Mucosal CCL28 Chemokine Improves Protection against Genital Herpes through Mobilization of Antiviral Effector Memory CCR10+CD44+ CD62L-CD8+ T Cells and Memory CCR10+B220+CD27+ B Cells into the Infected Vaginal Mucosa
In this study, we investigated the role of the CCL28/CCR10 chemokine axis in mobilizing protective antiviral B and T cell subsets into the VM site of herpes infection. We report a significant increase in the frequencies of HSV-specific memory CCR10+CD44+CD8+ T cells, expressing high levels of CCR10, in herpes-infected asymptomatic (ASYMP) women compared with symptomatic women. Similarly, a significant increase in the CCL28 chemokine (a ligand of CCR10), was detected in the VM of herpes-infected ASYMP C57BL/6 mice, associated with the mobilization of high frequencies of HSV-specific effector memory CCR10+CD44+CD62L-CD8+ TEM...
Source: Herpes - May 24, 2023 Category: Infectious Diseases Authors: Nisha Rajeswari Dhanushkodi Swayam Prakash Afshana Quadiri Latifa Zayou Ruchi Srivastava Jennifer Tran Vivian Dang Amin Mohammed Shaik Amruth Chilukurri Berfin Suzer Phil De Vera Miyo Sun Pauline Nguyen Ashley Lee Amirah Salem Joyce Loi Mahmoud Singer Tak Source Type: research
Mucosal CCL28 Chemokine Improves Protection against Genital Herpes through Mobilization of Antiviral Effector Memory CCR10+CD44+ CD62L-CD8+ T Cells and Memory CCR10+B220+CD27+ B Cells into the Infected Vaginal Mucosa
In this study, we investigated the role of the CCL28/CCR10 chemokine axis in mobilizing protective antiviral B and T cell subsets into the VM site of herpes infection. We report a significant increase in the frequencies of HSV-specific memory CCR10+CD44+CD8+ T cells, expressing high levels of CCR10, in herpes-infected asymptomatic (ASYMP) women compared with symptomatic women. Similarly, a significant increase in the CCL28 chemokine (a ligand of CCR10), was detected in the VM of herpes-infected ASYMP C57BL/6 mice, associated with the mobilization of high frequencies of HSV-specific effector memory CCR10+CD44+CD62L-CD8+ TEM...
Source: Journal of Immunology - May 24, 2023 Category: Allergy & Immunology Authors: Nisha Rajeswari Dhanushkodi Swayam Prakash Afshana Quadiri Latifa Zayou Ruchi Srivastava Jennifer Tran Vivian Dang Amin Mohammed Shaik Amruth Chilukurri Berfin Suzer Phil De Vera Miyo Sun Pauline Nguyen Ashley Lee Amirah Salem Joyce Loi Mahmoud Singer Tak Source Type: research
Mucosal CCL28 Chemokine Improves Protection against Genital Herpes through Mobilization of Antiviral Effector Memory CCR10+CD44+ CD62L-CD8+ T Cells and Memory CCR10+B220+CD27+ B Cells into the Infected Vaginal Mucosa
In this study, we investigated the role of the CCL28/CCR10 chemokine axis in mobilizing protective antiviral B and T cell subsets into the VM site of herpes infection. We report a significant increase in the frequencies of HSV-specific memory CCR10+CD44+CD8+ T cells, expressing high levels of CCR10, in herpes-infected asymptomatic (ASYMP) women compared with symptomatic women. Similarly, a significant increase in the CCL28 chemokine (a ligand of CCR10), was detected in the VM of herpes-infected ASYMP C57BL/6 mice, associated with the mobilization of high frequencies of HSV-specific effector memory CCR10+CD44+CD62L-CD8+ TEM...
Source: Herpes - May 24, 2023 Category: Infectious Diseases Authors: Nisha Rajeswari Dhanushkodi Swayam Prakash Afshana Quadiri Latifa Zayou Ruchi Srivastava Jennifer Tran Vivian Dang Amin Mohammed Shaik Amruth Chilukurri Berfin Suzer Phil De Vera Miyo Sun Pauline Nguyen Ashley Lee Amirah Salem Joyce Loi Mahmoud Singer Tak Source Type: research
Mucosal CCL28 Chemokine Improves Protection against Genital Herpes through Mobilization of Antiviral Effector Memory CCR10+CD44+ CD62L-CD8+ T Cells and Memory CCR10+B220+CD27+ B Cells into the Infected Vaginal Mucosa
In this study, we investigated the role of the CCL28/CCR10 chemokine axis in mobilizing protective antiviral B and T cell subsets into the VM site of herpes infection. We report a significant increase in the frequencies of HSV-specific memory CCR10+CD44+CD8+ T cells, expressing high levels of CCR10, in herpes-infected asymptomatic (ASYMP) women compared with symptomatic women. Similarly, a significant increase in the CCL28 chemokine (a ligand of CCR10), was detected in the VM of herpes-infected ASYMP C57BL/6 mice, associated with the mobilization of high frequencies of HSV-specific effector memory CCR10+CD44+CD62L-CD8+ TEM...
Source: Journal of Immunology - May 24, 2023 Category: Allergy & Immunology Authors: Nisha Rajeswari Dhanushkodi Swayam Prakash Afshana Quadiri Latifa Zayou Ruchi Srivastava Jennifer Tran Vivian Dang Amin Mohammed Shaik Amruth Chilukurri Berfin Suzer Phil De Vera Miyo Sun Pauline Nguyen Ashley Lee Amirah Salem Joyce Loi Mahmoud Singer Tak Source Type: research
Mucosal CCL28 Chemokine Improves Protection against Genital Herpes through Mobilization of Antiviral Effector Memory CCR10+CD44+ CD62L-CD8+ T Cells and Memory CCR10+B220+CD27+ B Cells into the Infected Vaginal Mucosa
In this study, we investigated the role of the CCL28/CCR10 chemokine axis in mobilizing protective antiviral B and T cell subsets into the VM site of herpes infection. We report a significant increase in the frequencies of HSV-specific memory CCR10+CD44+CD8+ T cells, expressing high levels of CCR10, in herpes-infected asymptomatic (ASYMP) women compared with symptomatic women. Similarly, a significant increase in the CCL28 chemokine (a ligand of CCR10), was detected in the VM of herpes-infected ASYMP C57BL/6 mice, associated with the mobilization of high frequencies of HSV-specific effector memory CCR10+CD44+CD62L-CD8+ TEM...
Source: Journal of Immunology - May 24, 2023 Category: Allergy & Immunology Authors: Nisha Rajeswari Dhanushkodi Swayam Prakash Afshana Quadiri Latifa Zayou Ruchi Srivastava Jennifer Tran Vivian Dang Amin Mohammed Shaik Amruth Chilukurri Berfin Suzer Phil De Vera Miyo Sun Pauline Nguyen Ashley Lee Amirah Salem Joyce Loi Mahmoud Singer Tak Source Type: research
Mucosal CCL28 Chemokine Improves Protection against Genital Herpes through Mobilization of Antiviral Effector Memory CCR10+CD44+ CD62L-CD8+ T Cells and Memory CCR10+B220+CD27+ B Cells into the Infected Vaginal Mucosa
In this study, we investigated the role of the CCL28/CCR10 chemokine axis in mobilizing protective antiviral B and T cell subsets into the VM site of herpes infection. We report a significant increase in the frequencies of HSV-specific memory CCR10+CD44+CD8+ T cells, expressing high levels of CCR10, in herpes-infected asymptomatic (ASYMP) women compared with symptomatic women. Similarly, a significant increase in the CCL28 chemokine (a ligand of CCR10), was detected in the VM of herpes-infected ASYMP C57BL/6 mice, associated with the mobilization of high frequencies of HSV-specific effector memory CCR10+CD44+CD62L-CD8+ TEM...
Source: Journal of Immunology - May 24, 2023 Category: Allergy & Immunology Authors: Nisha Rajeswari Dhanushkodi Swayam Prakash Afshana Quadiri Latifa Zayou Ruchi Srivastava Jennifer Tran Vivian Dang Amin Mohammed Shaik Amruth Chilukurri Berfin Suzer Phil De Vera Miyo Sun Pauline Nguyen Ashley Lee Amirah Salem Joyce Loi Mahmoud Singer Tak Source Type: research
Mucosal CCL28 Chemokine Improves Protection against Genital Herpes through Mobilization of Antiviral Effector Memory CCR10+CD44+ CD62L-CD8+ T Cells and Memory CCR10+B220+CD27+ B Cells into the Infected Vaginal Mucosa
In this study, we investigated the role of the CCL28/CCR10 chemokine axis in mobilizing protective antiviral B and T cell subsets into the VM site of herpes infection. We report a significant increase in the frequencies of HSV-specific memory CCR10+CD44+CD8+ T cells, expressing high levels of CCR10, in herpes-infected asymptomatic (ASYMP) women compared with symptomatic women. Similarly, a significant increase in the CCL28 chemokine (a ligand of CCR10), was detected in the VM of herpes-infected ASYMP C57BL/6 mice, associated with the mobilization of high frequencies of HSV-specific effector memory CCR10+CD44+CD62L-CD8+ TEM...
Source: Journal of Immunology - May 24, 2023 Category: Allergy & Immunology Authors: Nisha Rajeswari Dhanushkodi Swayam Prakash Afshana Quadiri Latifa Zayou Ruchi Srivastava Jennifer Tran Vivian Dang Amin Mohammed Shaik Amruth Chilukurri Berfin Suzer Phil De Vera Miyo Sun Pauline Nguyen Ashley Lee Amirah Salem Joyce Loi Mahmoud Singer Tak Source Type: research
Contemporary Trends in Cesarean Delivery Rates and Indications
CONCLUSIONS: Despite changes in labor management definitions and guidelines encouraging vaginal birth, the rates of overall cesarean delivery did not decrease over time. The indications for delivery, particularly failed labor, repeat cesarean delivery, and malpresentation have not significantly changed over time.PMID:37216971 | DOI:10.1055/a-2097-1958 (Source: Herpes)
Source: Herpes - May 22, 2023 Category: Infectious Diseases Authors: Sara Jaber Christina Blanchard Michelle Y Lu Gabriella D Cozzi Brian M Casey Alan Tita Dhong-Jin Kim Jeff M Szychowski Akila Subramaniam Source Type: research
Knowledge, attitudes, and testing preferences for Herpes Simplex Virus infections among undergraduate students at a large university in Los Angeles, California
CONCLUSION: University students have low knowledge regarding genital herpes. Genital herpes education is needed to improve sexual health and wellness.PMID:37205777 | DOI:10.1080/07448481.2023.2194431 (Source: Herpes)
Source: Herpes - May 19, 2023 Category: Infectious Diseases Authors: A P Tadanki C Hernandez-Tamayo N Saremi C Stafylis J D Klausner Source Type: research
Effects of Melatonin Alone or Associated with Acyclovir on the Suppressive Treatment of Recurrent Genital Herpes: A Prospective, Randomized, and Double-Blind Study
CONCLUSION: Our data suggest that melatonin may be an option for the suppressive treatment of recurrent genital herpes.PMID:37189706 | DOI:10.3390/biomedicines11041088 (Source: Herpes)
Source: Herpes - May 16, 2023 Category: Infectious Diseases Authors: Cristiane Lima Roa Jos é Cipolla-Neto Russel J Reiter Iara Moreno Linhares Ana Paula Lepique Lana Maria de Aguiar Isadora Braga Seganfredo Edson Santos Ferreira-Filho Sebasti ão Freitas de Medeiros Edmund Chada Baracat Jos é Maria Soares-Júnior Source Type: research
Effects of Melatonin Alone or Associated with Acyclovir on the Suppressive Treatment of Recurrent Genital Herpes: A Prospective, Randomized, and Double-Blind Study
CONCLUSION: Our data suggest that melatonin may be an option for the suppressive treatment of recurrent genital herpes.PMID:37189706 | PMC:PMC10135732 | DOI:10.3390/biomedicines11041088 (Source: Herpes)
Source: Herpes - May 16, 2023 Category: Infectious Diseases Authors: Cristiane Lima Roa Jos é Cipolla-Neto Russel J Reiter Iara Moreno Linhares Ana Paula Lepique Lana Maria de Aguiar Isadora Braga Seganfredo Edson Santos Ferreira-Filho Sebasti ão Freitas de Medeiros Edmund Chada Baracat Jos é Maria Soares-Júnior Source Type: research
Transmission of the Herpes Simplex Virus in the Preclinical Phase of Disease Progression during Childbirth
JMA J. 2023 Apr 14;6(2):223-225. doi: 10.31662/jmaj.2022-0200. Epub 2023 Mar 13.ABSTRACTVertical transmission of the herpes simplex virus (HSV) in the preclinical phase of the disease progression is rare. Here, we present a case of perinatal-acquired herpes from an asymptomatic mother. Our findings suggest that clinicians should consider screening predisposed mothers for HSV as part of prenatal care to identify asymptomatic primary genital HSV infections.PMID:37179720 | PMC:PMC10169254 | DOI:10.31662/jmaj.2022-0200 (Source: Herpes)
Source: Herpes - May 14, 2023 Category: Infectious Diseases Authors: Shunji Suzuki Source Type: research
Transmission of the Herpes Simplex Virus in the Preclinical Phase of Disease Progression during Childbirth
JMA J. 2023 Apr 14;6(2):223-225. doi: 10.31662/jmaj.2022-0200. Epub 2023 Mar 13.ABSTRACTVertical transmission of the herpes simplex virus (HSV) in the preclinical phase of the disease progression is rare. Here, we present a case of perinatal-acquired herpes from an asymptomatic mother. Our findings suggest that clinicians should consider screening predisposed mothers for HSV as part of prenatal care to identify asymptomatic primary genital HSV infections.PMID:37179720 | PMC:PMC10169254 | DOI:10.31662/jmaj.2022-0200 (Source: Herpes)
Source: Herpes - May 14, 2023 Category: Infectious Diseases Authors: Shunji Suzuki Source Type: research
Bacterial Vaginosis and Post-Operative Pelvic Infections
Healthcare (Basel). 2023 Apr 25;11(9):1218. doi: 10.3390/healthcare11091218.ABSTRACTBacterial vaginosis (BV) represents a condition in which the normal protective Lactobacilli, especially those that produce H2O2, are replaced by high quantities of facultative anaerobes, leading to gynecologic and obstetric post-operative complications. BV is an important cause of obstetric and gynecological adverse sequelae and it could lead to an increased risk of contracting sexually transmitted infections such as gonorrhea, genital herpes, Chlamydia, Trichomonas, and human immunodeficiency virus. Herein, we reviewed bacterial vaginosis ...
Source: Herpes - May 13, 2023 Category: Infectious Diseases Authors: Afroditi Ziogou Eleftherios Ziogos Ilias Giannakodimos Alexios Giannakodimos Stavros Sifakis Petros Ioannou Sotirios Tsiodras Source Type: research
Bacterial Vaginosis and Post-Operative Pelvic Infections
Healthcare (Basel). 2023 Apr 25;11(9):1218. doi: 10.3390/healthcare11091218.ABSTRACTBacterial vaginosis (BV) represents a condition in which the normal protective Lactobacilli, especially those that produce H2O2, are replaced by high quantities of facultative anaerobes, leading to gynecologic and obstetric post-operative complications. BV is an important cause of obstetric and gynecological adverse sequelae and it could lead to an increased risk of contracting sexually transmitted infections such as gonorrhea, genital herpes, Chlamydia, Trichomonas, and human immunodeficiency virus. Herein, we reviewed bacterial vaginosis ...
Source: Herpes - May 13, 2023 Category: Infectious Diseases Authors: Afroditi Ziogou Eleftherios Ziogos Ilias Giannakodimos Alexios Giannakodimos Stavros Sifakis Petros Ioannou Sotirios Tsiodras Source Type: research
