Genetic Polymorphisms of Endothelial Nitric Oxide Synthase Associated with Hypertension and Blood Homocysteine Levels
CONCLUSION: eNOS variants rs1799983 and rs2070744 may be risk factors for hypertension linked to hyperhomocysteinemia. These findings provide potentially useful healthcare strategies for the management of hypertension.PMID:38660143 | PMC:PMC11041984 | DOI:10.2147/IJGM.S456519 (Source: Molecular Medicine)
Source: Molecular Medicine - April 25, 2024 Category: Molecular Biology Authors: Charinya Chaichanabut Piyamitr Sritara Jintana Sirivarasai Source Type: research
Differential inhibition of sildenafil and macitentan on saxagliptin metabolism
Toxicol Appl Pharmacol. 2024 Apr 23:116934. doi: 10.1016/j.taap.2024.116934. Online ahead of print.ABSTRACTThe development of diabetes mellitus (DM) is generally accompanied by erectile dysfunction (ED) and pulmonary arterial hypertension (PAH), which increase the use of combination drug therapy and the risk of drug-drug interactions. Saxagliptin for the treatment of DM, sildenafil for the treatment of ED and PAH, and macitentan for the treatment of PAH are all substrates of CYP3A4, which indicates their potential involvement in drug-drug interactions. Therefore, we investigated potential pharmacokinetic interactions betwe...
Source: Toxicology and Applied Pharmacology - April 25, 2024 Category: Toxicology Authors: Ge-Xin Dai Wei Tan Yuxin Shen Dongdong Lin Ren-Ai Xu Qianmeng Lin Zhen Wei Source Type: research
Effects of residential socioeconomic polarization on high blood pressure among nursing home residents
CONCLUSIONS: We achieved our objective by demonstrating that concentrated deprivation is associated with worse cardiovascular outcomes even in a population with equal access to care. Measures that jointly consider economic and racial/ethnic polarization elucidate larger disparities than single domain measures.PMID:38663339 | DOI:10.1016/j.healthplace.2024.103243 (Source: Health and Place)
Source: Health and Place - April 25, 2024 Category: Environmental Health Authors: Hoda S Abdel Magid Samuel Jaros Yongmei Li Michael A Steinman Sei Lee Carmen Peralta Bocheng Jing Kathy Fung Christine K Liu Xiaojuan Liu Laura A Graham Michelle C Odden Source Type: research
Bayesian network-based survival prediction model for patients having undergone post-transjugular intrahepatic portosystemic shunt for portal hypertension
CONCLUSION: This study successfully developed a BN-based survival prediction model with good predictive capabilities. It offers valuable insights for treatment strategies and prognostic evaluations in patients having undergone TIPS surgery for PHT.PMID:38659484 | PMC:PMC11036496 | DOI:10.3748/wjg.v30.i13.1859 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 25, 2024 Category: Gastroenterology Authors: Rong Chen Ling Luo Yun-Zhi Zhang Zhen Liu An-Lin Liu Yi-Wen Zhang Source Type: research
Survival of medical treatment success in primary open-angle glaucoma and ocular hypertension
CONCLUSION: Large-scale survival analyses provide the expected duration of treatment success from topical glaucoma medication.PMID:38664004 | DOI:10.1136/bjo-2023-323708 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - April 25, 2024 Category: Opthalmology Authors: Dun Jack Fu Ebenezer Ademisoye Vanessa Shih Andrew Ian McNaught Anthony Khawaja Source Type: research
Bridging the Gap: Addressing Immigrant Health Through Community-initiated Screening Events
CONCLUSIONS: Working directly with the community, we designed and implemented health prevention events which served to meet a growing need and to identify and address health concerns among the Hispanic immigrant community.PMID:38661823 (Source: Progress in Community Health Partnerships)
Source: Progress in Community Health Partnerships - April 25, 2024 Category: International Medicine & Public Health Authors: Sally Moyce Nathaniel Sisson Madeline Metcalf Source Type: research
Greenspaces And Cardiovascular Health
Circ Res. 2024 Apr 26;134(9):1179-1196. doi: 10.1161/CIRCRESAHA.124.323583. Epub 2024 Apr 25.ABSTRACTAccumulating evidence suggests that living in areas of high surrounding greenness or even brief exposures to areas of high greenery is conducive to cardiovascular health, which may be related to the environmental, social, psychological, and physiological benefits of greenspaces. Recent data from multiple cross-sectional, longitudinal, and cohort studies suggest that living in areas of high surrounding greenness is associated with a lower risk of all-cause and cardiovascular mortality. High levels of neighborhood greenery ha...
Source: Circulation Research - April 25, 2024 Category: Cardiology Authors: Rachel J Keith Joy L Hart Aruni Bhatnagar Source Type: research
Environmental Impacts on Cardiovascular Health and Biology: An Overview
Circ Res. 2024 Apr 26;134(9):1048-1060. doi: 10.1161/CIRCRESAHA.123.323613. Epub 2024 Apr 25.ABSTRACTEnvironmental stressors associated with human activities (eg, air and noise pollution, light disturbance at night) and climate change (eg, heat, wildfires, extreme weather events) are increasingly recognized as contributing to cardiovascular morbidity and mortality. These harmful exposures have been shown to elicit changes in stress responses, circadian rhythms, immune cell activation, and oxidative stress, as well as traditional cardiovascular risk factors (eg, hypertension, diabetes, obesity) that promote cardiovascular d...
Source: Circulation Research - April 25, 2024 Category: Cardiology Authors: Jacob R Blaustein Matthew J Quisel Naomi M Hamburg Sharine Wittkopp Source Type: research
Heavy Metal Exposure and Cardiovascular Disease
Circ Res. 2024 Apr 26;134(9):1160-1178. doi: 10.1161/CIRCRESAHA.123.323617. Epub 2024 Apr 25.ABSTRACTHeavy metals are harmful environmental pollutants that have attracted widespread attention due to their health hazards to human cardiovascular disease. Heavy metals, including lead, cadmium, mercury, arsenic, and chromium, are found in various sources such as air, water, soil, food, and industrial products. Recent research strongly suggests a connection between cardiovascular disease and exposure to toxic heavy metals. Epidemiological, basic, and clinical studies have revealed that heavy metals can promote the production of...
Source: Circulation Research - April 25, 2024 Category: Cardiology Authors: Ziwei Pan Tingyu Gong Ping Liang Source Type: research
Perfluoroalkyl/Polyfluoroalkyl Substances: Links to Cardiovascular Disease Risk
Circ Res. 2024 Apr 26;134(9):1136-1159. doi: 10.1161/CIRCRESAHA.124.323697. Epub 2024 Apr 25.ABSTRACTConservative estimates by the World Health Organization suggest that at least a quarter of global cardiovascular diseases are attributable to environmental exposures. Associations between air pollution and cardiovascular risk have garnered the most headlines and are strong, but less attention has been paid to other omnipresent toxicants in our ecosystem. Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are man-made chemicals that are extensively used in industrial and consumer products worldwide and in aqueous film-for...
Source: Circulation Research - April 25, 2024 Category: Cardiology Authors: Jennifer J Schlezinger Noyan Gokce Source Type: research
Transportation Noise Pollution and Cardiovascular Health
Circ Res. 2024 Apr 26;134(9):1113-1135. doi: 10.1161/CIRCRESAHA.123.323584. Epub 2024 Apr 25.ABSTRACTEpidemiological studies have found that transportation noise increases the risk for cardiovascular morbidity and mortality, with solid evidence for ischemic heart disease, heart failure, and stroke. According to the World Health Organization, at least 1.6 million healthy life years are lost annually from traffic-related noise in Western Europe. Traffic noise at night causes fragmentation and shortening of sleep, elevation of stress hormone levels, and increased oxidative stress in the vasculature and the brain. These factor...
Source: Circulation Research - April 25, 2024 Category: Cardiology Authors: Thomas M ünzel Michael Molitor Marin Kuntic Omar Hahad Martin R öösli Nicole Engelmann Mathias Basner Andreas Daiber Mette S ørensen Source Type: research
Single cell transcriptomics of cerebrospinal fluid cells from patients with recent-onset narcolepsy
J Autoimmun. 2024 Apr 24;146:103234. doi: 10.1016/j.jaut.2024.103234. Online ahead of print.ABSTRACTNarcolepsy is a rare cause of hypersomnolence and may be associated or not with cataplexy, i.e. sudden muscle weakness. These forms are designated narcolepsy-type 1 (NT1) and -type 2 (NT2), respectively. Notable characteristics of narcolepsy are that most patients carry the HLA-DQB1*06:02 allele and NT1-patients have strongly decreased levels of hypocretin-1 (synonym orexin-A) in the cerebrospinal fluid (CSF). The pathogenesis of narcolepsy is still not completely understood but the strong HLA-bias and increased frequencies ...
Source: Journal of Autoimmunity - April 25, 2024 Category: Allergy & Immunology Authors: Alina Huth Ikram Ayoub Lucie Barateau Lisa Ann Gerdes Dany Severac Stefan Krebs Helmut Blum Hayrettin Tumani J ürgen Haas Brigitte Wildemann Tania K ümpfel Eduardo Beltr án Roland S Liblau Yves Dauvilliers Klaus Dornmair Source Type: research
AI-enabled cardiac chambers volumetry in coronary artery calcium scans (AI-CAC(TM)) predicts heart failure and outperforms NT-proBNP: The multi-ethnic study of Atherosclerosis
CONCLUSION: AI-CAC volumetry significantly outperformed NT-proBNP and the Agatston CAC score, and significantly improved the AUC and category-free NRI of clinical risk factors for incident HF prediction.PMID:38664073 | DOI:10.1016/j.jcct.2024.04.006 (Source: Atherosclerosis)
Source: Atherosclerosis - April 25, 2024 Category: Cardiology Authors: Morteza Naghavi Anthony Reeves Matthew Budoff Dong Li Kyle Atlas Chenyu Zhang Thomas Atlas Sion K Roy Claudia I Henschke Nathan D Wong Christopher Defilippi Daniel Levy David F Yankelevitz Source Type: research
Perfluoroalkyl/Polyfluoroalkyl Substances: Links to Cardiovascular Disease Risk
Circ Res. 2024 Apr 26;134(9):1136-1159. doi: 10.1161/CIRCRESAHA.124.323697. Epub 2024 Apr 25.ABSTRACTConservative estimates by the World Health Organization suggest that at least a quarter of global cardiovascular diseases are attributable to environmental exposures. Associations between air pollution and cardiovascular risk have garnered the most headlines and are strong, but less attention has been paid to other omnipresent toxicants in our ecosystem. Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are man-made chemicals that are extensively used in industrial and consumer products worldwide and in aqueous film-for...
Source: Atherosclerosis - April 25, 2024 Category: Cardiology Authors: Jennifer J Schlezinger Noyan Gokce Source Type: research
Heavy Metal Exposure and Cardiovascular Disease
Circ Res. 2024 Apr 26;134(9):1160-1178. doi: 10.1161/CIRCRESAHA.123.323617. Epub 2024 Apr 25.ABSTRACTHeavy metals are harmful environmental pollutants that have attracted widespread attention due to their health hazards to human cardiovascular disease. Heavy metals, including lead, cadmium, mercury, arsenic, and chromium, are found in various sources such as air, water, soil, food, and industrial products. Recent research strongly suggests a connection between cardiovascular disease and exposure to toxic heavy metals. Epidemiological, basic, and clinical studies have revealed that heavy metals can promote the production of...
Source: Atherosclerosis - April 25, 2024 Category: Cardiology Authors: Ziwei Pan Tingyu Gong Ping Liang Source Type: research
