Polyphenylene carboxymethylene (PPCM), the active component of the topical contraceptive Yaso-GEL, exhibits potent antimicrobial activity against Neisseria gonorrhoeae in preclinical studies
Conclusions
Yaso-GEL containing the API PPCM showed significant activity against N. gonorrhoeae in vitro and in vivo in a female mouse model. These data support further development of Yaso-GEL as an inexpensive, non-hormonal and non-systemic product with both contraceptive and antimicrobial activity against gonorrhea and other common sexually transmitted infections (STIs). Such multipurpose prevention technology products are needed by women in all economic, social and cultural circumstances to prevent unintended pregnancy and STIs. (Source: Sexually Transmitted Infections)
Source: Sexually Transmitted Infections - August 17, 2023 Category: Sexual Medicine Authors: Pilligua-Lucas, M., Tkavc, R., Bash, S. K., North, B. B., Weitzel, M. B., Jerse, A. E. Tags: Open access Original research Source Type: research
Influence of sexually transmitted infections on the cervical cytological abnormalities among Iranian women: A cross-sectional study
CONCLUSION: High percentages of the participants with non-HPV STIs and HPV infection had normal cervical cytology. It is advised to use STIs and HPV diagnostic tests along with cytology examinations for cervical cancer screening.PMID:37560071 | PMC:PMC10407913 | DOI:10.18502/ijrm.v21i6.13636 (Source: Herpes)
Source: Herpes - August 10, 2023 Category: Infectious Diseases Authors: Azam Shafaei Seyyed Ali Akbar Shamsian Mohammad Ghodsi Fatemeh Sadabadi Maryam Shahi Source Type: research
Epidemiology of herpes simplex virus type 1 in Canada: systematic review, meta-analyses, and meta-regressions
CONCLUSIONS: HSV-1 epidemiology in Canada appears to be shifting toward less oral acquisition in childhood and more genital acquisition in adulthood, particularly among youth. Both HSV-1 seroprevalence and proportion of HSV-1 detection in genital herpes are increasing with time.PMID:37521995 | PMC:PMC10375289 | DOI:10.3389/fpubh.2023.1118249 (Source: Herpes)
Source: Herpes - July 31, 2023 Category: Infectious Diseases Authors: Sawsan AlMukdad Manale Harfouche Uzma S Farooqui Lana Aldos Laith J Abu-Raddad Source Type: research
ICP8-vhs- HSV-2 Vaccine Expressing B7 Costimulation Molecules Optimizes Safety and Efficacy against HSV-2 Infection in Mice
Viruses. 2023 Jul 18;15(7):1570. doi: 10.3390/v15071570.ABSTRACTHerpes simplex virus 2 (HSV-2) causes most sexually transmitted genital ulcerative disease. No effective prophylactic vaccine is currently available. Replication-defective (ICP8-) HSV stimulates immune responses in animals without producing progeny virus, making it potentially useful as a safe form of a live vaccine against HSV. We previously demonstrated that mice generate a stronger response to ICP8- virus encoding B7-2 costimulation molecules than to the parental replication-defective virus. We have also demonstrated enhanced immunogenicity of an ICP8-, vir...
Source: Herpes - July 29, 2023 Category: Infectious Diseases Authors: Maria Korom Hong Wang Kaelin M Bernier Brian J Geiss Lynda A Morrison Source Type: research
A Trivalent HSV-2 gC2, gD2, gE2 Nucleoside-Modified mRNA-LNP Vaccine Provides Outstanding Protection in Mice against Genital and Non-Genital HSV-1 Infection, Comparable to the Same Antigens Derived from HSV-1
Viruses. 2023 Jun 30;15(7):1483. doi: 10.3390/v15071483.ABSTRACTHSV-1 disease is a significant public health burden causing orofacial, genital, cornea, and brain infection. We previously reported that a trivalent HSV-2 gC2, gD2, gE2 nucleoside-modified mRNA-lipid nanoparticle (LNP) vaccine provides excellent protection against vaginal HSV-1 infection in mice. Here, we evaluated whether this HSV-2 gC2, gD2, gE2 vaccine is as effective as a similar HSV-1 mRNA LNP vaccine containing gC1, gD1, and gE1 in the murine lip and genital infection models. Mice were immunized twice with a total mRNA dose of 1 or 10 µg. The two vaccin...
Source: Herpes - July 29, 2023 Category: Infectious Diseases Authors: Kevin P Egan Sita Awasthi Giulia Tebaldi Lauren M Hook Alexis M Naughton Bernard T Fowler Mitchell Beattie Mohamad-Gabriel Alameh Drew Weissman Gary H Cohen Harvey M Friedman Source Type: research
ICP8-vhs- HSV-2 Vaccine Expressing B7 Costimulation Molecules Optimizes Safety and Efficacy against HSV-2 Infection in Mice
Viruses. 2023 Jul 18;15(7):1570. doi: 10.3390/v15071570.ABSTRACTHerpes simplex virus 2 (HSV-2) causes most sexually transmitted genital ulcerative disease. No effective prophylactic vaccine is currently available. Replication-defective (ICP8-) HSV stimulates immune responses in animals without producing progeny virus, making it potentially useful as a safe form of a live vaccine against HSV. We previously demonstrated that mice generate a stronger response to ICP8- virus encoding B7-2 costimulation molecules than to the parental replication-defective virus. We have also demonstrated enhanced immunogenicity of an ICP8-, vir...
Source: Herpes - July 29, 2023 Category: Infectious Diseases Authors: Maria Korom Hong Wang Kaelin M Bernier Brian J Geiss Lynda A Morrison Source Type: research
A Trivalent HSV-2 gC2, gD2, gE2 Nucleoside-Modified mRNA-LNP Vaccine Provides Outstanding Protection in Mice against Genital and Non-Genital HSV-1 Infection, Comparable to the Same Antigens Derived from HSV-1
Viruses. 2023 Jun 30;15(7):1483. doi: 10.3390/v15071483.ABSTRACTHSV-1 disease is a significant public health burden causing orofacial, genital, cornea, and brain infection. We previously reported that a trivalent HSV-2 gC2, gD2, gE2 nucleoside-modified mRNA-lipid nanoparticle (LNP) vaccine provides excellent protection against vaginal HSV-1 infection in mice. Here, we evaluated whether this HSV-2 gC2, gD2, gE2 vaccine is as effective as a similar HSV-1 mRNA LNP vaccine containing gC1, gD1, and gE1 in the murine lip and genital infection models. Mice were immunized twice with a total mRNA dose of 1 or 10 µg. The two vaccin...
Source: Herpes - July 29, 2023 Category: Infectious Diseases Authors: Kevin P Egan Sita Awasthi Giulia Tebaldi Lauren M Hook Alexis M Naughton Bernard T Fowler Mitchell Beattie Mohamad-Gabriel Alameh Drew Weissman Gary H Cohen Harvey M Friedman Source Type: research
Recurrent Genital Herpes Triggering Ulcerative Pyoderma Gangrenosum
Cureus. 2023 Jun 25;15(6):e40953. doi: 10.7759/cureus.40953. eCollection 2023 Jun.ABSTRACTPyoderma gangrenosum (PG) is a neutrophilic dermatosis that presents as painful, rapidly growing skin ulcers with undermined edges and a violaceous, ragged border at the periphery and is non-responsive to conventional treatments. The average onset age is in the fourth decade, with a female preponderance. Genital PG is uncommon and may present singly or coexist with common sexually transmitted genital ulcerative diseases, which causes delays in the diagnosis and treatment of genital PG, thereby adding to the morbidity. Here, we highlig...
Source: Herpes - July 28, 2023 Category: Infectious Diseases Authors: Shreya Deoghare Shailya Gupta Devayani Pol Anuja Masare Ajay Kumar Source Type: research
