Dose fusion and efficacy evaluation of different radical radiotherapy doses for cervical cancer
In this study, 45-Gy and 50.4-Gy treatment groups were compared for fused doses to target tumor areas and organs at risk (OARs), clinical efficacy, and quality of life. (Source: Brachytherapy)
Source: Brachytherapy - January 20, 2021 Category: Cancer & Oncology Authors: Hui Yu, Xi Tang, Xinglong Yang, Danxia Wen, Zhouyu Li, Xiaomin Wen, Jinquan Liu, Mingyi Li Source Type: research

Incidence and dosimetric predictive factors of late rectal toxicity after low-dose-rate brachytherapy combined with volumetric modulated arc therapy in high-risk prostate cancer at a single institution: Retrospective study
The purpose of this study is to investigate the incidence of rectal toxicity and to identify the associated dosimetric predictive parameters after I-125 seed low-dose-rate brachytherapy (LDR-BT) combined with volumetric modulated arc therapy (VMAT) and dose constraints. (Source: Brachytherapy)
Source: Brachytherapy - January 20, 2021 Category: Cancer & Oncology Authors: Takayuki Sakurai, Shigeyuki Takamatsu, Satoshi Shibata, Masashi Taka, Mizuho Ishiyama, Masahiro Yamazaki, Hironori Kojima, Atsushi Mizokami, Tomoyasu Kumano, Toshifumi Gabata Source Type: research

Substantial lymphovascular space invasion predicts worse outcomes in early-stage endometrioid endometrial cancer
Substantial as opposed to focal or no lymphovascular space invasion (LVSI) is proposed as an independent adverse prognostic factor in patients with early-stage endometrioid endometrial cancer (EEC). We reviewed outcomes of patients treated with adjuvant vaginal brachytherapy (VB) alone in a single institution, stratified by LVSI extent. (Source: Brachytherapy)
Source: Brachytherapy - January 20, 2021 Category: Cancer & Oncology Authors: Elizabeth A. Barnes, Kevin Martell, Carlos Parra-Herran, Amandeep S. Taggar, Elysia Donovan, Eric Leung Source Type: research

Complications of intracavitary brachytherapy for gynecologic cancers and their management: A comprehensive review
Intracavitary gynecologic brachytherapy in the form of tandem-based brachytherapy and vaginal cylinder –based brachytherapy represents a fundamental component of the treatment of women with cervical or uterine cancer due to the ability to deliver a therapeutic dose of radiation with sharp dose falloff. This results in highly effective treatment in terms of oncologic outcomes with an overall favorab le toxicity profile. Still, complications and side effects of brachytherapy do exist. While advances in brachytherapy techniques have led to a significant decrease in the rates of toxicity, a thorough understanding of the ...
Source: Brachytherapy - January 19, 2021 Category: Cancer & Oncology Authors: Scott M. Glaser, Pranshu Mohindra, Umesh Mahantshetty, Sushil Beriwal Source Type: research

HDR brachytherapy boost using MR-only workflow for intermediate- and high-risk prostate cancer: 8-year results of a pilot study
To report 8-year clinical outcome with high-dose-rate brachytherapy (HDRBT) boost using MRI-only workflow for intermediate (IR) and high-risk (HR) prostate cancer (PC) patients. (Source: Brachytherapy)
Source: Brachytherapy - January 18, 2021 Category: Cancer & Oncology Authors: Ferenc Lakosi, Gergely Antal, Janos Pall, Andrea Farkas, Tibor Jenei, Denes Nagy, Jozsef Liptak, Istvan Sipocz, Akos Pytel, Melinda Csima, Akos Gulyban, Gabor Toller Source Type: research

HDR brachytherapy as monotherapy for prostate cancer: A systematic review with meta-analysis
The effectiveness and safety of high dose brachytherapy as monotherapy (HDR-BRT-M) in prostate cancer is limited to retrospective studies. We performed a meta-analysis to summarize existing data and identify trends in biochemical recurrence-free survival (bRFS) and toxicity after HDR-BRT-M in patients with prostate cancer. (Source: Brachytherapy)
Source: Brachytherapy - January 15, 2021 Category: Cancer & Oncology Authors: Gustavo Arruda Viani, Caio Viani Arruda, Antonio Cassio Assis Pellizzon, Ligia Issa De Fendi Source Type: research

Dose homogeneity analysis of adjuvant radiation treatment in surgically resected brain metastases: Comparison of IORT, SRS, and IMRT indices
Although surgery remains a treatment option for symptomatic brain metastases, the need for adjuvant radiation after surgery is widely accepted as standard. Despite a multitude of randomized trials aimed at identifying the ideal radiation treatment plan for surgically resected metastases, the development of new delivery regiments necessitates a periodic re-evaluation of dosimetric performance/outcome. Here, we compare the homogeneity index (HI) across three platforms: single-session stereotactic radiosurgery (SRS), multisession stereotactic radiotherapy, and intraoperative radiotherapy (IORT). (Source: Brachytherapy)
Source: Brachytherapy - January 13, 2021 Category: Cancer & Oncology Authors: Basem A. Dahshan, Joshua S. Weir, Robert P. Bice, Paul Renz, Daniel T. Cifarelli, Linda Poplawski, Joshua Hack, John A. Vargo, Christopher P. Cifarelli Source Type: research

Automatic optimization of treatment dosimetry to improve visual outcomes in episcleral plaque brachytherapy
The aim of this study was to develop an automated dose optimization algorithm, powered by simulated annealing, for inverse planning of ocular plaque brachytherapy treatments, to improve tumor coverage and critical structure sparing for reduced treatment-related morbidity. (Source: Brachytherapy)
Source: Brachytherapy - January 8, 2021 Category: Cancer & Oncology Authors: Gawon Han, Matthew Larocque, Ezekiel Weis, Geetha Menon Source Type: research

Do air gaps with image-guided vaginal cuff brachytherapy impact failure  rates in patients with high-intermediate risk FIGO Stage I endometrial cancer?
The aim of this study was to assess the impact of air gaps at the cylinder surface on the rate of vaginal cuff failure (VCF) after image-guided adjuvant vaginal cuff brachytherapy (VCBT) in the treatment of high-intermediate risk (HIR) FIGO (F édération Internationale de Gynécologie et d'Obstétrique (International Federation of Gynecology and Obstetrics)) Stage I endometrial cancer. (Source: Brachytherapy)
Source: Brachytherapy - December 29, 2020 Category: Cancer & Oncology Authors: Adam H. Richman, Ankur K. Patel, Joshua L. Rodr íguez-López, Andrew Keller, John A. Vargo, Hayeon Kim, Paniti Sukumvanich, Jessica L. Berger, Michelle M. Boisen, Robert Edwards, Sarah E. Taylor, Madeleine B. Courtney-Brooks, Alexander Olawaiye, Brian C. Source Type: research

Letter to the editor regarding “125I seed implantation for hepatocellular carcinoma with portal vein tumor thrombus: A systematic review and metaanalysis”
With interest, we have read the recent paper by Yuan et  al. (1) that was published in Brachytherapy in 2019. They concluded that 125I seed implantation could obtain good local control, improve the survival rate, and reduce the mortality risk and portal venous pressure in hepatocellular carcinoma (HCC) patients with portal vein tumor thrombus (PVTT). Be fore these results can be accepted, we have serious concerns about their use of the HR to estimate pooled survival rate and their study selection. (Source: Brachytherapy)
Source: Brachytherapy - December 26, 2020 Category: Cancer & Oncology Authors: Yingxing Guo, Ting Li, Jingxin Yan Tags: Letter to the Editor Source Type: research

Brachytherapy for lung cancer
Brachytherapy (BT) is a minimally invasive anticancer radiotherapeutic modality where the tumor is directly irradiated via a radioactive source that is precisely implanted in or adjacent to the tumor. BT for lung cancer may be conducted in the form of endobronchial BT and radioactive seed implantation (RSI-BT), mainly for nonsmall cell lung cancer (NSCLC). For patients with early-stage lung cancer who are not suitable for surgery or external beam radiotherapy (EBRT), BT may be used as an alternative treatment, and curative results could be achieved in certain patients with cancer confined to the trachea lumen. (Source: Brachytherapy)
Source: Brachytherapy - December 24, 2020 Category: Cancer & Oncology Authors: Bin Qiu, Ping Jiang, Zhe Ji, Xiaodong Huo, Haitao Sun, Junjie Wang Tags: Review Article Source Type: research

Review of brachytherapy complications – Upper gastrointestinal tract
While brachytherapy applications are not widely used for cancer diagnoses in the upper GI tract (including the esophagus, liver, stomach, and pancreas), they have a clear role in palliation and symptom management and occasionally definitive locoregional treatment. With the increasing use of image-guided techniques, the incidence of side effects and complications has shown to be lower than many other alternative treatment modalities, making brachytherapy approaches a preferred treatment option. This review examines procedural complications and acute and chronic adverse effects from radiation associated with esophageal, hepa...
Source: Brachytherapy - December 22, 2020 Category: Cancer & Oncology Authors: Michael R. Folkert, Sujana Gottumukkala, Nhu Tram Nguyen, Amandeep Taggar, Ranjan Kumar Sur Source Type: research

Dosimetric consequences of seed placement accuracy in permanent breast seed implant brachytherapy
This study quantifies the dosimetric impact of implant accuracy and derives a quantitative relationship relating implant accuracy to target dosimetry. (Source: Brachytherapy)
Source: Brachytherapy - December 21, 2020 Category: Cancer & Oncology Authors: Alexandra Guebert, Michael Roumeliotis, Elizabeth Watt, Tyler Meyer, Sarah Quirk Source Type: research

Comparison of TG43 and Hounsfield Unit –based TG186 brachytherapy dose metrics in Oncentra Brachy for 100 patients receiving interstitial partial breast irradiation
The aim of the study was to conduct a retrospective analysis of 100 patients who received interstitial accelerated partial breast irradiation at a single institution, comparing the standard American Association of Physicists in Medicine Task Group (TG) 43 dose calculation algorithm to the model-based dose calculation algorithms (MBDCAs) available in the Oncentra Brachy treatment planning system. (Source: Brachytherapy)
Source: Brachytherapy - December 21, 2020 Category: Cancer & Oncology Authors: Andrew Howie, Joel Poder, Ryan Brown, Kristine Schreiber, Andrej Bece, Peter Graham, Yaw Sinn Chin Source Type: research

Breast brachytherapy
Accelerated partial breast irradiation with brachytherapy is a treatment method with a very low risk profile. In fact, accelerated partial breast irradiation brachytherapy has been proven in randomized trials to have fewer late side effects than whole-breast irradiation. Notably, Grade 3 late side effects are extremely rare, and excellent to good cosmetic results are observed in well over 90% of patients. In this article, published side effects of breast brachytherapy are reviewed and appropriate management discussed. (Source: Brachytherapy)
Source: Brachytherapy - December 19, 2020 Category: Cancer & Oncology Authors: Vratislav Strnad, Catheryn Yashar Source Type: research

A dosimetric and centeredness comparison of the conventional and novel endobronchial applicators: A preliminary study
This study compared the applicator position relative to the tracheal wall and dosimetric parameters between conventional and novel applicators among patients receiving endobronchial brachytherapy (EBBT) for intratracheal tumors. (Source: Brachytherapy)
Source: Brachytherapy - December 19, 2020 Category: Cancer & Oncology Authors: Kotaro Iijima, Naoya Murakami, Hiroyuki Okamoto, Satoshi Nakamura, Shie Nishioka, Takahito Chiba, Junichi Kuwahara, Hiroki Nakayama, Mihiro Takemori, Ako Aikawa, Shibata Yoshihiro, Tairo Kashihara, Kana Takahashi, Koji Inaba, Kae Okuma, Hiroshi Igaki, Yuk Source Type: research

Toxicity and outcomes associated with high-dose rate brachytherapy for medically inoperable endometrial cancer
To evaluate toxicity in inoperable endometrial cancer (EC) treated with definitive radiation therapy (RT). (Source: Brachytherapy)
Source: Brachytherapy - December 19, 2020 Category: Cancer & Oncology Authors: Alexander Yaney, Erin Healy, Patrick Wald, Meghan Olsen, Xueliang Pan, Douglas Martin, Allison Quick Source Type: research

Benchmarking failure mode and effects analysis of electronic brachytherapy with data from incident learning systems
Failure modes and effects analysis (FMEA) is a prospective risk assessment tool for identifying failure modes in equipment or processes and informing the design of quality control systems. This work aims to benchmark the performance of FMEAs for electronic brachytherapy (eBT) of the skin and for breast by comparing predicted versus actual failure modes reported in multiple incident learning systems (ILS). (Source: Brachytherapy)
Source: Brachytherapy - December 19, 2020 Category: Cancer & Oncology Authors: Jeremy D.P. Hoisak, Ryan Manger, Irena Dragojevi ć Source Type: research

Brachytherapy-based radiotherapy is associated with improved survival for newly diagnosed metastatic cervical cancer
The purpose of this study was to explore the value of brachytherapy (BT) in metastatic cervical cancer, as it has not been well evaluated before. (Source: Brachytherapy)
Source: Brachytherapy - December 11, 2020 Category: Cancer & Oncology Authors: Lin Ding, Zhuofei Bi, Zihao Pan, Xiaoli Yu, Xiaohui Zhao, Shoumin Bai, Herui Yao, Yimin Liu Source Type: research

Management of ductal carcinoma in situ with accelerated partial breast irradiation brachytherapy: Implications for guideline expansion
Accelerated partial breast irradiation (APBI) for patients with ductal carcinoma in situ (DCIS) is controversial, and the suitability criteria from the American Brachytherapy Society (ABS), American Society of Therapeutic Radiology and Oncology (ASTRO), and the European Society for Radiotherapy and Oncology (GEC-ESTRO) have important differences. (Source: Brachytherapy)
Source: Brachytherapy - December 11, 2020 Category: Cancer & Oncology Authors: Matthew N. Mills, Nicholas W. Russo, Ronica H. Nanda, Jason P. Wilson, Taghrid A. Altoos, Debra L. Caldwell, Lisa L. Stout, Scott Dube, Peter W. Blumencranz, Kathleen G. Allen, Roberto Diaz Source Type: research

An in silico study on the effect of host tissue at brachytherapy dose enhancement by gold nanoparticles
Iridium-192 brachytherapy dose enhancement by gold nanoparticles was investigated in five different tumor tissues to observe the tissue-related differences as an effective environmental factor in the applications of nanoparticles as radio-enhancer agents. (Source: Brachytherapy)
Source: Brachytherapy - December 11, 2020 Category: Cancer & Oncology Authors: Samaneh Hashemi, Seyed Mahmoud Reza Aghamiri, Ramin Jaberi, Zahra Siavashpour Source Type: research

A Role of brachytherapy in bilateral Wilms tumors: A long-term follow-up of three highly selected cases and literature review
To describe experience with partial nephrectomy combined with brachytherapy as part of the local management of bilateral Wilms tumor (WT) including a review of the available literature. (Source: Brachytherapy)
Source: Brachytherapy - December 9, 2020 Category: Cancer & Oncology Authors: Raquel D ávila Fajardo, Bradley R. Pieters, Jim C.H. Wilde, Hugo A. Heij, Rafal Chrzan, Godelieve Tytgat, Annelies M.C. Mavinkurve-Groothuis, Anne Smets, Petra S. Kroon, An Van Damme, Kees P. van de Ven, Ronald R. de Krijger, Marc R. Lilien, Marc H. Wijn Tags: Case Report Source Type: research

Surgery combined with iodine-125 interstitial brachytherapy for treatment of parotid adenoid cystic carcinoma: A single-institution experience
The purpose of this study was to analyze the effectiveness and safety of the combination of surgery plus postoperative iodine-125 interstitial brachytherapy for treatment of adenoid cystic carcinoma (ACC) of the parotid. (Source: Brachytherapy)
Source: Brachytherapy - December 9, 2020 Category: Cancer & Oncology Authors: Ya Gao, Lei Zheng, Jian-Guo Zhang, Shu-Ming Liu, Jian-Yun Zhang, Shuang Dong Source Type: research

An iodine-125 seed strand combined with a metal stent versus a metal stent alone for obstructive jaundice caused by pancreatic ductal adenocarcinoma
The purpose of this study was to assess the efficacy of an iodine-125 (125I) seed strand combined with a metal stent compared with a metal stent for treatment of obstructive jaundice caused by pancreatic ductal adenocarcinoma (PDAC). (Source: Brachytherapy)
Source: Brachytherapy - December 8, 2020 Category: Cancer & Oncology Authors: Junhao Li, Tianzhu Yu, Li Zhang, Minjie Yang, Shanshan Gao, Ning Pu, Changyu Li, Chenggang Wang, Gaoquan Gong, Jiemin Cheng, Liangwen Wang, Guoping Li, Xiaolin Wang, Yi Chen Source Type: research

Mammographically guided noninvasive breast brachytherapy: Preoperative partial breast radiotherapy markedly improves targeting accuracy and decreases irradiated volume
Mammographically based noninvasive image-guided breast brachytherapy (NIBB) partial breast irradiation (PBI) is ideally suited for preoperative treatment. We hypothesize that delivering NIBB PBI to the preoperative tumor volume compared with the postoperative lumpectomy bed would simplify target identification and allow for a reduction in irradiated volume along each orthogonal axis. (Source: Brachytherapy)
Source: Brachytherapy - December 5, 2020 Category: Cancer & Oncology Authors: Kara L. Leonard, David E. Wazer, Matthew Listo, Jaroslaw T. Hepel Source Type: research

Clinically-implementable template plans for multidwell treatments using Leipzig-style applicators in 192Ir surface brachytherapy
Multiple dwell positions ( “multidwell”) within a Leipzig-style applicator can be used to increase dose uniformity and treatment area. Model-based dose calculation algorithms (MBDCAs) are necessary for accurate calculations involving these applicators because of their nonwater equivalency and complex geometry. The purpose of this work was to create template plans from MBDCA calculations and present their dwell times and positions for users of these applicators without access to MBDCAs. (Source: Brachytherapy)
Source: Brachytherapy - December 5, 2020 Category: Cancer & Oncology Authors: Emily Draeger, Daniel W. Pinkham, Zhe (Jay) Chen, Christopher J. Tien Source Type: research

Results of postoperative interstitial brachytherapy of resectable floor of mouth tumors
The purpose of this study was to describe the results of postoperative sole interstitial brachytherapy (BT) in patients with resectable floor of mouth tumors. (Source: Brachytherapy)
Source: Brachytherapy - November 26, 2020 Category: Cancer & Oncology Authors: Örs Ferenczi, Tibor Major, Hironori Akiyama, Georgina Fröhlich, Ferenc Oberna, Mónika Révész, Márton Poósz, Csaba Polgár, Zoltán Takácsi-Nagy Source Type: research

Risk factors for urethral stricture following external beam radiotherapy and HDR brachytherapy for prostate cancer
A potential late side effect of high-dose-rate (HDR) prostate brachytherapy combined with external beam radiotherapy (EBRT) is urethral stricture. The purpose of this study was to evaluate dosimetric parameters possibly contributing to stricture development, including dose to bladder base and D2cc(Gy) within 10  mm of prostatic urethra (D2cc 10 mm), which has, so far, not been reported in the literature. (Source: Brachytherapy)
Source: Brachytherapy - November 21, 2020 Category: Cancer & Oncology Authors: Nicki Groom, Yatman Tsang, Gerry Lowe, Peter Hoskin Source Type: research

A comparison of treatment planning techniques for low-dose-rate (LDR) prostate brachytherapy
The purpose of this study was to compare low-dose-rate prostate brachytherapy treatment plans created using three retrospectively applied planning techniques with plans delivered to patients. (Source: Brachytherapy)
Source: Brachytherapy - November 21, 2020 Category: Cancer & Oncology Authors: David Connolly, Gordon Sands, Helen Winter, Mark J. Foley, Christoph Kleefeld Source Type: research

Feasibility of deploying a U.S. simulation-based gynecological brachytherapy educational workshop to an international setting
A decline in brachytherapy (BT) use for cervical cancer has negatively affected cure rates in the United States and abroad. To improve trainee exposure to BT, a simulation-based educational curriculum incorporating a pelvic mannequin was developed and implemented at several U.S. residency programs. We sought to describe an initial experience with deployment of this curriculum to an international setting. (Source: Brachytherapy)
Source: Brachytherapy - November 19, 2020 Category: Cancer & Oncology Authors: Shari Damast, Shira Felder, Emma Fields, Lisa Singer Source Type: research

Is stereotactic CyberKnife radiotherapy or multicatheter HDR brachytherapy the better option dosimetrically for accelerated partial breast irradiation?
To compare dosimetrically the stereotactic CyberKnife (CK) therapy and multicatheter high-dose-rate (HDR) brachytherapy (BT) for accelerated partial breast irradiation (APBI). (Source: Brachytherapy)
Source: Brachytherapy - November 19, 2020 Category: Cancer & Oncology Authors: Georgina Fr öhlich, Norbert Mészáros, Viktor Smanykó, Gábor Stelczer, András Herein, Csaba Polgár, Tibor Major Source Type: research

Very accelerated partial breast irradiation Phase I –II multicenter trial (VAPBI): Feasibility and early results
This is a multicenter Phase I –II trial endorsed by the GEC-ESTRO Breast Working Group, to analyze if very accelerated partial breast irradiation (VAPBI) with multicatheter interstitial brachytherapy is feasible and safe compared with the standard APBI treatment in 4–5 days for early stage breast carcinomas. (Source: Brachytherapy)
Source: Brachytherapy - November 19, 2020 Category: Cancer & Oncology Authors: Jose Luis Guinot, Victor Gonzalez-Perez, Norbert Meszaros, Tibor Major, Dina Najjari-Jamal, Cristina Gutierrez-Miguelez, Miguel Angel Santos, Viktor Smanyko, Maria Laplana, Csaba Polgar, GEC-ESTRO Breast Working Group2 Source Type: research

The impact of a rectal hydrogel spacer on dosimetric and toxicity outcomes among patients undergoing combination therapy with external beam radiotherapy and low-dose-rate brachytherapy
In this study, we compared prostate and rectal dosimetry and acute toxicity outcomes in patients who had and had not received a rectal hydrogel spacer prior to combination therapy with external beam radiotherapy and low-dose-rate brachytherapy. (Source: Brachytherapy)
Source: Brachytherapy - November 13, 2020 Category: Cancer & Oncology Authors: Anthony D. Nehlsen, Kunal K. Sindhu, Erin Moshier, John P. Sfakianos, Richard G. Stock Source Type: research

Results of accelerated partial breast irradiation in patients not suitable for external beam irradiation stratified by GEC-ESTRO, ASTRO, and ABS guidelines
This study aims to review the outcome of an institution in multicatheter/interstitial accelerated partial breast irradiation (MC-APBI) for treatment of patients with breast cancer, either with strong criteria for APBI or unable to be treated with whole-breast irradiation. The outcomes were also stratified by the American Society for Radiation Oncology, American Brachytherapy Society, and Groupe Europ éen de Curiethérapie-European Society for Therapeutic Radiology and Oncology patient selection criteria. (Source: Brachytherapy)
Source: Brachytherapy - November 13, 2020 Category: Cancer & Oncology Authors: Lu ísa Sofia Campos Magalhães Garcia, Maria Lurdes Garcia Trigo Source Type: research

EyeDose: An open-source tool for using published Monte Carlo results to estimate the radiation dose delivered to the tumor and critical ocular structures for 125I Collaborative Ocular Melanoma Study eye plaques
Radiation side effects and visual outcome for uveal melanoma patients managed with plaque radiotherapy are dependent on the radiation dose administered to the tumor and nearby healthy tissues. We have developed an open-source software tool, EyeDose, to simplify and standardize tumor and critical structure dose reporting for Collaborative Ocular Melanoma Study eye plaques. (Source: Brachytherapy)
Source: Brachytherapy - November 10, 2020 Category: Cancer & Oncology Authors: Christopher L. Deufel, Sarah McCauley Cutsinger, Kimberly S. Corbin, Lauren A. Dalvin, Ivy A. Petersen Source Type: research

Feasibility of improving patient ’s safety with in vivo dose tracking in intracavitary and interstitial HDR brachytherapy
In this study, we present a new in vivo dose measurement system with a plastic scintillating detector (PSD) for GYN HDR brachyther apy. (Source: Brachytherapy)
Source: Brachytherapy - November 10, 2020 Category: Cancer & Oncology Authors: Jessica Muenkel, Zhengzheng Xu, Bryan J. Traughber, Tanvir Baig, Keying Xu, Christian Langmack, Eleanor Harris, Tarun K. Podder Source Type: research

Simulation-based graduate medical education in MR-guided brachytherapy for cervical cancer
This study aimed to address these gaps by developing and piloting a simulation-based education (SBE) workshop for MR-guided cervical cancer brachytherapy. (Source: Brachytherapy)
Source: Brachytherapy - November 9, 2020 Category: Cancer & Oncology Authors: Lisa Singer, Pierre-Yves McLaughlin, Gabriela Alban, Melissa Joyner, Martin King, Larissa Lee Source Type: research

A new development in ultrasound-compatible gynecologic brachytherapy simulators
Gynecologic brachytherapy is an essential component in the curative treatment of cervical cancer. With the decline in brachytherapy utilization, gynecologic brachytherapy simulators are being used to provide a mechanism to enhance proficiency-based resident training. However, most models that have been used lack procedural fidelity as they are either repurposed from OB/GYN basic models or from physics phantoms. Therefore, we set out to develop a high-fidelity, ultrasound- and CT-compatible gynecologic brachytherapy training simulator. (Source: Brachytherapy)
Source: Brachytherapy - November 7, 2020 Category: Cancer & Oncology Authors: Emma C. Fields, Melissa M. Joyner, Lisa Singer, Dorin Todor Source Type: research

Simulation-based learning for enhanced gynecologic brachytherapy training among radiation oncology residents
Brachytherapy is an irreplaceable component of gynecologic cancer treatment. Resident training has declined, and procedural exposure is variable. We evaluated whether simulation-based gynecologic brachytherapy training among radiation oncology residents could improve knowledge, confidence, and interest. (Source: Brachytherapy)
Source: Brachytherapy - November 4, 2020 Category: Cancer & Oncology Authors: Vonetta M. Williams, Bahar Mansoori, Lori Young, Nina A. Mayr, Lia M. Halasz, Brandon A. Dyer Source Type: research

Computed tomography versus magnetic resonance imaging in high-dose-rate prostate brachytherapy planning: The impact on patient-reported health-related quality of life
This study aimed to compare the patient-reported health-related quality of life (hrQOL) and physician-graded toxicity outcomes of CT-based and MRI-based HDR prostate brachytherapy. (Source: Brachytherapy)
Source: Brachytherapy - November 4, 2020 Category: Cancer & Oncology Authors: Alexander A. Harris, Megan Wu, Jacqueline M. Deirmenjian, Steven M. Shea, Hyejoo Kang, Rakesh Patel, Derek Fielder, Michael L. Mysz, Matthew M. Harkenrider, Abhishek A. Solanki Source Type: research

A novel combination of percutaneous stenting with iodine-125 seed implantation and chemotherapy for the treatment of pancreatic head cancer with obstructive jaundice
Insertion of radioactive strips through the biliary stent has been reported to offer longer survival and patency than an uncovered conventional self-expanding metal stent in patients with unresectable malignant biliary obstruction. The aim of this study was to investigate the safety and effectiveness of intraluminal brachytherapy combined with 125I seed implantation and transarterial infusion chemotherapy for the treatment of pancreatic head cancer with obstructive jaundice. (Source: Brachytherapy)
Source: Brachytherapy - November 4, 2020 Category: Cancer & Oncology Authors: Zhen Chi, Lihong Chen, Jingyao Huang, Na Jiang, Qubin Zheng, Ning Huang, Weizhu Yang Source Type: research

Relapse patterns after low-dose-rate prostate brachytherapy
When biochemical failure (BF) develops after low-dose-rate prostate brachytherapy, the relapse site is frequently not found. We set out to find whether prostate-specific membrane antigen positron emission tomography -CT (PSMA PET-CT) scanning has improved knowledge of relapse patterns. (Source: Brachytherapy)
Source: Brachytherapy - November 3, 2020 Category: Cancer & Oncology Authors: David S. Lamb, Lynne Greig, Trevor FitzJohn, Grant L. Russell, John N. Nacey, Douglas Iupati, Lisa Woods Source Type: research

Acknowledgement of Referees
We would like to thank the following people who have contributed their time and talents to the peer review of manuscripts over the past year (Source: Brachytherapy)
Source: Brachytherapy - November 1, 2020 Category: Cancer & Oncology Source Type: research

Editorial Board
(Source: Brachytherapy)
Source: Brachytherapy - November 1, 2020 Category: Cancer & Oncology Source Type: research

Masthead
(Source: Brachytherapy)
Source: Brachytherapy - November 1, 2020 Category: Cancer & Oncology Source Type: research

Table of Contents
(Source: Brachytherapy)
Source: Brachytherapy - November 1, 2020 Category: Cancer & Oncology Source Type: research

Accelerated partial breast irradiation in the elderly: 8-year oncological outcomes and prognostic factors
The purpose of the study is to evaluate long-term clinical outcomes and prognostic factors after accelerated partial breast irradiation (APBI) in the elderly using high-dose-rate interstitial multicatheter brachytherapy (HIBT). (Source: Brachytherapy)
Source: Brachytherapy - October 29, 2020 Category: Cancer & Oncology Authors: Shakeel Sumodhee, Marc Pujalte, Jocelyn Gal, Daniel Lam Cham Kee, Mathieu Gautier, Renaud Schiappa, Marie-Eve Chand, Jean-Michel Hannoun-Levi Source Type: research

Predicting which patients may benefit from the hybrid intracavitary+interstitial needle (IC/IS) applicator for advanced cervical cancer: A dosimetric comparison and toxicity benefit analysis
The purpose of this study is to compare the predicted rate of local control and bladder and rectum toxicity rates for image-guided adaptive brachytherapy plans using a tandem and ovoid (T/O) applicator versus using a simulated hybrid intracavitary/interstitial tandem and ring applicator with needles (T/R  + N) for patients with locally advanced cervical cancer (LACC). (Source: Brachytherapy)
Source: Brachytherapy - October 29, 2020 Category: Cancer & Oncology Authors: Yesenia Gonzalez, Fantine Giap, Peter Klages, Amir Owrangi, Xun Jia, Kevin Albuquerque Source Type: research

Utilization of multimodality therapy with primary radical prostatectomy versus radiation therapy for Gleason 8 –10 prostate cancer
The role of multimodality therapy (MMT) in the treatment of Gleason 8 –10 prostate cancer remains controversial. We sought to evaluate factors associated with MMT utilization for primary radical prostatectomy (RP) and primary radiation therapy (RT). (Source: Brachytherapy)
Source: Brachytherapy - October 29, 2020 Category: Cancer & Oncology Authors: Martin T. King, Vinayak Muralidhar, David D. Yang, Kent W. Mouw, Neil E. Martin, Anthony V. D'Amico, Paul L. Nguyen, Peter F. Orio Source Type: research

The birth, decline, and contemporary re-emergence of endovascular brachytherapy for prevention of in-stent restenosis
Despite the advent of drug-eluting stents and dual antiplatelet therapy in the interventional management of cardiovascular disease, restenosis rates remain high with significant sequelae. Endovascular brachytherapy —popular in the 1990s and early 2000s—has recently resurfaced as a cost-effective treatment option. In this work, we outline the history of endovascular brachytherapy starting with its earliest promise in the 1990s. We discuss the development of drug-eluting stents and dual antiplatelet strategi es and their impact on the perceived benefit of endovascular brachytherapy. (Source: Brachytherapy)
Source: Brachytherapy - October 29, 2020 Category: Cancer & Oncology Authors: Mohamed H. Khattab, Alexander D. Sherry, Colin M. Barker Source Type: research