The Chinese herbal prescription JZ-1 promotes extracellular vesicle production and protects against herpes simplex virus type 2 infection in vitro
CONCLUSION: JZ-1 had an anti-HSV-2 efficacy. After JZ-1 stimulation, VK2/E6E7 cells secreted extracellular vesicles which protect host cells from HSV-2 infection. High-throughput sequencing showed that these extracellular vesicles contained a large number of miRNAs targeting PI3K/AKT/mTOR pathway. JZ-1 group extracellular vesicles could inhibit the activation of AKT/mTOR pathway and induce the host cells autophagy.PMID:38495169 | PMC:PMC10940933 | DOI:10.1016/j.heliyon.2024.e27019 (Source: Herpes)
Source: Herpes - March 18, 2024 Category: Infectious Diseases Authors: Wenjia Wang Ximing Jin Qingqing Shao Tong Liu Tianli Liu Xinwei Zhao Lijun Xu Wen Gao Liu Hu Zhuo Chen Source Type: research
The Chinese herbal prescription JZ-1 promotes extracellular vesicle production and protects against herpes simplex virus type 2 infection in vitro
CONCLUSION: JZ-1 had an anti-HSV-2 efficacy. After JZ-1 stimulation, VK2/E6E7 cells secreted extracellular vesicles which protect host cells from HSV-2 infection. High-throughput sequencing showed that these extracellular vesicles contained a large number of miRNAs targeting PI3K/AKT/mTOR pathway. JZ-1 group extracellular vesicles could inhibit the activation of AKT/mTOR pathway and induce the host cells autophagy.PMID:38495169 | PMC:PMC10940933 | DOI:10.1016/j.heliyon.2024.e27019 (Source: Herpes)
Source: Herpes - March 18, 2024 Category: Infectious Diseases Authors: Wenjia Wang Ximing Jin Qingqing Shao Tong Liu Tianli Liu Xinwei Zhao Lijun Xu Wen Gao Liu Hu Zhuo Chen Source Type: research
GSE261599 Therapeutic Prime/Pull Vaccination of HSV-2 Infected Guinea Pigs with the Ribonucleotide Reductase 2 (RR2) and CXCL11 boosts TRM and TEM CD4+/CD8+ T cells to protect from recurrent genital herpes
Contributors : Afshana Quadiri ; Swayam Prakash ; Lbachir BenMohamedSeries Type : Expression profiling by high throughput sequencingOrganism : Cavia porcellusFollowing acute herpes simplex virus type 2 (HSV-2) infection, the virus undergoes an asymptomatic latent infection of sensory neurons of dorsal root ganglia (DRG). Chemical and physical stress cause intermittent virus reactivation from latently infected DRG and recurrent virus shedding in the genital mucosal epithelium causing genital herpes in symptomatic patients. While T-cells appear to play a role in controlling virus reactivation from DRG and reducing the sev...
Source: GEO: Gene Expression Omnibus - March 14, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Cavia porcellus Source Type: research
Effects of pubic hair grooming on women's sexual health: a systematic review and meta-analysis
CONCLUSION: This review aligns with previous observational studies regarding sexual health outcomes of pubic hair grooming. There is a need to raise awareness among women regarding the safe practice of pubic hair grooming, emphasizing the clarification of hazards and benefits.PMID:38468306 | DOI:10.1186/s12905-024-02951-1 (Source: Herpes)
Source: Herpes - March 12, 2024 Category: Infectious Diseases Authors: Asmaa Eltobgy Ahmed Aljabali Ahmed Farag Mohammad Elshorbgy Mona Hamed Esraa Hamouda Heba Hamouda Neveen Refaey Marwa Kabeel Sarah Amro Toka Abouheseba Mohammed Tarek Source Type: research
Effects of pubic hair grooming on women's sexual health: a systematic review and meta-analysis
CONCLUSION: This review aligns with previous observational studies regarding sexual health outcomes of pubic hair grooming. There is a need to raise awareness among women regarding the safe practice of pubic hair grooming, emphasizing the clarification of hazards and benefits.PMID:38468306 | DOI:10.1186/s12905-024-02951-1 (Source: Herpes)
Source: Herpes - March 12, 2024 Category: Infectious Diseases Authors: Asmaa Eltobgy Ahmed Aljabali Ahmed Farag Mohammad Elshorbgy Mona Hamed Esraa Hamouda Heba Hamouda Neveen Refaey Marwa Kabeel Sarah Amro Toka Abouheseba Mohammed Tarek Source Type: research
Interferon lambda restricts herpes simplex virus skin disease by suppressing neutrophil-mediated pathology
mBio. 2024 Mar 1:e0262323. doi: 10.1128/mbio.02623-23. Online ahead of print.ABSTRACTType III interferons (IFN-λ) are antiviral and immunomodulatory cytokines that have been best characterized in respiratory and gastrointestinal infections, but the effects of IFN-λ against skin infections have not been extensively investigated. We sought to define the skin-specific effects of IFN-λ against the highly prevalent human pathogen, herpes simplex virus (HSV). We infected mice lacking the IFN-λ receptor (Ifnlr1-/-), both the IFN-λ and the IFN-α/β receptors (Ifnar1-/-Ifnlr1-/-), or IFN-λ cytokines (Ifnl2/3-/-) and found th...
Source: Herpes - March 1, 2024 Category: Infectious Diseases Authors: Drake T Philip Nigel M Goins Nicholas J Catanzaro Ichiro Misumi Jason K Whitmire Hannah M Atkins Helen M Lazear Source Type: research
Interferon lambda restricts herpes simplex virus skin disease by suppressing neutrophil-mediated pathology
mBio. 2024 Mar 1:e0262323. doi: 10.1128/mbio.02623-23. Online ahead of print.ABSTRACTType III interferons (IFN-λ) are antiviral and immunomodulatory cytokines that have been best characterized in respiratory and gastrointestinal infections, but the effects of IFN-λ against skin infections have not been extensively investigated. We sought to define the skin-specific effects of IFN-λ against the highly prevalent human pathogen, herpes simplex virus (HSV). We infected mice lacking the IFN-λ receptor (Ifnlr1-/-), both the IFN-λ and the IFN-α/β receptors (Ifnar1-/-Ifnlr1-/-), or IFN-λ cytokines (Ifnl2/3-/-) and found th...
Source: Herpes - March 1, 2024 Category: Infectious Diseases Authors: Drake T Philip Nigel M Goins Nicholas J Catanzaro Ichiro Misumi Jason K Whitmire Hannah M Atkins Helen M Lazear Source Type: research
Dermatology Images: Herpes simplex
Herpes simplex virus infection is characterized by grouped vesicles on an erythematous background, which may progress into erosions, punctate ulcerations, or white macerated vesicles resembling pustules. In immunosuppressed individuals, chronic progressive ulcers with rolled pearly scalloped borders are characteristic.1 Herpes simplex virus-1 is usually associated with orofacial infections and may produce ocular infection and encephalitis, whereas herpes simplex virus-2 usually causes genital infections which can be transmitted sexually and from mothers to neonates (Figs 1-7). (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - February 27, 2024 Category: Dermatology Authors: Pelin Sagut, Dirk Elston Tags: Dermatology images Source Type: research
Seroepidemiology of Herpes Simplex Viruses Type 1 and 2 in Pregnant Women in Croatia
Conclusions: HSV-1 infection is widely prevalent among pregnant women with a stable trend over time. However, a declining trend in the HSV-2 seroprevalence was observed compared to 2005-2010. Serological screening in pregnant women is important in identifying seronegative women who are susceptible to HSV infection as well as seropositive women who are at risk for genital herpes recurrence during delivery.PMID:38399571 | PMC:PMC10890541 | DOI:10.3390/medicina60020284 (Source: Herpes)
Source: Herpes - February 24, 2024 Category: Infectious Diseases Authors: Tatjana Vilibic-Cavlek Marko Belamaric Thomas Ferenc Dan Navolan Branko Kolaric Ljiljana Milasincic Ljiljana Antolasic Mateja Vujica Ferenc Maja Vilibic Adriana Lukunic Maja Bogdanic Source Type: research
Aetiological molecular identification of sexually transmitted infections that cause urethral discharge syndrome and genital ulcer disease in Brazilian men: a nationwide study
CONCLUSION: This study provided the acquisition of unprecedented data on the aetiology of UDS and GUD in Brazil, demonstrated the presence of a variety of pathogens in both sample types and reaffirmed the aetiologies known to be most prevalent globally.PMID:38360847 | DOI:10.1136/sextrans-2023-055950 (Source: Herpes)
Source: Herpes - February 15, 2024 Category: Infectious Diseases Authors: Maria Luiza Bazzo Hanalydia de Melo Machado Jessica Motta Martins Marcos Andr é Schörner Ketlyn Buss Fernando Hartmann Barazzetti Pamela Cristina Gaspar Alisson Bigolin Adele Benzaken Simone Veloso Faria de Carvalho Lidiane da Fonseca Andrade William An Source Type: research
Viral MicroRNAs in Herpes Simplex Virus 1 Pathobiology
Curr Pharm Des. 2024 Feb 12. doi: 10.2174/0113816128286469240129100313. Online ahead of print.ABSTRACTSimplexvirus humanalpha1 infects millions of people globally, manifesting as vesiculo-ulcerative lesions of the oral or genital mucosa. After primary infection, the virus establishes latency in the peripheral neurons and reactivates sporadically in response to various environmental and genetic factors. A unique feature of herpesviruses is their ability to encode tiny noncoding RNAs called microRNA, (miRNAs). Simplexvirus humanalpha1 encodes eighteen miRNA precursors that generate twenty-seven different mature miRNA sequenc...
Source: Herpes - February 13, 2024 Category: Infectious Diseases Authors: Raza Ali Naqvi Araceli Valverde Tejabhiram Yadavalli Fatima Ismail Bobat Kristelle J Capistrano Deepak Shukla Afsar R Naqvi Source Type: research
Viral MicroRNAs in Herpes Simplex Virus 1 Pathobiology
Curr Pharm Des. 2024 Feb 12. doi: 10.2174/0113816128286469240129100313. Online ahead of print.ABSTRACTSimplexvirus humanalpha1 infects millions of people globally, manifesting as vesiculo-ulcerative lesions of the oral or genital mucosa. After primary infection, the virus establishes latency in the peripheral neurons and reactivates sporadically in response to various environmental and genetic factors. A unique feature of herpesviruses is their ability to encode tiny noncoding RNAs called microRNA, (miRNAs). Simplexvirus humanalpha1 encodes eighteen miRNA precursors that generate twenty-seven different mature miRNA sequenc...
Source: Current Pharmaceutical Design - February 13, 2024 Category: Drugs & Pharmacology Authors: Raza Ali Naqvi Araceli Valverde Tejabhiram Yadavalli Fatima Ismail Bobat Kristelle J Capistrano Deepak Shukla Afsar R Naqvi Source Type: research
Herpes Simplex Virus: A Practical Guide to Diagnosis, Management, and Patient Counseling for the Primary Care Clinician
Med Clin North Am. 2024 Mar;108(2):311-323. doi: 10.1016/j.mcna.2023.08.016. Epub 2023 Oct 8.ABSTRACTGenital herpes is a chronic, lifelong sexually transmitted viral infection, which can cause recurrent, self-limited genital ulcers. It is caused by herpes simplex virus (HSV) type 1 and type 2 viruses. Genital HSV infection is a very prevalent STI, which causes self-limited, recurrent genital ulcers. Treatment decreases duration of symptoms and signs and can be provided as episodic or suppressive therapy. Genital herpes can have a substantial impact during pregnancy and on sexual health in general. Counseling on natural his...
Source: Herpes - February 8, 2024 Category: Infectious Diseases Authors: Teresa A Batteiger Cornelis A Rietmeijer Source Type: research
Herpes Simplex Virus: A Practical Guide to Diagnosis, Management, and Patient Counseling for the Primary Care Clinician
Med Clin North Am. 2024 Mar;108(2):311-323. doi: 10.1016/j.mcna.2023.08.016. Epub 2023 Oct 8.ABSTRACTGenital herpes is a chronic, lifelong sexually transmitted viral infection, which can cause recurrent, self-limited genital ulcers. It is caused by herpes simplex virus (HSV) type 1 and type 2 viruses. Genital HSV infection is a very prevalent STI, which causes self-limited, recurrent genital ulcers. Treatment decreases duration of symptoms and signs and can be provided as episodic or suppressive therapy. Genital herpes can have a substantial impact during pregnancy and on sexual health in general. Counseling on natural his...
Source: The Medical Clinics of North America - February 8, 2024 Category: General Medicine Authors: Teresa A Batteiger Cornelis A Rietmeijer Source Type: research
Herpes Simplex Virus: A Practical Guide to Diagnosis, Management, and Patient Counseling for the Primary Care Clinician
Med Clin North Am. 2024 Mar;108(2):311-323. doi: 10.1016/j.mcna.2023.08.016. Epub 2023 Oct 8.ABSTRACTGenital herpes is a chronic, lifelong sexually transmitted viral infection, which can cause recurrent, self-limited genital ulcers. It is caused by herpes simplex virus (HSV) type 1 and type 2 viruses. Genital HSV infection is a very prevalent STI, which causes self-limited, recurrent genital ulcers. Treatment decreases duration of symptoms and signs and can be provided as episodic or suppressive therapy. Genital herpes can have a substantial impact during pregnancy and on sexual health in general. Counseling on natural his...
Source: The Medical Clinics of North America - February 8, 2024 Category: General Medicine Authors: Teresa A Batteiger Cornelis A Rietmeijer Source Type: research
