Pharmacology of repair after peripheral nerve injury
Int J Clin Pharmacol Ther. 2021 Feb 24. doi: 10.5414/CP203893. Online ahead of print.ABSTRACTPeripheral nerve injuries are common and present with a broad spectrum of symptoms, some of which may be the cause of life-long disabilities. The peripheral nerves show a far greater capacity for regeneration than those in the central nervous system, and the process of nerve regeneration resembles developmental processes to a certain degree. The regeneration of peripheral nerves does not always lead to a full functional recovery. That is why surgical methods are still the most reliable therapeutic options after injuries of peripher...
Source: International Journal of Clinical Pharmacology and Therapeutics - February 24, 2021 Category: Drugs & Pharmacology Authors: Nevena Divac Milan Aksi ć Lukas Rasuli ć Maja Jakov čevski Milo š Basailović Igor Jakov čevski Source Type: research

Lopinavir-ritonavir alone or combined with arbidol in the treatment of 73 hospitalized patients with COVID-19: A pilot retrospective study
CONCLUSION: No benefit was observed in the antiviral effect of lopinavir-ritonavir combined with arbidol compared with lopinavir-ritonavir alone in the hospitalized patients with COVID-19. More clinical observations in COVID-19 patients may help to confirm or exclude the effect of antiviral agents.PMID:33624583 | DOI:10.5414/CP203861 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - February 24, 2021 Category: Drugs & Pharmacology Authors: Xiu Lan Chuxiao Shao Xu Zeng Zhenbo Wu Yanyan Xu Source Type: research

Bioequivalence study of two favipiravir tablet formulations in healthy male subjects
CONCLUSION: This single-dose study has shown that the test and reference favipiravir products met the required bioequivalence criteria. Besides, both products were well tolerated and safe.PMID:33624584 | DOI:10.5414/CP203936 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - February 24, 2021 Category: Drugs & Pharmacology Authors: Onursal Sa ğlam Berrak G üney Nihal Saraner Gamze Sevici Emel Do ğan-Kurtoğlu Merve G Ulusoy G ökçe Demiray Muradiye Nacak Ayd ın Erenmemişoğlu Mahmut Ozbek Peri Ayta ç Source Type: research

COVID-19 double whammy - Vaccine and variants.
Authors: Woodcock BG PMID: 33605875 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - February 21, 2021 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

COVID-19: Predictions for SARS-CoV-2 vaccination on the course of the pandemic and critical occupancy of intensive-care facilities in Germany.
CONCLUSION: Predictions made using the model show that vaccination with a SARS-CoV-2 vaccine can markedly reduce the spread of the COVID-19 disease and the period of critical occupancy of intensive-care facilities in Germany. PMID: 33605876 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - February 21, 2021 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

A case report of duodenal perforation caused  by imatinib mesylate during adjuvant treatment of gastric stromal tumor.
This study reported that imatinib mesylate caused bowel perforation in one patient with gastric stromal tumors after its use for 3 months. PMID: 33605877 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - February 21, 2021 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

Safety profiles of new xanthine oxidase inhibitors: A post-marketing study.
CONCLUSION: The strength of the associations of XO inhibitors with adverse events is variable, and further studies are required to evaluate the identified signals. PMID: 33560211 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - February 11, 2021 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

CYP51A1 polymorphism and voriconazole-associated hepatotoxicity in children undergoing hematopoietic cell transplant.
Authors: Takahashi T, Smith AR, Jacobson PA, Alharbi AF, Fisher J, Rubin NT, Kirstein MN Abstract Fungal CYP51A (14α-sterol demethylase) is the target of an azole antifungal, voriconazole (VCZ), which also partially inhibits human CYP51A1. Hepatotoxicity is a common adverse effect of azoles, which is reported to be caused by altered gene expressions secondary to cholesterol synthesis inhibition by azoles. This is a post-hoc analysis of a previously conducted phase 1 dose-finding study of prophylactic VCZ in 56 pediatric hematopoietic cell transplant recipients. We explored an association between variants in h...
Source: International Journal of Clinical Pharmacology and Therapeutics - February 11, 2021 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

Signal detection of botulinum toxin type A (BoNT/A) using the Korea Adverse Event Reporting System Database, 1999  - 2016.
CONCLUSION: The number of AE reports after BTX has increased, the majority of which were from females. Safety signals such as "medicine ineffective" and "concentration impaired" may be due to increasing off-label use, which warrants long-term surveillance, especially among females after BTX injection. PMID: 33480840 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - January 24, 2021 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

Population pharmacokinetics of meropenem among post-operative patients in Pakistan.
CONCLUSION: The CL of meropenem depends on the renal status of the patients. The model can be used for dosing simulations based on the CRCL of the patients in order to tailor the dose of meropenem in Pakistani patients. PMID: 33480841 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - January 24, 2021 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

Relationship between polypharmacy and adverse events.
Authors: Mabuchi T, Hosomi K, Yokoyama S, Takada M Abstract A retrospective data analysis was performed to investigate the association between polypharmacy and adverse events using three different spontaneous adverse event reporting system databases. Multivariate logistic regression analyses were performed to investigate the association between the number of drugs and adverse events, including hepatic disorders, renal disorders, hypersensitivity, and extrapyramidal syndrome. The results showed that the risk of hepatic and renal disorders increased with the number of drugs. Thus, decreasing the number of drugs may r...
Source: International Journal of Clinical Pharmacology and Therapeutics - January 24, 2021 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

Methotrexate for treating polymyalgia rheumatica: A meta-analysis of randomized controlled trials.
The objective of this study was to evaluate the efficacy and steroid-sparing effect of methotrexate (MTX) in patients with active polymyalgia rheumatica (PMR) undergoing prednisone therapy. MATERIALS AND METHODS: A meta-analysis of randomized controlled trial (RCT) was conducted to compare the efficacy and steroid-sparing effect of MTX with those of placebo in patients with PMR. RESULTS: Four RCTs (97 patients and 97 controls) were used in this meta-analysis. The remission rate was significantly higher in the MTX group than in the placebo group (odds ratio (OR) = 5.699, 95% confidence interval (CI) = 2.401 - 13.53, p 
Source: International Journal of Clinical Pharmacology and Therapeutics - January 24, 2021 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

Evaluation of tofacitinib citrate bioequivalence based on pharmacokinetic parameters in healthy Chinese subjects.
CONCLUSION: Two types of tofacitinib citrate tablets were bioequivalent under both fasted and fed conditions, and both were generally well tolerated; moreover, food-drug interaction may affect drug pharmacokinetics. PMID: 33433317 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - January 14, 2021 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

Exacerbation of atrioventricular block associated with concomitant use of amlodipine and aprepitant in a lung cancer patient: A  case report.
CONCLUSION: The drug-drug interaction between aprepitant and amlodipine was considered to have deteriorated his atrioventricular block, conceivably due to the inhibition of cytochrome P450 (CYP) 3A-mediated metabolism of amlodipine by aprepitant. PMID: 33355084 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - December 29, 2020 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

Hydrochlorothiazide use and risk of non-melanoma skin cancer in Spain: A case/non-case study.
CONCLUSION: The results in Spain, where sun exposure is significant, are consistent with the data in the Pharmacological Risk Assessment Committee's alert, which were obtained in Denmark for both basal cell carcinoma and malignant melanoma. However, the results for squamous cell carcinoma did not reach statistical significance, although the reporting odds ratio value suggested a potential relationship between hydrochlorothiazide and squamous cell carcinoma. PMID: 33355085 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - December 29, 2020 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

Prevalence of and factors associated with referrals to hospitals in Germany: A  retrospective study including 2,050,453 patients.
CONCLUSION: The proportion of patients referred to hospitals is high, and hospital care plays an important role in treating several gastrointestinal, oncological, cardiovascular, and respiratory disorders. PMID: 33355086 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - December 29, 2020 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

Quetiapine may complete the best match with suvorexant in psychiatric patients with insomnia.
Authors: Murata T PMID: 33355087 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - December 29, 2020 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

Severe hypoglycemia in children treated with nadolol: A case report and FDA adverse event reporting system (FAERS) database analysis.
CONCLUSION: Hypoglycemia is a reported life-threatening ADR associated with nadolol, especially in infants, in whom this drug should be used with caution. PMID: 33300862 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - December 12, 2020 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

Short and mid-term impact of community pharmacy-based medication reviews on medication- and patient-related outcomes in  Germany.
Short and mid-term impact of community pharmacy-based medication reviews on medication- and patient-related outcomes in Germany. Int J Clin Pharmacol Ther. 2020 Dec 10;: Authors: Seidling HM, Wien K, Fabricius J, John C, Hauser J, Renner K, Schäfer P, Krisam J, Haefeli WE Abstract OBJECTIVE: To assess the effect of a routine medication review service in German community pharmacies (ATHINA) on drug-related problems (DRPs) and patient-related outcomes. MATERIALS AND METHODS: From 2015 to 2017, ATHINA patients were invited by their pharmacists to participate in a prospective, observational t...
Source: International Journal of Clinical Pharmacology and Therapeutics - December 12, 2020 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

First-line treatments for chronic lymphocytic leukemia: Analysis of 7 trials based on the restricted mean survival time.
CONCLUSION: Our results provide an updated overview of the efficacy of the newest first-line treatments for CLL. Our findings confirm the good performance of RMST in this type of analyses. PMID: 33300864 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - December 12, 2020 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

Antibiotics prescriptions for pneumonia analyzed by claim information in Japan.
Authors: Yamazaki S, Yamagishi K, Murata S, Yokoyama I, Yahaba M, Takayanagi S, Kawasaki Y, Taniguchi T, Ishii I, Igari H Abstract OBJECTIVE: Japan is an aging society, and pneumonia is the leading cause of death, but the suitability of antibiotics for treating community-acquired pneumonia (CAP) in Japan is not clear. The purpose of this study was to investigate antibacterial drugs for treating CAP according to age. MATERIALS AND METHODS: Using the Japanese national database from 2011 to 2014, we analyzed the usage of antibiotics for CAP according to age. RESULTS: The numbers of claim information were 9,386...
Source: International Journal of Clinical Pharmacology and Therapeutics - December 9, 2020 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

Occurrence of metabolic diseases associated with antipsychotic use among Korean patients with schizophrenia.
CONCLUSION: The use of both typical and atypical antipsychotics, and clozapine and quetiapine treatment, may be associated with the occurrence of metabolic diseases in patients with SCZ. Additional prospective studies with accurate dosage information are needed to validate our findings. PMID: 33250073 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - December 3, 2020 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

Successful use of golimumab in a patient with ulcerative colitis refractory to infliximab and adalimumab.
Authors: Cortes X, Borrás-Blasco J, Flor L, Antequera B, Fernandez-Martinez S, Molés JR, Casterá E Abstract OBJECTIVE: To report a case of successful use of golimumab (GLB) in a patient with ulcerative colitis (UC) refractory to infliximab (IFX) and adalimumab (ADA). CASE SUMMARY: A 60-year-old man was diagnosed with left UC and was given azathioprine 2.5 mg/kg to control UC symptoms and decrease corticosteroid patient dependence. Four years later, he developed adverse reaction to azathioprine and began treatment with mercaptopurine 1.5 mg/kg/day. Despite this treatment, he develo...
Source: International Journal of Clinical Pharmacology and Therapeutics - December 3, 2020 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

Impact of green tea intake on the pharmacokinetics of celiprolol in healthy  subjects.
CONCLUSION: Green tea intake might have a negative impact on the clinical effectiveness of celiprolol. PMID: 33210993 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 20, 2020 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

Long short-term memory recurrent neural network for pharmacokinetic-pharmacodynamic modeling.
CONCLUSION: The results demonstrated that the generic LSTM model can approximate the complex underlying mechanistic biological processes. PMID: 33210994 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 20, 2020 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

Prevalence of and reasons for referral of  primary care outpatients to dentists in Germany.
CONCLUSION: Our study reflects an interaction between doctors and dentists that clearly shows that oral health cannot be separated from general health. PMID: 33210995 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 20, 2020 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

Relative efficacy and safety of tofacitinib for  treating psoriasis: A Bayesian network meta-analysis of randomized controlled trials.
CONCLUSION: Tofacitinib (10 mg) showed the highest efficacy for the intervention for psoriasis, followed by 50 mg etanercept and 5 mg tofacitinib, and was not associated with a significant risk for SAEs or AE-induced withdrawals. PMID: 33210996 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 20, 2020 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

A UPLC-MS/MS method for simultaneous quantification of sildenafil and N-desmethyl sildenafil applied in pharmacokinetic and bioequivalence studies in a Chinese population.
CONCLUSION: The UPLC-MS/MS method was successfully established to evaluate the pharmacokinetic parameters of sildenafil in healthy Chinese subjects. The trial preparation was bioequivalent to the reference preparation. PMID: 33210997 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 20, 2020 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

Docetaxel exposure and hematological toxicity in Chinese patients with locally advanced/metastatic nasopharyngeal carcinoma.
This study aimed to describe the area under the plasma concentration-time curve (AUC) and the relationship with hematological toxicity plus clinical responses of docetaxel in patients with nasopharyngeal carcinoma. Furthermore, a suitable docetaxel exposure level would be identified to guide clinical dosing. MATERIALS AND METHODS: 96 patients with locally advanced or metastatic nasopharyngeal carcinoma treated with docetaxel-based chemotherapy were enrolled. Docetaxel was measured by turbidimetric immunoassay. Associations between docetaxel exposure and hematologic toxicity, effect, and recurrence time were analyzed. R...
Source: International Journal of Clinical Pharmacology and Therapeutics - November 18, 2020 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

Disproportionality analysis of spontaneously reported hypoglycemia events due to insulin use: A comparison between insulin detemir and insulin degludec using the Korea Adverse Event Reporting System.
CONCLUSION: When we compared the proportionality of hypoglycemic events among the total number of reported AEs for each of the two basal insulins through disproportionality analysis using the spontaneous ADR reporting system, IDeg showed a relatively lower rate of reported hypoglycemic events than IDet. PMID: 33191903 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 18, 2020 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

Relative contributions of metabolic enzymes to  systemic elimination can be estimated from clinical DDI studies: Validation using an in silico approach.
Relative contributions of metabolic enzymes to systemic elimination can be estimated from clinical DDI studies: Validation using an in silico approach. Int J Clin Pharmacol Ther. 2020 Nov 16;: Authors: Koinuma K, Tsuchitani T, Imaoka A, Akiyoshi T, Ohtani H Abstract OBJECTIVE: The contribution ratios (CR) of metabolic enzymes to the systemic clearance of a drug can be estimated from in vitro studies. Another feasible approach is to calculate them based on the increase in the area under the time-concentration curve (AUC) caused by the co-administration of a potent and selective inhibitor in a clini...
Source: International Journal of Clinical Pharmacology and Therapeutics - November 18, 2020 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

A case report of hydroxychloroquine-induced auditory and visual hallucination.
DISCUSSION: Previous studies and the lack of another explanation for the patient's hallucinations imply a strong correlation between hydroxychloroquine and hallucinations. The mechanism of these side effects has not been fully elucidated. However, this side effect has only been reported in cases of connective tissue diseases. As currently hydroxychloroquine is widely used in the treatment of COVID-19 and other diseases, its potential risk of psychiatric complications should be considered in clinical practice. PMID: 33191905 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 18, 2020 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

Comparison of the efficacy and safety of biological agents in patients with systemic juvenile idiopathic arthritis: A Bayesian network meta-analysis of randomized controlled trials.
CONCLUSION: In patients with sJIA, canakinumab had the highest probability of being the best treatment in terms of the modified ACRpedi30 response rate; neither of the tested biological agents were associated with a significant risk of serious adverse events. PMID: 33191906 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 18, 2020 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

Association of long-term inhalation of caffeine-sodium benzoate with coronary heart disease in men.
The objective of this study was to explore the effect of long-term inhalation of caffeine-sodium benzoate (CSB) on the development of CHD in men, the severity of coronary artery lesions and the possible contributing effects of smoking. MATERIALS: A retrospective analysis was performed on 2,001 consecutive men who underwent selective coronary angiography. These men were assigned to a CSB inhalation group (CSB; 1 - 6 times/d, 274 - 1,644 mg/d,> 10 years; n = 326) or a non-inhalation group (non-CSB; n = 1,675). METHODS: The two groups were compared for the prev...
Source: International Journal of Clinical Pharmacology and Therapeutics - November 18, 2020 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

Drug therapy strategies for COVID-19 infection during pregnancy.
Authors: Wang H, Gao Y, Wu B Abstract Acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has spread rapidly in numerous countries and caused a massive number of deaths. Interferon-α (IFN-α), lopinavir/ritonavir, chloroquine phosphate, arbidol, ribavirin, remdesivir, and dexamethasone are the therapeutic drugs recommended for treating 2019-nCoV disease (COVID-19 disease). Due to the particularity of immune function, pregnant women seem to be more susceptible to the virus. We searched the literature to find effective and safe drugs for patients with COVID-19 during pregnancy and to provide drug therapy...
Source: International Journal of Clinical Pharmacology and Therapeutics - November 18, 2020 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

Proposal of a prediction model describing the metabolic interaction between warfarin and sorafenib using a population pharmacokinetic approach.
CONCLUSION: The proposed population PK-PD model has the potential to predict an increase in INR quantitatively after concurrent administration of warfarin and sorafenib. PMID: 33191909 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 18, 2020 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

The successful treatment of 5-fluorouracil overdose caused by the combination of capecitabine and S-1 in an elderly patient.
CONCLUSION: 5-FU overdose caused by the combination of capecitabine and S-1 can cause serious adverse reactions. Careful checking of the medical orders and extensive education of patients to recognize the symptoms of toxicity may reduce the occurrence of such adverse reactions. PMID: 33191910 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 18, 2020 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

The mode of action of sugammadex on coagulation.
CONCLUSION: Adapted, rather than standard, experiments show that sugammadex is likely to decrease factor Xa activity in the common pathway and activation of factor X specifically in the intrinsic pathway. PMID: 33155541 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 10, 2020 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

Unintended drug exposure during pregnancy in clinical trials - a survey in early drug development.
CONCLUSION: The methods to avoid unintended pregnancies during participation in a clinical trial need improvement and should include (i) pregnancy tests, (ii) documentation of last menstrual period before the first dose, (iii) compliance checks of the appropriate use of contraceptive methods, and (iv) training of trial physicians. Procedures should be in place for what to do if contraceptive methods fail. PMID: 33141016 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 5, 2020 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

Relative efficacy and tolerability of 2.5,  5, and 10 mg tanezumab for the treatment of osteoarthritis: A Bayesian network meta-analysis of randomized controlled trials based on patient withdrawal.
CONCLUSION: Tanezumab (5 mg) had the highest probability of being the best treatment based on the number of withdrawals due to lack of efficacy among the medications, while 2.5 mg tanezumab and placebo had the highest probability of being the most tolerable treatment. PMID: 33141017 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 5, 2020 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

COVID-19: Cytokine storm modulation/blockade with oral polyvalent immunoglobulins (PVIG, KMP01D): A potential and safe therapeutic agent (Primum nil nocere).
Conclusion: PVIG appears to be a potential and safe anti-inflammatory agent and can be recommended as a candidate medication for studies in COVID-19 patients. PMID: 33141018 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 5, 2020 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

COVID-19 and the orphan biologic polyvalent immunoglobulin - "Let food be thy medication" (Hippocrates of Kos c. 460 - c. 370 BC).
COVID-19 and the orphan biologic polyvalent immunoglobulin - "Let food be thy medication" (Hippocrates of Kos c. 460 - c. 370 BC). Int J Clin Pharmacol Ther. 2020 Nov 03;: Authors: Woodcock BG PMID: 33141019 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 5, 2020 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

Effects of empagliflozin on proinflammatory cytokines and other coronary risk factors in patients with type 2 diabetes mellitus: A single-arm real-world observation.
CONCLUSION: It is possible that EMPA administration can cause a significant decline in pro-inflammatory cytokines along with blood glucose, Hb1c, oxidative stress, uric acid, blood pressures, and ACE with an increase in antioxidant vitamins and nitrite. Randomized, controlled intervention trials would be necessary to confirm our findings. PMID: 33094728 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - October 24, 2020 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

Analysis of influence factors of pharmacodynamics of propofol with target-controlled infusion during anesthetic recovery period.
CONCLUSION: NI provided a more stable and adequate assessment of the depth of anesthesia than OAA/S, and the influence factors should be taken into account for precise dosing. PMID: 33094729 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - October 24, 2020 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

Antithyroid arthritis syndrome: A case report and review of the literature.
Authors: Xu M, Hou L, Chen M, Deng D Abstract A 29-year-old woman was diagnosed with Graves' disease because of her symptoms of thyrotoxicosis. After a 15-day treatment with methimazole, she began to suffer from a repeated fever, rash, and polyarticular migratory arthralgias. The clinical examination on admission showed that her white blood cell count, neutrophil count, and erythrocyte sedimentation rate (ESR) were within normal limits, while the concentration of C-creative protein (CRP) was 26.14 mg/L (ref. 0 - 10) and anti-nuclear immune body (ANA) and anti-neutrophil cytoplasmic antibody (ANCA) we...
Source: International Journal of Clinical Pharmacology and Therapeutics - October 24, 2020 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

Linezolid-induced thrombocytopenia in a child with a liver transplant: A case report.
We report a case of a 7-month-old liver-transplanted child who suffered from thrombocytopenia induced by linezolid. We simulated the pharmacokinetics of linezolid in a healthy adult using the physiologically based pharmacokinetic (PBPK) model and found that the liver is the most abundant organ for the distribution of linezolid. PRACTICE IMPLICATIONS: Linezolid has a high distribution in the liver. As a result, an increased awareness about the risk of linezolid-induced thrombocytopenia should be strengthened in patients with liver injury. Effects of ethnicity: The differences between Chinese patients and patients of oth...
Source: International Journal of Clinical Pharmacology and Therapeutics - October 21, 2020 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

How the cytochrome 7a1 (CYP7A1) and ATP-binding cassette G8 (ABCG8) genetic variants affect atorvastatin response among type 2 diabetic patients attending the University of Jordan Hospital.
CONCLUSION: It seems that the CYP7A1 rs3808607, ABCG8 rs11887534, and ABCG8 rs4148217 genetic variants do not explain the inter-individual variation in atorvastatin response and lipid baseline profile among Jordanian T2DM patients of Arabic origin. PMID: 33074092 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - October 21, 2020 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

Consumption of high-dose statins in patients older than 65 years in the Republic of Croatia in the period 2005 - 2015.
CONCLUSION: Consumption of all statins increased, mostly high-dose statins in the 65+ age group, the most sensitive population for adverse effects. The number of 65+ patients on high-dose statins grew much faster than the general statin user group, thus increasing the risk potential. Women are dominating all age and dose groups of statin users. PMID: 33040840 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - October 14, 2020 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

Investigations on dose proportionality and  drug-drug interaction for a fixed-dose combination of trazodone and gabapentin.
CONCLUSION: To our knowledge, for the first time, proportionality for trazodone at doses of 2.5 to 30 mg and for gabapentin at doses of 25 to 300 mg was investigated. Absence of a pharmacokinetic interaction was shown. PMID: 33040841 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - October 14, 2020 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

Dietary supplements - use and safety perception: A study among hospitalized dermatology patients.
CONCLUSION: The examined cohort of dermatology patients presented a dietary supplement user profile similar to the general population. The study confirmed that these products are considered to be safe by the majority of participants. Factors indicative of a healthy lifestyle and higher education were predictive for their use. PMID: 33040842 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - October 14, 2020 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research