Diabetes mellitus and impaired fasting glucose in ART-naïve patients with HIV-1, HIV-2 and HIV-1/2 dual infection in Guinea-Bissau: a cross-sectional study
Conclusions
DM prevalence was higher among younger patients compared with the background population in Bissau. Traditional risk factors for DM such as advancing age and a family history of DM apply also for ART-naïve patients with HIV. (Source: Transactions of the Royal Society of Tropical Medicine and Hygiene)
Source: Transactions of the Royal Society of Tropical Medicine and Hygiene - April 12, 2016 Category: Tropical Medicine Authors: Steiniche, D., Jespersen, S., Erikstrup, C., Krarup, H., Handberg, A., Ostergaard, L., Haraldsdottir, T., Medina, C., Gomes Correira, F., Laursen, A. L., Bjerregaard-Andersen, M., Wejse, C., Honge, B. L., for the Bissau HIV Cohort study group, for the Bis Tags: ORIGINAL ARTICLES Source Type: research
Cost-Effectiveness of Antivenoms for Snakebite Envenoming in 16 Countries in West Africa
Conclusions Therapy for SBE with AV in countries of WA is highly cost-effective at commonly accepted thresholds. Broadening access to effective AVs in rural communities in West Africa is a priority. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - March 29, 2016 Category: Tropical Medicine Authors: Muhammad Hamza Source Type: research
High-Dose Chloroquine for Treatment of Chloroquine-Resistant Plasmodium falciparum Malaria
Conclusions. Chloroquine resistance is dose dependent and can be overcome by higher, still well-tolerated doses. (Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - March 19, 2016 Category: Infectious Diseases Authors: Ursing, J., Rombo, L., Bergqvist, Y., Rodrigues, A., Kofoed, P.-E. Tags: PARASITES Source Type: research
Detection and Quantification of Vibrio cholerae, Vibrio parahaemolyticus , and Vibrio vulnificus in Coastal Waters of Guinea-Bissau (West Africa)
This study represents the first detection and quantification of co-occurring Vibrio species in West African coastal waters, highlighting the potential health risk associated with the persistence of human pathogenic Vibrio species. (Source: EcoHealth)
Source: EcoHealth - March 3, 2016 Category: Environmental Health Source Type: research
Validation and Identification of Invasive Salmonella Serotypes in Sub-Saharan Africa by Multiplex Polymerase Chain Reaction
Salmonella enterica serovar Typhi and nontyphoidal Salmonella (NTS) cause the majority of bloodstream infections in sub-Saharan Africa; however, serotyping is rarely performed. We validated a multiplex polymerase chain reaction (PCR) assay with the White–Kauffmann–Le Minor (WKLM) scheme of serotyping using 110 Salmonella isolates from blood cultures of febrile children in Ghana and applied the method in other Typhoid Fever Surveillance in Africa Program study sites. In Ghana, 47 (43%) S. Typhi, 36 (33%) Salmonella enterica serovar Typhimurium, 14 (13%) Salmonella enterica serovar Dublin, and 13 (12%) Salmonella...
Source: Clinical Infectious Diseases - March 1, 2016 Category: Infectious Diseases Authors: Al-Emran, H. M., Krumkamp, R., Dekker, D. M., Eibach, D., Aaby, P., Adu-Sarkodie, Y., Ali, M., Rubach, M. P., Bjerregaard-Andersen, M., Crump, J. A., Cruz Espinoza, L. M., Lofberg, S. V., Gassama Sow, A., Hertz, J. T., Im, J., Jaeger, A., Kabore, L. P., K Tags: TYPHOID FEVER SURVEILLANCE IN AFRICA PROGRAM (TSAP) Source Type: research
Utilization of Healthcare in the Typhoid Fever Surveillance in Africa Program
Conclusions. Healthcare utilization for fever varied greatly across sites, and revealed that not all studied populations were under optimal surveillance. This demonstrates the importance of assessing healthcare utilization. Survey data were pivotal for the adjustment of the program's estimates of salmonellosis and other conditions associated with fever. (Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - March 1, 2016 Category: Infectious Diseases Authors: Panzner, U., Pak, G. D., Aaby, P., Adu-Sarkodie, Y., Ali, M., Aseffa, A., Baker, S., Bjerregaard-Andersen, M., Crump, J. A., Deerin, J., Cruz Espinoza, L. M., Gasmelseed, N., Heriniaina, J. N., Hertz, J. T., Im, J., von Kalckreuth, V., Keddy, K. H., Lanko Tags: TYPHOID FEVER SURVEILLANCE IN AFRICA PROGRAM (TSAP) Source Type: research
Prevalence of Salmonella Excretion in Stool: A Community Survey in 2 Sites, Guinea-Bissau and Senegal
Conclusions. Evidence of NTS excretion in stool in both study populations indicates a possible NTS transmission route in these settings. (Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - March 1, 2016 Category: Infectious Diseases Authors: Im, J., Nichols, C., Bjerregaard-Andersen, M., Sow, A. G., Lofberg, S., Tall, A., Pak, G. D., Aaby, P., Baker, S., Clemens, J. D., Espinoza, L. M. C., Konings, F., May, J., Monteiro, M., Niang, A., Panzner, U., Park, S. E., Schütt-Gerowitt, H., Wi Tags: TYPHOID FEVER SURVEILLANCE IN AFRICA PROGRAM (TSAP) Source Type: research
The Relationship Between Invasive Nontyphoidal Salmonella Disease, Other Bacterial Bloodstream Infections, and Malaria in Sub-Saharan Africa
Conclusions. A positive correlation between iNTS disease and malaria endemicity, and the association between Plasmodium parasite positivity and iNTS disease across sub-Saharan Africa, indicates the necessity to consider iNTS as a major cause of febrile illness in malaria-holoendemic areas. Prevention of iNTS disease through iNTS vaccines for areas of high malaria endemicity, targeting high-risk groups for Plasmodium parasitic infection, should be considered. (Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - March 1, 2016 Category: Infectious Diseases Authors: Park, S. E., Pak, G. D., Aaby, P., Adu-Sarkodie, Y., Ali, M., Aseffa, A., Biggs, H. M., Bjerregaard-Andersen, M., Breiman, R. F., Crump, J. A., Cruz Espinoza, L. M., Eltayeb, M. A., Gasmelseed, N., Hertz, J. T., Im, J., Jaeger, A., Parfait Kabore, L., von Tags: TYPHOID FEVER SURVEILLANCE IN AFRICA PROGRAM (TSAP) Source Type: research
The Typhoid Fever Surveillance in Africa Program (TSAP): Clinical, Diagnostic, and Epidemiological Methodologies
Conclusions. By providing standardized data on the incidence of typhoid fever and iNTS disease in sub-Saharan Africa, TSAP will provide vital input for targeted typhoid fever prevention programs. (Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - March 1, 2016 Category: Infectious Diseases Authors: von Kalckreuth, V., Konings, F., Aaby, P., Adu-Sarkodie, Y., Ali, M., Aseffa, A., Baker, S., Breiman, R. F., Bjerregaard-Andersen, M., Clemens, J. D., Crump, J. A., Cruz Espinoza, L. M., Deerin, J. F., Gasmelseed, N., Sow, A. G., Im, J., Keddy, K. H., Cos Tags: TYPHOID FEVER SURVEILLANCE IN AFRICA PROGRAM (TSAP) Source Type: research
Human t-lymphotropic virus 1 (htlv-1) and human t-lymphotropic virus 2 (htlv-2): geographical research trends and collaboration networks (1989-2012).
This article describes a bibliometric review and a coauthorship network analysis of literature on HTLV indexed in PubMed in a 24-year period. A total of 7,564 documents were retrieved, showing a decrease in the number of documents from 1996 to 2007. HTLV manuscripts were published in 1,074 journals. Japan and USA were the countries with the highest contribution in this field (61%) followed by France (8%). Production ranking changed when the number of publications was normalized by population (Dominican Republic and Japan), by gross domestic product (Guinea-Bissau and Gambia), and by gross national income per capita (Brazil...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - February 26, 2016 Category: Tropical Medicine Authors: González-Alcaide G, Ramos JM, Huamaní C, Mendoza Cd, Soriano V Tags: Rev Inst Med Trop Sao Paulo Source Type: research
Medicinal plants of Guinea-Bissau: Therapeutic applications, ethnic diversity and knowledge transfer
Conclusions This multi-disciplinary, country-wide study identifies a great diversity of plants used by indigenous communities as medicinal, which constitute an important common reservoir of botanical species and therapeutic knowledge. The regional overlap of many indigenous species, the consensual nature of disease groups based upon local perceptions of health conditions, and the relevance of local vernacular including Guinean Creole are key factors specific to the country which enhance the potential for the circulation and transmission of ethno-botanical and therapeutic knowledge. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - February 24, 2016 Category: Drugs & Pharmacology Source Type: research
A Randomized Controlled Trial Offering Higher- Compared with Lower-Dairy Second Meals Daily in Preschools in Guinea-Bissau Demonstrates an Attendance-Dependent Increase in Weight Gain for Both Meal Types and an Increase in Mid-Upper Arm Circumference for the Higher-Dairy Meal [Community and International Nutrition]
Conclusions: Implementation of 2-meal preschool feeding programs is feasible in low-income countries, and there are measurable benefits relative to 1-meal programs in children attending preschool regularly. In addition, MUAC and hemoglobin measurements indicate that meals with 33% compared with 15% of protein from dairy may help prevent wasting and anemia. (Source: Journal of Nutrition)
Source: Journal of Nutrition - January 4, 2016 Category: Nutrition Authors: Batra, P., Schlossman, N., Balan, I., Pruzensky, W., Balan, A., Brown, C., Gamache, M. G., Schleicher, M. M., Braima de Sa, A., Saltzman, E., Wood, L., Roberts, S. B. Tags: Community and International Nutrition Source Type: research
Differential effects of sex in a West African cohort of HIV‐1, HIV‐2 and HIV‐1/2 dually infected patients: men are worse off
ConclusionSignificant differences exist between HIV‐infected men and women regardless of HIV type. Men seek treatment at a later stage and, despite better socio‐economic status, have higher mortality and loss to follow‐up than women. (Source: Tropical Medicine and International Health)
Source: Tropical Medicine and International Health - December 21, 2015 Category: Tropical Medicine Authors: Sanne Jespersen, Bo Langhoff Hønge, Joakim Esbjörnsson, Candida Medina, David Silva Té, Faustino Gomes Correira, Alex Lund Laursen, Lars Østergaard, Andreas Andersen, Peter Aaby, Christian Erikstrup, Christian Wejse, Tags: Original Article Source Type: research
The effects of vitamin A supplementation with measles vaccine on leucocyte counts and in vitro cytokine production.
Abstract
As WHO recommends vitamin A supplementation (VAS) at vaccination contacts after age 6 months, many children receive VAS together with measles vaccine (MV). We aimed to investigate the immunological effect of VAS given with MV. Within a randomised placebo-controlled trial investigating the effect on overall mortality of providing VAS with vaccines in Guinea-Bissau, we conducted an immunological sub-study of VAS v. placebo with MV, analysing leucocyte counts, whole blood in vitro cytokine production, vitamin A status and concentration of C-reactive protein (CRP). VAS compared with placebo was associ...
Source: The British Journal of Nutrition - December 18, 2015 Category: Nutrition Authors: Jensen KJ, Fisker AB, Andersen A, Sartono E, Yazdanbakhsh M, Aaby P, Erikstrup C, Benn CS Tags: Br J Nutr Source Type: research
Neutralizing antibody response and antibody-dependent cellular cytotoxicity in HIV-1 infected individuals from Guinea-Bissau and Denmark.
Abstract
The development of therapeutic and prophylactic HIV vaccines for African countries is urgently needed, but the question of what immunogens to use needs to be answered. One approach is to include HIV envelope immunogens derived from HIV-positive individuals from a geographically concentrated epidemic with more limited viral genetic diversity for a region-based vaccine. To address if there is a basis for a regional selected antibody vaccine, we have screened two regionally separate cohorts from Guinea-Bissau and Denmark for neutralizing antibody activity and antibody-dependent cellular cytotoxicity ...
Source: Clin Med Res - December 1, 2015 Category: Research Authors: Borgren M, Jensen SS, Heyndrickx L, Palm A, Gerstoft J, Kronborg G, Hønge BL, Jespersen S, da Silva ZJ, Karlsson I, Fomsgaard A Tags: AIDS Res Hum Retroviruses Source Type: research
