HTLV infected individuals have increased B-cell activation and proinflammatory regulatory T-cells.
This study corroborates previous findings and offers new insight into the effects of HTLV by providing a broad flowcytometric analysis of immune cells in HTLV + individuals.
PMID: 31810824 [PubMed - as supplied by publisher] (Source: Immunobiology)
Source: Immunobiology - November 28, 2019 Category: Allergy & Immunology Authors: Kjerulff B, Petersen MS, Rodrigues CM, da Silva Té D, Christiansen M, Erikstrup C, Hønge BL Tags: Immunobiology Source Type: research
Second Order Segmented Polynomials for Syphilis and Gonorrhea Prevalence and Incidence Trends Estimation: Application to Spectrum ’s Guinea-Bissau and South Africa Data
Journal Name: The International Journal of Biostatistics Volume: 15 Issue: 2 Pages: null-null (Source: The International Journal of Biostatistics)
Source: The International Journal of Biostatistics - November 25, 2019 Category: Statistics Source Type: research
The prevalence of scabies, pyoderma and other communicable dermatoses in the Bijagos Archipelago, Guinea-Bissau
ConclusionsOur study, which utilised robust population-based cluster random sampling methodology, demonstrates the substantial disease burden caused by common communicable dermatoses in this setting. Given these findings, there is a need to consider common dermatoses as part of Universal Health Coverage to deliver ‘skin-health for all’. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - November 17, 2019 Category: Tropical Medicine Authors: Michael Marks Source Type: research
Acceptance and Feasibility of Partner Notification to HIV Infected Individuals in Guinea-Bissau
AbstractAs partner notification (PN) has shown effective in increasing the number of partners of HIV infected patients being tested we aimed to evaluate the feasibility of implementing PN in the West-African country Guinea-Bissau. Patients enrolled were offered the choice of three different PN methods. Acceptance, successful referrals and HIV status of partners were evaluated. Of 697 patients offered PN, 495 (71.0%) accepted and listed 547 partners. At end of follow-up 118 (21.5%) partners had been tested of which 44 (37.3%) were HIV infected. HIV infected partners had a higher median CD4 count at diagnosis compared with i...
Source: AIDS and Behavior - November 7, 2019 Category: Infectious Diseases Source Type: research
Stopping live vaccines after disease eradication may increase mortality.
Abstract
Several live vaccines may have beneficial non-specific effects (NSEs) reducing mortality more than can be explained by the prevention of the target infection, a phenomenon which has been linked to innate immune training. Most randomised controlled trials (RCTs) of oral polio vaccine (OPV) and measles vaccine (MV) have shown a large reduction in mortality that must have been at least partly nonspecific because it was much larger than the reduction explained by prevention of the target disease. Hence, stopping a live vaccine after disease-eradication could have negative health effects if the potenti...
Source: Vaccine - October 20, 2019 Category: Allergy & Immunology Authors: Aaby P, Benn CS Tags: Vaccine Source Type: research
African Histoplasmosis in a Guinea Bissau Patient with HIV-2: Case Report and Review
We present the case of a 30-year-old Bissau-Guinean man with HIV-2 infection known for 16 years, irregularly treated, admitted with two weeks of fever, diarrhoea and cutaneous lesions. Examination revealed multiple subcutaneous nodes, Molluscum contagiosum-like lesions, generalized lymphadenopathy and painful palpation of the left iliac fossa. Laboratory tests showed severe nonhaemolytic anaemia and CD4+ count of 9/mm3, with normal creatinine and hepatic enzymes. Chest roentgenogram was unremarkable and a research for Mycobacterium tuberculosis by GeneXpert® was negative. Nonetheless, given the lack of further diagnostic ...
Source: Journal of Medical Mycology - October 19, 2019 Category: Biology Source Type: research
Proof of concept: used malaria rapid diagnostic tests applied for parallel sequencing for surveillance of molecular markers of anti-malarial resistance in Bissau, Guinea-Bissau during 2014 –2017
Large-scale surveillance of molecular markers of anti-malarial drug resistance is an attractive method of resistance monitoring, to complement therapeutic efficacy studies in settings where the latter are logi... (Source: Malaria Journal)
Source: Malaria Journal - July 26, 2019 Category: Infectious Diseases Authors: Sidsel Nag, Johan Ursing, Amabelia Rodrigues, Marina Crespo, Camilla Krogsgaard, Ole Lund, Frank M. Aarestrup, Michael Alifrangis and PouL-Erik Kofoed Tags: Research Source Type: research
The Guinea-Bissau Twin Registry Update: A Platform for Studying Twin Mortality and Metabolic Disease.
Abstract
Sub-Saharan Africa has the highest natural twinning rate in the world. Unfortunately, due to lack of adequate care during pregnancy, labor and postnatally, twin mortality in Sub-Saharan Africa also remains very high. Thus, it has been estimated that one in five twins dies during the childhood years. In spite of this, surprisingly few twin studies have been conducted in the region, making additional epidemiological data much needed. In 2009, we established one of the first twin registries in Sub-Saharan Africa at the Bandim Health Project in Guinea-Bissau. The registry had two main objectives. Firs...
Source: Twin Research and Human Genetics - July 17, 2019 Category: Genetics & Stem Cells Authors: Bjerregaard-Andersen M, Gomes GM, Hennild DE, Jensen DM, Christensen K, Sodemann M, Beck-Nielsen H, Aaby P Tags: Twin Res Hum Genet Source Type: research
Second Order Segmented Polynomials for Syphilis and Gonorrhea Prevalence and Incidence Trends Estimation: Application to Spectrum ’s Guinea-Bissau and South Africa Data
Journal Name: The International Journal of Biostatistics Issue: Ahead of print (Source: The International Journal of Biostatistics)
Source: The International Journal of Biostatistics - June 13, 2019 Category: Statistics Source Type: research
T-cell and B-cell perturbations identify distinct differences in HIV-2 compared with HIV-1-induced immunodeficiency
Conclusion:
HIV-2 is characterized by lower viral load, and lower T-cell activation, which may account for the slower disease progression. (Source: AIDS)
Source: AIDS - May 3, 2019 Category: Infectious Diseases Tags: BASIC SCIENCE Source Type: research
T-cell and B-cell perturbations are similar in ART-naive HIV-1 and HIV-1/2 dually infected patients
Conclusion:
HIV-1/2 was not associated with less immune perturbations than for HIV-1 infection. (Source: AIDS)
Source: AIDS - May 3, 2019 Category: Infectious Diseases Tags: BASIC SCIENCE Source Type: research
“Moving like birds”: A qualitative study of population mobility and health implications in the Bijagós Islands, Guinea Bissau
Publication date: Available online 14 March 2019Source: Social Science & MedicineAuthor(s): Sophie Durrans, Anna Last, Hamadou Boiro, Adriana Goncalves, David Mabey, Katie GreenlandAbstractPopulation movement is a major driver for infectious disease transmission and can impact the success of disease control and elimination strategies. The relationship between disease transmission and permanent migration is well documented, but fewer studies have considered how different types of population mobility affects disease transmission and control programmes.This qualitative study was conducted on two islands of the Bijagós archip...
Source: Social Science and Medicine - March 15, 2019 Category: Psychiatry & Psychology Source Type: research
Performance of Bio-Rad Geenius HIV-1/2 Confirmatory Assay in HIV-1, HIV-2 and HIV-1/2 dually reactive patients - comparison with INNO-LIA and Immunocomb discriminatory assays.
CONCLUSIONS: Geenius has similar performance characteristics as INNO-LIA, and performs considerably better than Immunocomb, for differentiating between HIV-types. This is especially true when using the Geenius reader while manual reading of the Geenius assay seemed to overestimate the numbers of HIV-1/2 dually reactive samples.
PMID: 30871983 [PubMed - as supplied by publisher] (Source: Journal of Virological Methods)
Source: Journal of Virological Methods - March 10, 2019 Category: Virology Authors: Lindman J, Langhoff Hønge B, Kjerulff B, Medina C, da Silva ZJ, Erikstrup C, Norrgren H, Månsson F, for Bissau HIV Cohort Study Group, SWEGUB CORE Group Tags: J Virol Methods Source Type: research
Fight against cancer in Portuguese-speaking African countries: echoes from the last cancer meetings
Portuguese-speaking countries in Africa include Angola, Mozambique, Guinea-Bissau, Cape Verde, S ão Tomé and Principe. These countries belong to an interstate organization known as PALOP. In June 2018, PALOP or... (Source: Infectious Agents and Cancer)
Source: Infectious Agents and Cancer - February 15, 2019 Category: Cancer & Oncology Authors: L úcio Lara Santos, Hirondina Borges Spencer, Fernando Miguel, Satish Tulsidás, Belmira Rodrigues and Lygia Vieira Lopes Tags: Meeting Report Source Type: research
HTLV prevalence is no longer following the decreasing HIV prevalence - 20 years of retroviral surveillance in Guinea-Bissau, West Africa.
CONCLUSIONS: The HTLV prevalence in Bissau showed a non-significant increase. We found evidence supporting continuous vertical and horizontal routes of transmissions.
PMID: 30771284 [PubMed - as supplied by publisher] (Source: Acta Tropica)
Source: Acta Tropica - February 13, 2019 Category: Infectious Diseases Authors: Jensen MM, Olesen JS, Kjerulff B, Byberg S, da Silva ZJ, Rodrigues A, Jespersen S, Wejse C, Aaby P, Erikstrup C, Hønge BL Tags: Acta Trop Source Type: research
