Heavy Metal Exposure and Cardiovascular Disease
Circ Res. 2024 Apr 26;134(9):1160-1178. doi: 10.1161/CIRCRESAHA.123.323617. Epub 2024 Apr 25.ABSTRACTHeavy metals are harmful environmental pollutants that have attracted widespread attention due to their health hazards to human cardiovascular disease. Heavy metals, including lead, cadmium, mercury, arsenic, and chromium, are found in various sources such as air, water, soil, food, and industrial products. Recent research strongly suggests a connection between cardiovascular disease and exposure to toxic heavy metals. Epidemiological, basic, and clinical studies have revealed that heavy metals can promote the production of...
Source: Circulation Research - April 25, 2024 Category: Cardiology Authors: Ziwei Pan Tingyu Gong Ping Liang Source Type: research
Perfluoroalkyl/Polyfluoroalkyl Substances: Links to Cardiovascular Disease Risk
Circ Res. 2024 Apr 26;134(9):1136-1159. doi: 10.1161/CIRCRESAHA.124.323697. Epub 2024 Apr 25.ABSTRACTConservative estimates by the World Health Organization suggest that at least a quarter of global cardiovascular diseases are attributable to environmental exposures. Associations between air pollution and cardiovascular risk have garnered the most headlines and are strong, but less attention has been paid to other omnipresent toxicants in our ecosystem. Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are man-made chemicals that are extensively used in industrial and consumer products worldwide and in aqueous film-for...
Source: Circulation Research - April 25, 2024 Category: Cardiology Authors: Jennifer J Schlezinger Noyan Gokce Source Type: research
Transportation Noise Pollution and Cardiovascular Health
Circ Res. 2024 Apr 26;134(9):1113-1135. doi: 10.1161/CIRCRESAHA.123.323584. Epub 2024 Apr 25.ABSTRACTEpidemiological studies have found that transportation noise increases the risk for cardiovascular morbidity and mortality, with solid evidence for ischemic heart disease, heart failure, and stroke. According to the World Health Organization, at least 1.6 million healthy life years are lost annually from traffic-related noise in Western Europe. Traffic noise at night causes fragmentation and shortening of sleep, elevation of stress hormone levels, and increased oxidative stress in the vasculature and the brain. These factor...
Source: Circulation Research - April 25, 2024 Category: Cardiology Authors: Thomas M ünzel Michael Molitor Marin Kuntic Omar Hahad Martin R öösli Nicole Engelmann Mathias Basner Andreas Daiber Mette S ørensen Source Type: research
Single cell transcriptomics of cerebrospinal fluid cells from patients with recent-onset narcolepsy
J Autoimmun. 2024 Apr 24;146:103234. doi: 10.1016/j.jaut.2024.103234. Online ahead of print.ABSTRACTNarcolepsy is a rare cause of hypersomnolence and may be associated or not with cataplexy, i.e. sudden muscle weakness. These forms are designated narcolepsy-type 1 (NT1) and -type 2 (NT2), respectively. Notable characteristics of narcolepsy are that most patients carry the HLA-DQB1*06:02 allele and NT1-patients have strongly decreased levels of hypocretin-1 (synonym orexin-A) in the cerebrospinal fluid (CSF). The pathogenesis of narcolepsy is still not completely understood but the strong HLA-bias and increased frequencies ...
Source: Journal of Autoimmunity - April 25, 2024 Category: Allergy & Immunology Authors: Alina Huth Ikram Ayoub Lucie Barateau Lisa Ann Gerdes Dany Severac Stefan Krebs Helmut Blum Hayrettin Tumani J ürgen Haas Brigitte Wildemann Tania K ümpfel Eduardo Beltr án Roland S Liblau Yves Dauvilliers Klaus Dornmair Source Type: research
AI-enabled cardiac chambers volumetry in coronary artery calcium scans (AI-CAC(TM)) predicts heart failure and outperforms NT-proBNP: The multi-ethnic study of Atherosclerosis
CONCLUSION: AI-CAC volumetry significantly outperformed NT-proBNP and the Agatston CAC score, and significantly improved the AUC and category-free NRI of clinical risk factors for incident HF prediction.PMID:38664073 | DOI:10.1016/j.jcct.2024.04.006 (Source: Atherosclerosis)
Source: Atherosclerosis - April 25, 2024 Category: Cardiology Authors: Morteza Naghavi Anthony Reeves Matthew Budoff Dong Li Kyle Atlas Chenyu Zhang Thomas Atlas Sion K Roy Claudia I Henschke Nathan D Wong Christopher Defilippi Daniel Levy David F Yankelevitz Source Type: research
Perfluoroalkyl/Polyfluoroalkyl Substances: Links to Cardiovascular Disease Risk
Circ Res. 2024 Apr 26;134(9):1136-1159. doi: 10.1161/CIRCRESAHA.124.323697. Epub 2024 Apr 25.ABSTRACTConservative estimates by the World Health Organization suggest that at least a quarter of global cardiovascular diseases are attributable to environmental exposures. Associations between air pollution and cardiovascular risk have garnered the most headlines and are strong, but less attention has been paid to other omnipresent toxicants in our ecosystem. Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are man-made chemicals that are extensively used in industrial and consumer products worldwide and in aqueous film-for...
Source: Atherosclerosis - April 25, 2024 Category: Cardiology Authors: Jennifer J Schlezinger Noyan Gokce Source Type: research
Heavy Metal Exposure and Cardiovascular Disease
Circ Res. 2024 Apr 26;134(9):1160-1178. doi: 10.1161/CIRCRESAHA.123.323617. Epub 2024 Apr 25.ABSTRACTHeavy metals are harmful environmental pollutants that have attracted widespread attention due to their health hazards to human cardiovascular disease. Heavy metals, including lead, cadmium, mercury, arsenic, and chromium, are found in various sources such as air, water, soil, food, and industrial products. Recent research strongly suggests a connection between cardiovascular disease and exposure to toxic heavy metals. Epidemiological, basic, and clinical studies have revealed that heavy metals can promote the production of...
Source: Atherosclerosis - April 25, 2024 Category: Cardiology Authors: Ziwei Pan Tingyu Gong Ping Liang Source Type: research
The Tricuspid Valve: A Review of Pathology, Imaging, and Current Treatment Options: A Scientific Statement From the American Heart Association
Circulation. 2024 Apr 25. doi: 10.1161/CIR.0000000000001232. Online ahead of print.ABSTRACTTricuspid valve disease is an often underrecognized clinical problem that is associated with significant morbidity and mortality. Unfortunately, patients will often present late in their disease course with severe right-sided heart failure, pulmonary hypertension, and life-limiting symptoms that have few durable treatment options. Traditionally, the only treatment for tricuspid valve disease has been medical therapy or surgery; however, there have been increasing interest and success with the use of transcatheter tricuspid valve ther...
Source: Circulation - April 25, 2024 Category: Cardiology Authors: Laura J Davidson Gilbert H L Tang Edwin C Ho Marat Fudim Tiberio Frisoli Anton Camaj Margaret T Bowers Sofia Carolina Masri Pavan Atluri Joanna Chikwe Peter J Mason Jason C Kovacic George D Dangas American Heart Association Interventional Committee of the Source Type: research
Performance of home-based and ambulatory blood pressure monitoring in obese children and their correlation with end organ damage
CONCLUSION: The study highlights 24-hour ABPM's vital role in classifying hypertensive status, especially in high-risk children. The diagnostic performance of HBPM shows poor sensitivity in detecting MH and lower specificity in identifying WCH compared to ABPM. This limitation translates to missed opportunities for early preventive interventions.PMID:38661395 | DOI:10.1093/ajh/hpae049 (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - April 25, 2024 Category: Cardiology Authors: Athira Puthukara Amber Kumar Girish Chandra Bhatt Mahesh Maheshwari Abhijit P Pakhare Shikha Malik Rupesh Raina Source Type: research
Effect of Histamine H2 Receptor Antagonists on All-Cause Mortality in Critically Ill Patients With Essential Hypertension: A Retrospective Cohort Study
In conclusion, H2RAs exposure was related to lower mortalities in critically ill patients with essential hypertension, which provided novel potential strategy for the use of H2RAs in essential hypertension patients.PMID:38659369 | DOI:10.1002/jcph.2445 (Source: The Journal of Clinical Pharmacology)
Source: The Journal of Clinical Pharmacology - April 25, 2024 Category: Drugs & Pharmacology Authors: Jian-Mei Pan Yu Guo Fang-Fang Jiang Ran Xu Xin Zhang Wen-Ke Cai Sun-Jun Yin Ping Wang Yan-Hua Huang Xue-Sha Zhang Yi-Hua Li Liao Cai Gong-Hao He Source Type: research
Bayesian network-based survival prediction model for patients having undergone post-transjugular intrahepatic portosystemic shunt for portal hypertension
CONCLUSION: This study successfully developed a BN-based survival prediction model with good predictive capabilities. It offers valuable insights for treatment strategies and prognostic evaluations in patients having undergone TIPS surgery for PHT.PMID:38659484 | PMC:PMC11036496 | DOI:10.3748/wjg.v30.i13.1859 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 25, 2024 Category: Gastroenterology Authors: Rong Chen Ling Luo Yun-Zhi Zhang Zhen Liu An-Lin Liu Yi-Wen Zhang Source Type: research
Neutrophil extracellular traps promote proliferation of pulmonary smooth muscle cells mediated by CCDC25 in pulmonary arterial hypertension
CONCLUSION: This study elucidated the involvement of NETs in pathogenesis of PAH through their influence on the function of PASMCs, thereby highlighting their potential as promising targets for the evaluation and treatment of PAH.PMID:38664728 | DOI:10.1186/s12931-024-02813-2 (Source: Cell Research)
Source: Cell Research - April 25, 2024 Category: Cytology Authors: Hongxiao Sun Zhanhui Du Xu Zhang Shuai Gao Zhixian Ji Gang Luo Silin Pan Source Type: research
Environmental Impacts on Cardiovascular Health and Biology: An Overview
Circ Res. 2024 Apr 26;134(9):1048-1060. doi: 10.1161/CIRCRESAHA.123.323613. Epub 2024 Apr 25.ABSTRACTEnvironmental stressors associated with human activities (eg, air and noise pollution, light disturbance at night) and climate change (eg, heat, wildfires, extreme weather events) are increasingly recognized as contributing to cardiovascular morbidity and mortality. These harmful exposures have been shown to elicit changes in stress responses, circadian rhythms, immune cell activation, and oxidative stress, as well as traditional cardiovascular risk factors (eg, hypertension, diabetes, obesity) that promote cardiovascular d...
Source: Cell Research - April 25, 2024 Category: Cytology Authors: Jacob R Blaustein Matthew J Quisel Naomi M Hamburg Sharine Wittkopp Source Type: research
Genetic Polymorphisms of Endothelial Nitric Oxide Synthase Associated with Hypertension and Blood Homocysteine Levels
CONCLUSION: eNOS variants rs1799983 and rs2070744 may be risk factors for hypertension linked to hyperhomocysteinemia. These findings provide potentially useful healthcare strategies for the management of hypertension.PMID:38660143 | PMC:PMC11041984 | DOI:10.2147/IJGM.S456519 (Source: Molecular Medicine)
Source: Molecular Medicine - April 25, 2024 Category: Molecular Biology Authors: Charinya Chaichanabut Piyamitr Sritara Jintana Sirivarasai Source Type: research
Mind the Gap in Kidney Care: Translating What We Know Into What We Do
Iran J Kidney Dis. 2024 Mar;18(2):68-86. doi: 10.5254/sqbbj216.ABSTRACTHistorically, it takes an average of 17 years to move new treatments from clinical evidence to daily practice. Given the highly effective treatments now available to prevent or delay kidney disease onset and progression, this is far too long. The time is now to narrow the gap between what we know and what we do. Clear guidelines exist for the prevention and management of common risk factors for kidney disease, such as hypertension and diabetes, but only a fraction of people with these conditions worldwide are diagnosed, and even fewer are treated to tar...
Source: Iranian Journal of Kidney Diseases - April 25, 2024 Category: Urology & Nephrology Authors: Valerie A Luyckx Katherine R Tuttle Dina Abdellatif Ricardo Correa-Rotter Winston W S Fung Agn ès Haris Li-Li Hsiao Makram Khalife Latha A Kumaraswami Fiona Loud Vasundhara Raghavan Stefanos Roumeliotis Marianella Sierra Ifeoma Ulasi Bill Wang Siu-Fai Lu Source Type: research
