Anti-herpes simplex virus activities and mechanisms of marine derived compounds
Herpes simplex virus (HSV) is the most widely prevalent herpes virus worldwide, and the herpetic encephalitis and genital herpes caused by HSV infection have caused serious harm to human health all over the world. Although many anti-HSV drugs such as nucleoside analogues have been ap-proved for clinical use during the past few decades, important issues, such as drug resistance, toxicity, and high cost of drugs, remain unresolved. Recently, the studies on the anti-HSV activities of marine natural products, such as marine polysaccharides, marine peptides and microbial secondary metabolites are attracting more and more attent...
Source: Frontiers in cellular and infection microbiology - January 8, 2024 Category: Microbiology Source Type: research
Global, regional, and national burden of HIV and other sexually transmitted infections in older adults aged 60-89 years from 1990 to 2019: results from the Global Burden of Disease Study 2019
Lancet Healthy Longev. 2024 Jan;5(1):e17-e30. doi: 10.1016/S2666-7568(23)00214-3.ABSTRACTBACKGROUND: Sexually active older adults are often more susceptible to HIV and other sexually transmitted infections (STIs) due to various health conditions (especially a weakened immune system) and low use of condoms. We aimed to assess the global, regional, and national burdens and trends of HIV and other STIs in older adults from 1990 to 2019.METHODS: We retrieved data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 on the incidence and disability-adjusted life-years (DALYs) of HIV and other STIs (syp...
Source: Herpes - January 6, 2024 Category: Infectious Diseases Authors: Leiwen Fu Tian Tian Bingyi Wang Zhen Lu Junye Bian Weijie Zhang Xinsheng Wu Xinyi Li Richard C Siow Evandro Fei Fang Na He Huachun Zou Source Type: research
Sexually and non ‐sexually transmitted infections and the risk of prostate cancer: Results from the EPICAP study
ConclusionOur results showed that sexually or non-sexually transmitted infections, either bacterial or viral, were not associated to prostate cancer. Therefore, further investigation is needed to help advance our understanding of the role of chronic inflammation in the etiology of prostate cancer, with a particular focus on its most aggressive types. (Source: Cancer Medicine)
Source: Cancer Medicine - January 4, 2024 Category: Cancer & Oncology Authors: Melissa Sawaya,
Emilie Cordina ‐Duverger,
Pierre‐Jean Lamy,
Xavier Rébillard,
Brigitte Trétarre,
Florence Menegaux Tags: RESEARCH ARTICLE Source Type: research
Sexually and non-sexually transmitted infections and the risk of prostate cancer: Results from the EPICAP study
CONCLUSION: Our results showed that sexually or non-sexually transmitted infections, either bacterial or viral, were not associated to prostate cancer. Therefore, further investigation is needed to help advance our understanding of the role of chronic inflammation in the etiology of prostate cancer, with a particular focus on its most aggressive types.PMID:38174802 | DOI:10.1002/cam4.6841 (Source: Cancer Control)
Source: Cancer Control - January 4, 2024 Category: Cancer & Oncology Authors: Melissa Sawaya Emilie Cordina-Duverger Pierre-Jean Lamy Xavier R ébillard Brigitte Tr étarre Florence Menegaux Source Type: research
Sexually and non-sexually transmitted infections and the risk of prostate cancer: Results from the EPICAP study
CONCLUSION: Our results showed that sexually or non-sexually transmitted infections, either bacterial or viral, were not associated to prostate cancer. Therefore, further investigation is needed to help advance our understanding of the role of chronic inflammation in the etiology of prostate cancer, with a particular focus on its most aggressive types.PMID:38174802 | DOI:10.1002/cam4.6841 (Source: Herpes)
Source: Herpes - January 4, 2024 Category: Infectious Diseases Authors: Melissa Sawaya Emilie Cordina-Duverger Pierre-Jean Lamy Xavier R ébillard Brigitte Tr étarre Florence Menegaux Source Type: research
Herpes Simplex Virus 1 (HSV-1) Uses the Rab6 Post-Golgi Secretory Pathway For Viral Egress
In this study, we used fluorescence microscopy to visualize individual virus particles exiting from cells, and found that HSV-1 particles use the pre-existing cellular secretory pathway, regulated by the cellular protein, Rab6.PMID:38168379 | PMC:PMC10760111 | DOI:10.1101/2023.12.13.571414 (Source: Herpes)
Source: Herpes - January 3, 2024 Category: Infectious Diseases Authors: Melissa H Bergeman Kimberly Velarde Honor L Glenn Ian B Hogue Source Type: research
Orogenital and anal infection by < em > Chlamydia trachomatis < /em > , < em > Neisseria gonorrhoeae < /em > , < em > Mycoplasma genitalium < /em > , and other sexually transmitted infections in men who have sex with men in Lisbon
CONCLUSION: The substantial extragenital prevalence of bacterial STIs in MSM, and HIV and syphilis coinfections, suggest screening has value in identifying hidden carriage and in contributing for providing better care.PMID:38166231 | DOI:10.1177/09564624231221591 (Source: Herpes)
Source: Herpes - January 2, 2024 Category: Infectious Diseases Authors: Corrado Minetti Miguel Rocha Lu ís Miguel Duque Paula Meireles Cristina Correia Dora Cordeiro In ês João Carla Manita Sofia Soeiro Jo ão Almeida Santos Rita Matos Catarina Almeida Helena Cortes Martins Elsa Vinagre S ílvia Lopo Maria Jos é Borrego Source Type: research
Orogenital and anal infection by < em > Chlamydia trachomatis < /em > , < em > Neisseria gonorrhoeae < /em > , < em > Mycoplasma genitalium < /em > , and other sexually transmitted infections in men who have sex with men in Lisbon
CONCLUSION: The substantial extragenital prevalence of bacterial STIs in MSM, and HIV and syphilis coinfections, suggest screening has value in identifying hidden carriage and in contributing for providing better care.PMID:38166231 | DOI:10.1177/09564624231221591 (Source: Herpes)
Source: Herpes - January 2, 2024 Category: Infectious Diseases Authors: Corrado Minetti Miguel Rocha Lu ís Miguel Duque Paula Meireles Cristina Correia Dora Cordeiro In ês João Carla Manita Sofia Soeiro Jo ão Almeida Santos Rita Matos Catarina Almeida Helena Cortes Martins Elsa Vinagre S ílvia Lopo Maria Jos é Borrego Source Type: research
The causal association between COVID-19 and herpes simplex virus: a Mendelian randomization study
This study utilized a Mendelian randomization (MR) approach for causality assessment between COVID-19 infection and HSV infection based on the latest public health data and Genome-Wide Association Study (GWAS) data. Multiple causal estimation methods, such as IVW, weighted median, simple mode, and weighted mode, were employed to validate the causal relation between COVID-19 infection and HSV infection, with COVID-19 infection, COVID-19 hospitalization, and severe COVID-19 as exposures, and HSV1/2 infection as the outcome. A reverse MR analysis was subsequently performed.RESULTS: MR analysis exhibited that COVID-19 infectio...
Source: Herpes - December 26, 2023 Category: Infectious Diseases Authors: Ming Yan Li-Yuan Xiao Martin Gosau Reinhard E Friedrich Ralf Smeets Ling-Ling Fu Hong-Chao Feng Simon Burg Source Type: research
The causal association between COVID-19 and herpes simplex virus: a Mendelian randomization study
This study utilized a Mendelian randomization (MR) approach for causality assessment between COVID-19 infection and HSV infection based on the latest public health data and Genome-Wide Association Study (GWAS) data. Multiple causal estimation methods, such as IVW, weighted median, simple mode, and weighted mode, were employed to validate the causal relation between COVID-19 infection and HSV infection, with COVID-19 infection, COVID-19 hospitalization, and severe COVID-19 as exposures, and HSV1/2 infection as the outcome. A reverse MR analysis was subsequently performed.RESULTS: MR analysis exhibited that COVID-19 infectio...
Source: Herpes - December 26, 2023 Category: Infectious Diseases Authors: Ming Yan Li-Yuan Xiao Martin Gosau Reinhard E Friedrich Ralf Smeets Ling-Ling Fu Hong-Chao Feng Simon Burg Source Type: research
The Global Burden of STIs
Clin Dermatol. 2023 Dec 22:S0738-081X(23)00254-7. doi: 10.1016/j.clindermatol.2023.12.002. Online ahead of print.ABSTRACTUnderstanding the global burden of STIs is fundamental to being able to address and control these infections and the health harms they cause. The WHO has renewed its global health sector strategy for the prevention and control of sexually transmitted infections. Reducing STIs remains an integral part of HIV prevention and of sexual and reproductive health programs. Data to measure and describe the global burden continue to improve with systematic reviews and modelling providing global and regional data f...
Source: Herpes - December 24, 2023 Category: Infectious Diseases Authors: Katy Sinka Source Type: research
Flavonoids with Anti-Herpes Simplex Virus Properties: Deciphering Their Mechanisms in Disrupting the Viral Life Cycle
Viruses. 2023 Nov 29;15(12):2340. doi: 10.3390/v15122340.ABSTRACTThe herpes simplex virus (HSV) is a double-stranded DNA human virus that causes persistent infections with recurrent outbreaks. HSV exists in two forms: HSV-1, responsible for oral herpes, and HSV-2, primarily causing genital herpes. Both types can lead to significant complications, including neurological issues. Conventional treatment, involving acyclovir and its derivatives, faces challenges due to drug resistance. This underscores the imperative for continual research and development of new drugs, with a particular emphasis on exploring the potential of na...
Source: Herpes - December 23, 2023 Category: Infectious Diseases Authors: Miroslava Šudomová Sherif T S Hassan Source Type: research
Flavonoids with Anti-Herpes Simplex Virus Properties: Deciphering Their Mechanisms in Disrupting the Viral Life Cycle
Viruses. 2023 Nov 29;15(12):2340. doi: 10.3390/v15122340.ABSTRACTThe herpes simplex virus (HSV) is a double-stranded DNA human virus that causes persistent infections with recurrent outbreaks. HSV exists in two forms: HSV-1, responsible for oral herpes, and HSV-2, primarily causing genital herpes. Both types can lead to significant complications, including neurological issues. Conventional treatment, involving acyclovir and its derivatives, faces challenges due to drug resistance. This underscores the imperative for continual research and development of new drugs, with a particular emphasis on exploring the potential of na...
Source: Herpes - December 23, 2023 Category: Infectious Diseases Authors: Miroslava Šudomová Sherif T S Hassan Source Type: research
Screening and verification of antiviral compounds against HSV-1 using a method based on a plaque inhibition assay
CONCLUSIONS: Our findings suggest that these five compounds have potential antiviral properties against HSV-1 and may have different mechanisms of action. Further studies are warranted to elucidate the antiviral mechanisms of these compounds and to explore their therapeutic potential for HSV-1 infection.PMID:38114935 | DOI:10.1186/s12879-023-08843-3 (Source: Herpes)
Source: Herpes - December 20, 2023 Category: Infectious Diseases Authors: Yingxian Yin Jiahui Li Ling Su Zhiying Ou Qingqun Lv Misi Xiao Changbing Wang Dan Zeng Yiling Gu Fengxia Yang Minxia Chen Shaojuan Feng Wanming Hu Fengling Bu Bing Zhu Yi Xu Source Type: research
Screening and verification of antiviral compounds against HSV-1 using a method based on a plaque inhibition assay
CONCLUSIONS: Our findings suggest that these five compounds have potential antiviral properties against HSV-1 and may have different mechanisms of action. Further studies are warranted to elucidate the antiviral mechanisms of these compounds and to explore their therapeutic potential for HSV-1 infection.PMID:38114935 | PMC:PMC10731695 | DOI:10.1186/s12879-023-08843-3 (Source: Herpes)
Source: Herpes - December 20, 2023 Category: Infectious Diseases Authors: Yingxian Yin Jiahui Li Ling Su Zhiying Ou Qingqun Lv Misi Xiao Changbing Wang Dan Zeng Yiling Gu Fengxia Yang Minxia Chen Shaojuan Feng Wanming Hu Fengling Bu Bing Zhu Yi Xu Source Type: research
