The Chinese herbal prescription JZ-1 promotes extracellular vesicle production and protects against herpes simplex virus type 2 infection in vitro

CONCLUSION: JZ-1 had an anti-HSV-2 efficacy. After JZ-1 stimulation, VK2/E6E7 cells secreted extracellular vesicles which protect host cells from HSV-2 infection. High-throughput sequencing showed that these extracellular vesicles contained a large number of miRNAs targeting PI3K/AKT/mTOR pathway. JZ-1 group extracellular vesicles could inhibit the activation of AKT/mTOR pathway and induce the host cells autophagy.PMID:38495169 | PMC:PMC10940933 | DOI:10.1016/j.heliyon.2024.e27019

Source: Herpes - March 18, 2024 Category: Infectious Diseases Authors: Wenjia Wang Ximing Jin Qingqing Shao Tong Liu Tianli Liu Xinwei Zhao Lijun Xu Wen Gao Liu Hu Zhuo Chen Source Type: research