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Antihypertensive treatment during pregnancy induces long-term changes in gut microbiota and the behaviors of the attention deficit hyperactivity disorder offspring
Toxicol Appl Pharmacol. 2024 Apr 26:116946. doi: 10.1016/j.taap.2024.116946. Online ahead of print.ABSTRACTThe pathogenesis of attention-deficit/hyperactivity disorder (ADHD) has not been fully elucidated. Gestational hypertension could double the probability of ADHD in the offspring, while the initial bacterial communication between the mother and offspring has been associated with psychiatric disorders. Thus, we hypothesize that antihypertensive treatment during pregnancy may abate the impairments in neurodevelopment of the offspring. To test this hypothesis, we chose Captopril and Labetalol, to apply to pregnant spontan...
Source: Toxicology and Applied Pharmacology - April 28, 2024 Category: Toxicology Authors: Hong-Bao Li Meng-Lu Xu Wen-Jie Xia Yuan-Yuan Dong Bo Peng Qing Su Xiao-Min Wang Jia-Yue Yu Ya-Nan Gao Jun-Zhe Wu Meng-Yue Xu Jin-Bao Yang Zhi-Ming Dai Lei Chen Ying Li Juan Bai Source Type: research

Fennel seeds extract prevents fructose-induced cardiac dysfunction in a rat model of metabolic syndrome via targeting abdominal obesity, hyperuricemia and NF- κβ inflammatory pathway
CONCLUSION: Findings could suggest FSE as a complementary supplement for preventing MetS and associated cardiac outcomes. However, well controlled clinical studies are still needed.PMID:38678740 | DOI:10.1016/j.tice.2024.102385 (Source: Tissue and Cell)
Source: Tissue and Cell - April 28, 2024 Category: Cytology Authors: Azza Mohamad El-Wakf Mamdouh Rashad El-Sawi Hadeer Mahmoud El-Nigomy Eman Mohamad El-Nashar Norah Saeed Al-Zahrani Nasser G Alqahtani Rashid A Aldahhan Zienab Helmy Eldken Source Type: research

Plasma levels of Sirtuin 7 are decreased in patients with essential hypertension
CONCLUSION: Plasma levels of SIRT7 are decreased in patients with essential hypertension, implying its potential as a biomarker for diagnosing essential hypertension.PMID:38679273 | DOI:10.1016/j.clinbiochem.2024.110766 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - April 28, 2024 Category: Biochemistry Authors: Ying Liu Ying Guo Ning Wang Zhaojie Dong Xiaoyan Yang Qian Liu Guohong Wang Mingzhao Qin Jiawei Song Jing Li Li Xu Ying Dong Jiuchang Zhong Source Type: research

Renal macrophages induce hypertension and kidney fibrosis in Angiotensin II salt mice model
This study aimed to determine the effects of angiotensin II (Ang II) salt-induced hypertension on renal immune cells and to determine whether renal macrophages are involved in the induction of hypertension. Hypertension was induced by administration of Ang II and saline for two weeks. The effects of hypertension on kidney immune cells were assessed using flow cytometry. Macrophage infiltration in the kidney was assessed by immunohistochemistry and kidney fibrosis was assessed using trichrome stain and kidney real time-qPCR. Liposome encapsulated clodronate was used to deplete macrophages in C57BL/6J mice and investigate th...
Source: Biochemical and Biophysical Research communications - April 28, 2024 Category: Biochemistry Authors: Joseph Kasyoki Peter Ryusuke Umene Chia-Hsien Wu Yasuna Nakamura Norito Washimine Ryoko Yamamoto Caroline Ngugi Kavoo Linge Joseph K Kweri Tsuyoshi Inoue Source Type: research

Awareness of having hypertension, diabetes and dyslipidaemia among US adults: The 2011-2018 NHANES data
CONCLUSIONS: Large proportions of US adults with hypertension, dyslipidaemia and diabetes are not aware of having the conditions. Interventions targeting groups at higher risk of being unaware of these conditions are needed.PMID:38679806 | DOI:10.1177/14034948241247612 (Source: Scandinavian Journal of Public Health)
Source: Scandinavian Journal of Public Health - April 28, 2024 Category: International Medicine & Public Health Authors: Kien G To Corneel Vandelanotte Anh N V Huynh Stephanie Schoeppe Stephanie Alley Aamir Raoof Memon Nhung T Q Nguyen Quyen G To Source Type: research

Interoceptive signals from the heart and coronary circulation in health and disease
Auton Neurosci. 2024 Apr 24;253:103180. doi: 10.1016/j.autneu.2024.103180. Online ahead of print.ABSTRACTThis review considers interoceptive signalling from the heart and coronary circulation. Vagal and cardiac sympathetic afferent sensory nerve endings are distributed throughout the atria, ventricles (mainly left), and coronary artery. A small proportion of cardiac receptors attached to thick myelinated vagal afferents are tonically active during the cardiac cycle. Dependent upon location, these mechanoreceptors detect fluctuations in atrial volume and coronary arterial perfusion. Atrial volume and coronary arterial signa...
Source: Autonomic Neuroscience - April 27, 2024 Category: Neuroscience Authors: Jonathan P Moore Source Type: research

Investigation of the Association between Bilateral Selective Anterograde Cerebral Perfusion and Postoperative Ischemic Stroke in Obese Patients with Emergency Surgery for Acute Type A Aortic Dissection
Conclusions: A patient-tailored strategy for cerebral perfusion should be considered in obese patients, considering the high atheromatous burden of the supra-aortic vessels in these patients and the potential risk of atheromatous embolization associated with this technique.PMID:38674307 | PMC:PMC11052173 | DOI:10.3390/medicina60040661 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Mircea Robu Bogdan Radulescu Irina Maria Margarint Cornel Robu Ovidiu Stiru Andrei Iosifescu Silvia Preda Mihai Cacoveanu Cristian Voica Vlad Anton Iliescu Horatiu Moldovan Source Type: research

Noninvasive Ambulatory Electrocardiographic Markers from Patients with COVID-19 Pneumonia: A Report of Three Cases
Medicina (Kaunas). 2024 Apr 19;60(4):655. doi: 10.3390/medicina60040655.ABSTRACTCoronavirus disease 2019 (COVID-19) has affected medical practice. More than 7,000,000 patients died worldwide after being infected with COVID-19; however, no specific laboratory markers have yet been established to predict death related to this disease. In contrast, electrocardiographic changes due to COVID-19 include QT prolongation and ST-T changes; however, there have not been studies on the ambulatory electrocardiographic markers of COVID-19. We encountered three patients diagnosed as having COVID-19 who did not have a prior history of sig...
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Motohiro Kimata Kenichi Hashimoto Naomi Harada Yusuke Kawamura Yoshifumi Kimizuka Yuji Fujikura Mayuko Kaneko Nobuaki Kiriu Yasumasa Sekine Natsumi Iwabuchi Tetsuro Kiyozumi Akihiko Kawana Susumu Matsukuma Yuji Tanaka Source Type: research

Treatment Nonadherence among Multimorbid Chronic Disease Patients: Evidence from 3515 Subjects in Indonesia
Conclusions: While the prevalence of multimorbidity in Indonesia is generally similar to that observed in previous studies, we have identified patient characteristics related to nonadherence. We suggest that patient's nonadherence was primarily dictated by their self-perception of health and treatment complexity. With the longstanding issue of nonadherence, this study indicated the need to consider creating patient-tailored treatment programs in clinical practice to improve adherence by considering individual patients' characteristics.PMID:38674280 | PMC:PMC11052292 | DOI:10.3390/medicina60040634 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Ivan Surya Pradipta Kevin Aprilio Yozi Fiedya Ningsih Mochammad Andhika Aji Pratama Sofa Dewi Alfian Rizky Abdulah Source Type: research

SARS-Cov-2 Infection: A New Risk Factor for Pituitary Apoplexy?
CONCLUSION: Alongside known risk factors (hypertension, anticoagulation, pregnancy, surgery, etc.), COVID-19 infection might represent an emerging predisposing factor for PA onset. The two cases hereby presented are both significant: the first confirms the role of "classic" vascular predisposing factors for PA, while the second demonstrates that PA might arise also in young patients without known risk factors.PMID:38676521 | DOI:10.2174/0118715303315494240419060719 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 27, 2024 Category: Endocrinology Authors: Alberto Ragni Giulia Bendotti Emilia Biamonte Beatrice Cavigiolo Enrico Gabellieri Paola Leporati Edoardo Luigi Maria Mollero Marco Gallo Source Type: research

A Case Report of Salmonella enterica Meningitis in an Infant: A Rare Entity not to Forget
CONCLUSION: Invasive Salmonella diseases, such as meningitis, are very uncommon in industrial countries nowadays, and the optimal management is yet not well established. Late onset of com-plications from Salmonella meningitis warrants more thorough neurodevelopmental follow-ups.PMID:38676483 | DOI:10.2174/0118715265286206240402050756 (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - April 27, 2024 Category: Infectious Diseases Authors: Maria Palyvou Evangelia Angeli George Syrogiannopoulos Evangelia Farmaki Marianna Tzanoudaki Gabriel Dimitriou Anastasia Varvarigou Despoina Gkentzi Source Type: research