The connection between Dr. Harold Griffith and Richard Gill: new insights into the history of curare use in anesthesia from previously unknown correspondence
AbstractDr. Harold R. Griffith and Richard C. Gill figure prominently in curare ’s storied history. In 1938, Gill returned from an Amazon expedition with over 11 kg of curare. After scientists at E. R. Squibb& Sons identified a plant source (Chondrodendron tomentosum) and isolated a stable extract of uniform potency (marketed as Intocostrin), Griffith administered it in the operating room in 1942, showing its advantages and safety. In this article, we report correspondence between Griffith and Gill, heretofore not appreciated, after finding a letter from Gill to Griffith affixed to the inside back cover of a book co...
Source: Canadian Journal of Anesthesia - April 23, 2024 Category: Anesthesiology Source Type: research
Platelet Physiology
Semin Thromb Hemost DOI: 10.1055/s-0044-1786387Platelets are the smallest blood cells, numbering 150 to 350 × 109/L in healthy individuals. The ability of activated platelets to adhere to an injured vessel wall and form aggregates was first described in the 19th century. Besides their long-established roles in thrombosis and hemostasis, platelets are increasingly recognized as pivotal players in numerous other pathophysiological processes including inflammation and atherogenesis, antimicrobial host defense, and tumor growth and metastasis. Consequently, profound knowledge of platelet structure and function is becoming...
Source: Seminars in Thrombosis and Hemostasis - April 23, 2024 Category: Hematology Authors: Gremmel, Thomas Frelinger, Andrew L. Michelson, Alan D. Tags: Historical Paper Source Type: research
Sensors, Vol. 24, Pages 2677: Resilient Event-Based Fuzzy Fault Detection for DC Microgrids in Finite-Frequency Domain against DoS Attacks
ou Gu
This paper addresses the problem of fault detection in DC microgrids in the presence of denial-of-service (DoS) attacks. To deal with the nonlinear term in DC microgrids, a Takagi-Sugeno (T-S) model is employed. In contrast to the conventional approach of utilizing current sampling data in the traditional event-triggered mechanism (ETM), a novel integrated ETM employs historical information from measured data. This innovative strategy mitigates the generation of additional triggering packets resulting from random perturbations, thus reducing redundant transmission data. Under the assumption of faults occurring wi...
Source: Sensors - April 23, 2024 Category: Biotechnology Authors: Bowen Ma Qing Lu Zhou Gu Tags: Communication Source Type: research
Race, immunity, and lifespan: Unraveling the effect of early-life exposure to malaria risk on lifespan
Econ Hum Biol. 2024 Apr 12;54:101382. doi: 10.1016/j.ehb.2024.101382. Online ahead of print.ABSTRACTWe investigate a historical experience to measure the long-term effect of malaria on lifespan among infected survivors and identify a factor that mitigates malaria's effect. Using a sample of Union Army veterans born during the mid-19th century and their lifetime records, we show that exposure to high risk of malaria at birth or in early life substantially shortened their lifespan. The legacy of exposure to malaria is robust while controlling for lifetime socioeconomic and health conditions, fixed effects, and considering se...
Source: Economics and Human Biology - April 22, 2024 Category: Biology Authors: Sok Chul Hong Inhyuk Hwang Source Type: research
Brazilian Women in Paralympic Sports: Uncovering Historical Milestones in the Summer Paralympic Games
Adapt Phys Activ Q. 2024 Apr 22:1-14. doi: 10.1123/apaq.2023-0139. Online ahead of print.ABSTRACTThe journey of Brazilian female Paralympians transcends mere statistical increases in women's participation. Behind the modest athlete growth lies the reality of women who are doubly marginalized by the intersection of gender and disability in an arena tailored for able-bodied men. Our study aimed to catalyze critical discourses surrounding the historical trajectory of Paralympic women's sports. Through a comprehensive documentary analysis based on the Brazilian Paralympic Committee's official documents from 1976 to 2021, we so...
Source: Adapted Physical Activity Quarterly : APAQ - April 22, 2024 Category: International Medicine & Public Health Authors: Luiz Gustavo T Fabricio Dos Santos Isabella Dos Santos Alves N áthali Fernanda Feliciano Africa Alejandra Ortu ño Torres Luis Felipe Castelli Correia de Campos Maria Luiza Tanure Alves Source Type: research
Reflections on assortative mating, social stratification, and genetics
J Genet. 2024;103:15.ABSTRACTA recent report by G. Clark points to a sustained persistence of social status in England that extends vertically across several generations and horizontally across many levels of kinship. We seek to put his findings in historical perspective. We do so by relating them to two lines of thinking related to biological inheritance. One predated the rediscovery of Mendel's work and led to the field of quantitative genetics, which dealt on the whole with quasi-continuously varying traits. The other is based on the rediscovery itself and led to a reconciliation between quantitative genetics and discre...
Source: Journal of Genetics - April 22, 2024 Category: Genetics & Stem Cells Authors: Oliver Mayo Vidyanand Nanjundiah Source Type: research
Training physiotherapy students in basic wheelchair provision. Experiences at two universities in Colombia
This study aimed to describe a training intervention for two groups of future physiotherapists in Colombia, assess cohort differences in performance on a knowledge test, and explore their post-training perceptions. A quantitative retrospective study with a historical, descriptive-comparative design was conducted. 525 sixth-semester participants completed the International Society of Wheelchair Professionals Wheelchair Service Provision - Basic Test online in Spanish after curriculum modifications were implemented. The test assesses knowledge in seven domains: Assessment; Prescription; Products; Fitting; User training; Foll...
Source: Disability and Rehabilitation. Assistive Technology. - April 22, 2024 Category: Rehabilitation Authors: Sandra Esperanza Velasco Forero Nidia Johana Arias Becerra Martha Roc ío Torres Narváez M ónica Alejandra Mondragón Barrera Sara Munera Orozco Mary Goldberg Krithika Kandavel Paola Rocio Esquivel Ortiz Source Type: research
Race, immunity, and lifespan: Unraveling the effect of early-life exposure to malaria risk on lifespan
Econ Hum Biol. 2024 Apr 12;54:101382. doi: 10.1016/j.ehb.2024.101382. Online ahead of print.ABSTRACTWe investigate a historical experience to measure the long-term effect of malaria on lifespan among infected survivors and identify a factor that mitigates malaria's effect. Using a sample of Union Army veterans born during the mid-19th century and their lifetime records, we show that exposure to high risk of malaria at birth or in early life substantially shortened their lifespan. The legacy of exposure to malaria is robust while controlling for lifetime socioeconomic and health conditions, fixed effects, and considering se...
Source: Economics and Human Biology - April 22, 2024 Category: Biology Authors: Sok Chul Hong Inhyuk Hwang Source Type: research
Training physiotherapy students in basic wheelchair provision. Experiences at two universities in Colombia
This study aimed to describe a training intervention for two groups of future physiotherapists in Colombia, assess cohort differences in performance on a knowledge test, and explore their post-training perceptions. A quantitative retrospective study with a historical, descriptive-comparative design was conducted. 525 sixth-semester participants completed the International Society of Wheelchair Professionals Wheelchair Service Provision - Basic Test online in Spanish after curriculum modifications were implemented. The test assesses knowledge in seven domains: Assessment; Prescription; Products; Fitting; User training; Foll...
Source: Disability and Rehabilitation. Assistive Technology. - April 22, 2024 Category: Rehabilitation Authors: Sandra Esperanza Velasco Forero Nidia Johana Arias Becerra Martha Roc ío Torres Narváez M ónica Alejandra Mondragón Barrera Sara Munera Orozco Mary Goldberg Krithika Kandavel Paola Rocio Esquivel Ortiz Source Type: research
Reflections on assortative mating, social stratification, and genetics
J Genet. 2024;103:15.ABSTRACTA recent report by G. Clark points to a sustained persistence of social status in England that extends vertically across several generations and horizontally across many levels of kinship. We seek to put his findings in historical perspective. We do so by relating them to two lines of thinking related to biological inheritance. One predated the rediscovery of Mendel's work and led to the field of quantitative genetics, which dealt on the whole with quasi-continuously varying traits. The other is based on the rediscovery itself and led to a reconciliation between quantitative genetics and discre...
Source: Journal of Genetics - April 22, 2024 Category: Genetics & Stem Cells Authors: Oliver Mayo Vidyanand Nanjundiah Source Type: research
Historical Redlining and Present-Day Nonsuicide Firearm Fatalities
CONCLUSION: Discriminatory redlining policies from 80 years ago are associated with nonsuicide firearm fatalities today.PRIMARY FUNDING SOURCE: Fred Lovejoy Housestaff Research and Education Fund.PMID:38648643 | DOI:10.7326/M23-2496 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 22, 2024 Category: Internal Medicine Authors: Ayesha Dholakia Kendall J Burdick Catherine Kreatsoulas Michael C Monuteaux Jennifer Tsai S V Subramanian Eric W Fleegler Source Type: research
Brazilian Women in Paralympic Sports: Uncovering Historical Milestones in the Summer Paralympic Games
Adapt Phys Activ Q. 2024 Apr 22:1-14. doi: 10.1123/apaq.2023-0139. Online ahead of print.ABSTRACTThe journey of Brazilian female Paralympians transcends mere statistical increases in women's participation. Behind the modest athlete growth lies the reality of women who are doubly marginalized by the intersection of gender and disability in an arena tailored for able-bodied men. Our study aimed to catalyze critical discourses surrounding the historical trajectory of Paralympic women's sports. Through a comprehensive documentary analysis based on the Brazilian Paralympic Committee's official documents from 1976 to 2021, we so...
Source: Adapted Physical Activity Quarterly : APAQ - April 22, 2024 Category: International Medicine & Public Health Authors: Luiz Gustavo T Fabricio Dos Santos Isabella Dos Santos Alves N áthali Fernanda Feliciano Africa Alejandra Ortu ño Torres Luis Felipe Castelli Correia de Campos Maria Luiza Tanure Alves Source Type: research
Race, immunity, and lifespan: Unraveling the effect of early-life exposure to malaria risk on lifespan
Econ Hum Biol. 2024 Apr 12;54:101382. doi: 10.1016/j.ehb.2024.101382. Online ahead of print.ABSTRACTWe investigate a historical experience to measure the long-term effect of malaria on lifespan among infected survivors and identify a factor that mitigates malaria's effect. Using a sample of Union Army veterans born during the mid-19th century and their lifetime records, we show that exposure to high risk of malaria at birth or in early life substantially shortened their lifespan. The legacy of exposure to malaria is robust while controlling for lifetime socioeconomic and health conditions, fixed effects, and considering se...
Source: Economics and Human Biology - April 22, 2024 Category: Biology Authors: Sok Chul Hong Inhyuk Hwang Source Type: research
Historical Redlining and Present-Day Nonsuicide Firearm Fatalities
CONCLUSION: Discriminatory redlining policies from 80 years ago are associated with nonsuicide firearm fatalities today.PRIMARY FUNDING SOURCE: Fred Lovejoy Housestaff Research and Education Fund.PMID:38648643 | DOI:10.7326/M23-2496 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 22, 2024 Category: Internal Medicine Authors: Ayesha Dholakia Kendall J Burdick Catherine Kreatsoulas Michael C Monuteaux Jennifer Tsai S V Subramanian Eric W Fleegler Source Type: research
