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Demographic and clinical characteristics of people diagnosed with active sexually transmitted infections among monkeypox cases in Brazil: the 2022 outbreak
Rev Inst Med Trop Sao Paulo. 2024 Apr 5;66:e20. doi: 10.1590/S1678-9946202466020. eCollection 2024.ABSTRACTThe worldwide monkeypox (mpox) outbreak in 2022 showed a high frequency of sexually transmitted infections (STI). A cross-sectional study was carried out using secondary data from the Brazilian official mpox surveillance systems. A total of 10,169 mpox cases were identified, with a median age of 32 years. Among them, 92.3% were male at birth and 57.5% were men who have sex with other men (MSM). Approximately 11% were diagnosed with STI, including 5.8% with syphilis and 2.5% with genital herpes. Individuals aged from 2...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - April 10, 2024 Category: Tropical Medicine Authors: Isabella Nepomuceno de Souza Ana Roberta Pati Pascom Matheus Funke Spinelli Guilherme Borges Dias Draurio Barreira Ang élica Espinosa Miranda Source Type: research

Therapeutic prime/pull vaccination of HSV-2-infected guinea pigs with the ribonucleotide reductase 2 (RR2) protein and CXCL11 chemokine boosts antiviral local tissue-resident and effector memory CD4(+) and CD8(+) T cells and protects against recurrent genital herpes
In this study, we used the strategy that involves immunization of herpes simplex virus type 2-infected guinea pigs using a recombinantly expressed herpes tegument protein-ribonucleotide reductase 2 (RR2; prime), followed by intravaginal treatment with the neurotropic adeno-associated virus type 8 expressing CXCL9, CXCL10, or CXCL11 T-cell-attracting chemokines to recruit T cells into the infected dorsal root ganglia (DRG) and vaginal mucosa (VM) (pull). We show that the RR2/CXCL11 prime-pull therapeutic vaccine strategy elicited a significant reduction in virus shedding in the vaginal mucosa and decreased the severity and ...
Source: Herpes - April 8, 2024 Category: Infectious Diseases Authors: Afshana Quadiri Swayam Prakash Nisha Rajeswari Dhanushkodi Mahmoud Singer Latifa Zayou Amin Mohammed Shaik Miyo Sun Berfin Suzer Lauren Su Lin Lau Amruth Chilukurri Hawa Vahed Hubert Schaefer Lbachir BenMohamed Source Type: research

A case report: recurrent anemia related to long term acyclovir use in a pregnant HIV infected Ugandan
Abstract: This case report describes a pregnant patient with recent diagnosis of Human Immuno-Deficiency Virus (HIV) infection initiated on Anti-Retroviral Therapy (ART) in the second trimester, as well as high dose acyclovir high for large infected genital warts. She had no other HIV related opportunistic infections, and no prior anti tuberculosis treatment or preventive medication. Despite little response to acyclovir, patient was continuing on acyclovir for over 4 months. She subsequently developed recurrent anemia requiring frequent transfusion (14 units in total) over a 6-week period.On stopping acyclovir, the anemia ...
Source: African Health Sciences - April 1, 2024 Category: African Health Authors: Mariam Nambuya, Harriet Mayanja-Kizza Source Type: research

AEDV Expert Document on the management of ulcerative venereal infections
Actas Dermosifiliogr. 2024 Mar 29:S0001-7310(24)00267-9. doi: 10.1016/j.ad.2024.03.021. Online ahead of print.ABSTRACTCurrently, ulcerative sexually transmitted infections, including syphilis, herpes simplex virus (HSV), lymphogranuloma venereum (LGV), chancroid, donovanosis and, more recently, monkeypox (MPOX), represent a growing challenge for health care professionals. The incidence of syphilis and LGV has increased in recent years in Spain. Additionally, HSV, syphilis and chancroid can also increase the risk of HIV acquisition and transmission. The population groups most vulnerable to these infections are young people,...
Source: Actas Dermo-Sifiliograficas - March 31, 2024 Category: Dermatology Authors: Caridad E Morales Francisco Montoya Nicol ás de Loredo Elena Sendagorta Source Type: research

AEDV Expert Document on the management of ulcerative venereal infections
Actas Dermosifiliogr. 2024 Mar 29:S0001-7310(24)00267-9. doi: 10.1016/j.ad.2024.03.021. Online ahead of print.ABSTRACTCurrently, ulcerative sexually transmitted infections, including syphilis, herpes simplex virus (HSV), lymphogranuloma venereum (LGV), chancroid, donovanosis and, more recently, monkeypox (MPOX), represent a growing challenge for health care professionals. The incidence of syphilis and LGV has increased in recent years in Spain. Additionally, HSV, syphilis and chancroid can also increase the risk of HIV acquisition and transmission. The population groups most vulnerable to these infections are young people,...
Source: Herpes - March 31, 2024 Category: Infectious Diseases Authors: Caridad E Morales Francisco Montoya Nicol ás de Loredo Elena Sendagorta Source Type: research

Impact of Genital Infections and Antibiotic Use on Incidence of Preterm Birth: A Retrospective Observational Study
This study investigates the complex interplay among genital infections, antibiotic usage, and preterm birth. This study aims to identify common genital pathogens associated with preterm births, assess the impact of various antibiotic treatments on pregnancy outcomes, and understand antibiotic resistance patterns among these pathogens. This study included 71 pregnant women who experienced preterm birth and 94 women with genital infections who delivered at term. Various maternal characteristics, medical history, signs and symptoms, gestational weight, gestational age, type of birth, vaginal pH, Nugent scores, and vaginal flo...
Source: Herpes - March 27, 2024 Category: Infectious Diseases Authors: Daniela Teodora Marti Felix Bratosin Ovidiu Rosca Roxana Folescu Cosmin Citu Adrian Ratiu Zoran Laurentiu Popa Source Type: research

Error in Conflict of Interest Disclosures
In the Editorial titled “Shedding Patterns of Genital Herpes Simplex Virus Infections,” published online on October 22, 2022, and in the November 1, 2022, issue of JAMA, Dr Whitley omitted potential conflict of interest disclosures. The disclosure statement has been corrected to include “serving on the board of direc tors for Gilead Sciences, Inc, with vested shares in the company at the time of this publication, and as cofounder and investor in Treovir LLC.” The article was corrected online. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - March 25, 2024 Category: General Medicine Source Type: research

Psychoeducational interventions for people living with chronic communicable disease: a systematic review
CONCLUSION: The findings of this review highlight potential benefits of psychoeducation but indicate more robust clinical trials will be required to examine their effectiveness and elucidate the mechanisms by which they best operate. Future interventions incorporating a broader focus on resilience enhancement and coping skills specific to stigmatisation could more comprehensively serve the needs of adults living with chronic communicable disease, particularly with HIV. The role of peer support in group psychoeducation merits further exploration.PROSPERO REGISTRATION NUMBER: CRD42021243058.PMID:38521523 | DOI:10.1136/bmjope...
Source: Herpes - March 23, 2024 Category: Infectious Diseases Authors: Aoife Burke Martin P Davoren Ella Arensman Janas M Harrington Source Type: research

Psychoeducational interventions for people living with chronic communicable disease: a systematic review
Conclusion The findings of this review highlight potential benefits of psychoeducation but indicate more robust clinical trials will be required to examine their effectiveness and elucidate the mechanisms by which they best operate. Future interventions incorporating a broader focus on resilience enhancement and coping skills specific to stigmatisation could more comprehensively serve the needs of adults living with chronic communicable disease, particularly with HIV. The role of peer support in group psychoeducation merits further exploration. PROSPERO registration number CRD42021243058. (Source: BMJ Open)
Source: BMJ Open - March 23, 2024 Category: General Medicine Authors: Burke, A., Davoren, M. P., Arensman, E., Harrington, J. M. Tags: Open access, Public health Source Type: research