampanelli Bas Voermans Cengiz A K Callender Pleun de Groen Bart O Roep Dani ël H van Raalte Filip K Knop Adriaan G Holleboom Max Nieuwdorp Nordin M J Hanssen Source Type: research
Outcomes of endoscopic sclerotherapy for jejunal varices at the site of choledochojejunostomy (with video): Three case reports
CONCLUSION: We conclude that endoscopic sclerotherapy with lauromacrogol/α-butyl cyanoacrylate injection can be an easy, effective, safe and low-cost treatment option for jejunal varicose bleeding at the site of choledochojejunostomy.PMID:38681128 | PMC:PMC11045488 | DOI:10.3748/wjg.v30.i14.2059 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 29, 2024 Category: Gastroenterology Authors: Jun Liu Peng Wang Li-Mei Wang Jing Guo Ning Zhong Source Type: research
Vacuolar H(+)-ATPase in Diabetes, Hypertension, and Atherosclerosis
Microcirculation. 2024 Apr 29:e12855. doi: 10.1111/micc.12855. Online ahead of print.ABSTRACTVacuolar H+-ATPase (V-ATPase) is a multisubunit protein complex which, along with its accessory proteins, resides in almost every eukaryotic cell. It acts as a proton pump and as such is responsible for regulating pH in lysosomes, endosomes, and the extracellular space. Moreover, V-ATPase has been implicated in receptor-mediated signaling. Although numerous studies have explored the role of V-ATPase in cancer, osteoporosis, and neurodegenerative diseases, research on its involvement in vascular disease remains limited. Vascular dis...
Source: Atherosclerosis - April 29, 2024 Category: Cardiology Authors: Na Wang Liwei Ren A H Jan Danser Source Type: research
Cellular Senescence as a Targetable Risk Factor for Cardiovascular Diseases: Therapeutic Implications: < em > JACC < /em > Family Series
JACC Basic Transl Sci. 2024 Apr 8;9(4):522-534. doi: 10.1016/j.jacbts.2023.12.003. eCollection 2024 Apr.ABSTRACTThe prevalence of cardiovascular diseases markedly rises with age. Cellular senescence, a hallmark of aging, is characterized by irreversible cell cycle arrest and the manifestation of a senescence-associated secretory phenotype, which has emerged as a significant contributor to aging, mortality, and a spectrum of chronic ailments. An increasing body of preclinical and clinical research has established connections between senescence, senescence-associated secretory phenotype, and age-related cardiac and vascular ...
Source: Atherosclerosis - April 29, 2024 Category: Cardiology Authors: Manish Kumar Pengyi Yan George A Kuchel Ming Xu Source Type: research
PDZ-Binding Kinase, a Novel Regulator of Vascular Remodeling in Pulmonary Arterial Hypertension
CONCLUSIONS: PBK is a newly described target for PAH that is upregulated in proliferating PA smooth muscle cells, where it contributes to proliferation through changes in cytokinesis and cell cycle dynamics to promote medial thickening, fibrosis, increased PA resistance, elevated right ventricular systolic pressure, right ventricular remodeling, and PH.PMID:38682326 | DOI:10.1161/CIRCULATIONAHA.123.067095 (Source: Circulation)
Source: Circulation - April 29, 2024 Category: Cardiology Authors: Zsuzsanna Bordan Robert Batori Stephen Haigh Xueyi Li Mary Louise Meadows Zach L Brown Madison A West Kunzhe Dong Weihong Han Yunchao Su Qian Ma Yuqing Huo Jiliang Zhou Mahmoud Abdelbary Jennifer Sullivan Neal L Weintraub David W Stepp Feng Chen Scott A B Source Type: research
Relationship Between Dietary Intakes and Elevated Diastolic Blood Pressure Among Children: A Cross-Sectional Study Using Wearable Devices
CONCLUSION: This study indicates that dietary intakes of high saturated fat, copper, and vitamin B12, but not parental blood pressure statuses, determine high diastolic blood pressure among children regardless of daily sodium intake. Early dietary consumption behavioral adaptation should be considered to prevent further hypertension in adulthood.PMID:38682517 | DOI:10.3233/SHTI240024 (Source: Studies in Health Technology and Informatics)
Source: Studies in Health Technology and Informatics - April 29, 2024 Category: Information Technology Authors: Kukiat Tudpor Panthicha Chinnakhot Montira Boonsorn Wiriyaporn Lomthaisong Worrameth Kareechum Charnyuth Sriphuwong Le Ke Nghiep Niruwan Turnbull Source Type: research
Guidelines-based therapeutic strategies for controlling hypertension in non-controlled hypertensive patients followed by family physicians in primary health care in Portugal: the GPHT-PT study
CONCLUSION: In patients with uncontrolled HTN, therapeutic measures in accordance with guidelines, with a fixed combination candesartan/amlodipine, allowed to overall achieve HTN control at 12 weeks in 82% of previously uncontrolled HTN patients, reinforcing the advantages of these strategies in primary clinical practice.PMID:38680045 | DOI:10.1080/08037051.2024.2345887 (Source: Blood Pressure)
Source: Blood Pressure - April 29, 2024 Category: Hematology Authors: Jorge Pol ónia Raul Marques Pereira Source Type: research
Alteration in maternal serum uric acid levels in pre-eclampsia and associated perinatal outcomes: a cross-sectional study in Ghana
CONCLUSION: hyperuricemia in pre-eclampsia was significantly associated with both maternal (caesarean section and severe hypertension) and neonatal (low birth weight) adverse outcomes. Hyperuricemia seems clinically useful in predicting pregnancy outcomes, especially in preterm pre-eclampsia. Further longitudinal study is recommended in exploring the clinical significance of maternal uric acid levels and pregnancy outcomes in pre-eclampsia.PMID:38681101 | PMC:PMC11055187 | DOI:10.11604/pamj.2024.47.49.37106 (Source: Molecular Medicine)
Source: Molecular Medicine - April 29, 2024 Category: Molecular Biology Authors: Kwame Adu-Bonsaffoh Daniel Quarshie Kudaya Bayor Fidelis Linda Ahenkorah Fondjo John Ahenkorah Source Type: research
Safety of marketed biosimilar monoclonal antibody cancer treatments in the US: a disproportionality analysis using the food and drug administration adverse event reporting system (FAERS) database
CONCLUSIONS: Findings call for large, longitudinal studies to examine causality of certain AEs with rituximab-pvvr and bevacizumab biosimilars.PMID:38680112 | DOI:10.1080/14740338.2024.2348577 (Source: Expert Opinion on Drug Safety)
Source: Expert Opinion on Drug Safety - April 29, 2024 Category: Drugs & Pharmacology Authors: Xiangzhong Xue Jingjing Qian Source Type: research
