Antigenic Characterization of Novel Human Norovirus GII.4 Variants San Francisco 2017 and Hong Kong 2019
Emerg Infect Dis. 2024 May;30(5):1026-1029. doi: 10.3201/eid3005.231694.ABSTRACTNorovirus is a major cause of acute gastroenteritis; GII.4 is the predominant strain in humans. Recently, 2 new GII.4 variants, Hong Kong 2019 and San Francisco 2017, were reported. Characterization using GII.4 monoclonal antibodies and serum demonstrated different antigenic profiles for the new variants compared with historical variants.PMID:38666659 | DOI:10.3201/eid3005.231694 (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - April 26, 2024 Category: Infectious Diseases Authors: Kentaro Tohma Michael Landivar Lauren A Ford-Siltz Kelsey A Pilewski Joseph A Kendra Sandra Niendorf Gabriel I Parra Source Type: research
Prognostic Factors Associated with Tumor Recurrence and Overall Survival in Soft Tissue Sarcomas of the Extremities in a Colombian Reference Cancer Center
Conclusions: This cohort showed that in addition to histologic grade and tumor size, tumor persistence at the time of admission has an impact on disease recurrence, so STS should be managed by a multidisciplinary team with experience in this pathology in high-volume reference centers.PMID:38668034 | DOI:10.3390/curroncol31040131 (Source: Current Oncology)
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Sandra E D íaz Casas Juanita Mart ínez Villacrés Carlos Lehmann Mosquera Mauricio Garc ía Mora Iv án Mariño Lozano Javier Ángel Aristizábal Ra úl Suarez Rodríguez Carlos Alfonso Duarte Torres Ricardo S ánchez Pedraza Source Type: research
Prediction interval: A powerful statistical tool for monitoring patients and analytical systems
Biochem Med (Zagreb). 2024 Jun 15;34(2):020101. doi: 10.11613/BM.2024.020101. Epub 2024 Apr 15.ABSTRACTMonitoring is indispensable for assessing disease prognosis and evaluating the effectiveness of treatment strategies, both of which rely on serial measurements of patients' data. It also plays a critical role in maintaining the stability of analytical systems, which is achieved through serial measurements of quality control samples. Accurate monitoring can be achieved through data collection, following a strict preanalytical and analytical protocol, and the application of a suitable statistical method. In a stable process...
Source: Biochemia Medica - April 26, 2024 Category: Biochemistry Authors: Abdurrahman Coskun Source Type: research
Historical trends of breast cancer burden attributable to metabolic factors among Chinese women, 1990 –2019: A population‐based epidemiological study
ConclusionsAge was the main reason for the increase of attributable burden, and postmenopausal women were the high-risk groups. Therefore, targeted prevention measures should be developed to improve postmenopausal women's awareness and effectively reduce the prevalence of obesity and diabetes, thereby reducing the breast cancer burden caused by metabolic factors in China. (Source: Thoracic Cancer)
Source: Thoracic Cancer - April 26, 2024 Category: Cancer & Oncology Authors: Liang ‐Zi Zhang,
Qi‐Cheng Sun,
Hang‐Hang Luan,
Qian‐Qian Yuan,
Tong Deng,
Li‐Sha Luo,
Xiao‐Lin Tan Tags: ORIGINAL ARTICLE Source Type: research
The Role of Neoadjuvant and Adjuvant Chemotherapy in Pancreatic Cancer
AbstractPancreatic cancer is an aggressive malignancy. Recurrences are very high despite high-quality surgery necessitating adjuvant therapy. The evolution of adjuvant therapy took several decades and gradually evolved from single-agent chemotherapy to multi-agent chemotherapy. The two important agents that are active in pancreatic cancer are 5-fluorouracil and gemcitabine, and with several combinations showing better results in the subsequent trials, the most recent trial PRODIGE 24 shows a median survival of 54.4 months. The role of neoadjuvant therapy is still evolving in resectable cancers. The role of adjuvant radio...
Source: Indian Journal of Surgical Oncology - April 26, 2024 Category: Cancer & Oncology Source Type: research
The motor unit: a chequered history
The Meryon Society has had two previous historical lectures on the motor unit. One by John Pearn from Brisbane in 2001[1] and another by Michael Swash in 2006 [2], both of which emphasised neural aspects of the motor unit. John Pearn spoke of the work of Swammerdam and the beginnings of experimentation on nerves, not just observation. Swammerdam challenged theories on how a nerve could make a muscle contract, beginning the ideas of the neuromuscular junction. Michael Swash also spoke on the historical aspects of innervation and the neuromuscular junction. (Source: Neuromuscular Disorders)
Source: Neuromuscular Disorders - April 26, 2024 Category: Neurology Authors: Caroline A Sewry Source Type: research
Sensors, Vol. 24, Pages 2761: Efficient Connectivity in Smart Homes: Enhancing Living Comfort through IoT Infrastructure
-Bary
Modern homes are experiencing unprecedented levels of convenience because of the proliferation of smart devices. In order to improve communication between smart home devices, this paper presents a novel approach that particularly addresses interference caused by different transmission systems. The core of the suggested framework is an intelligent Internet of Things (IoT) system designed to reduce interference. By using adaptive communication protocols and sophisticated interference management algorithms, the framework minimizes interference caused by overlapping transmissions and guarantees effective data sharing...
Source: Sensors - April 26, 2024 Category: Biotechnology Authors: Hamdy M. Youssef Radwa Ahmed Osman Alaa A. El-Bary Tags: Article Source Type: research
Multimodal approach utilising a weight management programme prior to bariatric surgery in patients with BMI ≥50 kg/m2: A propensity score matching retrospective cohort study
SummaryWe evaluated preoperative weight loss and days from initial consult to surgery in patients with BMI ≥50 kg/m2 who were and were not enrolled in medical weight management (MWM) prior to laparoscopic sleeve gastrectomy. We retrospectively identified patients with BMI ≥50 kg/m2 who had primary sleeve gastrectomy between 2014 and 2019 at two bariatric surgery centres in our healthcare system. Patients presenting after 2017 that received preoperative MWM (n = 28) were compared to a historical cohort of non-MWM patients (n = 118) presenting prior to programme initiation in 2017 on preoperative percent tota...
Source: Clinical Obesity - April 25, 2024 Category: Eating Disorders & Weight Management Authors: Cetin Sari,
Connie Santana,
Richard L. Seip,
Dale Bond,
Aziz Benbrahim,
Edward Hannoush,
Tara McLaughlin,
Ya ‐Huei Li,
Ilene Staff,
Yin Wu,
Pavlos Papasavas,
Darren Tishler,
Devika Umashanker Tags: ORIGINAL RESEARCH Source Type: research
Pharmacokinetics of apixaban in patients undergoing pancreaticoduodenectomy (PAP-UP)
CONCLUSION: The pharmacokinetic characteristics of apixaban in subjects who had undergone pancreaticoduodenectomy are not significantly different from those of healthy controls. Though the sample size of this study is small, results suggest that no change to apixaban dose regimen is needed in patients who have had a pancreaticoduodenectomy.PMID:38660886 | DOI:10.5414/CP204502 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - April 25, 2024 Category: Drugs & Pharmacology Authors: Richard Zheng Edwin Lam Peter Altshuler Madison Crutcher Harish Lavu Charles J Yeo Douglas Stickle Benjamin Leiby Walter K Kraft Source Type: research
Historical Lessons on Vaccine Hesitancy: Smallpox, Polio, and Measles, and Implications for COVID-19
This study examines the history of US vaccination efforts against smallpox, polio, and measles, highlighting persistent drivers of vaccine hesitancy as well as factors that helped overcome it. The research reveals that logistical barriers, negative portrayals in the media, and fears about safety stymied inoculation efforts as early as the 18th century and continue to do so. However, vaccine hesitancy has been markedly diminished when trusted community leaders have guided efforts, when ordinary citizens have felt personally invested in the success of the vaccine, and when vaccination efforts have been tied to broader projec...
Source: Perspectives in Biology and Medicine - April 25, 2024 Category: Medical Ethics Authors: J J Eddy H A Smith J E Abrams Source Type: research
On Antiscience and Antisemitism
This article provides both historical and recent perspectives on the links between antiscience and antisemitism, together with the author's personal experience as a Jewish vaccine scientist targeted by both dark forces. New approaches to uncoupling antisemitism from antiscience, while combating both, are essential for saving lives and preserving democratic values.PMID:38661936 | DOI:10.1353/pbm.2023.a902035 (Source: Perspectives in Biology and Medicine)
Source: Perspectives in Biology and Medicine - April 25, 2024 Category: Medical Ethics Authors: Peter Hotez Source Type: research
Pharmacokinetics of apixaban in patients undergoing pancreaticoduodenectomy (PAP-UP)
CONCLUSION: The pharmacokinetic characteristics of apixaban in subjects who had undergone pancreaticoduodenectomy are not significantly different from those of healthy controls. Though the sample size of this study is small, results suggest that no change to apixaban dose regimen is needed in patients who have had a pancreaticoduodenectomy.PMID:38660886 | DOI:10.5414/CP204502 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - April 25, 2024 Category: Drugs & Pharmacology Authors: Richard Zheng Edwin Lam Peter Altshuler Madison Crutcher Harish Lavu Charles J Yeo Douglas Stickle Benjamin Leiby Walter K Kraft Source Type: research
Historical Lessons on Vaccine Hesitancy: Smallpox, Polio, and Measles, and Implications for COVID-19
This study examines the history of US vaccination efforts against smallpox, polio, and measles, highlighting persistent drivers of vaccine hesitancy as well as factors that helped overcome it. The research reveals that logistical barriers, negative portrayals in the media, and fears about safety stymied inoculation efforts as early as the 18th century and continue to do so. However, vaccine hesitancy has been markedly diminished when trusted community leaders have guided efforts, when ordinary citizens have felt personally invested in the success of the vaccine, and when vaccination efforts have been tied to broader projec...
Source: Perspectives in Biology and Medicine - April 25, 2024 Category: Medical Ethics Authors: J J Eddy H A Smith J E Abrams Source Type: research
On Antiscience and Antisemitism
This article provides both historical and recent perspectives on the links between antiscience and antisemitism, together with the author's personal experience as a Jewish vaccine scientist targeted by both dark forces. New approaches to uncoupling antisemitism from antiscience, while combating both, are essential for saving lives and preserving democratic values.PMID:38661936 | DOI:10.1353/pbm.2023.a902035 (Source: Perspectives in Biology and Medicine)
Source: Perspectives in Biology and Medicine - April 25, 2024 Category: Medical Ethics Authors: Peter Hotez Source Type: research
Challenges and Lessons from Conducting a Community-Engaged Evaluation of a Community Advisory Board-A Case Study from Flint
Prog Community Health Partnersh. 2024;18(1):31-36.ABSTRACTCommunity-engaged research often poses challenges due to exactly those qualities that make it desirable: it provides a new model of research that differs in many ways from top-down, university-led, prospectively designed approaches. While many have discussed the challenges to conducting community-engaged research, few have provided precise and generalizable lessons for how to surmount these challenges. Here we discuss the challenges experienced in a project that was community-engaged at three levels: 1) a research team consisting of an academic and a community partn...
Source: Progress in Community Health Partnerships - April 25, 2024 Category: International Medicine & Public Health Authors: Stephanie Solomon Cargill Bryan Spencer Briah Spencer Source Type: research
