COVID 19: Pandemic assessment and management using Incidence < sub > calc < /sub > (t+14) and herd immunity - < em > Habere nos alia modum? < /em >
Int J Clin Pharmacol Ther. 2021 Dec 2. doi: 10.5414/CPP60001. Online ahead of print.NO ABSTRACTPMID:34854373 | DOI:10.5414/CPP60001 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - December 2, 2021 Category: Drugs & Pharmacology Authors: Peter Braun Barry G Woodcock Source Type: research

Association between < em > ABCB1 C3435T < /em > polymorphism and antiepileptic drug resistance in epilepsy: An updated meta-analysis based on 62 studies
CONCLUSION: AED resistance in Caucasian and Tunisian populations may benefit from ABCB1 C3435T genotyping. We recommend that more details, such as gender and etiology of epilepsy, should be taken into account to draw a reliable conclusion in future studies.PMID:34846299 | DOI:10.5414/CP204045 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 30, 2021 Category: Drugs & Pharmacology Authors: Yue-Yue Chen Yu-Yi Feng Yin-Nan Chen Yun-Ming Cao Chun-Zhi Ai Cai-Li Bi Yong Liu Wei Li Source Type: research

Investigation of the representativeness of the German IQVIA Vaccine Analyzer database
CONCLUSION: The study indicates good accordance between the VA and official reference data for different vaccination rates, especially for children, and indicates that the VA database is suitable for epidemiological studies on vaccines.PMID:34846300 | DOI:10.5414/CP204098 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 30, 2021 Category: Drugs & Pharmacology Authors: Nadine Ohl Rebecca Zingel Karel Kostev Source Type: research

Association between < em > ABCB1 C3435T < /em > polymorphism and antiepileptic drug resistance in epilepsy: An updated meta-analysis based on 62 studies
CONCLUSION: AED resistance in Caucasian and Tunisian populations may benefit from ABCB1 C3435T genotyping. We recommend that more details, such as gender and etiology of epilepsy, should be taken into account to draw a reliable conclusion in future studies.PMID:34846299 | DOI:10.5414/CP204045 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 30, 2021 Category: Drugs & Pharmacology Authors: Yue-Yue Chen Yu-Yi Feng Yin-Nan Chen Yun-Ming Cao Chun-Zhi Ai Cai-Li Bi Yong Liu Wei Li Source Type: research

Investigation of the representativeness of the German IQVIA Vaccine Analyzer database
CONCLUSION: The study indicates good accordance between the VA and official reference data for different vaccination rates, especially for children, and indicates that the VA database is suitable for epidemiological studies on vaccines.PMID:34846300 | DOI:10.5414/CP204098 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 30, 2021 Category: Drugs & Pharmacology Authors: Nadine Ohl Rebecca Zingel Karel Kostev Source Type: research

Dose-dependent atorvastatin associated with angioedema
CONCLUSION: While atorvastatin use is not commonly associated with angioedema, the prescriber should be mindful of this possible adverse effect, especially when increasing the dose, or when prescribing together with medications known to cause angioedema (e.g., angiotensin II receptor blockers and calcium channel blockers), which may increase the risk of this adverse event.PMID:34779391 | DOI:10.5414/CP204025 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 15, 2021 Category: Drugs & Pharmacology Authors: Ayman M Al-Qaaneh Waleed T Obaid Osama S Al-Mohammadi Ahmad M Al-Qaaneh Ali A Rabaan Shadi M Mustafa Source Type: research

Randomized, double-blind, two-way crossover bioequivalence and adhesion study, in healthy women, of a transdermal contraceptive patch with a newly sourced adhesive component at the end of shelf life vs. the EVRA patch at the beginning of shelf life
CONCLUSION: NGMN-EE transdermal test patch at EOSL was bioequivalent to the marketed patch at BOSL, supporting widening the product's shelf-life specification. Adhesive properties and safety profiles were comparable between patches.PMID:34779392 | DOI:10.5414/CP204034 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 15, 2021 Category: Drugs & Pharmacology Authors: Madhu Sanga Subusola Vaughan Julius Nangosyah Veronika Scholz Sergio Fonseca Source Type: research

Comparative efficacy and safety of  dotinurad, febuxostat, and benzbromarone in hyperuricemic patients with or without gout: A network meta-analysis of randomized controlled trials
Int J Clin Pharmacol Ther. 2021 Nov 15. doi: 10.5414/CP204097. Online ahead of print.ABSTRACTOBJECTIVE: We aimed to assess the relative efficacy and safety of dotinurad (2 mg), benzbromarone (50 mg), and febuxostat (40 mg) in hyperuricemic patients with or without gout.MATERIALS AND METHODS: A Bayesian network meta-analysis was performed to combine direct and indirect evidence from randomized controlled trials (RCTs) to evaluate the efficacy and safety of dotinurad (2 mg), benzbromarone (50 mg), febuxostat (40 mg), and placebo in hyperuricemic patients with or without gout.RESULTS: Four RCTs, including 516 patients, fulfil...
Source: International Journal of Clinical Pharmacology and Therapeutics - November 15, 2021 Category: Drugs & Pharmacology Authors: Young Ho Lee Gwan Gyu Song Source Type: research

Evaluation of maintenance treatment with PARP inhibitors in ovarian carcinoma patients responding to platinum therapy: Use of restricted mean survival time as an index of efficacy
CONCLUSION: Maintenance therapy studies provide evidence that olaparib, niraparib, rucaparib are effective treatments for advanced ovarian cancer.PMID:34779394 | DOI:10.5414/CP204113 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 15, 2021 Category: Drugs & Pharmacology Authors: Luca Cancanelli Daniele Mengato Lorenzo Di Spazio Melania Rivano Marco Chiumente Andrea Messori Source Type: research

Is increased rho kinase activity/oxidative stress relationship the missing link for linezolid-induced thrombocytopenia in dialysis patients?
Int J Clin Pharmacol Ther. 2021 Nov 15. doi: 10.5414/CP204134. Online ahead of print.NO ABSTRACTPMID:34779395 | DOI:10.5414/CP204134 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 15, 2021 Category: Drugs & Pharmacology Authors: Luca Sgarabotto Laura Gobbi Lorenzo A Cal ò Source Type: research

Dose-dependent atorvastatin associated with angioedema
CONCLUSION: While atorvastatin use is not commonly associated with angioedema, the prescriber should be mindful of this possible adverse effect, especially when increasing the dose, or when prescribing together with medications known to cause angioedema (e.g., angiotensin II receptor blockers and calcium channel blockers), which may increase the risk of this adverse event.PMID:34779391 | DOI:10.5414/CP204025 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 15, 2021 Category: Drugs & Pharmacology Authors: Ayman M Al-Qaaneh Waleed T Obaid Osama S Al-Mohammadi Ahmad M Al-Qaaneh Ali A Rabaan Shadi M Mustafa Source Type: research

Randomized, double-blind, two-way crossover bioequivalence and adhesion study, in healthy women, of a transdermal contraceptive patch with a newly sourced adhesive component at the end of shelf life vs. the EVRA patch at the beginning of shelf life
CONCLUSION: NGMN-EE transdermal test patch at EOSL was bioequivalent to the marketed patch at BOSL, supporting widening the product's shelf-life specification. Adhesive properties and safety profiles were comparable between patches.PMID:34779392 | DOI:10.5414/CP204034 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 15, 2021 Category: Drugs & Pharmacology Authors: Madhu Sanga Subusola Vaughan Julius Nangosyah Veronika Scholz Sergio Fonseca Source Type: research

Comparative efficacy and safety of  dotinurad, febuxostat, and benzbromarone in hyperuricemic patients with or without gout: A network meta-analysis of randomized controlled trials
Int J Clin Pharmacol Ther. 2021 Nov 15. doi: 10.5414/CP204097. Online ahead of print.ABSTRACTOBJECTIVE: We aimed to assess the relative efficacy and safety of dotinurad (2 mg), benzbromarone (50 mg), and febuxostat (40 mg) in hyperuricemic patients with or without gout.MATERIALS AND METHODS: A Bayesian network meta-analysis was performed to combine direct and indirect evidence from randomized controlled trials (RCTs) to evaluate the efficacy and safety of dotinurad (2 mg), benzbromarone (50 mg), febuxostat (40 mg), and placebo in hyperuricemic patients with or without gout.RESULTS: Four RCTs, including 516 patients, fulfil...
Source: International Journal of Clinical Pharmacology and Therapeutics - November 15, 2021 Category: Drugs & Pharmacology Authors: Young Ho Lee Gwan Gyu Song Source Type: research

Evaluation of maintenance treatment with PARP inhibitors in ovarian carcinoma patients responding to platinum therapy: Use of restricted mean survival time as an index of efficacy
CONCLUSION: Maintenance therapy studies provide evidence that olaparib, niraparib, rucaparib are effective treatments for advanced ovarian cancer.PMID:34779394 | DOI:10.5414/CP204113 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 15, 2021 Category: Drugs & Pharmacology Authors: Luca Cancanelli Daniele Mengato Lorenzo Di Spazio Melania Rivano Marco Chiumente Andrea Messori Source Type: research

Is increased rho kinase activity/oxidative stress relationship the missing link for linezolid-induced thrombocytopenia in dialysis patients?
Int J Clin Pharmacol Ther. 2021 Nov 15. doi: 10.5414/CP204134. Online ahead of print.NO ABSTRACTPMID:34779395 | DOI:10.5414/CP204134 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 15, 2021 Category: Drugs & Pharmacology Authors: Luca Sgarabotto Laura Gobbi Lorenzo A Cal ò Source Type: research

Dose-dependent atorvastatin associated with angioedema
CONCLUSION: While atorvastatin use is not commonly associated with angioedema, the prescriber should be mindful of this possible adverse effect, especially when increasing the dose, or when prescribing together with medications known to cause angioedema (e.g., angiotensin II receptor blockers and calcium channel blockers), which may increase the risk of this adverse event.PMID:34779391 | DOI:10.5414/CP204025 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 15, 2021 Category: Drugs & Pharmacology Authors: Ayman M Al-Qaaneh Waleed T Obaid Osama S Al-Mohammadi Ahmad M Al-Qaaneh Ali A Rabaan Shadi M Mustafa Source Type: research

Randomized, double-blind, two-way crossover bioequivalence and adhesion study, in healthy women, of a transdermal contraceptive patch with a newly sourced adhesive component at the end of shelf life vs. the EVRA patch at the beginning of shelf life
CONCLUSION: NGMN-EE transdermal test patch at EOSL was bioequivalent to the marketed patch at BOSL, supporting widening the product's shelf-life specification. Adhesive properties and safety profiles were comparable between patches.PMID:34779392 | DOI:10.5414/CP204034 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 15, 2021 Category: Drugs & Pharmacology Authors: Madhu Sanga Subusola Vaughan Julius Nangosyah Veronika Scholz Sergio Fonseca Source Type: research

Comparative efficacy and safety of  dotinurad, febuxostat, and benzbromarone in hyperuricemic patients with or without gout: A network meta-analysis of randomized controlled trials
Int J Clin Pharmacol Ther. 2021 Nov 15. doi: 10.5414/CP204097. Online ahead of print.ABSTRACTOBJECTIVE: We aimed to assess the relative efficacy and safety of dotinurad (2 mg), benzbromarone (50 mg), and febuxostat (40 mg) in hyperuricemic patients with or without gout.MATERIALS AND METHODS: A Bayesian network meta-analysis was performed to combine direct and indirect evidence from randomized controlled trials (RCTs) to evaluate the efficacy and safety of dotinurad (2 mg), benzbromarone (50 mg), febuxostat (40 mg), and placebo in hyperuricemic patients with or without gout.RESULTS: Four RCTs, including 516 patients, fulfil...
Source: International Journal of Clinical Pharmacology and Therapeutics - November 15, 2021 Category: Drugs & Pharmacology Authors: Young Ho Lee Gwan Gyu Song Source Type: research

Evaluation of maintenance treatment with PARP inhibitors in ovarian carcinoma patients responding to platinum therapy: Use of restricted mean survival time as an index of efficacy
CONCLUSION: Maintenance therapy studies provide evidence that olaparib, niraparib, rucaparib are effective treatments for advanced ovarian cancer.PMID:34779394 | DOI:10.5414/CP204113 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 15, 2021 Category: Drugs & Pharmacology Authors: Luca Cancanelli Daniele Mengato Lorenzo Di Spazio Melania Rivano Marco Chiumente Andrea Messori Source Type: research

Is increased rho kinase activity/oxidative stress relationship the missing link for linezolid-induced thrombocytopenia in dialysis patients?
Int J Clin Pharmacol Ther. 2021 Nov 15. doi: 10.5414/CP204134. Online ahead of print.NO ABSTRACTPMID:34779395 | DOI:10.5414/CP204134 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 15, 2021 Category: Drugs & Pharmacology Authors: Luca Sgarabotto Laura Gobbi Lorenzo A Cal ò Source Type: research

Dose-dependent atorvastatin associated with angioedema
CONCLUSION: While atorvastatin use is not commonly associated with angioedema, the prescriber should be mindful of this possible adverse effect, especially when increasing the dose, or when prescribing together with medications known to cause angioedema (e.g., angiotensin II receptor blockers and calcium channel blockers), which may increase the risk of this adverse event.PMID:34779391 | DOI:10.5414/CP204025 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 15, 2021 Category: Drugs & Pharmacology Authors: Ayman M Al-Qaaneh Waleed T Obaid Osama S Al-Mohammadi Ahmad M Al-Qaaneh Ali A Rabaan Shadi M Mustafa Source Type: research

Randomized, double-blind, two-way crossover bioequivalence and adhesion study, in healthy women, of a transdermal contraceptive patch with a newly sourced adhesive component at the end of shelf life vs. the EVRA patch at the beginning of shelf life
CONCLUSION: NGMN-EE transdermal test patch at EOSL was bioequivalent to the marketed patch at BOSL, supporting widening the product's shelf-life specification. Adhesive properties and safety profiles were comparable between patches.PMID:34779392 | DOI:10.5414/CP204034 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 15, 2021 Category: Drugs & Pharmacology Authors: Madhu Sanga Subusola Vaughan Julius Nangosyah Veronika Scholz Sergio Fonseca Source Type: research

Comparative efficacy and safety of  dotinurad, febuxostat, and benzbromarone in hyperuricemic patients with or without gout: A network meta-analysis of randomized controlled trials
Int J Clin Pharmacol Ther. 2021 Nov 15. doi: 10.5414/CP204097. Online ahead of print.ABSTRACTOBJECTIVE: We aimed to assess the relative efficacy and safety of dotinurad (2 mg), benzbromarone (50 mg), and febuxostat (40 mg) in hyperuricemic patients with or without gout.MATERIALS AND METHODS: A Bayesian network meta-analysis was performed to combine direct and indirect evidence from randomized controlled trials (RCTs) to evaluate the efficacy and safety of dotinurad (2 mg), benzbromarone (50 mg), febuxostat (40 mg), and placebo in hyperuricemic patients with or without gout.RESULTS: Four RCTs, including 516 patients, fulfil...
Source: International Journal of Clinical Pharmacology and Therapeutics - November 15, 2021 Category: Drugs & Pharmacology Authors: Young Ho Lee Gwan Gyu Song Source Type: research

Evaluation of maintenance treatment with PARP inhibitors in ovarian carcinoma patients responding to platinum therapy: Use of restricted mean survival time as an index of efficacy
CONCLUSION: Maintenance therapy studies provide evidence that olaparib, niraparib, rucaparib are effective treatments for advanced ovarian cancer.PMID:34779394 | DOI:10.5414/CP204113 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 15, 2021 Category: Drugs & Pharmacology Authors: Luca Cancanelli Daniele Mengato Lorenzo Di Spazio Melania Rivano Marco Chiumente Andrea Messori Source Type: research

Is increased rho kinase activity/oxidative stress relationship the missing link for linezolid-induced thrombocytopenia in dialysis patients?
Int J Clin Pharmacol Ther. 2021 Nov 15. doi: 10.5414/CP204134. Online ahead of print.NO ABSTRACTPMID:34779395 | DOI:10.5414/CP204134 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 15, 2021 Category: Drugs & Pharmacology Authors: Luca Sgarabotto Laura Gobbi Lorenzo A Cal ò Source Type: research

Dose-dependent atorvastatin associated with angioedema
CONCLUSION: While atorvastatin use is not commonly associated with angioedema, the prescriber should be mindful of this possible adverse effect, especially when increasing the dose, or when prescribing together with medications known to cause angioedema (e.g., angiotensin II receptor blockers and calcium channel blockers), which may increase the risk of this adverse event.PMID:34779391 | DOI:10.5414/CP204025 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 15, 2021 Category: Drugs & Pharmacology Authors: Ayman M Al-Qaaneh Waleed T Obaid Osama S Al-Mohammadi Ahmad M Al-Qaaneh Ali A Rabaan Shadi M Mustafa Source Type: research

Randomized, double-blind, two-way crossover bioequivalence and adhesion study, in healthy women, of a transdermal contraceptive patch with a newly sourced adhesive component at the end of shelf life vs. the EVRA patch at the beginning of shelf life
CONCLUSION: NGMN-EE transdermal test patch at EOSL was bioequivalent to the marketed patch at BOSL, supporting widening the product's shelf-life specification. Adhesive properties and safety profiles were comparable between patches.PMID:34779392 | DOI:10.5414/CP204034 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 15, 2021 Category: Drugs & Pharmacology Authors: Madhu Sanga Subusola Vaughan Julius Nangosyah Veronika Scholz Sergio Fonseca Source Type: research

Comparative efficacy and safety of  dotinurad, febuxostat, and benzbromarone in hyperuricemic patients with or without gout: A network meta-analysis of randomized controlled trials
Int J Clin Pharmacol Ther. 2021 Nov 15. doi: 10.5414/CP204097. Online ahead of print.ABSTRACTOBJECTIVE: We aimed to assess the relative efficacy and safety of dotinurad (2 mg), benzbromarone (50 mg), and febuxostat (40 mg) in hyperuricemic patients with or without gout.MATERIALS AND METHODS: A Bayesian network meta-analysis was performed to combine direct and indirect evidence from randomized controlled trials (RCTs) to evaluate the efficacy and safety of dotinurad (2 mg), benzbromarone (50 mg), febuxostat (40 mg), and placebo in hyperuricemic patients with or without gout.RESULTS: Four RCTs, including 516 patients, fulfil...
Source: International Journal of Clinical Pharmacology and Therapeutics - November 15, 2021 Category: Drugs & Pharmacology Authors: Young Ho Lee Gwan Gyu Song Source Type: research

Evaluation of maintenance treatment with PARP inhibitors in ovarian carcinoma patients responding to platinum therapy: Use of restricted mean survival time as an index of efficacy
CONCLUSION: Maintenance therapy studies provide evidence that olaparib, niraparib, rucaparib are effective treatments for advanced ovarian cancer.PMID:34779394 | DOI:10.5414/CP204113 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 15, 2021 Category: Drugs & Pharmacology Authors: Luca Cancanelli Daniele Mengato Lorenzo Di Spazio Melania Rivano Marco Chiumente Andrea Messori Source Type: research

Is increased rho kinase activity/oxidative stress relationship the missing link for linezolid-induced thrombocytopenia in dialysis patients?
Int J Clin Pharmacol Ther. 2021 Nov 15. doi: 10.5414/CP204134. Online ahead of print.NO ABSTRACTPMID:34779395 | DOI:10.5414/CP204134 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 15, 2021 Category: Drugs & Pharmacology Authors: Luca Sgarabotto Laura Gobbi Lorenzo A Cal ò Source Type: research

Dose-dependent atorvastatin associated with angioedema
CONCLUSION: While atorvastatin use is not commonly associated with angioedema, the prescriber should be mindful of this possible adverse effect, especially when increasing the dose, or when prescribing together with medications known to cause angioedema (e.g., angiotensin II receptor blockers and calcium channel blockers), which may increase the risk of this adverse event.PMID:34779391 | DOI:10.5414/CP204025 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 15, 2021 Category: Drugs & Pharmacology Authors: Ayman M Al-Qaaneh Waleed T Obaid Osama S Al-Mohammadi Ahmad M Al-Qaaneh Ali A Rabaan Shadi M Mustafa Source Type: research

Randomized, double-blind, two-way crossover bioequivalence and adhesion study, in healthy women, of a transdermal contraceptive patch with a newly sourced adhesive component at the end of shelf life vs. the EVRA patch at the beginning of shelf life
CONCLUSION: NGMN-EE transdermal test patch at EOSL was bioequivalent to the marketed patch at BOSL, supporting widening the product's shelf-life specification. Adhesive properties and safety profiles were comparable between patches.PMID:34779392 | DOI:10.5414/CP204034 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 15, 2021 Category: Drugs & Pharmacology Authors: Madhu Sanga Subusola Vaughan Julius Nangosyah Veronika Scholz Sergio Fonseca Source Type: research

Comparative efficacy and safety of  dotinurad, febuxostat, and benzbromarone in hyperuricemic patients with or without gout: A network meta-analysis of randomized controlled trials
Int J Clin Pharmacol Ther. 2021 Nov 15. doi: 10.5414/CP204097. Online ahead of print.ABSTRACTOBJECTIVE: We aimed to assess the relative efficacy and safety of dotinurad (2 mg), benzbromarone (50 mg), and febuxostat (40 mg) in hyperuricemic patients with or without gout.MATERIALS AND METHODS: A Bayesian network meta-analysis was performed to combine direct and indirect evidence from randomized controlled trials (RCTs) to evaluate the efficacy and safety of dotinurad (2 mg), benzbromarone (50 mg), febuxostat (40 mg), and placebo in hyperuricemic patients with or without gout.RESULTS: Four RCTs, including 516 patients, fulfil...
Source: International Journal of Clinical Pharmacology and Therapeutics - November 15, 2021 Category: Drugs & Pharmacology Authors: Young Ho Lee Gwan Gyu Song Source Type: research

Evaluation of maintenance treatment with PARP inhibitors in ovarian carcinoma patients responding to platinum therapy: Use of restricted mean survival time as an index of efficacy
CONCLUSION: Maintenance therapy studies provide evidence that olaparib, niraparib, rucaparib are effective treatments for advanced ovarian cancer.PMID:34779394 | DOI:10.5414/CP204113 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 15, 2021 Category: Drugs & Pharmacology Authors: Luca Cancanelli Daniele Mengato Lorenzo Di Spazio Melania Rivano Marco Chiumente Andrea Messori Source Type: research

Is increased rho kinase activity/oxidative stress relationship the missing link for linezolid-induced thrombocytopenia in dialysis patients?
Int J Clin Pharmacol Ther. 2021 Nov 15. doi: 10.5414/CP204134. Online ahead of print.NO ABSTRACTPMID:34779395 | DOI:10.5414/CP204134 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 15, 2021 Category: Drugs & Pharmacology Authors: Luca Sgarabotto Laura Gobbi Lorenzo A Cal ò Source Type: research

Dose-dependent atorvastatin associated with angioedema
CONCLUSION: While atorvastatin use is not commonly associated with angioedema, the prescriber should be mindful of this possible adverse effect, especially when increasing the dose, or when prescribing together with medications known to cause angioedema (e.g., angiotensin II receptor blockers and calcium channel blockers), which may increase the risk of this adverse event.PMID:34779391 | DOI:10.5414/CP204025 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 15, 2021 Category: Drugs & Pharmacology Authors: Ayman M Al-Qaaneh Waleed T Obaid Osama S Al-Mohammadi Ahmad M Al-Qaaneh Ali A Rabaan Shadi M Mustafa Source Type: research

Randomized, double-blind, two-way crossover bioequivalence and adhesion study, in healthy women, of a transdermal contraceptive patch with a newly sourced adhesive component at the end of shelf life vs. the EVRA patch at the beginning of shelf life
CONCLUSION: NGMN-EE transdermal test patch at EOSL was bioequivalent to the marketed patch at BOSL, supporting widening the product's shelf-life specification. Adhesive properties and safety profiles were comparable between patches.PMID:34779392 | DOI:10.5414/CP204034 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 15, 2021 Category: Drugs & Pharmacology Authors: Madhu Sanga Subusola Vaughan Julius Nangosyah Veronika Scholz Sergio Fonseca Source Type: research

Comparative efficacy and safety of  dotinurad, febuxostat, and benzbromarone in hyperuricemic patients with or without gout: A network meta-analysis of randomized controlled trials
Int J Clin Pharmacol Ther. 2021 Nov 15. doi: 10.5414/CP204097. Online ahead of print.ABSTRACTOBJECTIVE: We aimed to assess the relative efficacy and safety of dotinurad (2 mg), benzbromarone (50 mg), and febuxostat (40 mg) in hyperuricemic patients with or without gout.MATERIALS AND METHODS: A Bayesian network meta-analysis was performed to combine direct and indirect evidence from randomized controlled trials (RCTs) to evaluate the efficacy and safety of dotinurad (2 mg), benzbromarone (50 mg), febuxostat (40 mg), and placebo in hyperuricemic patients with or without gout.RESULTS: Four RCTs, including 516 patients, fulfil...
Source: International Journal of Clinical Pharmacology and Therapeutics - November 15, 2021 Category: Drugs & Pharmacology Authors: Young Ho Lee Gwan Gyu Song Source Type: research

Evaluation of maintenance treatment with PARP inhibitors in ovarian carcinoma patients responding to platinum therapy: Use of restricted mean survival time as an index of efficacy
CONCLUSION: Maintenance therapy studies provide evidence that olaparib, niraparib, rucaparib are effective treatments for advanced ovarian cancer.PMID:34779394 | DOI:10.5414/CP204113 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 15, 2021 Category: Drugs & Pharmacology Authors: Luca Cancanelli Daniele Mengato Lorenzo Di Spazio Melania Rivano Marco Chiumente Andrea Messori Source Type: research

Is increased rho kinase activity/oxidative stress relationship the missing link for linezolid-induced thrombocytopenia in dialysis patients?
Int J Clin Pharmacol Ther. 2021 Nov 15. doi: 10.5414/CP204134. Online ahead of print.NO ABSTRACTPMID:34779395 | DOI:10.5414/CP204134 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 15, 2021 Category: Drugs & Pharmacology Authors: Luca Sgarabotto Laura Gobbi Lorenzo A Cal ò Source Type: research

Dose-dependent atorvastatin associated with angioedema
CONCLUSION: While atorvastatin use is not commonly associated with angioedema, the prescriber should be mindful of this possible adverse effect, especially when increasing the dose, or when prescribing together with medications known to cause angioedema (e.g., angiotensin II receptor blockers and calcium channel blockers), which may increase the risk of this adverse event.PMID:34779391 | DOI:10.5414/CP204025 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 15, 2021 Category: Drugs & Pharmacology Authors: Ayman M Al-Qaaneh Waleed T Obaid Osama S Al-Mohammadi Ahmad M Al-Qaaneh Ali A Rabaan Shadi M Mustafa Source Type: research

Randomized, double-blind, two-way crossover bioequivalence and adhesion study, in healthy women, of a transdermal contraceptive patch with a newly sourced adhesive component at the end of shelf life vs. the EVRA patch at the beginning of shelf life
CONCLUSION: NGMN-EE transdermal test patch at EOSL was bioequivalent to the marketed patch at BOSL, supporting widening the product's shelf-life specification. Adhesive properties and safety profiles were comparable between patches.PMID:34779392 | DOI:10.5414/CP204034 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 15, 2021 Category: Drugs & Pharmacology Authors: Madhu Sanga Subusola Vaughan Julius Nangosyah Veronika Scholz Sergio Fonseca Source Type: research

Comparative efficacy and safety of  dotinurad, febuxostat, and benzbromarone in hyperuricemic patients with or without gout: A network meta-analysis of randomized controlled trials
Int J Clin Pharmacol Ther. 2021 Nov 15. doi: 10.5414/CP204097. Online ahead of print.ABSTRACTOBJECTIVE: We aimed to assess the relative efficacy and safety of dotinurad (2 mg), benzbromarone (50 mg), and febuxostat (40 mg) in hyperuricemic patients with or without gout.MATERIALS AND METHODS: A Bayesian network meta-analysis was performed to combine direct and indirect evidence from randomized controlled trials (RCTs) to evaluate the efficacy and safety of dotinurad (2 mg), benzbromarone (50 mg), febuxostat (40 mg), and placebo in hyperuricemic patients with or without gout.RESULTS: Four RCTs, including 516 patients, fulfil...
Source: International Journal of Clinical Pharmacology and Therapeutics - November 15, 2021 Category: Drugs & Pharmacology Authors: Young Ho Lee Gwan Gyu Song Source Type: research

Evaluation of maintenance treatment with PARP inhibitors in ovarian carcinoma patients responding to platinum therapy: Use of restricted mean survival time as an index of efficacy
CONCLUSION: Maintenance therapy studies provide evidence that olaparib, niraparib, rucaparib are effective treatments for advanced ovarian cancer.PMID:34779394 | DOI:10.5414/CP204113 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 15, 2021 Category: Drugs & Pharmacology Authors: Luca Cancanelli Daniele Mengato Lorenzo Di Spazio Melania Rivano Marco Chiumente Andrea Messori Source Type: research

Is increased rho kinase activity/oxidative stress relationship the missing link for linezolid-induced thrombocytopenia in dialysis patients?
Int J Clin Pharmacol Ther. 2021 Nov 15. doi: 10.5414/CP204134. Online ahead of print.NO ABSTRACTPMID:34779395 | DOI:10.5414/CP204134 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 15, 2021 Category: Drugs & Pharmacology Authors: Luca Sgarabotto Laura Gobbi Lorenzo A Cal ò Source Type: research

Dose-dependent atorvastatin associated with angioedema
CONCLUSION: While atorvastatin use is not commonly associated with angioedema, the prescriber should be mindful of this possible adverse effect, especially when increasing the dose, or when prescribing together with medications known to cause angioedema (e.g., angiotensin II receptor blockers and calcium channel blockers), which may increase the risk of this adverse event.PMID:34779391 | DOI:10.5414/CP204025 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 15, 2021 Category: Drugs & Pharmacology Authors: Ayman M Al-Qaaneh Waleed T Obaid Osama S Al-Mohammadi Ahmad M Al-Qaaneh Ali A Rabaan Shadi M Mustafa Source Type: research

Randomized, double-blind, two-way crossover bioequivalence and adhesion study, in healthy women, of a transdermal contraceptive patch with a newly sourced adhesive component at the end of shelf life vs. the EVRA patch at the beginning of shelf life
CONCLUSION: NGMN-EE transdermal test patch at EOSL was bioequivalent to the marketed patch at BOSL, supporting widening the product's shelf-life specification. Adhesive properties and safety profiles were comparable between patches.PMID:34779392 | DOI:10.5414/CP204034 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 15, 2021 Category: Drugs & Pharmacology Authors: Madhu Sanga Subusola Vaughan Julius Nangosyah Veronika Scholz Sergio Fonseca Source Type: research

Comparative efficacy and safety of  dotinurad, febuxostat, and benzbromarone in hyperuricemic patients with or without gout: A network meta-analysis of randomized controlled trials
Int J Clin Pharmacol Ther. 2021 Nov 15. doi: 10.5414/CP204097. Online ahead of print.ABSTRACTOBJECTIVE: We aimed to assess the relative efficacy and safety of dotinurad (2 mg), benzbromarone (50 mg), and febuxostat (40 mg) in hyperuricemic patients with or without gout.MATERIALS AND METHODS: A Bayesian network meta-analysis was performed to combine direct and indirect evidence from randomized controlled trials (RCTs) to evaluate the efficacy and safety of dotinurad (2 mg), benzbromarone (50 mg), febuxostat (40 mg), and placebo in hyperuricemic patients with or without gout.RESULTS: Four RCTs, including 516 patients, fulfil...
Source: International Journal of Clinical Pharmacology and Therapeutics - November 15, 2021 Category: Drugs & Pharmacology Authors: Young Ho Lee Gwan Gyu Song Source Type: research

Evaluation of maintenance treatment with PARP inhibitors in ovarian carcinoma patients responding to platinum therapy: Use of restricted mean survival time as an index of efficacy
CONCLUSION: Maintenance therapy studies provide evidence that olaparib, niraparib, rucaparib are effective treatments for advanced ovarian cancer.PMID:34779394 | DOI:10.5414/CP204113 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 15, 2021 Category: Drugs & Pharmacology Authors: Luca Cancanelli Daniele Mengato Lorenzo Di Spazio Melania Rivano Marco Chiumente Andrea Messori Source Type: research