Hypertensive disorders of pregnancy and cardiovascular disease risk: a Mendelian randomisation study
Conclusions
Genetic liability to HDPs is associated with higher CVD risk, lower blood pressure levels and earlier hypertension diagnosis. Our study suggests similar findings in ever pregnant women, nulligravidae and men, implying biological mechanisms relating to HDPs are causally related to CVD risk. (Source: Heart)
Source: Heart - April 25, 2024 Category: Cardiology Authors: Tschiderer, L., van der Schouw, Y. T., Burgess, S., Bloemenkamp, K. W. M., Seekircher, L., Willeit, P., Onland-Moret, C., Peters, S. A. E. Tags: Open access Cardiac risk factors and prevention Source Type: research
Effect of proteinuria on the rapid kidney function decline in chronic kidney disease depends on the underlying disease: A post hoc analysis of the BRIGHTEN study
The rapidity of kidney function decline in patients with nephrosclerosis (NS) is less rapid than in those with diabetic kidney disease (DKD) presumably because of a relatively low level of proteinuria [1 –3]. Several studies demonstrated that chronic kidney disease (CKD) patients with NS undergo a favourable clinical course as compared with those with DKD [1–4]. The presence of diabetes and proteinuria, but not that of hypertension, were independent predictors for rapid kidney function decline i n Taiwanese CKD patients [5]. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 25, 2024 Category: Endocrinology Authors: Tomohito Gohda, Maki Murakoshi, Yusuke Suzuki, Tatsuo Kagimura, Takashi Wada, Ichiei Narita Source Type: research
Idiopathic intracranial hypertension associated with SARS-CoV-2 infection in an adult male patient: a case report and review of the literature
ConclusionIdiopathic intracranial hypertension (IIH) may occur in association with SARS-CoV-2 infection and should be considered when making a differential diagnosis for headache and blurring of vision. COVID-19 may play a role in the development of intracranial hypertension, even in the absence of known risk factors. Early diagnosis and treatment of IIH has paramount importance to prevent vision loss and other morbidities. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - April 25, 2024 Category: General Medicine Source Type: research
Breaking the Barrier: The Role of Gut Epithelial Permeability in the Pathogenesis of Hypertension
AbstractPurpose of the ReviewTo review what intestinal permeability is and how it is measured, and to summarise the current evidence linking altered intestinal permeability with the development of hypertension.Recent FindingsIncreased gastrointestinal permeability, directly measuredin vivo, has been demonstrated in experimental and genetic animal models of hypertension. This is consistent with the passage of microbial substances to the systemic circulation and the activation of inflammatory pathways. Evidence for increased gut permeability in human hypertension has been reliant of a handful of blood biomarkers, with no stu...
Source: Current Hypertension Reports - April 25, 2024 Category: Primary Care Source Type: research
B-cells in pulmonary arterial hypertension: friend, foe or bystander?
There is an unmet need for new therapeutic strategies that target alternative pathways to improve the prognosis of patients with pulmonary arterial hypertension (PAH). As immunity has been involved in the development and progression of vascular lesions in PAH, we review the potential contribution of B-cells in its pathogenesis and evaluate the relevance of B-cell-targeted therapies. Circulating B-cell homeostasis is altered in PAH patients, with total B-cell lymphopenia, abnormal subset distribution (expansion of naïve and antibody-secreting cells, reduction of memory B-cells) and chronic activation. B-cells are re...
Source: European Respiratory Journal - April 25, 2024 Category: Respiratory Medicine Authors: Sanges, S., Tian, W., Dubucquoi, S., Chang, J. L., Collet, A., Launay, D., Nicolls, M. R. Tags: Pulmonary vascular disease Review Source Type: research
Safety and complications of continuation of aspirin therapy in patients undergoing robot-assisted laparoscopic simple prostatectomy
AbstractTo evaluate the safety and feasibility of continued perioperative aspirin at the time of robotic assisted simple prostatectomy (RASP). We performed a retrospective review of our IRB approved institutional database of patients who underwent RASP between 2013 and 2022. Comparative groups included patients taking aspirin in the perioperative period and those not taking aspirin pre-operatively. The primary outcome was any post-operative bleeding related complication using the modified Clavien –Dindo classification. Secondary outcomes included the identification of risk factors for increased blood loss in the entire s...
Source: Journal of Robotic Surgery - April 25, 2024 Category: Surgery Source Type: research
Association between lipoprotein(a) and cardiovascular disease in patients undergoing coronary angiography
CONCLUSION: The findings indicated that elevated lipoprotein(a) had no obvious relationship with hypertension and obesity. Elevated lipoprotein(a) increases the risk of high total cholesterol, high LDL‑c, and premature CAD, and increases the occurrence and severity of coronary heart disease.PMID:38658408 | DOI:10.1007/s00059-024-05247-0 (Source: Herz)
Source: Herz - April 24, 2024 Category: Cardiology Authors: Azhi ShaMa Chunmei Xu Yingying Huang Chunlan Ma Jingyue Hu Zhuxin Li Chunyu Zeng Source Type: research
Beta Blockers in Contemporary Cardiology: Is It Better to Cast Them Out?
Korean Circ J. 2024 Apr;54(4):165-171. doi: 10.4070/kcj.2023.0209.ABSTRACTBeta blockers are one of the commonest prescription drugs in medicine and they have been thought to revolutionize the treatment of heart failure (HF) with reduced ejection fraction (HFrEF) in the last century. In addition to HFrEF, they are prescribed for a variety of diseases in cardiology from hypertension to HF, angina, and stable coronary artery disease (CAD). The increased prescription of beta blockers in conditions like HF with preserved ejection fraction (HFpEF), and stable CAD may be doing more harm than good as per the data we have so far. T...
Source: Korean Circulation Journal - April 24, 2024 Category: Cardiology Authors: Javaid Ahmad Dar John Roshan Jacob Source Type: research
Blood Pressure Control and Associated Factors among Hypertension Comorbid Type 2 Diabetic Patients in Southeast Ethiopia
CONCLUSION: Uncontrolled hypertension was found to be high among hypertension comorbid type 2 diabetic patients. Patients' adherence to antihypertensive medication, physical activity, and alcohol abstinence should be maximized. Loss of weight is also crucial, as is the early detection and management of comorbidities.PMID:38655153 | PMC:PMC11039015 | DOI:10.1155/2024/6668436 (Source: International Journal of Hypertension)
Source: International Journal of Hypertension - April 24, 2024 Category: Cardiology Authors: Fikreab Desta Selamawit Mengesha Fanuel Belayneh Demelash Woldeyohannes Yohannes Tekalegn Demisu Zenbaba Biniyam Sahiledengle Dejene Hailu Source Type: research
Effect of experimental pulmonary arterial hypertension on renal and bone parameters of rats submitted to resistance exercise training
This study aimed to assess the impacts of stable PAH induced by monocrotaline (MCT) and RT on renal morphometry, as well as bone morphometry and biomechanical properties in male Wistar rats. Four experimental groups, untrained control (UC, n=7), trained control (TC, n=7), untrained hypertensive (UH, n=7), trained hypertensive (TH, n=7), were defined. After the first MCT or saline injection (20 mg/kg), trained rats were submitted to a RT program (i.e., Ladder climbing), 5 times/week. Seven days later the rats received the second MCT or saline dose. After euthanasia, renal and femoral histomorphometry and femoral biomechanic...
Source: An Acad Bras Cienc - April 24, 2024 Category: Science Authors: Le ôncio L Soares Luciano B Leite Ma íra O Freitas Luiz Ot ávio G Ervilha Mayra S P íccolo Alexandre M O Portes Filipe R Drummond Leonardo Mateus T DE Rezende Mariana M Neves Emily C C Reis Miguel A Carneiro-J únior Ant ônio José Natali Source Type: research
Efficacy of a Telemonitoring System as a Complementary Strategy in the Treatment of Patients With Heart Failure: Randomized Clinical Trial
Comput Inform Nurs. 2024 Apr 24. doi: 10.1097/CIN.0000000000001115. Online ahead of print.ABSTRACTEpisodes of decompensation are the main cause of hospital admissions in patients with heart failure. For this reason, the use of mobile apps emerges as an excellent strategy to improve coverage, real-time monitoring, and timeliness of care. ControlVit is an electronic application for early detection of complications studied within the context of a tertiary university hospital. Patients were randomized to the use of ControlVit versus placebo, during a 6-month follow-up. The primary outcome was the difference in numbers of readm...
Source: Computers, Informatics, Nursing : CIN - April 24, 2024 Category: Nursing Authors: Diana M Achury-Salda ña Rafael A Gonzalez Angel Garcia Alejandro Mari ño Wilson R Bohorquez Source Type: research
Cardiovascular diseases in Switzerland - Prevalence and care
Praxis (Bern 1994). 2024 Mar;113(3):57-66.ABSTRACTCardiovascular diseases (CVD) represent a significant health problem worldwide and in Switzerland. Despite preventive measures and advances in treatment, cardiovascular diseases still lead to a significant number of hospitalizations in Switzerland (133 000 in 2021) and are for responsible for almost 1/3 of all deaths (19 600 in 2021). Emergency care for acute cardiovascular events now has a very high standard in Switzerland compared to other countries. However, there is a large discrepancy between evidence and daily practice (evidence-performance gap) in cardiovascular risk...
Source: Praxis - April 24, 2024 Category: General Medicine Authors: Thomas Rosemann Agn ès Bachofner Oliver Strehle Source Type: research
Association between lipoprotein(a) and cardiovascular disease in patients undergoing coronary angiography
CONCLUSION: The findings indicated that elevated lipoprotein(a) had no obvious relationship with hypertension and obesity. Elevated lipoprotein(a) increases the risk of high total cholesterol, high LDL‑c, and premature CAD, and increases the occurrence and severity of coronary heart disease.PMID:38658408 | DOI:10.1007/s00059-024-05247-0 (Source: Herz)
Source: Herz - April 24, 2024 Category: Cardiology Authors: Azhi ShaMa Chunmei Xu Yingying Huang Chunlan Ma Jingyue Hu Zhuxin Li Chunyu Zeng Source Type: research
Beta Blockers in Contemporary Cardiology: Is It Better to Cast Them Out?
Korean Circ J. 2024 Apr;54(4):165-171. doi: 10.4070/kcj.2023.0209.ABSTRACTBeta blockers are one of the commonest prescription drugs in medicine and they have been thought to revolutionize the treatment of heart failure (HF) with reduced ejection fraction (HFrEF) in the last century. In addition to HFrEF, they are prescribed for a variety of diseases in cardiology from hypertension to HF, angina, and stable coronary artery disease (CAD). The increased prescription of beta blockers in conditions like HF with preserved ejection fraction (HFpEF), and stable CAD may be doing more harm than good as per the data we have so far. T...
Source: Korean Circulation Journal - April 24, 2024 Category: Cardiology Authors: Javaid Ahmad Dar John Roshan Jacob Source Type: research
Blood Pressure Control and Associated Factors among Hypertension Comorbid Type 2 Diabetic Patients in Southeast Ethiopia
CONCLUSION: Uncontrolled hypertension was found to be high among hypertension comorbid type 2 diabetic patients. Patients' adherence to antihypertensive medication, physical activity, and alcohol abstinence should be maximized. Loss of weight is also crucial, as is the early detection and management of comorbidities.PMID:38655153 | PMC:PMC11039015 | DOI:10.1155/2024/6668436 (Source: International Journal of Hypertension)
Source: International Journal of Hypertension - April 24, 2024 Category: Cardiology Authors: Fikreab Desta Selamawit Mengesha Fanuel Belayneh Demelash Woldeyohannes Yohannes Tekalegn Demisu Zenbaba Biniyam Sahiledengle Dejene Hailu Source Type: research
