Tri-ponderal mass index and left ventricular hypertrophy in a cohort of caucasian children and adolescents with obesity
ConclusionLeft ventricular remodeling is associated with the cardio-metabolic risk markers WC and WHR, but not with the adiposity index TMI among children with obesity. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - April 19, 2024 Category: Pediatrics Source Type: research
Effect of the DASH diet on the sodium-chloride cotransporter and aquaporin-2 in urinary extracellular vesicles
Am J Physiol Renal Physiol. 2024 Apr 18. doi: 10.1152/ajprenal.00274.2023. Online ahead of print.ABSTRACTThe Dietary Approach to Stop Hypertension (DASH) diet, with its low sodium and high potassium content, acts like a diuretic by reducing sodium reabsorption in the kidney's distal convoluted tubule but without the side effects. Previous studies based on animal models didn't explore changes in human ion channel proteins. Recent insights into urinary extracellular vesicles (uEVs) suggest they reflect kidney tissue and physiological modifications. In our inpatient study, we shifted hypertensive volunteers from an American d...
Source: American Journal of Physiology. Renal Physiology - April 18, 2024 Category: Physiology Authors: Dana Bielopolski Luca Musante Ewout J Hoorn Henrik Molina Douglas Barrows Thomas Carroll Michael A Harding Samantha Upson Adam Qureshi Max M Weder Jonathan N Tobin Rhonda G Kost U Erdbr ügger Source Type: research
Commensal Microbiota Regulate Aldosterone
In this study, we aimed to determine whether gut microbiota regulate host aldosterone. We employed enzyme-linked immunosorbent assays (ELISAs) to assess plasma aldosterone and plasma renin activity (PRA) in female and male mice in which gut microbiota are intact, suppressed, or absent. In addition, we examined urinary aldosterone. Our findings demonstrated that when the gut microbiota is suppressed following antibiotic treatment, there is an increase in plasma and urinary aldosterone in both female and male mice. In contrast, an increase in PRA is seen only in males. We also found that when gut microbiota are absent (germ-...
Source: American Journal of Physiology. Renal Physiology - April 18, 2024 Category: Physiology Authors: Brittni N Moore Alexandra D Medcalf Rachel Q Muir Chudan Xu Francine Z Marques Jennifer L Pluznick Source Type: research
Hemodynamic Mechanisms Initiating Salt-Sensitive Hypertension in Rat Model of Primary Aldosteronism
Physiol Res. 2024 Apr 18. Online ahead of print.ABSTRACTFew studies have investigated the hemodynamic mechanism whereby primary hyperaldosteronism causes hypertension. The traditional view holds that hyperaldosteronism initiates hypertension by amplifying salt-dependent increases in cardiac output (CO) by promoting increases in sodium retention and blood volume. Systemic vascular resistance (SVR) is said to increase only as a secondary consequence of the increased CO and blood pressure. Recently, we investigated the primary hemodynamic mechanism whereby hyperaldosteronism promotes salt sensitivity and initiation of salt-de...
Source: Physiological Research - April 18, 2024 Category: Physiology Authors: M Pravenec P Mlejnek M Šimáková J Šilhavý Source Type: research
Gliflozins in the Treatment of Non-diabetic Experimental Cardiovascular Diseases
Physiol Res. 2024 Apr 18. Online ahead of print.ABSTRACTA new class of antidiabetic drugs - gliflozins (inhibitors of sodium glucose cotransporter-2; SGLT-2i) stimulate glucose and sodium excretion, thereby contributing to improved glycemic control, weight loss and blood pressure reduction in diabetic patients. Large clinical trials in patients with type 2 diabetes treated with empagliflozin, canagliflozin or dapagliflozin have demonstrated their excellent efficacy in improving many cardiovascular outcomes, including the reduction of death from cardiovascular diseases, non-fatal myocardial infarction or stroke, and hospita...
Source: Physiological Research - April 18, 2024 Category: Physiology Authors: I Van ěčková J Zicha Source Type: research
Effect of the DASH diet on the sodium-chloride cotransporter and aquaporin-2 in urinary extracellular vesicles
Am J Physiol Renal Physiol. 2024 Apr 18. doi: 10.1152/ajprenal.00274.2023. Online ahead of print.ABSTRACTThe Dietary Approach to Stop Hypertension (DASH) diet, with its low sodium and high potassium content, acts like a diuretic by reducing sodium reabsorption in the kidney's distal convoluted tubule but without the side effects. Previous studies based on animal models didn't explore changes in human ion channel proteins. Recent insights into urinary extracellular vesicles (uEVs) suggest they reflect kidney tissue and physiological modifications. In our inpatient study, we shifted hypertensive volunteers from an American d...
Source: Am J Physiol Renal P... - April 18, 2024 Category: Urology & Nephrology Authors: Dana Bielopolski Luca Musante Ewout J Hoorn Henrik Molina Douglas Barrows Thomas Carroll Michael A Harding Samantha Upson Adam Qureshi Max M Weder Jonathan N Tobin Rhonda G Kost U Erdbr ügger Source Type: research
Commensal Microbiota Regulate Aldosterone
In this study, we aimed to determine whether gut microbiota regulate host aldosterone. We employed enzyme-linked immunosorbent assays (ELISAs) to assess plasma aldosterone and plasma renin activity (PRA) in female and male mice in which gut microbiota are intact, suppressed, or absent. In addition, we examined urinary aldosterone. Our findings demonstrated that when the gut microbiota is suppressed following antibiotic treatment, there is an increase in plasma and urinary aldosterone in both female and male mice. In contrast, an increase in PRA is seen only in males. We also found that when gut microbiota are absent (germ-...
Source: Am J Physiol Renal P... - April 18, 2024 Category: Urology & Nephrology Authors: Brittni N Moore Alexandra D Medcalf Rachel Q Muir Chudan Xu Francine Z Marques Jennifer L Pluznick Source Type: research
Preconception diet in adolescence and its association with hypertensive disorders of pregnancy and preterm birth. Results from The HUNT study
Br J Nutr. 2024 Apr 18:1-22. doi: 10.1017/S0007114524000746. Online ahead of print.ABSTRACTOur aim was to estimate associations of adolescent dietary patterns and meal habits with hypertensive disorders of pregnancy (HDP) and preterm birth. We used data from a prospective cohort study (Norwegian Young-HUNT1) where dietary information was collected during adolescence and pregnancy outcomes were obtained through record linkage to the Norwegian national birth registry. The outcomes were HDP, hypertension, preeclampsia/ eclampsia, and preterm birth in the first pregnancy and in any pregnancy. Diet was self-reported from valida...
Source: The British Journal of Nutrition - April 18, 2024 Category: Nutrition Authors: Andrew Keith Wills Elisabet Rudjord Hillesund Wendy Van Lippevelde Mary Barker Fr øydis Nordgård Vik Nina Cecilie Øverby Source Type: research
Work-, lifestyle-, and health-related factors among women and men working in the emergency medical services
Conclusions. Exposure to work-related factors that might affect health was common among ambulance personnel. Lifestyle- and health-related factors were somewhat contradictory, with a low proportion reporting lifestyle-related risk factors, but a high proportion having risk factors for CVD.PMID:38632949 | DOI:10.1080/10803548.2024.2332115 (Source: International Journal of Occupational Safety and Ergonomics)
Source: International Journal of Occupational Safety and Ergonomics - April 18, 2024 Category: Occupational Health Authors: Anna M Johnsen Petra Wagman Anders Brostr öm Eleonor I Fransson Source Type: research
Correlation Analysis of NAMPT rs61330082 Polymorphism in Type 2 Diabetes Mellitus Combined with Hypertension
(Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - April 18, 2024 Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity Source Type: research
Analysis of Factors Influencing Prognosis and Assessment of 60 Cases of Decompensated Cirrhotic Patients with Portal Hypertension
(Source: International Journal of General Medicine)
Source: International Journal of General Medicine - April 18, 2024 Category: General Medicine Tags: International Journal of General Medicine Source Type: research
When pulmonary arterial hypertension complicates connective tissue diseases: we still have not found what we are looking for
(Source: Internal and Emergency Medicine)
Source: Internal and Emergency Medicine - April 18, 2024 Category: Emergency Medicine Source Type: research
Optimal Method for Assessing Right Ventricular to Pulmonary Arterial Coupling and Subclinical Right Ventricular Dysfunction in Older Aged Healthy Adults: The Multi-Ethnic Study of Atherosclerosis.
The ability of the right ventricle (RV) to adapt to increasing afterload, particularly in diseases such as pulmonary arterial hypertension (PAH)1, is a primary determinant of morbidity and mortality. In the early stages of pulmonary hypertension (PH), cardiac output is maintained through compensatory hypertrophy of the RV chamber to enhance contractility. However, with sustained pressure overload, these maladaptive compensatory mechanisms are insufficient, and the chamber begins to dilate to maintain cardiac output, known as uncoupling of the RV to pulmonary artery (PA) and the onset of clinical heart failure (HF)2,3. (Sou...
Source: The American Journal of Cardiology - April 18, 2024 Category: Cardiology Authors: Vivek P. Jani, Jordan B. Strom, Abhishek Gami, Lauren Beussink-Nelson, Ravi Patel, Erin D. Michos, Sanjiv J. Shah, Benjamin H. Freed, Monica Mukherjee Source Type: research
Nomogram-based geometric and hemodynamic parameters for predicting the growth of small untreated intracranial aneurysms
This study aimed to construct a nomogram for predicting the growth of small IAs based on geometric and hemodynamic parameters. We retrospectively collected the baseline and follow-up angiographic images (CTA/ MRA) of 96 small untreated saccular IAs, created patient-specific vascular models and performed computational fluid dynamics (CFD) simulations. Geometric and hemodynamic parameters were calculated. A stepwise Cox proportional hazards regression analysis was employed to construct a nomogram. IAs were stratified into low-, intermediate-, and high-risk groups based on the total points from the nomogram. Receiver operatin...
Source: Neurosurgical Review - April 18, 2024 Category: Neurosurgery Source Type: research
IJERPH, Vol. 21, Pages 500: Cognitive Profile and Cardiovascular Risk Factors in Older Adults with Mild Cognitive Impairment
The DIALCAT Consortium
The prevalence of cardiovascular risk factors (CVRFs) in the older adults population and their specific impact on their cognitive profiles still requires further research. For this purpose, a cross-sectional study was carried out to describe the presence of CVRFs and their association with cognitive performance in a sample of older adults (65–85 years old) with Mild Cognitive Impairment (MCI). Participants (n = 185) were divided into three groups concerning their cardiovascular risk level determined by the presence of different CVRFs, including Type 2 Diabetes (T2D), dyslipidemia,...
Source: International Journal of Environmental Research and Public Health - April 18, 2024 Category: Environmental Health Authors: Sebasti án Ortiz-Zu ñiga Ciudin Ars Inzitari Sim ó Hern ández Ari ño-Blasco Barahona Franco Giron ès Crespo-Maraver Rovira Castellano-Tejedor The DIALCAT Consortium Tags: Article Source Type: research
