Historical Lessons on Vaccine Hesitancy: Smallpox, Polio, and Measles, and Implications for COVID-19
This study examines the history of US vaccination efforts against smallpox, polio, and measles, highlighting persistent drivers of vaccine hesitancy as well as factors that helped overcome it. The research reveals that logistical barriers, negative portrayals in the media, and fears about safety stymied inoculation efforts as early as the 18th century and continue to do so. However, vaccine hesitancy has been markedly diminished when trusted community leaders have guided efforts, when ordinary citizens have felt personally invested in the success of the vaccine, and when vaccination efforts have been tied to broader projec...
Source: Perspectives in Biology and Medicine - April 25, 2024 Category: Medical Ethics Authors: J J Eddy H A Smith J E Abrams Source Type: research
On Antiscience and Antisemitism
This article provides both historical and recent perspectives on the links between antiscience and antisemitism, together with the author's personal experience as a Jewish vaccine scientist targeted by both dark forces. New approaches to uncoupling antisemitism from antiscience, while combating both, are essential for saving lives and preserving democratic values.PMID:38661936 | DOI:10.1353/pbm.2023.a902035 (Source: Perspectives in Biology and Medicine)
Source: Perspectives in Biology and Medicine - April 25, 2024 Category: Medical Ethics Authors: Peter Hotez Source Type: research
Evolutionary characteristics of the mitochondrial NADH dehydrogenase subunit 6 gene in some populations of four sympatric Mustela species (Mustelidae, Mammalia) from central Europe
CONCLUSIONS: Negative selection for MT-ND6 within the genus Mustela suggests absence of both environmental and species-specific effects of cellular energy metabolism despite large species-specific differences in body size. The presently found shared polymorphism in European polecats and steppe polecats may result from ancestral polymorphism before speciation and historical or recent introgressive hybridization; it may indicate mtDNA capture of steppe polecats by M. putorius in Europe.PMID:38664260 | DOI:10.1007/s11033-024-09505-6 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 25, 2024 Category: Molecular Biology Authors: Ghada Tissaoui Franz Suchentrunk Asma Awadi Steve Smith Antje Weber Hichem Ben Slimen Source Type: research
Spatiotemporal dynamics of forest fires in the context of climate change: a review
Environ Sci Pollut Res Int. 2024 Apr 25. doi: 10.1007/s11356-024-33305-x. Online ahead of print.ABSTRACTForest fires are sudden, destructive, hazardous, and challenging to manage and rescue, earning them a place on UNESCO's list of the world's eight major natural disasters. Currently, amid global warming, all countries worldwide have entered a period of high forest fire incidence. Due to global warming, the frequency of forest fires has accelerated, the likelihood of large fires has increased, and the spatial and temporal dynamics of forest fires have shown different trends. Therefore, the impact of climate change on the s...
Source: Environmental Science and Pollution Research International - April 25, 2024 Category: Environmental Health Authors: Yuanjun Zhang Hwee San Lim Chengyu Hu Rui Zhang Source Type: research
Assessing autosomal aneuploidy in ancient genomes
Trends Genet. 2024 Apr 24:S0168-9525(24)00080-5. doi: 10.1016/j.tig.2024.04.006. Online ahead of print.ABSTRACTUsing genetic methods, aneuploidies can be detected in ancient human remains, which is so far the only way to reliably prove their existence in the past. As highlighted in recent studies by Rohrlach et al. and by Anastasiadou et al., this initial step enables a deeper exploration of the history of rare diseases, encompassing the social and historical contexts of the afflicted individuals.PMID:38664113 | DOI:10.1016/j.tig.2024.04.006 (Source: Trends in Genetics : TIG)
Source: Trends in Genetics : TIG - April 25, 2024 Category: Genetics & Stem Cells Authors: Julia Gresky Source Type: research
Pharmacokinetics of apixaban in patients undergoing pancreaticoduodenectomy (PAP-UP)
CONCLUSION: The pharmacokinetic characteristics of apixaban in subjects who had undergone pancreaticoduodenectomy are not significantly different from those of healthy controls. Though the sample size of this study is small, results suggest that no change to apixaban dose regimen is needed in patients who have had a pancreaticoduodenectomy.PMID:38660886 | DOI:10.5414/CP204502 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - April 25, 2024 Category: Drugs & Pharmacology Authors: Richard Zheng Edwin Lam Peter Altshuler Madison Crutcher Harish Lavu Charles J Yeo Douglas Stickle Benjamin Leiby Walter K Kraft Source Type: research
Challenges and Lessons from Conducting a Community-Engaged Evaluation of a Community Advisory Board-A Case Study from Flint
Prog Community Health Partnersh. 2024;18(1):31-36.ABSTRACTCommunity-engaged research often poses challenges due to exactly those qualities that make it desirable: it provides a new model of research that differs in many ways from top-down, university-led, prospectively designed approaches. While many have discussed the challenges to conducting community-engaged research, few have provided precise and generalizable lessons for how to surmount these challenges. Here we discuss the challenges experienced in a project that was community-engaged at three levels: 1) a research team consisting of an academic and a community partn...
Source: Progress in Community Health Partnerships - April 25, 2024 Category: International Medicine & Public Health Authors: Stephanie Solomon Cargill Bryan Spencer Briah Spencer Source Type: research
Pharmacokinetics of apixaban in patients undergoing pancreaticoduodenectomy (PAP-UP)
CONCLUSION: The pharmacokinetic characteristics of apixaban in subjects who had undergone pancreaticoduodenectomy are not significantly different from those of healthy controls. Though the sample size of this study is small, results suggest that no change to apixaban dose regimen is needed in patients who have had a pancreaticoduodenectomy.PMID:38660886 | DOI:10.5414/CP204502 (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - April 25, 2024 Category: Drugs & Pharmacology Authors: Richard Zheng Edwin Lam Peter Altshuler Madison Crutcher Harish Lavu Charles J Yeo Douglas Stickle Benjamin Leiby Walter K Kraft Source Type: research
Historical Lessons on Vaccine Hesitancy: Smallpox, Polio, and Measles, and Implications for COVID-19
This study examines the history of US vaccination efforts against smallpox, polio, and measles, highlighting persistent drivers of vaccine hesitancy as well as factors that helped overcome it. The research reveals that logistical barriers, negative portrayals in the media, and fears about safety stymied inoculation efforts as early as the 18th century and continue to do so. However, vaccine hesitancy has been markedly diminished when trusted community leaders have guided efforts, when ordinary citizens have felt personally invested in the success of the vaccine, and when vaccination efforts have been tied to broader projec...
Source: Perspectives in Biology and Medicine - April 25, 2024 Category: Medical Ethics Authors: J J Eddy H A Smith J E Abrams Source Type: research
On Antiscience and Antisemitism
This article provides both historical and recent perspectives on the links between antiscience and antisemitism, together with the author's personal experience as a Jewish vaccine scientist targeted by both dark forces. New approaches to uncoupling antisemitism from antiscience, while combating both, are essential for saving lives and preserving democratic values.PMID:38661936 | DOI:10.1353/pbm.2023.a902035 (Source: Perspectives in Biology and Medicine)
Source: Perspectives in Biology and Medicine - April 25, 2024 Category: Medical Ethics Authors: Peter Hotez Source Type: research
Evolutionary characteristics of the mitochondrial NADH dehydrogenase subunit 6 gene in some populations of four sympatric Mustela species (Mustelidae, Mammalia) from central Europe
CONCLUSIONS: Negative selection for MT-ND6 within the genus Mustela suggests absence of both environmental and species-specific effects of cellular energy metabolism despite large species-specific differences in body size. The presently found shared polymorphism in European polecats and steppe polecats may result from ancestral polymorphism before speciation and historical or recent introgressive hybridization; it may indicate mtDNA capture of steppe polecats by M. putorius in Europe.PMID:38664260 | DOI:10.1007/s11033-024-09505-6 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 25, 2024 Category: Molecular Biology Authors: Ghada Tissaoui Franz Suchentrunk Asma Awadi Steve Smith Antje Weber Hichem Ben Slimen Source Type: research
Spatiotemporal dynamics of forest fires in the context of climate change: a review
Environ Sci Pollut Res Int. 2024 Apr 25. doi: 10.1007/s11356-024-33305-x. Online ahead of print.ABSTRACTForest fires are sudden, destructive, hazardous, and challenging to manage and rescue, earning them a place on UNESCO's list of the world's eight major natural disasters. Currently, amid global warming, all countries worldwide have entered a period of high forest fire incidence. Due to global warming, the frequency of forest fires has accelerated, the likelihood of large fires has increased, and the spatial and temporal dynamics of forest fires have shown different trends. Therefore, the impact of climate change on the s...
Source: Environmental Science and Pollution Research International - April 25, 2024 Category: Environmental Health Authors: Yuanjun Zhang Hwee San Lim Chengyu Hu Rui Zhang Source Type: research
Pharmacokinetics of apixaban in patients undergoing pancreaticoduodenectomy (PAP-UP)
CONCLUSION: The pharmacokinetic characteristics of apixaban in subjects who had undergone pancreaticoduodenectomy are not significantly different from those of healthy controls. Though the sample size of this study is small, results suggest that no change to apixaban dose regimen is needed in patients who have had a pancreaticoduodenectomy.PMID:38660886 | DOI:10.5414/CP204502 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - April 25, 2024 Category: Drugs & Pharmacology Authors: Richard Zheng Edwin Lam Peter Altshuler Madison Crutcher Harish Lavu Charles J Yeo Douglas Stickle Benjamin Leiby Walter K Kraft Source Type: research
Challenges and Lessons from Conducting a Community-Engaged Evaluation of a Community Advisory Board-A Case Study from Flint
Prog Community Health Partnersh. 2024;18(1):31-36.ABSTRACTCommunity-engaged research often poses challenges due to exactly those qualities that make it desirable: it provides a new model of research that differs in many ways from top-down, university-led, prospectively designed approaches. While many have discussed the challenges to conducting community-engaged research, few have provided precise and generalizable lessons for how to surmount these challenges. Here we discuss the challenges experienced in a project that was community-engaged at three levels: 1) a research team consisting of an academic and a community partn...
Source: Progress in Community Health Partnerships - April 25, 2024 Category: International Medicine & Public Health Authors: Stephanie Solomon Cargill Bryan Spencer Briah Spencer Source Type: research
Pharmacokinetics of apixaban in patients undergoing pancreaticoduodenectomy (PAP-UP)
CONCLUSION: The pharmacokinetic characteristics of apixaban in subjects who had undergone pancreaticoduodenectomy are not significantly different from those of healthy controls. Though the sample size of this study is small, results suggest that no change to apixaban dose regimen is needed in patients who have had a pancreaticoduodenectomy.PMID:38660886 | DOI:10.5414/CP204502 (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - April 25, 2024 Category: Drugs & Pharmacology Authors: Richard Zheng Edwin Lam Peter Altshuler Madison Crutcher Harish Lavu Charles J Yeo Douglas Stickle Benjamin Leiby Walter K Kraft Source Type: research
