SARS-Cov-2 Infection: A New Risk Factor for Pituitary Apoplexy?
CONCLUSION: Alongside known risk factors (hypertension, anticoagulation, pregnancy, surgery, etc.), COVID-19 infection might represent an emerging predisposing factor for PA onset. The two cases hereby presented are both significant: the first confirms the role of "classic" vascular predisposing factors for PA, while the second demonstrates that PA might arise also in young patients without known risk factors.PMID:38676521 | DOI:10.2174/0118715303315494240419060719 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 27, 2024 Category: Drugs & Pharmacology Authors: Alberto Ragni Giulia Bendotti Emilia Biamonte Beatrice Cavigiolo Enrico Gabellieri Paola Leporati Edoardo Luigi Maria Mollero Marco Gallo Source Type: research
Novel Leptin-Cardiac TRH pathway responsible for the cardiac alterations in the Hyperleptinemic obesity
Mol Cell Biochem. 2024 Apr 27. doi: 10.1007/s11010-024-05008-x. Online ahead of print.ABSTRACTThe association between hypertension and obesity-induced cardiac damage is usually accepted. However, no studies have been focused on cardiac alterations in obesity, independently of blood pressure increase. It is well known that Cardiac TRH induces Left Ventricular Hypertrophy (LVH) and fibrosis, and its inhibition prevents the development of hypertrophy. Also, it has been described that the adiponectin leptin induces TRH expression. Thus, we hypothesized that in obesity, the increase in TRH induced by hyperleptinemia is responsi...
Source: Molecular and Cellular Biochemistry - April 27, 2024 Category: Biochemistry Authors: Ludmila Soledad Peres D íaz Maia Aisicovich Mariano Luis Schuman Macarena Rosati Jorge Eduardo Toblli Ana Uceda Graciela Giardina Mar ía Silvina Landa Silvia In és García Source Type: research
Impression life with pulmonary hypertension: clinically relevant characteristics and quality of life among patients in Gansu, China
CONCLUSION: HRQoL was substantially reduced among PAH patients in the resource-limited area, mainly the physiological functions. WHO-FC and anxiety scores were independently associated with both PCS and MCS in SF-36. Clinicians should make reasonable rehabilitation programs and plans for patients according to their cardiac function grade and the severity of clinical symptoms. In addition, psychological interventions should also be taken, especially for those with anxiety symptoms, so as to improve their HRQoL.PMID:38676370 | PMC:PMC11055475 | DOI:10.1177/17534666241246428 (Source: Adv Data)
Source: Adv Data - April 27, 2024 Category: Epidemiology Authors: Juxia Zhang Yujie Wen Yuhuan Yin Yiyin Zhang Rong Zhang Xiaoli Zhang Jianying Ye Yuping Feng Hongyan Meng Source Type: research
The short and long-term efficacy of nurse-led interventions for improving blood pressure control in people with hypertension in primary care settings: a systematic review and meta-analysis
CONCLUSIONS: Nurse-led interventions may be more effective than usual care for achieving BP control at long-term follow-up. It is important to continue lifestyle modification for people with hypertension. We must pay attention to adverse events, and more studies examining appropriate BP targets are needed. Nurse-led care represents an important complement to primary physician-led usual care.PMID:38678180 | PMC:PMC11056068 | DOI:10.1186/s12875-024-02380-x (Source: Primary Care)
Source: Primary Care - April 27, 2024 Category: Primary Care Authors: Masami Ito Aran Tajika Rie Toyomoto Hissei Imai Masatsugu Sakata Yukiko Honda Sanae Kishimoto Memori Fukuda Noboru Horinouchi Ethan Sahker Toshi A Furukawa Source Type: research
Investigation of the Association between Bilateral Selective Anterograde Cerebral Perfusion and Postoperative Ischemic Stroke in Obese Patients with Emergency Surgery for Acute Type A Aortic Dissection
Conclusions: A patient-tailored strategy for cerebral perfusion should be considered in obese patients, considering the high atheromatous burden of the supra-aortic vessels in these patients and the potential risk of atheromatous embolization associated with this technique.PMID:38674307 | PMC:PMC11052173 | DOI:10.3390/medicina60040661 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Mircea Robu Bogdan Radulescu Irina Maria Margarint Cornel Robu Ovidiu Stiru Andrei Iosifescu Silvia Preda Mihai Cacoveanu Cristian Voica Vlad Anton Iliescu Horatiu Moldovan Source Type: research
Noninvasive Ambulatory Electrocardiographic Markers from Patients with COVID-19 Pneumonia: A Report of Three Cases
Medicina (Kaunas). 2024 Apr 19;60(4):655. doi: 10.3390/medicina60040655.ABSTRACTCoronavirus disease 2019 (COVID-19) has affected medical practice. More than 7,000,000 patients died worldwide after being infected with COVID-19; however, no specific laboratory markers have yet been established to predict death related to this disease. In contrast, electrocardiographic changes due to COVID-19 include QT prolongation and ST-T changes; however, there have not been studies on the ambulatory electrocardiographic markers of COVID-19. We encountered three patients diagnosed as having COVID-19 who did not have a prior history of sig...
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Motohiro Kimata Kenichi Hashimoto Naomi Harada Yusuke Kawamura Yoshifumi Kimizuka Yuji Fujikura Mayuko Kaneko Nobuaki Kiriu Yasumasa Sekine Natsumi Iwabuchi Tetsuro Kiyozumi Akihiko Kawana Susumu Matsukuma Yuji Tanaka Source Type: research
Treatment Nonadherence among Multimorbid Chronic Disease Patients: Evidence from 3515 Subjects in Indonesia
Conclusions: While the prevalence of multimorbidity in Indonesia is generally similar to that observed in previous studies, we have identified patient characteristics related to nonadherence. We suggest that patient's nonadherence was primarily dictated by their self-perception of health and treatment complexity. With the longstanding issue of nonadherence, this study indicated the need to consider creating patient-tailored treatment programs in clinical practice to improve adherence by considering individual patients' characteristics.PMID:38674280 | PMC:PMC11052292 | DOI:10.3390/medicina60040634 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Ivan Surya Pradipta Kevin Aprilio Yozi Fiedya Ningsih Mochammad Andhika Aji Pratama Sofa Dewi Alfian Rizky Abdulah Source Type: research
Diagnosis of chronic thromboembolic pulmonary hypertension after acute pulmonary embolism: data from a practice-based longitudinal cohort
CONCLUSIONS: The low CTEPH incidence rate after acute PE in the present analysis suggests low awareness of CTEPH. It further suggests a lack of systematic follow-up protocols for acute PE survivors in the real world. Improved implementation of existing recommendations on follow-up strategies post PE is warranted.PMID:38677594 | DOI:10.1016/j.jtha.2024.04.009 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 27, 2024 Category: Hematology Authors: Lukas Hobohm Lena Marie Paschke Ioannis T Farmakis Stefano Barco Sasan Partovi Thomas M ünzel Stavros Konstantinides Karsten Keller Maike Below Source Type: research
Hypotensive drugs mitigate the high-sodium diet-induced pro-inflammatory activation of mouse macrophages in vivo
Biomed Pharmacother. 2024 Apr 26;175:116648. doi: 10.1016/j.biopha.2024.116648. Online ahead of print.ABSTRACTNowadays, there is an increasing emphasis on the need to alleviate the chronic inflammatory response to effectively treat hypertension. However, there are still gaps in our understanding on how to achieve this. Therefore, research on interaction of antihypertensive drugs with the immune system is extremely interesting, since their therapeutic effect could partly result from amelioration of hypertension-related inflammation, in which macrophages seem to play a pivotal role. Thus, current comprehensive studies have i...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 27, 2024 Category: Drugs & Pharmacology Authors: Martyna Cie ślik Spencer D Strobel Pawe ł Bryniarski Hanna Twardowska Adam Chmielowski Micha ł Rudek Dominik Felkle Katarzyna Zi ęba Konrad Kaleta Mateusz Jarczy ński Bernadeta Nowak Krzysztof Bryniarski Katarzyna Nazimek Source Type: research
SARS-Cov-2 Infection: A New Risk Factor for Pituitary Apoplexy?
CONCLUSION: Alongside known risk factors (hypertension, anticoagulation, pregnancy, surgery, etc.), COVID-19 infection might represent an emerging predisposing factor for PA onset. The two cases hereby presented are both significant: the first confirms the role of "classic" vascular predisposing factors for PA, while the second demonstrates that PA might arise also in young patients without known risk factors.PMID:38676521 | DOI:10.2174/0118715303315494240419060719 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 27, 2024 Category: Endocrinology Authors: Alberto Ragni Giulia Bendotti Emilia Biamonte Beatrice Cavigiolo Enrico Gabellieri Paola Leporati Edoardo Luigi Maria Mollero Marco Gallo Source Type: research
A Case Report of Salmonella enterica Meningitis in an Infant: A Rare Entity not to Forget
CONCLUSION: Invasive Salmonella diseases, such as meningitis, are very uncommon in industrial countries nowadays, and the optimal management is yet not well established. Late onset of com-plications from Salmonella meningitis warrants more thorough neurodevelopmental follow-ups.PMID:38676483 | DOI:10.2174/0118715265286206240402050756 (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - April 27, 2024 Category: Infectious Diseases Authors: Maria Palyvou Evangelia Angeli George Syrogiannopoulos Evangelia Farmaki Marianna Tzanoudaki Gabriel Dimitriou Anastasia Varvarigou Despoina Gkentzi Source Type: research
Can Early Post-Operative Scoring of Non-Traumatic Amputees Decrease Rates of Revision Surgery?
Conclusions: Our results describe novel scoring systems for risk assessment for non-traumatic amputations and for revision surgery at non-traumatic amputations. It may be used after further prospective evaluation as an early-warning system for amputated limbs at risk of revision.PMID:38674211 | PMC:PMC11052005 | DOI:10.3390/medicina60040565 (Source: Atherosclerosis)
Source: Atherosclerosis - April 27, 2024 Category: Cardiology Authors: Vesta Brauckmann Ole Moritz Block Luis A Pardo Wolfgang Lehmann Frank Braatz Gunther Felmerer Sebastian M önnighoff Jennifer Ernst Source Type: research
Integrative Bioinformatics-Gene Network Approach Reveals Linkage between Estrogenic Endocrine Disruptors and Vascular Remodeling in Peripheral Arterial Disease
Int J Mol Sci. 2024 Apr 19;25(8):4502. doi: 10.3390/ijms25084502.ABSTRACTVascular diseases, including peripheral arterial disease (PAD), pulmonary arterial hypertension, and atherosclerosis, significantly impact global health due to their intricate relationship with vascular remodeling. This process, characterized by structural alterations in resistance vessels, is a hallmark of heightened vascular resistance seen in these disorders. The influence of environmental estrogenic endocrine disruptors (EEDs) on the vasculature suggests a potential exacerbation of these alterations. Our study employs an integrative approach, comb...
Source: Atherosclerosis - April 27, 2024 Category: Cardiology Authors: Vincent Avecilla Mayur Doke Madhumita Das Oscar Alcazar Sandeep Appunni Arthur Rech Tondin Brandon Watts Venkataraghavan Ramamoorthy Muni Rubens Jayanta Kumar Das Source Type: research
Results of a pilot study of the structure and evaluation of the therapy for chronic sleep disorders in comorbid patients with chronic cerebral ischemia
CONCLUSIONS: The clinical effectiveness of the drug Cortexin has been proven for all types of sleep disorders. The clinical effectiveness of the drug Cortexin at a dose of 10 mg IM for 10 days has been proven in patients with chronic sleep disorders due to CHI.PMID:38676686 | DOI:10.17116/jnevro2024124041118 (Source: Atherosclerosis)
Source: Atherosclerosis - April 27, 2024 Category: Cardiology Authors: M V Putilina N I Shabalina Source Type: research
Diabetic Cardiomyopathy-From Basics through Diagnosis to Treatment
Biomedicines. 2024 Mar 29;12(4):765. doi: 10.3390/biomedicines12040765.ABSTRACTDiabetic cardiomyopathy (DCM) is the development of myocardial dysfunction in patients with diabetes despite the absence of comorbidities such as hypertension, atherosclerosis or valvular defect. The cardiovascular complications of poorly controlled diabetes are very well illustrated by the U.K. Prospective Diabetes Study (UKPDS), which showed a clear association between increasing levels of glycated hemoglobin and the development of heart failure (HF). The incidence of HF in patients with diabetes is projected to increase significantly, which i...
Source: Atherosclerosis - April 27, 2024 Category: Cardiology Authors: Ewa Radzioch Bart łomiej Dąbek Marta Balcerczyk-Lis Weronika Fr ąk Piotr Fularski Ewelina M łynarska Jacek Rysz Beata Franczyk Source Type: research
