Reflections on assortative mating, social stratification, and genetics
J Genet. 2024;103:15.ABSTRACTA recent report by G. Clark points to a sustained persistence of social status in England that extends vertically across several generations and horizontally across many levels of kinship. We seek to put his findings in historical perspective. We do so by relating them to two lines of thinking related to biological inheritance. One predated the rediscovery of Mendel's work and led to the field of quantitative genetics, which dealt on the whole with quasi-continuously varying traits. The other is based on the rediscovery itself and led to a reconciliation between quantitative genetics and discre...
Source: Journal of Genetics - April 22, 2024 Category: Genetics & Stem Cells Authors: Oliver Mayo Vidyanand Nanjundiah Source Type: research
Historical Redlining and Present-Day Nonsuicide Firearm Fatalities
CONCLUSION: Discriminatory redlining policies from 80 years ago are associated with nonsuicide firearm fatalities today.PRIMARY FUNDING SOURCE: Fred Lovejoy Housestaff Research and Education Fund.PMID:38648643 | DOI:10.7326/M23-2496 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 22, 2024 Category: Internal Medicine Authors: Ayesha Dholakia Kendall J Burdick Catherine Kreatsoulas Michael C Monuteaux Jennifer Tsai S V Subramanian Eric W Fleegler Source Type: research
Training physiotherapy students in basic wheelchair provision. Experiences at two universities in Colombia
This study aimed to describe a training intervention for two groups of future physiotherapists in Colombia, assess cohort differences in performance on a knowledge test, and explore their post-training perceptions. A quantitative retrospective study with a historical, descriptive-comparative design was conducted. 525 sixth-semester participants completed the International Society of Wheelchair Professionals Wheelchair Service Provision - Basic Test online in Spanish after curriculum modifications were implemented. The test assesses knowledge in seven domains: Assessment; Prescription; Products; Fitting; User training; Foll...
Source: Disability and Rehabilitation. Assistive Technology. - April 22, 2024 Category: Rehabilitation Authors: Sandra Esperanza Velasco Forero Nidia Johana Arias Becerra Martha Roc ío Torres Narváez M ónica Alejandra Mondragón Barrera Sara Munera Orozco Mary Goldberg Krithika Kandavel Paola Rocio Esquivel Ortiz Source Type: research
Race, immunity, and lifespan: Unraveling the effect of early-life exposure to malaria risk on lifespan
Econ Hum Biol. 2024 Apr 12;54:101382. doi: 10.1016/j.ehb.2024.101382. Online ahead of print.ABSTRACTWe investigate a historical experience to measure the long-term effect of malaria on lifespan among infected survivors and identify a factor that mitigates malaria's effect. Using a sample of Union Army veterans born during the mid-19th century and their lifetime records, we show that exposure to high risk of malaria at birth or in early life substantially shortened their lifespan. The legacy of exposure to malaria is robust while controlling for lifetime socioeconomic and health conditions, fixed effects, and considering se...
Source: Economics and Human Biology - April 22, 2024 Category: Biology Authors: Sok Chul Hong Inhyuk Hwang Source Type: research
Training physiotherapy students in basic wheelchair provision. Experiences at two universities in Colombia
This study aimed to describe a training intervention for two groups of future physiotherapists in Colombia, assess cohort differences in performance on a knowledge test, and explore their post-training perceptions. A quantitative retrospective study with a historical, descriptive-comparative design was conducted. 525 sixth-semester participants completed the International Society of Wheelchair Professionals Wheelchair Service Provision - Basic Test online in Spanish after curriculum modifications were implemented. The test assesses knowledge in seven domains: Assessment; Prescription; Products; Fitting; User training; Foll...
Source: Disability and Rehabilitation. Assistive Technology. - April 22, 2024 Category: Rehabilitation Authors: Sandra Esperanza Velasco Forero Nidia Johana Arias Becerra Martha Roc ío Torres Narváez M ónica Alejandra Mondragón Barrera Sara Munera Orozco Mary Goldberg Krithika Kandavel Paola Rocio Esquivel Ortiz Source Type: research
Brazilian Women in Paralympic Sports: Uncovering Historical Milestones in the Summer Paralympic Games
Adapt Phys Activ Q. 2024 Apr 22:1-14. doi: 10.1123/apaq.2023-0139. Online ahead of print.ABSTRACTThe journey of Brazilian female Paralympians transcends mere statistical increases in women's participation. Behind the modest athlete growth lies the reality of women who are doubly marginalized by the intersection of gender and disability in an arena tailored for able-bodied men. Our study aimed to catalyze critical discourses surrounding the historical trajectory of Paralympic women's sports. Through a comprehensive documentary analysis based on the Brazilian Paralympic Committee's official documents from 1976 to 2021, we so...
Source: Adapted Physical Activity Quarterly : APAQ - April 22, 2024 Category: International Medicine & Public Health Authors: Luiz Gustavo T Fabricio Dos Santos Isabella Dos Santos Alves N áthali Fernanda Feliciano Africa Alejandra Ortu ño Torres Luis Felipe Castelli Correia de Campos Maria Luiza Tanure Alves Source Type: research
Reflections on assortative mating, social stratification, and genetics
J Genet. 2024;103:15.ABSTRACTA recent report by G. Clark points to a sustained persistence of social status in England that extends vertically across several generations and horizontally across many levels of kinship. We seek to put his findings in historical perspective. We do so by relating them to two lines of thinking related to biological inheritance. One predated the rediscovery of Mendel's work and led to the field of quantitative genetics, which dealt on the whole with quasi-continuously varying traits. The other is based on the rediscovery itself and led to a reconciliation between quantitative genetics and discre...
Source: Journal of Genetics - April 22, 2024 Category: Genetics & Stem Cells Authors: Oliver Mayo Vidyanand Nanjundiah Source Type: research
Historical Redlining and Present-Day Nonsuicide Firearm Fatalities
CONCLUSION: Discriminatory redlining policies from 80 years ago are associated with nonsuicide firearm fatalities today.PRIMARY FUNDING SOURCE: Fred Lovejoy Housestaff Research and Education Fund.PMID:38648643 | DOI:10.7326/M23-2496 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 22, 2024 Category: Internal Medicine Authors: Ayesha Dholakia Kendall J Burdick Catherine Kreatsoulas Michael C Monuteaux Jennifer Tsai S V Subramanian Eric W Fleegler Source Type: research
Efficacy and safety of tislelizumab plus lenvatinib as first-line treatment in patients with unresectable hepatocellular carcinoma: a multicenter, single-arm, phase 2 trial
CONCLUSIONS: Tislelizumab plus lenvatinib demonstrated promising antitumor activity with favourable tolerability as first-line therapy for patients with uHCC.TRIAL REGISTRATION: ClinicalTrials.gov (NCT04401800).PMID:38650037 | DOI:10.1186/s12916-024-03356-5 (Source: Cancer Control)
Source: Cancer Control - April 22, 2024 Category: Cancer & Oncology Authors: Li Xu Jinzhang Chen Chang Liu Xiaoling Song Yanqiao Zhang Haitao Zhao Sheng Yan Weidong Jia Zheng Wu Yabing Guo Jiayin Yang Wei Gong Yue Ma Xiaobo Yang Zhenzhen Gao Nu Zhang Xin Zheng Mengyu Li Dan Su Minshan Chen Source Type: research
Plasma neurological biomarkers as a measure of neurotoxicity in pediatric dental general anesthesia: a prospective observational feasibility study
ConclusionCaspase-3 reduced significantly in the short time frames during day-care DGA; this might be due to the relatively short anesthesia duration associated with dental treatment as compared with more extensive medical-related treatments. Therefore, further studies on Caspase-3 as a potential biomarker in pediatric DGA neurotoxicity are required to further ascertain results of this study. (Source: European Archives of Paediatric Dentistry)
Source: European Archives of Paediatric Dentistry - April 22, 2024 Category: Dentistry Source Type: research
A historical approach to models of emotional laterality
Brain Res. 2024 Apr 19:148948. doi: 10.1016/j.brainres.2024.148948. Online ahead of print.ABSTRACTIn this paper I discuss the main models that have tried to explain brain asymmetries for emotions. The first models, based on clinical observations, proposed either a general right hemisphere dominance for emotions (the'right hemisphere') model or a different specialization of the right hemisphere for negative and of the left hemisphere for positive emotions (the'valence' model). In more recent times new models, based on partly modified versions of the previous ones have been proposed. The revised version of the 'valence' mode...
Source: Brain Research - April 21, 2024 Category: Neurology Authors: Guido Gainotti Source Type: research
Bio-analog dissipative structures and principles of biological behavior
Biosystems. 2024 Apr 18;239:105214. doi: 10.1016/j.biosystems.2024.105214. Online ahead of print.ABSTRACTThe place of living organisms in the natural world is a nearly perennial question in philosophy and the sciences; how can inanimate matter yield animate beings? A dominant answer for several centuries has been to treat organisms as sophisticated machines, studying them with the mechanistic physics and chemistry that have given rise to technology and complex machines. Since the early 20th century, many scholars have sought instead to naturalize biology through thermodynamics, recognizing the precarious far-from-equilibri...
Source: Biosystems - April 20, 2024 Category: Biotechnology Authors: Benjamin De Bari Dilip K Kondepudi Ashwin Vaidya James A Dixon Source Type: research
Landslide susceptibility assessment based on frequency ratio and semi-supervised heterogeneous ensemble learning model
Environ Sci Pollut Res Int. 2024 Apr 20. doi: 10.1007/s11356-024-33287-w. Online ahead of print.ABSTRACTEpistemic uncertainty in data-driven landslide susceptibility assessment often tends to be increased by the limited accuracy of an individual model, as well as uncertainties associated with the selection of non-landslide samples. To address these issues, this paper centers on the landslide disaster in Ji'an City, China, and proposes a heterogeneous ensemble learning method incorporating frequency ratio (FR) and semi-supervised sample expansion. Based on the superimposed results of 12 environmental factor frequency ratios...
Source: Environmental Science and Pollution Research International - April 20, 2024 Category: Environmental Health Authors: Yangyang Zhao Shengwu Qin Chaobiao Zhang Jingyu Yao Ziyang Xing Jiasheng Cao Renchao Zhang Source Type: research
A historical cohort study on predictors for successful weaning from prolonged mechanical ventilation and up to 3-year survival follow-up in a rehabilitation center
CONCLUSION: Successful weaning from PMV may be associated with better survival and allows chronically ventilated patients to become independent on a ventilator. A larger study is needed to further validate our findings.PMID:38642907 | DOI:10.1016/j.rmed.2024.107636 (Source: Respiratory Care)
Source: Respiratory Care - April 20, 2024 Category: Respiratory Medicine Authors: Mila Fradkin Maya Elyashiv Amasha Camel Nirit Agay Michael Brik Pierre Singer Rachel Dankner Source Type: research
Volume expansion mitigates Shiga toxin-producing E. coli-hemolytic uremic syndrome in children
ConclusionsThis study suggests that volume expansion may be associated with the mitigation of the acute course of STEC-HUS, especially severe neurological involvement and the development of CKD. Prospective trials should lead to standardized protocols for volume expansion in children with STEC-HUS.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - April 19, 2024 Category: Urology & Nephrology Source Type: research
