Clinical characteristics of neonatal and infant osteomyelitis and septic arthritis: a multicenter retrospective study
CONCLUSION: Distinct differences were found between neonatal and infants with osteoarticular infections. Future studies should focus on improving diagnosis and subsequent treatment regimens for younger age groups.PMID:38642591 | DOI:10.1016/j.jped.2024.03.003 (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - April 20, 2024 Category: Pediatrics Authors: Keming Sun Chunxu Zhang Ziwen Mao Chen Wang Hua Zhu Huiqing Sun Kang Wang Weyland Cheng Source Type: research
Clinical characteristics of neonatal and infant osteomyelitis and septic arthritis: a multicenter retrospective study
CONCLUSION: Distinct differences were found between neonatal and infants with osteoarticular infections. Future studies should focus on improving diagnosis and subsequent treatment regimens for younger age groups.PMID:38642591 | DOI:10.1016/j.jped.2024.03.003 (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - April 20, 2024 Category: Pediatrics Authors: Keming Sun Chunxu Zhang Ziwen Mao Chen Wang Hua Zhu Huiqing Sun Kang Wang Weyland Cheng Source Type: research
Effects of p-coumaric acid on probiotic properties of Lactobacillus acidophilus LA-5 and lacticaseibacillus rhamnosus GG
Arch Microbiol. 2024 Apr 20;206(5):223. doi: 10.1007/s00203-024-03957-x.ABSTRACTProbiotics are defined as "live microorganisms that provide health benefits to the host when administered in adequate amounts." Probiotics have beneficial effects on human health, including antibacterial activity against intestinal pathogens, regulation of blood cholesterol levels, reduction of colitis and inflammation incidence, regulation of the immune system, and prevention of colon cancer. In addition to probiotic bacteria, some phenolic compounds found in foods we consume (both food and beverages) have positive effects on human health. p-c...
Source: Archives of Microbiology - April 20, 2024 Category: Microbiology Authors: Buse Nur Derebasi Sena Davran Bulut Busra Aksoy Erden Nastaran Sadeghian Parham Taslimi Hasan Ufuk Celebioglu Source Type: research
Clinical characteristics of neonatal and infant osteomyelitis and septic arthritis: a multicenter retrospective study
CONCLUSION: Distinct differences were found between neonatal and infants with osteoarticular infections. Future studies should focus on improving diagnosis and subsequent treatment regimens for younger age groups.PMID:38642591 | DOI:10.1016/j.jped.2024.03.003 (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - April 20, 2024 Category: Pediatrics Authors: Keming Sun Chunxu Zhang Ziwen Mao Chen Wang Hua Zhu Huiqing Sun Kang Wang Weyland Cheng Source Type: research
JAK1/2 Regulates Synergy Between Interferon Gamma and Lipopolysaccharides in Microglia
AbstractMicroglia, the resident immune cells of the brain, regulate neuroinflammation which can lead to secondary neuronal damage and cognitive impairment under pathological conditions. Two of the many molecules that can elicit an inflammatory response from microglia are lipopolysaccharide (LPS), a component of gram-negative bacteria, and interferon gamma (IFN γ), an endogenous pro-inflammatory cytokine. We thoroughly examined the concentration-dependent relationship between LPS from multiple bacterial species and IFNγ in cultured microglia and macrophages. We measured the effects that these immunostimulatory molecules h...
Source: Journal of NeuroImmune Pharmacology - April 20, 2024 Category: Drugs & Pharmacology Source Type: research
Freshly Prepared Graphene Oxide Nanoparticles ’ Wound-Healing Potential and Antibacterial Activity Specifically Against Staphylococcus aureus: In Vivo Efficacy and Clinical Isolate Evaluation
AbstractGraphene oxide (GO) exhibits several characteristics worthy of biomedical applications. The current study aimed to synthesize graphene oxide nanoparticles (GONPs) for antibacterial and wound-healing efficacy evaluations. The GONPs were prepared using Hummer ’s method and characterized by FT-IR, UV-Vis, Raman, SEM spectroscopic, and electron micrograph-based analyses, respectively, to confirm the structure and morphology. The analyses revealed GONPs as flaky, nano-sheeted structures with irregular shapes and sizes that were stacked on top of each othe r. The clinical isolates of gram-negative, i.e.,Escherichia col...
Source: Plasmonics - April 20, 2024 Category: Biomedical Science Source Type: research
Volume expansion mitigates Shiga toxin-producing E. coli-hemolytic uremic syndrome in children
ConclusionsThis study suggests that volume expansion may be associated with the mitigation of the acute course of STEC-HUS, especially severe neurological involvement and the development of CKD. Prospective trials should lead to standardized protocols for volume expansion in children with STEC-HUS.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - April 19, 2024 Category: Urology & Nephrology Source Type: research
Current understanding and knowledge gaps regarding wildlife as reservoirs of antimicrobial resistance
Am J Vet Res. 2024 Apr 22:1-9. doi: 10.2460/ajvr.24.02.0040. Online ahead of print.ABSTRACTAntimicrobial resistance (AMR) is a serious health issue shared across all One Health domains. Wildlife species represent a key intersection of the animal and environmental domains. They are a relevant but understudied reservoir and route of spread for AMR throughout the environment. Most wildlife AMR research thus far has focused on avian species, terrestrial mammals, and a selection of aquatic and marine species. Pathogens often identified in terrestrial wildlife include enteric zoonotic organisms such as Eschericia coli and Salmon...
Source: American Journal of Veterinary Research - April 19, 2024 Category: Veterinary Research Authors: Neil Vezeau Laura Kahn Source Type: research
Current understanding and knowledge gaps regarding wildlife as reservoirs of antimicrobial resistance
Am J Vet Res. 2024 Apr 22:1-9. doi: 10.2460/ajvr.24.02.0040. Online ahead of print.ABSTRACTAntimicrobial resistance (AMR) is a serious health issue shared across all One Health domains. Wildlife species represent a key intersection of the animal and environmental domains. They are a relevant but understudied reservoir and route of spread for AMR throughout the environment. Most wildlife AMR research thus far has focused on avian species, terrestrial mammals, and a selection of aquatic and marine species. Pathogens often identified in terrestrial wildlife include enteric zoonotic organisms such as Eschericia coli and Salmon...
Source: American Journal of Veterinary Research - April 19, 2024 Category: Veterinary Research Authors: Neil Vezeau Laura Kahn Source Type: research
Preparation and brain targeting effects study of recombinant human ferritin nanoparticles
This study aims to utilize a prokaryotic expression system to produce recombinant human heavy-chain ferritin nanoparticles and investigate their targeting ability in brain tissue. The human heavy-chain ferritin gene was cloned into the prokaryotic expression vector pET28a and transformed into Escherichia coli BL21 (DE3) competent cells to explore optimal expression conditions. The recombinant protein was then purified to evaluate its immunoreactivity and characteristics. Additionally, the distribution of the administered protein in normal mice and its permeability in an in vitro blood-brain barrier (BBB) model were measure...
Source: Biochemical and Biophysical Research communications - April 19, 2024 Category: Biochemistry Authors: Zhixian Wang Xiaoling Xu Yunhuan Zhu Yuncheng Qian Yilu Feng Hongyu Li Guoheng Hu Source Type: research
Virulence, antibiotic resistance phenotypes and molecular characterisation of Vibrio furnissii isolates from patients with diarrhoea
Vibrio furnissii is an emerging human pathogen closely related to V. fluvialis that causes acute gastroenteritis. V. furnissii infection has been reported to be rarer than V. fluvialis, but a multi-drug resistanc... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - April 19, 2024 Category: Infectious Diseases Authors: Yanyan Zhou, Li Yu, Ming Liu, Weili Liang, Zhenpeng Li, Zheng Nan and Biao Kan Tags: Research Source Type: research
Design of a multi-epitope-based vaccine candidate against Bovine Genital Campylobacteriosis using a reverse vaccinology approach
Bovine Genital Campylobacteriosis (BGC), a worldwide distributed venereal disease caused by Campylobacter fetus subsp. venerealis (Cfv), has a relevant negative economic impact in cattle herds. The control of BGC... (Source: BMC Veterinary Research)
Source: BMC Veterinary Research - April 19, 2024 Category: Veterinary Research Authors: Marta Filipa Silva, Gon çalo Pereira, Luísa Mateus, Luís Lopes da Costa and Elisabete Silva Tags: Research Source Type: research
Molecules, Vol. 29, Pages 1861: A Study on the Efficient Preparation of & alpha;-Ketoglutarate with L-Glutamate Oxidase
Molecules, Vol. 29, Pages 1861: A Study on the Efficient Preparation of α-Ketoglutarate with L-Glutamate Oxidase
Molecules doi: 10.3390/molecules29081861
Authors:
Shuhui Niu
Fang Liu
Yaping Wang
Ben Rao
Yueying Wang
Alpha-ketoglutaric acid (α-KG), as an intermediate product of the tricarboxylic acid cycle, plays a crucial role in peptide and amino acid synthesis. In order to reduce costs and improve efficiency in the oxidative production of α-ketoglutaric acid, this study successfully synthesized and expressed L-glutamate oxidase (LGOXStr) from Streptomyces viridosporus...
Source: Molecules - April 19, 2024 Category: Chemistry Authors: Shuhui Niu Fang Liu Yaping Wang Ben Rao Yueying Wang Tags: Article Source Type: research
Characterization of diarrheagenic Escherichia coli from different cattle production systems in Brazil
This study aimed to characterize the distribution of DEC [Shiga toxin-producing E. coli (STEC), enteroinvasive E. coli (EIEC), enteropathogenic E. coli (EPEC), enterotoxigenic E. coli (ETEC), and enteroaggregative E. coli (EAEC)] from extensive and intensive cattle production systems in Brazil. Samples (n = 919) were collected from animal feces (n = 200), carcasses (n = 600), meat cuts (n = 90), employee feces (n = 9), and slaughterhouse water (n = 20). Virulence genes were detected by PCR in 10% of animal samples (94/919), with STEC (n = 81) as the higher prevalence, followed by EIEC (n = 8), and lastly EPEC (n = 5). Anim...
Source: Food Microbiology - April 18, 2024 Category: Food Science Authors: Rafaela de Melo Tavares Mallu Jagnow Sereno Aryele Nunes da Cruz Encide Sampaio Juliano Gon çalves Pereira Luciano Dos Santos Bersot Ricardo Seiti Yamatogi Douglas Ruben Call Lu ís Augusto Nero Source Type: research
Survival of O157 and non-O157 shiga toxin-producing Escherichia coli in Korean style kimchi
Food Microbiol. 2024 Aug;121:104526. doi: 10.1016/j.fm.2024.104526. Epub 2024 Mar 30.ABSTRACTKorean style kimchi contaminated with Shiga toxin-producing Escherichia coli (STEC) O157:H7 was the cause of an outbreak in Canada from December 2021 to January 2022. To determine if this STEC O157:H7 has greater potential for survival in kimchi than other STEC, the outbreak strain and six other STEC strains (O26:H11, O91:H21, O103:H2, O121:H19, and two O157:H7) were inoculated individually at 6 to 6.5 log CFU/g into commercially sourced kimchi and incubation at 4 °C. At intervals of seven days inoculated and control kimchi was pl...
Source: Food Microbiology - April 18, 2024 Category: Food Science Authors: Alexander Gill Tanis McMahon Christina Ferrato Linda Chui Source Type: research
