A systematic review of cardiac surgery clinical prediction models that include intra-operative variables
CONCLUSION: Weak reporting and methodological limitations may restrict wider applicability and adoption of existing CPMs that include intra-operative variables. There is some evidence that CPM discrimination is improved with the addition of intra-operative variables. Further work is required to understand the role of intra-operative CPMs in the management of cardiac surgery patients.PMID:38649154 | DOI:10.1177/02676591241237758 (Source: Perfusion)
Source: Perfusion - April 22, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Ceri Jones Marcus Taylor Matthew Sperrin Stuart W Grant Source Type: research
Performance of receive head arrays versus ultimate intrinsic SNR at 7 T and 10.5 T
CONCLUSIONS: Major uiSNR gains are predicted for human head imaging in going from 7 T to 10.5 T, ranging from ˜2-fold at locations corresponding to the edge of the brain to 2.6-fold at the center, corresponding to approximately quadratic increase with the magnetic field. Realistic 31- and 63-channel receive arrays, however, approach the central uiSNR at 7 T, but fail to do so at 10.5 T, suggesting that more coils and/or different type of coils will be needed at 10.5 T and higher magnetic fields.PMID:38649922 | DOI:10.1002/mrm.30108 (Source: Magnetic Resonance in Medicine)
Source: Magnetic Resonance in Medicine - April 22, 2024 Category: Radiology Authors: Bei Zhang Jerahmie Radder Ilias Giannakopoulos Andrea Grant Russell Lagore Matt Waks Nader Tavaf Pierre-Francois Van de Moortele Gregor Adriany Alireza Sadeghi-Tarakameh Yigitcan Eryaman Riccardo Lattanzi Kamil U ğurbil Source Type: research
Trem2 promotes foamy macrophage lipid uptake and survival in atherosclerosis
Nat Cardiovasc Res. 2023 Nov;2(11):1015-1031. doi: 10.1038/s44161-023-00354-3. Epub 2023 Oct 30.ABSTRACTAtherosclerosis is driven by the expansion of cholesterol-loaded 'foamy' macrophages in the arterial intima. Factors regulating foamy macrophage differentiation and survival in plaque remain poorly understood. Here we show, using trajectory analysis of integrated single-cell RNA sequencing data and a genome-wide CRISPR screen, that triggering receptor expressed on myeloid cells 2 (Trem2) is associated with foamy macrophage specification. Loss of Trem2 led to a reduced ability of foamy macrophages to take up oxidized low-...
Source: Atherosclerosis - April 22, 2024 Category: Cardiology Authors: Michael T Patterson Maria M Firulyova Yingzheng Xu Hannah Hillman Courtney Bishop Alisha Zhu Grant H Hickok Patricia R Schrank Christine E Ronayne Zakariya Caillot Gavin Fredrickson Ainsley E Kennedy Nisha Acharya Jaap G Neels Giulia Chinetti Xavier Revel Source Type: research
The Role of Axillary Lymph Node Dissection versus Sentinel Lymph Node Dissection in Breast Cancer Patients with Clinical N2b-N3c Disease Who Receive Adjuvant Radiotherapy
CONCLUSIONS: ALND in patients with advanced nodal disease was not associated with improved survival compared with SLNB for women who receive adjuvant radiotherapy.PMID:38647915 | DOI:10.1245/s10434-024-15280-2 (Source: Ann Oncol)
Source: Ann Oncol - April 22, 2024 Category: Cancer & Oncology Authors: Eric A Roach Christopher R Weil George Cannon Jon Grant Margaret Van Meter Dustin Boothe Source Type: research
Trem2 promotes foamy macrophage lipid uptake and survival in atherosclerosis
Nat Cardiovasc Res. 2023 Nov;2(11):1015-1031. doi: 10.1038/s44161-023-00354-3. Epub 2023 Oct 30.ABSTRACTAtherosclerosis is driven by the expansion of cholesterol-loaded 'foamy' macrophages in the arterial intima. Factors regulating foamy macrophage differentiation and survival in plaque remain poorly understood. Here we show, using trajectory analysis of integrated single-cell RNA sequencing data and a genome-wide CRISPR screen, that triggering receptor expressed on myeloid cells 2 (Trem2) is associated with foamy macrophage specification. Loss of Trem2 led to a reduced ability of foamy macrophages to take up oxidized low-...
Source: Cell Research - April 22, 2024 Category: Cytology Authors: Michael T Patterson Maria M Firulyova Yingzheng Xu Hannah Hillman Courtney Bishop Alisha Zhu Grant H Hickok Patricia R Schrank Christine E Ronayne Zakariya Caillot Gavin Fredrickson Ainsley E Kennedy Nisha Acharya Jaap G Neels Giulia Chinetti Xavier Revel Source Type: research
A mismatch between early and recent life stress predicts better response inhibition, but not cognitive inhibition
Stress. 2024 Jan;27(1):2341626. doi: 10.1080/10253890.2024.2341626. Epub 2024 Apr 22.ABSTRACTA growing body of work has found that a mismatch between early and recent life stress, more than a cumulative influence of stress, contributes to detrimental stress-related health outcomes. To date, however, no work has examined how such a mismatch might relate to stress-related cognitive outcomes. We addressed this gap in the current study by assessing participants' (N = 154, Mage = 18.7, 104 female) early and recent life stress using the same inventory, and subsequently assessing their inhibitory control in a hybrid stop-signal/f...
Source: Stress - April 22, 2024 Category: Research Authors: Grant S Shields Colton L Hunter Source Type: research
New Discoveries in the genetics and genomics of systemic juvenile idiopathic arthritis
Expert Rev Clin Immunol. 2024 Apr 20. doi: 10.1080/1744666X.2024.2345868. Online ahead of print.ABSTRACTINTRODUCTION: Systemic juvenile idiopathic arthritis (sJIA) is a severe inflammatory condition with onset in childhood. It is sporadic, but elements of its stereotypical innate immune responses are likely genetically encoded by both common variants with small effect sizes and rare variants with larger effects.AREAS COVERED: Genomic investigations have defined the unique genetic architecture of sJIA. Identification of the class II HLA locus as the strongest sJIA risk factor for the first time brought attention to T lympho...
Source: Expert Review of Clinical Immunology - April 20, 2024 Category: Allergy & Immunology Authors: Mariana Correia Marques Michael J Ombrello Grant S Schulert Source Type: research
Does psychological distress predict risk of orthopaedic surgery and postoperative opioid prescribing in patients with hip pain? A retrospective study
Clinicians and public health professionals have allocated resources to curb opioid over-prescription and address psychological needs among patients with musculoskeletal pain. However, associations between psyc... (Source: BMC Musculoskeletal Disorders)
Source: BMC Musculoskeletal Disorders - April 20, 2024 Category: Orthopaedics Authors: Kent F. Sutton, Grant H. Cabell, Lucas W. Ashley, Trevor A. Lentz, Brian D. Lewis, Steven A. Olson and Richard C. Mather III Tags: Research Source Type: research
Unmasking Distorted Reflections: Exploring Body Image, Alcohol, and Drug Use in Nighttime Entertainment Districts
Conclusions: Findings indicated a distortion in participants' perceived body image, with a desire for muscularity among both males and females. These results underscore the complex interplay between self-perception, societal ideals, and drug use in young NED patrons.PMID:38640402 | DOI:10.1080/10826084.2024.2320377 (Source: Substance Use and Misuse)
Source: Substance Use and Misuse - April 19, 2024 Category: Addiction Authors: Grant J Devilly Petra Wilkinson Corey Allen Timothy Piatkowski Source Type: research
PC in Advanced Heart Failure: Eligibility and Referral Criteria and PilotPprojects at Four Sites
1. Characterize disease-based eligibility criteria and needs-based referral criteria for specialist PC for heart failure patients.2. Apply principles of implementation science to develop, implement and evaluate pilot projects to increase referrals to specialist PC and improve timeliness of services. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Torrie K. Fields, J Brian Cassel, Peter Bordokoff, Jon Broyles, Christin Engelhardt, Melanie Phelps, Marian Grant Source Type: research
Mid-Career Breakout Session (CAR402)
1. Identify approaches for efficient team and grant management.2. Compare and contrast team management and communication techniques.3. Outline team member accountability and conflict management strategiesThe mid-career breakout session will focus on grant management and leading research teams. T hree mid/senior investigators will share their multi-disciplinary perspectives about research team and grant management strategies and lessons learned. During this moderated session, the presenters will relay successes and challenges in stepping into a leadership role, maintaining an environment of inclusion and effective co...
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Jessica Merlin, Areej A. El-Jawahri, Stephanie White, Jill M. Steiner, Daniel David Source Type: research
Equipping Scientists to Conduct Palliative Care Clinical Trials: The Clinical Trials Intensive (CTI) (RP307)
1. Understand the background, context, and curricular content of a training program to teach clinical trials skills for palliative care research.2. Describe the the impact (satisfaction, skill confidence, number of grants acquired, and total $ amount) of the palliative care Clinical Trials Intensi ve. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Christine S. Ritchie, Kathryn I. Pollak, Ana-Maria Vranceanu, Karen Kehl, Jean S. Kutner Source Type: research
Locally Advanced Esophageal Cancer Patients With Complete Clinical Response Post Neoadjuvant Chemoradiotherapy: A Markov Decision Analysis of Esophagectomy versus Active Surveillance
This study aims to compare surgery versus active surveillance for LAEC patients with complete clinical response (cCR) after neoadjuvant chemoradiotherapy (nCRT). (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 19, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Adom Bondzi-Simpson, Tiago Ribeiro, Angelo Grant, Michael Ko, Natalie Coburn, Julie Hallet, Girish S. Kulkarni, Biniam Kidane Source Type: research
Dosimetric and toxicity comparison between Syed-Neblett and Fletcher-Suit-Delclos Tandem and Ovoid applicators in high dose rate cervix cancer brachytherapy
To compare patient and tumor characteristics, dosimetry, and toxicities between interstitial Syed-Neblett and intracavitary Fletcher-Suit-Delclos Tandem and Ovoid (T&O) applicators in high dose rate (HDR) cervical cancer brachytherapy. (Source: Brachytherapy)
Source: Brachytherapy - April 19, 2024 Category: Cancer & Oncology Authors: Andres Portocarrero-Bonifaz, Salman Syed, Maxwell Kassel, Grant W. McKenzie, Vishwa M. Shah, Bryce M. Forry, Jeremy T. Gaskins, Keith T. Sowards, Thulasi Babitha Avula, Adrianna Masters, Scott R. Silva Tags: Original Article Source Type: research
