The Interplay of Genital Herpes with Cellular Processes: A Pathogenesis and Therapeutic Perspective
Viruses. 2023 Oct 31;15(11):2195. doi: 10.3390/v15112195.ABSTRACTGenital herpes, primarily caused by herpes simplex virus-2 (HSV-2), remains a pressing global health concern. Its remarkable ability to intertwine with cellular processes, from harnessing host machinery for replication to subverting antiviral defenses like autophagy and programmed cell death, exemplifies the intricate interplay at the heart of its pathogenesis. While the biomedical community has extensively researched antiviral interventions, the efficiency of these strategies in managing HSV-2 remains suboptimal. Recognizing this, attention has shifted towar...
Source: Herpes - November 25, 2023 Category: Infectious Diseases Authors: Hemant Borase Deepak Shukla Source Type: research
The Interplay of Genital Herpes with Cellular Processes: A Pathogenesis and Therapeutic Perspective
Viruses. 2023 Oct 31;15(11):2195. doi: 10.3390/v15112195.ABSTRACTGenital herpes, primarily caused by herpes simplex virus-2 (HSV-2), remains a pressing global health concern. Its remarkable ability to intertwine with cellular processes, from harnessing host machinery for replication to subverting antiviral defenses like autophagy and programmed cell death, exemplifies the intricate interplay at the heart of its pathogenesis. While the biomedical community has extensively researched antiviral interventions, the efficiency of these strategies in managing HSV-2 remains suboptimal. Recognizing this, attention has shifted towar...
Source: Herpes - November 25, 2023 Category: Infectious Diseases Authors: Hemant Borase Deepak Shukla Source Type: research
HPV co-infections with other pathogens in cancer development: A comprehensive review
J Med Virol. 2023 Nov;95(11):e29236. doi: 10.1002/jmv.29236.ABSTRACTHigh-risk human papillomaviruses (HR-HPVs) cause various malignancies in the anogenital and oropharyngeal regions. About 70% of cervical and oropharyngeal cancers are caused by HPV types 16 and 18. Notably, some viruses including herpes simplex virus, Epstein-Barr virus, and human immunodeficiency virus along with various bacteria often interact with HPV, potentially impacting its replication, persistence, and cancer progression. Thus, HPV infection can be significantly influenced by co-infecting agents that influence infection dynamics and disease progres...
Source: Herpes - November 24, 2023 Category: Infectious Diseases Authors: Elahe Akbari Alireza Milani Masoud Seyedinkhorasani Azam Bolhassani Source Type: research
Diagnostic Methods and Management Strategies of Herpes Simplex and Herpes Zoster Infections
Clin Geriatr Med. 2024 Feb;40(1):147-175. doi: 10.1016/j.cger.2023.09.003. Epub 2023 Oct 8.ABSTRACTHerpesviruses are medium-sized double-stranded DNA viruses. Of more than 80 herpesviruses identified, only 9 human herpesviruses have been found to cause infection in humans. These include herpes simplex viruses 1 and 2 (HSV-1 and HSV-2), varicella-zoster virus (VZV), human cyto-megalovirus (HCMV), Epstein-Barr virus (EBV), and human herpesvirus (HHV-6A, HHV-6B, HHV-7, HHV-8). HSV-1, HSV-2, and VZV can be problematic given their characteristic neurotropism which is the ability to invade via fusion of its plasma membrane and r...
Source: Herpes - November 24, 2023 Category: Infectious Diseases Authors: Sino Mehrmal Rafael Mojica Aibing Mary Guo Tricia A Missall Source Type: research
HPV co-infections with other pathogens in cancer development: A comprehensive review
J Med Virol. 2023 Nov;95(11):e29236. doi: 10.1002/jmv.29236.ABSTRACTHigh-risk human papillomaviruses (HR-HPVs) cause various malignancies in the anogenital and oropharyngeal regions. About 70% of cervical and oropharyngeal cancers are caused by HPV types 16 and 18. Notably, some viruses including herpes simplex virus, Epstein-Barr virus, and human immunodeficiency virus along with various bacteria often interact with HPV, potentially impacting its replication, persistence, and cancer progression. Thus, HPV infection can be significantly influenced by co-infecting agents that influence infection dynamics and disease progres...
Source: Herpes - November 24, 2023 Category: Infectious Diseases Authors: Elahe Akbari Alireza Milani Masoud Seyedinkhorasani Azam Bolhassani Source Type: research
Genital herpes linked to accelerated brain shrinkage
People who tested positive for the virus behind genital herpes tended to have reduced thickness of their outermost brain layer, which has been linked to Alzheimer ' s disease (Source: New Scientist - Health)
Source: New Scientist - Health - November 17, 2023 Category: Consumer Health News Source Type: research
Recalcitrant ulcerative genital herpes in an immunocompetent individual treated successfully with imiquimod
CONCLUSION: This case report illustrates the efficacy of imiquimod cream as a topical treatment for genital herpes simplex in an immunocompetent patient who had previously been unresponsive to treatment with acyclovir.PMID:37938029 | DOI:10.1177/09564624231213110 (Source: Herpes)
Source: Herpes - November 8, 2023 Category: Infectious Diseases Authors: Suvigya Sachan Vijay Kiran Potluri Hima Gopinath Kode Leela Sravanthi Prabhakaran N Jyotsna Naresh Bharti Thiruveedhula Haritha Source Type: research
Does genital herpes symptom history predict herpes simplex virus type 2 antibody positivity?
CONCLUSIONS: With currently available tests, recommendations to screen individuals based on genital herpes symptom history may not be useful. More discriminatory symptom screening tools or HSV-2 antibody tests with better performance are needed.PMID:37937339 | DOI:10.1177/09564624231213116 (Source: Herpes)
Source: Herpes - November 8, 2023 Category: Infectious Diseases Authors: Jessica Perez Katherine A Lewis Silver Vargas Jeffrey D Klausner Kelika A Konda Source Type: research
Recalcitrant ulcerative genital herpes in an immunocompetent individual treated successfully with imiquimod
CONCLUSION: This case report illustrates the efficacy of imiquimod cream as a topical treatment for genital herpes simplex in an immunocompetent patient who had previously been unresponsive to treatment with acyclovir.PMID:37938029 | DOI:10.1177/09564624231213110 (Source: Herpes)
Source: Herpes - November 8, 2023 Category: Infectious Diseases Authors: Suvigya Sachan Vijay Kiran Potluri Hima Gopinath Kode Leela Sravanthi Prabhakaran N Jyotsna Naresh Bharti Thiruveedhula Haritha Source Type: research
Does genital herpes symptom history predict herpes simplex virus type 2 antibody positivity?
CONCLUSIONS: With currently available tests, recommendations to screen individuals based on genital herpes symptom history may not be useful. More discriminatory symptom screening tools or HSV-2 antibody tests with better performance are needed.PMID:37937339 | DOI:10.1177/09564624231213116 (Source: Herpes)
Source: Herpes - November 8, 2023 Category: Infectious Diseases Authors: Jessica Perez Katherine A Lewis Silver Vargas Jeffrey D Klausner Kelika A Konda Source Type: research
Viral lumbosacral radiculitis (Elsberg syndrome) in Denmark
CONCLUSIONS: Urinary retention resolved within weeks in most patients with viral lumbosacral radiculitis, but moderate disabilities according to the Glasgow Outcome Scale were common at the end of follow-up.PMID:37917395 | DOI:10.1007/s15010-023-02113-9 (Source: Herpes)
Source: Herpes - November 2, 2023 Category: Infectious Diseases Authors: Pelle Trier Petersen Jacob Bodilsen Micha Phill Gr ønholm Jepsen Lykke Larsen Merete Storgaard Birgitte R ønde Hansen Hans Rudolf L üttichau Jannik Helweg-Larsen Lothar Wiese Christian Østergaard Andersen Henrik Nielsen Christian Thomas Brandt Danish Source Type: research
Viral lumbosacral radiculitis (Elsberg syndrome) in Denmark
ConclusionsUrinary retention resolved within weeks in most patients with viral lumbosacral radiculitis, but moderate disabilities according to the Glasgow Outcome Scale were common at the end of follow-up. (Source: Infection)
Source: Infection - November 2, 2023 Category: Infectious Diseases Source Type: research
221 Extracellular granzyme B drives immunopathology by compromising epithelial barrier integrity during genital Herpes Simplex Virus-2 infections
Genital Herpes Simplex Virus-2 (HSV-2) infection is a highly prevalent and chronic sexually transmitted disease without any cures or FDA-approved vaccines. Symptomatic recurrences occur episodically to trigger genital lesions, compromising the barrier function of the vaginal epithelium and perivaginal skin and tripling the risk of secondary human immunodeficiency virus (HIV)-1 acquisition. Understanding how the immune system interacts with HSV-2 would thus enable us to develop better therapeutics against novel inflammatory and pathological targets. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - November 1, 2023 Category: Dermatology Authors: Y.S. Lim, H. Shin, A. Lee, D. Granville, J. Common Source Type: research
Viruses, Vol. 15, Pages 2195: The Interplay of Genital Herpes with Cellular Processes: A Pathogenesis and Therapeutic Perspective
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Genital herpes, primarily caused by herpes simplex virus-2 (HSV-2), remains a pressing global health concern. Its remarkable ability to intertwine with cellular processes, from harnessing host machinery for replication to subverting antiviral defenses like autophagy and programmed cell death, exemplifies the intricate interplay at the heart of its pathogenesis. While the biomedical community has extensively researched antiviral interventions, the efficiency of these strategies in managing HSV-2 remains suboptimal. Recognizing this, attention has shifted toward leveraging host cellular components to regulate HSV-2 r...
Source: Viruses - October 31, 2023 Category: Virology Authors: Hemant Borase Deepak Shukla Tags: Review Source Type: research
