Quantitative Neuromuscular Monitoring Permits Early Diagnosis of Abnormal Butyrylcholinestrase: Two Case Studies Demonstrating Prevention of Awareness from Premature Awakening
We present two patients with abnormal BChE gene variants. In the first case, quantitative monitoring was applied too late to prevent awareness, but allowed diagnosis and prevented admission to the intensive care unit. In the second case, monitoring was applied prior to NMB, which enabled early diagnosis and prevented premature awakening from anesthesia. These cases illustrate the importance of quantitative NMM, even in short cases and with short-acting depolarizing agents such as succinylcholine. The clinical implications of this report include a more consistent use of NMM to identify and manage patients with undiagnosed a...
Source: AANA Journal - April 2, 2024 Category: Anesthesiology Authors: Erica M Harris Emily M Funk Daniel Plezia Judson Elliott Ryland Elliott Jessica Szydlowski Pitman Stuart A Grant Source Type: research
Expression of IL-4 in Tumors: A Safety Surrogate to Predict Cancer Survival Associated With Biologic Therapies
J Drugs Dermatol. 2024 Apr 1;23(4):e118-e119. doi: 10.36849/JDD.7941.NO ABSTRACTPMID:38564398 | DOI:10.36849/JDD.7941 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - April 2, 2024 Category: Dermatology Authors: Nikolai Klebanov Carly Grant Jeffrey S Smith Lourdes M Perez-Chada Joseph F Merola Source Type: research
Quantitative Neuromuscular Monitoring Permits Early Diagnosis of Abnormal Butyrylcholinestrase: Two Case Studies Demonstrating Prevention of Awareness from Premature Awakening
We present two patients with abnormal BChE gene variants. In the first case, quantitative monitoring was applied too late to prevent awareness, but allowed diagnosis and prevented admission to the intensive care unit. In the second case, monitoring was applied prior to NMB, which enabled early diagnosis and prevented premature awakening from anesthesia. These cases illustrate the importance of quantitative NMM, even in short cases and with short-acting depolarizing agents such as succinylcholine. The clinical implications of this report include a more consistent use of NMM to identify and manage patients with undiagnosed a...
Source: AANA Journal - April 2, 2024 Category: Anesthesiology Authors: Erica M Harris Emily M Funk Daniel Plezia Judson Elliott Ryland Elliott Jessica Szydlowski Pitman Stuart A Grant Source Type: research
The after-effects of occupational whole-body vibration on human cognitive, visual, and motor function: A systematic review
Appl Ergon. 2024 Apr 1;118:104264. doi: 10.1016/j.apergo.2024.104264. Online ahead of print.ABSTRACTWhole-body vibration (WBV) is prevalent in labour-related activities and can have adverse effects on the health and performance of the individuals exposed. However, evidence regarding the extent to which human functionality is affected following occupational WBV exposure has not been collated. The current systematic review sought to synthesize existing literature and assess the strength and direction of evidence regarding the acute after-effects of occupational WBV exposure on cognition, visual function, postural stability, ...
Source: Applied Ergonomics - April 2, 2024 Category: Occupational Health Authors: Barbara Halmai Timothy P Holsgrove Samuel J Vine David J Harris Genevieve K R Williams Source Type: research
Expression of IL-4 in Tumors: A Safety Surrogate to Predict Cancer Survival Associated With Biologic Therapies
J Drugs Dermatol. 2024 Apr 1;23(4):e118-e119. doi: 10.36849/JDD.7941.NO ABSTRACTPMID:38564398 | DOI:10.36849/JDD.7941 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - April 2, 2024 Category: Dermatology Authors: Nikolai Klebanov Carly Grant Jeffrey S Smith Lourdes M Perez-Chada Joseph F Merola Source Type: research
Quantitative Neuromuscular Monitoring Permits Early Diagnosis of Abnormal Butyrylcholinestrase: Two Case Studies Demonstrating Prevention of Awareness from Premature Awakening
We present two patients with abnormal BChE gene variants. In the first case, quantitative monitoring was applied too late to prevent awareness, but allowed diagnosis and prevented admission to the intensive care unit. In the second case, monitoring was applied prior to NMB, which enabled early diagnosis and prevented premature awakening from anesthesia. These cases illustrate the importance of quantitative NMM, even in short cases and with short-acting depolarizing agents such as succinylcholine. The clinical implications of this report include a more consistent use of NMM to identify and manage patients with undiagnosed a...
Source: AANA Journal - April 2, 2024 Category: Anesthesiology Authors: Erica M Harris Emily M Funk Daniel Plezia Judson Elliott Ryland Elliott Jessica Szydlowski Pitman Stuart A Grant Source Type: research
Expression of IL-4 in Tumors: A Safety Surrogate to Predict Cancer Survival Associated With Biologic Therapies
J Drugs Dermatol. 2024 Apr 1;23(4):e118-e119. doi: 10.36849/JDD.7941.NO ABSTRACTPMID:38564398 | DOI:10.36849/JDD.7941 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - April 2, 2024 Category: Dermatology Authors: Nikolai Klebanov Carly Grant Jeffrey S Smith Lourdes M Perez-Chada Joseph F Merola Source Type: research
The Dutch multidisciplinary guideline osteoporosis and fracture prevention, taking a local guideline to the international arena
ConclusionIn our new multidisciplinary guideline osteoporosis and fracture prevention, we developed 5 “relatively new statements” that are all a crucial step forward in the optimization of diagnosis and treatment for fracture prevention. We also developed 5 flowcharts, and we suppose that this may be helpful for individual doctors and their patients in daily practice and may facilitate implement ation. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - April 2, 2024 Category: Orthopaedics Source Type: research
ERAS ® Cardiac Society Turnkey Order Set for Surgical Site Infection Prevention: Proceedings from the AATS ERAS Conclave 2023
Surgical site infections (SSIs) after cardiac surgery increase morbidity and mortality, consume healthcare resources, impair recovery, and diminish patients ’ quality of life. Numerous guidelines and expert consensus documents have been published to address the prevention and management of SSIs. Our objective is to integrate these documents into an order set that will facilitate the adoption and implementation of evidence-based best practices for prev enting and managing SSIs following cardiac surgery. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 2, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Cheryl Crisafi, Michael C. Grant, Amanda Rea, Vicki Morton-Bailey, Alexander J. Gregory, Rakesh C. Arora, Subhasis Chatterjee, Sylvain A. Lother, Busra Cangut, Daniel T. Engelman, ERAS Cardiac Working Group Source Type: research
The Dutch multidisciplinary guideline osteoporosis and fracture prevention, taking a local guideline to the international arena
ConclusionIn our new multidisciplinary guideline osteoporosis and fracture prevention, we developed 5 “relatively new statements” that are all a crucial step forward in the optimization of diagnosis and treatment for fracture prevention. We also developed 5 flowcharts, and we suppose that this may be helpful for individual doctors and their patients in daily practice and may facilitate implement ation. (Source: Archives of Osteoporosis)
Source: Archives of Osteoporosis - April 2, 2024 Category: Orthopaedics Source Type: research
The global landscape of kidney registries: immense challenges and unique opportunities
Nature Reviews Nephrology, Published online: 02 April 2024; doi:10.1038/s41581-024-00833-1Kidney registries are essential to understanding the burden of kidney disease and facilitating the development of sustainable and effective programs for kidney disease prevention and care. Key barriers to implementation of registries at a global scale include funding and data quality. These issues warrant the attention of the global nephrology community. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 2, 2024 Category: Urology & Nephrology Authors: Christopher H. Grant Fergus J. Caskey M. Razeen Davids Manisha Sahay Aminu K. Bello Dorothea Nitsch Samira Bell Source Type: research
The use of telepsychiatry during COVID-19 in Aotearoa New Zealand: experiences, learnings and cultural safety
This study aims to provide a better understanding of telepsychiatry in the Aotearoa context and identify potential gaps with the current practice, with a focus on exploring telepsychiatry use with Maori, Pacific peoples and Asians.This qualitative study was guided by the principles of the Kaupapa Maori methodology and the “Give Way Rule” from Pan-Pacific studies, to ensure culturally appropriate analysis and outcomes. Semi-structured interviews were conducted with a sample of psychiatrists and trainees recruited from Aotearoa members of the Royal Australian and New Zealand College of Psychiatrists. The qualitative data...
Source: The Journal of Mental Health Training, Education and Practice - April 2, 2024 Category: Psychiatry & Psychology Authors: Lauren Barnett Alisha Vara Mark Lawrence Etuini Ma'u Rodrigo Ramalho Yan Chen Grant Christie Gary Cheung Source Type: research
In a bold bid to avoid open-access fees, Gates foundation says grantees must post preprints
The world’s largest philanthropy, the Bill & Melinda Gates Foundation, last week took a radical step aimed at giving preprints—freely available draft manuscripts that have not been peer reviewed—a much more prominent role in science. Starting in 2025, the foundation will require grantees to post as preprints all manuscripts that result from research it funds. It will also stop paying for researchers to publish their papers in journals that charge a fee to make papers free.
The Gates foundation says the preprint mandate is needed to accelerate the dissemination of research findings and because too many autho...
Source: Science of Aging Knowledge Environment - April 1, 2024 Category: Geriatrics Source Type: research
Just-departed head of DOE science wing discusses successes and barriers
Last week, Asmeret Asefaw Berhe stepped down as the director of the Department of Energy’s (DOE’s) basic research wing, the Office of Science. An unexpected choice in many quarters, Berhe is a soil scientist and was the first person of color to lead the office, which has an annual budget of $8.2 billion and is the nation’s largest funder of the physical sciences. It is also the United States’s premier builder of large scientific facilities such as atom smashers and x-ray synchrotrons.
Berhe championed efforts to make DOE’s basic research more relevant to climate and more diverse. During her 22-month tenure,...
Source: Science of Aging Knowledge Environment - April 1, 2024 Category: Geriatrics Source Type: research
A randomized first-in-human phase I trial of differentially adjuvanted Pfs48/45 malaria vaccines in Burkinabé adults
CONCLUSION All formulations were safe and well tolerated in a malaria-endemic area of Africa in healthy adults. The ProC6C-AlOH/Matrix-M vaccine elicited the highest levels of functional antibodies, meriting further investigation.TRIAL REGISTRATION Pan-African Clinical Trials Registry (https://pactr.samrc.ac.za) PACTR202201848463189.FUNDING The study was funded by the European and Developing Countries Clinical Trials Partnership (grant RIA2018SV-2311). (Source: Journal of Clinical Investigation)
Source: Journal of Clinical Investigation - April 1, 2024 Category: Biomedical Science Authors: Alfred B. Tiono, Jordan L. Plieskatt, Alphonse Ouedraogo, Ben Idriss Soulama, Kazutoyo Miura, Edith C. Bougouma, Mohammad Naghizadeh, Aissata Barry, Jean Baptist B. Yaro, Sem Ezinmegnon, Noelie Henry, Ebenezer Addo Ofori, Bright Adu, Susheel K. Singh, Aug Source Type: research
