Bayesian network-based survival prediction model for patients having undergone post-transjugular intrahepatic portosystemic shunt for portal hypertension
CONCLUSION: This study successfully developed a BN-based survival prediction model with good predictive capabilities. It offers valuable insights for treatment strategies and prognostic evaluations in patients having undergone TIPS surgery for PHT.PMID:38659484 | PMC:PMC11036496 | DOI:10.3748/wjg.v30.i13.1859 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 25, 2024 Category: Gastroenterology Authors: Rong Chen Ling Luo Yun-Zhi Zhang Zhen Liu An-Lin Liu Yi-Wen Zhang Source Type: research
Survival of medical treatment success in primary open-angle glaucoma and ocular hypertension
CONCLUSION: Large-scale survival analyses provide the expected duration of treatment success from topical glaucoma medication.PMID:38664004 | DOI:10.1136/bjo-2023-323708 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - April 25, 2024 Category: Opthalmology Authors: Dun Jack Fu Ebenezer Ademisoye Vanessa Shih Andrew Ian McNaught Anthony Khawaja Source Type: research
Bayesian network-based survival prediction model for patients having undergone post-transjugular intrahepatic portosystemic shunt for portal hypertension
CONCLUSION: This study successfully developed a BN-based survival prediction model with good predictive capabilities. It offers valuable insights for treatment strategies and prognostic evaluations in patients having undergone TIPS surgery for PHT.PMID:38659484 | PMC:PMC11036496 | DOI:10.3748/wjg.v30.i13.1859 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 25, 2024 Category: Gastroenterology Authors: Rong Chen Ling Luo Yun-Zhi Zhang Zhen Liu An-Lin Liu Yi-Wen Zhang Source Type: research
Effect of Histamine H2 Receptor Antagonists on All-Cause Mortality in Critically Ill Patients With Essential Hypertension: A Retrospective Cohort Study
In conclusion, H2RAs exposure was related to lower mortalities in critically ill patients with essential hypertension, which provided novel potential strategy for the use of H2RAs in essential hypertension patients.PMID:38659369 | DOI:10.1002/jcph.2445 (Source: The Journal of Clinical Pharmacology)
Source: The Journal of Clinical Pharmacology - April 25, 2024 Category: Drugs & Pharmacology Authors: Jian-Mei Pan Yu Guo Fang-Fang Jiang Ran Xu Xin Zhang Wen-Ke Cai Sun-Jun Yin Ping Wang Yan-Hua Huang Xue-Sha Zhang Yi-Hua Li Liao Cai Gong-Hao He Source Type: research
Single cell transcriptomics of cerebrospinal fluid cells from patients with recent-onset narcolepsy
J Autoimmun. 2024 Apr 24;146:103234. doi: 10.1016/j.jaut.2024.103234. Online ahead of print.ABSTRACTNarcolepsy is a rare cause of hypersomnolence and may be associated or not with cataplexy, i.e. sudden muscle weakness. These forms are designated narcolepsy-type 1 (NT1) and -type 2 (NT2), respectively. Notable characteristics of narcolepsy are that most patients carry the HLA-DQB1*06:02 allele and NT1-patients have strongly decreased levels of hypocretin-1 (synonym orexin-A) in the cerebrospinal fluid (CSF). The pathogenesis of narcolepsy is still not completely understood but the strong HLA-bias and increased frequencies ...
Source: Journal of Autoimmunity - April 25, 2024 Category: Allergy & Immunology Authors: Alina Huth Ikram Ayoub Lucie Barateau Lisa Ann Gerdes Dany Severac Stefan Krebs Helmut Blum Hayrettin Tumani J ürgen Haas Brigitte Wildemann Tania K ümpfel Eduardo Beltr án Roland S Liblau Yves Dauvilliers Klaus Dornmair Source Type: research
Mind the Gap in Kidney Care: Translating What We Know Into What We Do
Iran J Kidney Dis. 2024 Mar;18(2):68-86. doi: 10.5254/sqbbj216.ABSTRACTHistorically, it takes an average of 17 years to move new treatments from clinical evidence to daily practice. Given the highly effective treatments now available to prevent or delay kidney disease onset and progression, this is far too long. The time is now to narrow the gap between what we know and what we do. Clear guidelines exist for the prevention and management of common risk factors for kidney disease, such as hypertension and diabetes, but only a fraction of people with these conditions worldwide are diagnosed, and even fewer are treated to tar...
Source: Iranian Journal of Kidney Diseases - April 25, 2024 Category: Urology & Nephrology Authors: Valerie A Luyckx Katherine R Tuttle Dina Abdellatif Ricardo Correa-Rotter Winston W S Fung Agn ès Haris Li-Li Hsiao Makram Khalife Latha A Kumaraswami Fiona Loud Vasundhara Raghavan Stefanos Roumeliotis Marianella Sierra Ifeoma Ulasi Bill Wang Siu-Fai Lu Source Type: research
Differential inhibition of sildenafil and macitentan on saxagliptin metabolism
Toxicol Appl Pharmacol. 2024 Apr 24;486:116934. doi: 10.1016/j.taap.2024.116934. Online ahead of print.ABSTRACTThe development of diabetes mellitus (DM) is generally accompanied by erectile dysfunction (ED) and pulmonary arterial hypertension (PAH), which increases the use of combination drug therapy and the risk of drug-drug interactions. Saxagliptin for the treatment of DM, sildenafil for the treatment of ED and PAH, and macitentan for the treatment of PAH are all substrates of CYP3A4, which indicates their potential involvement in drug-drug interactions. Therefore, we investigated potential pharmacokinetic interactions ...
Source: Toxicology and Applied Pharmacology - April 25, 2024 Category: Toxicology Authors: Ge-Xin Dai Wei Tan Yuxin Shen Dongdong Lin Ren-Ai Xu Qianmeng Lin Zhen Wei Source Type: research
Effects of residential socioeconomic polarization on high blood pressure among nursing home residents
CONCLUSIONS: We achieved our objective by demonstrating that concentrated deprivation is associated with worse cardiovascular outcomes even in a population with equal access to care. Measures that jointly consider economic and racial/ethnic polarization elucidate larger disparities than single domain measures.PMID:38663339 | DOI:10.1016/j.healthplace.2024.103243 (Source: Health and Place)
Source: Health and Place - April 25, 2024 Category: Environmental Health Authors: Hoda S Abdel Magid Samuel Jaros Yongmei Li Michael A Steinman Sei Lee Carmen Peralta Bocheng Jing Kathy Fung Christine K Liu Xiaojuan Liu Laura A Graham Michelle C Odden Source Type: research
Survival of medical treatment success in primary open-angle glaucoma and ocular hypertension
CONCLUSION: Large-scale survival analyses provide the expected duration of treatment success from topical glaucoma medication.PMID:38664004 | DOI:10.1136/bjo-2023-323708 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - April 25, 2024 Category: Opthalmology Authors: Dun Jack Fu Ebenezer Ademisoye Vanessa Shih Andrew Ian McNaught Anthony Khawaja Source Type: research
Bayesian network-based survival prediction model for patients having undergone post-transjugular intrahepatic portosystemic shunt for portal hypertension
CONCLUSION: This study successfully developed a BN-based survival prediction model with good predictive capabilities. It offers valuable insights for treatment strategies and prognostic evaluations in patients having undergone TIPS surgery for PHT.PMID:38659484 | PMC:PMC11036496 | DOI:10.3748/wjg.v30.i13.1859 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 25, 2024 Category: Gastroenterology Authors: Rong Chen Ling Luo Yun-Zhi Zhang Zhen Liu An-Lin Liu Yi-Wen Zhang Source Type: research
Bridging the Gap: Addressing Immigrant Health Through Community-initiated Screening Events
CONCLUSIONS: Working directly with the community, we designed and implemented health prevention events which served to meet a growing need and to identify and address health concerns among the Hispanic immigrant community.PMID:38661823 (Source: Progress in Community Health Partnerships)
Source: Progress in Community Health Partnerships - April 25, 2024 Category: International Medicine & Public Health Authors: Sally Moyce Nathaniel Sisson Madeline Metcalf Source Type: research
Bayesian network-based survival prediction model for patients having undergone post-transjugular intrahepatic portosystemic shunt for portal hypertension
CONCLUSION: This study successfully developed a BN-based survival prediction model with good predictive capabilities. It offers valuable insights for treatment strategies and prognostic evaluations in patients having undergone TIPS surgery for PHT.PMID:38659484 | PMC:PMC11036496 | DOI:10.3748/wjg.v30.i13.1859 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 25, 2024 Category: Gastroenterology Authors: Rong Chen Ling Luo Yun-Zhi Zhang Zhen Liu An-Lin Liu Yi-Wen Zhang Source Type: research
Effect of Histamine H2 Receptor Antagonists on All-Cause Mortality in Critically Ill Patients With Essential Hypertension: A Retrospective Cohort Study
In conclusion, H2RAs exposure was related to lower mortalities in critically ill patients with essential hypertension, which provided novel potential strategy for the use of H2RAs in essential hypertension patients.PMID:38659369 | DOI:10.1002/jcph.2445 (Source: The Journal of Clinical Pharmacology)
Source: The Journal of Clinical Pharmacology - April 25, 2024 Category: Drugs & Pharmacology Authors: Jian-Mei Pan Yu Guo Fang-Fang Jiang Ran Xu Xin Zhang Wen-Ke Cai Sun-Jun Yin Ping Wang Yan-Hua Huang Xue-Sha Zhang Yi-Hua Li Liao Cai Gong-Hao He Source Type: research
Single cell transcriptomics of cerebrospinal fluid cells from patients with recent-onset narcolepsy
J Autoimmun. 2024 Apr 24;146:103234. doi: 10.1016/j.jaut.2024.103234. Online ahead of print.ABSTRACTNarcolepsy is a rare cause of hypersomnolence and may be associated or not with cataplexy, i.e. sudden muscle weakness. These forms are designated narcolepsy-type 1 (NT1) and -type 2 (NT2), respectively. Notable characteristics of narcolepsy are that most patients carry the HLA-DQB1*06:02 allele and NT1-patients have strongly decreased levels of hypocretin-1 (synonym orexin-A) in the cerebrospinal fluid (CSF). The pathogenesis of narcolepsy is still not completely understood but the strong HLA-bias and increased frequencies ...
Source: Journal of Autoimmunity - April 25, 2024 Category: Allergy & Immunology Authors: Alina Huth Ikram Ayoub Lucie Barateau Lisa Ann Gerdes Dany Severac Stefan Krebs Helmut Blum Hayrettin Tumani J ürgen Haas Brigitte Wildemann Tania K ümpfel Eduardo Beltr án Roland S Liblau Yves Dauvilliers Klaus Dornmair Source Type: research
Mind the Gap in Kidney Care: Translating What We Know Into What We Do
Iran J Kidney Dis. 2024 Mar;18(2):68-86. doi: 10.5254/sqbbj216.ABSTRACTHistorically, it takes an average of 17 years to move new treatments from clinical evidence to daily practice. Given the highly effective treatments now available to prevent or delay kidney disease onset and progression, this is far too long. The time is now to narrow the gap between what we know and what we do. Clear guidelines exist for the prevention and management of common risk factors for kidney disease, such as hypertension and diabetes, but only a fraction of people with these conditions worldwide are diagnosed, and even fewer are treated to tar...
Source: Iranian Journal of Kidney Diseases - April 25, 2024 Category: Urology & Nephrology Authors: Valerie A Luyckx Katherine R Tuttle Dina Abdellatif Ricardo Correa-Rotter Winston W S Fung Agn ès Haris Li-Li Hsiao Makram Khalife Latha A Kumaraswami Fiona Loud Vasundhara Raghavan Stefanos Roumeliotis Marianella Sierra Ifeoma Ulasi Bill Wang Siu-Fai Lu Source Type: research
