Reply to Johnson
(Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - January 16, 2017 Category: Infectious Diseases Authors: Wagenlehner, F. M., Newell, P., Yates, K., Gasink, L. B. Tags: Correspondence Source Type: research

Definitions of Complicated Urinary Tract Infection and Pyelonephritis
(Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - January 16, 2017 Category: Infectious Diseases Authors: Johnson, J. R. Tags: Correspondence Source Type: research

Reply to Meijide et al
(Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - January 16, 2017 Category: Infectious Diseases Authors: Borges, A. H., Neuhaus, J., Babiker, A., Wilkin, T., Mitsuyasu, R. Tags: Correspondence Source Type: research

Cancer Incidence in Persons Living With HIV
(Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - January 16, 2017 Category: Infectious Diseases Authors: Meijide, H., Mena, A., Rodriguez-Osorio, I., Castro-Iglesias, A., Poveda, E. Tags: Correspondence Source Type: research

Reply to Daniels et al.
(Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - January 16, 2017 Category: Infectious Diseases Authors: Palmer, L. B., Sweeney, D. A., Metersky, M. L., Kalil, A. C. Tags: Correspondence Source Type: research

Inhaled Antibiotics for Hospital-Acquired and Ventilator-Associated Pneumonia
(Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - January 16, 2017 Category: Infectious Diseases Authors: Daniels, L. M., Juliano, J., Marx, A., Weber, D. J. Tags: Correspondence Source Type: research

Persistent Mouth Ulceration in a Renal Allograft Recipient
(Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - January 16, 2017 Category: Infectious Diseases Authors: Arasaratnam, R. J., Restrepo, A. Tags: Answer to the Photo Quiz Source Type: research

Expert Consensus on Metrics to Assess the Impact of Patient-Level Antimicrobial Stewardship Interventions in Acute-Care Settings
Antimicrobial stewardship programs (ASPs) positively impact patient care, but metrics to assess ASP impact are poorly defined. We used a modified Delphi approach to select relevant metrics for assessing patient-level interventions in acute-care settings for the purposes of internal program decision making. An expert panel rated 90 candidate metrics on a 9-point Likert scale for association with 4 criteria: improved antimicrobial prescribing, improved patient care, utility in targeting stewardship efforts, and feasibility in hospitals with electronic health records. Experts further refined, added, or removed metrics during ...
Source: Clinical Infectious Diseases - January 16, 2017 Category: Infectious Diseases Authors: Moehring, R. W., Anderson, D. J., Cochran, R. L., Hicks, L. A., Srinivasan, A., Dodds Ashley, E. S., for the Structured Taskforce of Experts Working at Reliable Standards for Stewardship (STEWARDS) Panel Tags: Invited Article Source Type: research

Emerging Public Health Challenges of Shiga Toxin-Producing Escherichia coli Related to Changes in the Pathogen, the Population, and the Environment
Emerging public health challenges of Shiga toxin (stx)–producing Escherichia coli (STEC) include the occurrence of more frequent or severe disease and risk factors shifts associated with changes, often interconnected, in the pathogen, the population, and the environment. In 3 outbreaks with heightened severity attributed to enhanced pathogen virulence, including the acquisition of an stx2 phage in 1 outbreak, population and environmental factors likely contributed significantly to disease outcomes. Evolving population risk factors that are associated with more severe disease include consumption of fresh produce, cont...
Source: Clinical Infectious Diseases - January 16, 2017 Category: Infectious Diseases Authors: Karmali, M. A. Tags: Food Safety Source Type: research

Persistent Mouth Ulceration in a Renal Allograft Recipient
(Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - January 16, 2017 Category: Infectious Diseases Tags: Photo Quiz Source Type: research

Use of Neuraminidase Inhibitors for Treatment of Severe Influenza: Times Are Changing
(Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - January 16, 2017 Category: Infectious Diseases Authors: Martin, E. T. Tags: Editorial Commentary Source Type: research

Proton Pump Inhibitor Use Is Associated With Extended-Spectrum {beta}-Lactamase-Producing Enterobacteriaceae Rectal Carriage at Hospital Admission: A Cross-Sectional Study
In this cross-sectional study, 8.5% of patients using proton pump inhibitors (PPIs) were rectal carriers of extended-spectrum β-lactamase–producing Enterobacteriaceae (ESBL-E), compared with 2.9% of non-PPI users. In multivariable analysis, PPI use was independently associated with ESBL-E rectal carriage at hospital admission (adjusted odds ratio, 3.89; 95% confidence interval, 1.65 – 9.19). (Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - January 16, 2017 Category: Infectious Diseases Authors: Huizinga, P., van den Bergh, M. K.-, van Rijen, M., Willemsen, I., van 't Veer, N., Kluytmans, J. Tags: Brief Report Source Type: research

MASTERMIND: Bringing Microbial Diagnostics to the Clinic
New diagnostics are urgently needed to address emerging antimicrobial resistance. The Antibacterial Resistance Leadership Group proposes a strategy called MASTERMIND (Master Protocol for Evaluating Multiple Infection Diagnostics) for advancement of infectious diseases diagnostics. The goal of this strategy is to generate the data necessary to support US Food and Drug Administration clearance of new diagnostic tests by promoting research that might not have otherwise been feasible with conventional trial designs. MASTERMIND uses a single subject’s sample(s) to evaluate multiple diagnostic tests at the same time, provi...
Source: Clinical Infectious Diseases - January 16, 2017 Category: Infectious Diseases Authors: Patel, R., Tsalik, E. L., Petzold, E., Fowler, V. G., Klausner, J. D., Evans, S., for the Antibacterial Resistance Leadership Group (ARLG) Tags: Viewpoints Source Type: research

Healthcare-Associated Mycobacterium chimaera Transmission and Infection Prevention Challenges: Role of Heater-Cooler Units as a Water Source in Cardiac Surgery
(Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - January 16, 2017 Category: Infectious Diseases Authors: Kanamori, H., Weber, D. J., Rutala, W. A. Tags: Editorial Commentary Source Type: research

Invasive Systemic Infection After Hospital Treatment for Diabetic Foot Ulcer: Risk of Occurrence and Effect on Survival
Conclusions. DFU-ISIs are important late complications of DFUs. Prevention of DFU-ISIs should be studied prospectively. Meanwhile, clinicians should aggressively incorporate treatment to accelerate ulcer healing and address MRSA into the care of diabetic patients with foot ulcers. (Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - January 16, 2017 Category: Infectious Diseases Authors: Chen, S.-Y., Giurini, J. M., Karchmer, A. W. Tags: Major Article Source Type: research