Viruses, Vol. 15, Pages 1642: BMS-265246, a Cyclin-Dependent Kinase Inhibitor, Inhibits the Infection of Herpes Simplex Virus Type 1
In this study, we examined a panel of CDK inhibitors that target CDKs in the present study. BMS-265246 (BMS), a CDK 1/2 inhibitor, was found to effectively limit HSV-1 multiplication in Vero, HepG2, and Hela cells. A mechanism of action study suggested that BMS inhibits the early stages of viral replication when added early in the viral infection. The suppression of multiple steps in viral replication by BMS was revealed when HSV-1 infected cells were treated at different time periods in the viral life cycle. Our results suggest that BMS is a potent anti-HSV-1 agent and unique in that it may interfere with multiple steps i...
Source: Viruses - July 28, 2023 Category: Virology Authors: Lefang Jiang Yang Yu Zhuogang Li Yarou Gao Haonan Zhang Mingxin Zhang Weihua Cao Qun Peng Xulin Chen Tags: Article Source Type: research
Functional interferon-epsilon gene polymorphisms and sexually transmitted infections of the endometrium
CONCLUSIONS: Few studies have examined IFNε gene variants, our study raises the possibility that IFNε gene variants may be a potential host contributor to STI pathogenesis.PMID:37491918 | DOI:10.1111/aji.13754 (Source: Herpes)
Source: Herpes - July 26, 2023 Category: Infectious Diseases Authors: Brandie DePaoli Taylor Michael F Criscitiello Fuller W Bazer Lauren S Richardson Akaninyene Noah Catherine L Haggerty Source Type: research
Functional interferon-epsilon gene polymorphisms and sexually transmitted infections of the endometrium
CONCLUSIONS: Few studies have examined IFNε gene variants, our study raises the possibility that IFNε gene variants may be a potential host contributor to STI pathogenesis.PMID:37491918 | DOI:10.1111/aji.13754 (Source: Herpes)
Source: Herpes - July 26, 2023 Category: Infectious Diseases Authors: Brandie DePaoli Taylor Michael F Criscitiello Fuller W Bazer Lauren S Richardson Akaninyene Noah Catherine L Haggerty Source Type: research
Detection of co-infection by Herpes simplex virus type 1 and type 2 in female genital ulcers
Rev Esp Quimioter. 2023 Jul 19:reina19jul2023. doi: 10.37201/req/041.2023. Online ahead of print.NO ABSTRACTPMID:37465868 | DOI:10.37201/req/041.2023 (Source: Revista Espanola de Quimioterapia)
Source: Revista Espanola de Quimioterapia - July 19, 2023 Category: Drugs & Pharmacology Authors: J Reina C Iglesias Source Type: research
Detection of co-infection by Herpes simplex virus type 1 and type 2 in female genital ulcers
Rev Esp Quimioter. 2023 Jul 19:reina19jul2023. doi: 10.37201/req/041.2023. Online ahead of print.NO ABSTRACTPMID:37465868 | DOI:10.37201/req/041.2023 (Source: Herpes)
Source: Herpes - July 19, 2023 Category: Infectious Diseases Authors: J Reina C Iglesias Source Type: research
Lipsch ütz Syndrome: Not All Genital Ulcers Are Herpes
Clin Pediatr (Phila). 2023 Jul 18:99228231186867. doi: 10.1177/00099228231186867. Online ahead of print.NO ABSTRACTPMID:37464778 | DOI:10.1177/00099228231186867 (Source: Herpes)
Source: Herpes - July 19, 2023 Category: Infectious Diseases Authors: Henry Michael Lerner Source Type: research
Detection of co-infection by Herpes simplex virus type 1 and type 2 in female genital ulcers
Rev Esp Quimioter. 2023 Jul 19:reina19jul2023. doi: 10.37201/req/041.2023. Online ahead of print.NO ABSTRACTPMID:37465868 | DOI:10.37201/req/041.2023 (Source: Revista Espanola de Quimioterapia)
Source: Revista Espanola de Quimioterapia - July 19, 2023 Category: Drugs & Pharmacology Authors: J Reina C Iglesias Source Type: research
Detection of co-infection by Herpes simplex virus type 1 and type 2 in female genital ulcers
Rev Esp Quimioter. 2023 Jul 19:reina19jul2023. doi: 10.37201/req/041.2023. Online ahead of print.NO ABSTRACTPMID:37465868 | DOI:10.37201/req/041.2023 (Source: Herpes)
Source: Herpes - July 19, 2023 Category: Infectious Diseases Authors: J Reina C Iglesias Source Type: research
Lipsch ütz Syndrome: Not All Genital Ulcers Are Herpes
Clin Pediatr (Phila). 2023 Jul 18:99228231186867. doi: 10.1177/00099228231186867. Online ahead of print.NO ABSTRACTPMID:37464778 | DOI:10.1177/00099228231186867 (Source: Herpes)
Source: Herpes - July 19, 2023 Category: Infectious Diseases Authors: Henry Michael Lerner Source Type: research
Detection of co-infection by Herpes simplex virus type 1 and type 2 in female genital ulcers
Rev Esp Quimioter. 2023 Jul 19:reina19jul2023. doi: 10.37201/req/041.2023. Online ahead of print.NO ABSTRACTPMID:37465868 | DOI:10.37201/req/041.2023 (Source: Revista Espanola de Quimioterapia)
Source: Revista Espanola de Quimioterapia - July 19, 2023 Category: Drugs & Pharmacology Authors: J Reina C Iglesias Source Type: research
Viruses, Vol. 15, Pages 1570: ICP8-vhs- HSV-2 Vaccine Expressing B7 Costimulation Molecules Optimizes Safety and Efficacy against HSV-2 Infection in Mice
Morrison
Herpes simplex virus 2 (HSV-2) causes most sexually transmitted genital ulcerative disease. No effective prophylactic vaccine is currently available. Replication-defective (ICP8-) HSV stimulates immune responses in animals without producing progeny virus, making it potentially useful as a safe form of a live vaccine against HSV. We previously demonstrated that mice generate a stronger response to ICP8- virus encoding B7-2 costimulation molecules than to the parental replication-defective virus. We have also demonstrated enhanced immunogenicity of an ICP8-, virion host shutoff (vhs)- virus which can no longer ...
Source: Viruses - July 18, 2023 Category: Virology Authors: Maria Korom Hong Wang Kaelin M. Bernier Brian J. Geiss Lynda A. Morrison Tags: Article Source Type: research
Clinico-epidemiological profile of genital dermatoses in people living with HIV: A shifting paradigm from venereal to nonvenereal dermatoses
CONCLUSION: This study showed that nonvenereal genital dermatoses are more common than STIs in people living with HIV. Our findings reiterate the fact that genital lesions should be approached with caution as a presumptive and hasty diagnosis of STI adds greatly to the morbidity of the patient in terms of guilt and shame, and adversely affects the quality of life.PMID:37457512 | PMC:PMC10343133 | DOI:10.4103/ijstd.ijstd_39_22 (Source: Herpes)
Source: Herpes - July 17, 2023 Category: Infectious Diseases Authors: Supreet Kaur Dhillon Mahendra M Kura Source Type: research
Clinico-epidemiological profile of genital dermatoses in people living with HIV: A shifting paradigm from venereal to nonvenereal dermatoses
CONCLUSION: This study showed that nonvenereal genital dermatoses are more common than STIs in people living with HIV. Our findings reiterate the fact that genital lesions should be approached with caution as a presumptive and hasty diagnosis of STI adds greatly to the morbidity of the patient in terms of guilt and shame, and adversely affects the quality of life.PMID:37457512 | PMC:PMC10343133 | DOI:10.4103/ijstd.ijstd_39_22 (Source: Herpes)
Source: Herpes - July 17, 2023 Category: Infectious Diseases Authors: Supreet Kaur Dhillon Mahendra M Kura Source Type: research
Cervical and systemic innate immunity predictors of HIV risk linked to genital herpes acquisition and time from HSV-2 seroconversion
Conclusions
A combination of systemic immunoinflammatory and cervical immunosuppressed states predicts HSV-2 acquisition. A persistently suppressed innate immunity during incident HSV-2 infection may add to the increased HIV-1 susceptibility. (Source: Sexually Transmitted Infections)
Source: Sexually Transmitted Infections - July 17, 2023 Category: Sexual Medicine Authors: Govender, Y., Morrison, C. S., Chen, P.-L., Gao, X., Yamamoto, H., Chipato, T., Anderson, S., Barbieri, R., Salata, R., Doncel, G. F., Fichorova, R. N. Tags: Open access Original research Source Type: research
Revisiting the therapeutic potential of homeopathic medicine Rhus Tox for herpes simplex virus and inflammatory conditions
CONCLUSION: The homeopathic medicine Rhus Tox has no cytotoxicity observed under in vitro conditions and can be used to treat herpes infection. Further studies are needed to confirm the results under in vitro and in vivo conditions as well as in clinical trials.PMID:37421729 | DOI:10.1016/j.jaim.2023.100739 (Source: Herpes)
Source: Herpes - July 8, 2023 Category: Infectious Diseases Authors: Mohini D Shinde Sheetal A Patil Anupam Mukherjee Vijay Nema Source Type: research
