Detection of OXA-181 Carbapenemase in Shigella flexneri
We report the detection of OXA-181 carbapenemase in an azithromycin-resistant Shigella spp. bacteria in an immunocompromised patient. The emergence of OXA-181 in Shigella spp. bacteria raises concerns about the global dissemination of carbapenem resistance in Enterobacterales and its implications for the treatment of infections caused by Shigella bacteria.PMID:38666725 | DOI:10.3201/eid3005.231558 (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - April 26, 2024 Category: Infectious Diseases Authors: Ghulam Dhabaan Hassan Jamal Danielle Ouellette Sarah Alexander Karen Arane Aaron Campigotto Manal Tadros Pierre-Philippe Pich é-Renaud Source Type: research
Economic Burden of Acute Gastroenteritis among Members of Integrated Healthcare Delivery System, United States, 2014-2016
Emerg Infect Dis. 2024 May;30(5):968-973. doi: 10.3201/eid3005.230356.ABSTRACTWe conducted a large surveillance study among members of an integrated healthcare delivery system in Pacific Northwest of the United States to estimate medical costs attributable to medically attended acute gastroenteritis (MAAGE) on the day care was sought and during 30-day follow-up. We used multivariable regression to compare costs of MAAGE and non-MAAGE cases matched on age, gender, and index time. Differences accounted for confounders, including race, ethnicity, and history of chronic underlying conditions. Analyses included 73,140 MAAGE epi...
Source: Emerging Infectious Diseases - April 26, 2024 Category: Infectious Diseases Authors: John F Dickerson Suzanne B Salas Judy Donald Holly C Groom Mi H Lee Claire P Mattison Aron J Hall Mark A Schmidt Source Type: research
Antimicrobial Resistance as Risk Factor for Recurrent Bacteremia after Staphylococcus aureus, Escherichia coli, or Klebsiella spp. Community-Onset Bacteremia
Emerg Infect Dis. 2024 May;30(5):974-983. doi: 10.3201/eid3005.231555.ABSTRACTWe investigated links between antimicrobial resistance in community-onset bacteremia and 1-year bacteremia recurrence by using the clinical data warehouse of Europe's largest university hospital group in France. We included adult patients hospitalized with an incident community-onset Staphylococcus aureus, Escherichia coli, or Klebsiella spp. bacteremia during 2017-2019. We assessed risk factors of 1-year recurrence using Fine-Gray regression models. Of the 3,617 patients included, 291 (8.0%) had >1 recurrence episode. Third-generation cephalo...
Source: Emerging Infectious Diseases - April 26, 2024 Category: Infectious Diseases Authors: Salam Abbara Didier Guillemot David R M Smith Salma El Oualydy Maeva Kos C écile Poret St éphane Breant Christian Brun-Buisson Laurence Watier Source Type: research
An Assessment of a New Rapid Multiplex PCR Assay for the Diagnosis of Meningoencephalitis
Conclusions: A high correlation of the QIAstat-Dx ME panel with reference methods was shown. QIAstat-Dx ME is a rapid-PCR technique to be applied in patients with suspected ME with a high accuracy.PMID:38667448 | DOI:10.3390/diagnostics14080802 (Source: Herpes)
Source: Herpes - April 26, 2024 Category: Infectious Diseases Authors: Genoveva Cuesta Pedro Puerta-Alcalde Andrea Vergara Enric Roses Jordi Bosch Climent Casals-Pascual Alex Soriano M ª Ángeles Marcos Sergi Sanz Jordi Vila Source Type: research
Microbial Features Linked to Medication Strategies in Cardiometabolic Disease Management
ACS Pharmacol Transl Sci. 2024 Feb 5;7(4):991-1001. doi: 10.1021/acsptsci.3c00261. eCollection 2024 Apr 12.ABSTRACTHuman gut microbiota are recognized as critical players in both metabolic disease and drug metabolism. However, medication-microbiota interactions in cardiometabolic diseases are not well understood. To gain a comprehensive understanding of how medication intake impacts the gut microbiota, we investigated the association of microbial structure with the use of single or multiple medications in a cohort of 134 middle-aged adults diagnosed with cardiometabolic disease, recruited from Alberta's Tomorrow Project. P...
Source: Cancer Control - April 26, 2024 Category: Cancer & Oncology Authors: Jane Shearer Shrushti Shah Grace Shen-Tu Kristina Schlicht Matthias Laudes Chunlong Mu Source Type: research
Short reads-based characterization of pathotype diversity and drug resistance among Escherichia coli isolated from patients attending regional referral hospitals in Tanzania
Escherichia coli is known to cause about 2 million deaths annually of which diarrhea infection is leading and typically occurs in children under 5 years old. Although Africa is the most affected region there is l... (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - April 26, 2024 Category: Genetics & Stem Cells Authors: Livin E. Kanje, Happiness Kumburu, Davis Kuchaka, Mariana Shayo, Masoud A. Juma, Patrick Kimu, Melkiory Beti, Marco van Zwetselaar, Boaz Wadugu, Blandina T. Mmbaga, Sixbert Isdory Mkumbaye and Tolbert Sonda Tags: Research Source Type: research
Molecules, Vol. 29, Pages 2009: Green Preparation and Antibacterial Activity Evaluation of AgNPs-Blumea balsamifera Oil Nanoemulsion
This study aimed to rapidly prepare a new type of green antibacterial nanoemulsion containing silver nanoparticles in one step by using Blumea balsamifera oil (BBO) as an oil phase and tea saponin (TS) as a natural emulsifier and reducing agent. The optimum preparation conditions of the AgNPs@BBO-TS NE were determined, as well as its physicochemical properties and antibacterial activity in vitro being investigated. The results showed that the average particle size of the AgNPs@BBO-TS NE was 249.47 ± 6.23 nm, the PDI was 0.239 ± 0.003, and the zeta potential was −35.82 &pl...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Chunfang Ma Bingnan Liu Lingfeng Du Wei Liu Yue Zhu Teng Chen Zuhua Wang Hongpeng Chen Yuxin Pang Tags: Article Source Type: research
Green Synthesis of Silver Nanoparticles Using Cirsium Congestum Extract Modified by Chitosan/Alginate: Bactericidal Activity against Pathogenic Bacteria and Cytotoxicity Analysis in Normal Cell Line
CONCLUSION: Current findings introduce novel gAgNPs modified with chitosan/alginate for use in medicine.PMID:38661036 | DOI:10.2174/0113816128304460240408085736 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 25, 2024 Category: Drugs & Pharmacology Authors: Mahnaz Mohtasham Alieh Rezagholizade-Shirvan Zahra Hojat Bonab Mohammad Reza Amiryousefi Majid Darroudi Mobina Sadat Ahmadi Solimani Sajad Yaghoobi Samaneh Dolatabadi Ahmad Ghasemi Amir Abbas Momtazi-Borojeni Source Type: research
Novel small multidrug resistance protein Tmt endows the Escherichia coli with triphenylmethane dyes bioremediation capability
Biotechnol Lett. 2024 Apr 25. doi: 10.1007/s10529-024-03480-5. Online ahead of print.ABSTRACTDye contamination in printing and dyeing wastewater has long been a major concern due to its serious impact on both the environment and human health. In the quest for bioremediation of these hazardous dyes, biological resources such as biodegradation bacteria and enzymes have been investigated in severely polluted environments. In this context, the triphenylmethane transporter gene (tmt) was identified in six distinct clones from a metagenomic library of the printing and dyeing wastewater treatment system. Escherichia coli expressi...
Source: Biotechnology Letters - April 25, 2024 Category: Biotechnology Authors: Zhou Wang Haoqiang Zhou Yilan Cheng Lijin An Dazhong Yan Hongjun Chao Jing Wu Source Type: research
Unveiling Therapeutic Avenues for Crohn's Disease Management: Exploring Inhibitors for Adherent-Invasive Escherichia coli Propanediol Dehydratase
CONCLUSION: Ultimately, the results of this study have revealed five compounds to possess the potential to serve as inhibitors of pduC of AIEC. However, experimental studies are still needed to validate the findings of this study.PMID:38659270 | DOI:10.2174/0115734064295521240227052730 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - April 25, 2024 Category: Chemistry Authors: Mohammed Bourhia Md Eram Hosen Md Omar Faruqe Faria Tasnim Mohamed Taibi Amine Elbouzidi Yousef A Bin Jardan Samir Ibenmoussa Abdeslam Asehraou Source Type: research
Biological effects of vanillic acid, iso-vanillic acid, and orto-vanillic acid as environmental pollutants
This study evaluated the toxicity of VA and its isomers, iso-VA and orto-VA. Firstly, the antimicrobial effect of VA and its isomers iso-VA and orto-VA (in doses of 1000; 100, 10, 1; 0.1; 0.01 mg/L) against Escherichia coli, Sarcina spp., Enterobacter homaechei, Staphylococcus aureus and Candida albicans were identified. The toxic effect and protein degradation potential of VA and its isomers were determined using E. coli grpE:luxCDABE and lac:luxCDABE biosensor strains. However, the genotoxicity and oxidative stress generation were assessed with the E. coli recA:luxCDABE biosensor and E. coli strain. The results showed th...
Source: Ecotoxicology and Environmental Safety - April 25, 2024 Category: Environmental Health Authors: Marzena Matejczyk Piotr Ofman Edyta Juszczuk-Kubiak Renata Świsłocka Wong Ling Shing Kavindra Kumar Kesari Balu Prakash W łodzimierz Lewandowski Source Type: research
Broad-Spectrum Activity of Membranolytic Cationic Macrocyclic Peptides Against Multi-Drug Resistant Bacteria and Fungi
Eur J Pharm Sci. 2024 Apr 23:106776. doi: 10.1016/j.ejps.2024.106776. Online ahead of print.ABSTRACTThe emergence of multidrug-resistant (MDR) strains causes severe problems in the treatment of microbial infections owing to limited treatment options. Antimicrobial peptides (AMPs) are drawing considerable attention as promising antibiotic alternative candidates to combat MDR bacterial and fungal infections. Herein, we present a series of small amphiphilic membrane-active cyclic peptides composed, in part, of various nongenetically encoded hydrophilic and hydrophobic amino acids. Notably, lead cyclic peptides 3b and 4b showe...
Source: European Journal of Pharmaceutical Sciences - April 25, 2024 Category: Drugs & Pharmacology Authors: Sandeep Lohan Anastasia G Konshina Rakesh K Tiwari Roman G Efremov Innokentiy Maslennikov Keykavous Parang Source Type: research
Green Synthesis of Silver Nanoparticles Using Cirsium Congestum Extract Modified by Chitosan/Alginate: Bactericidal Activity against Pathogenic Bacteria and Cytotoxicity Analysis in Normal Cell Line
CONCLUSION: Current findings introduce novel gAgNPs modified with chitosan/alginate for use in medicine.PMID:38661036 | DOI:10.2174/0113816128304460240408085736 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 25, 2024 Category: Drugs & Pharmacology Authors: Mahnaz Mohtasham Alieh Rezagholizade-Shirvan Zahra Hojat Bonab Mohammad Reza Amiryousefi Majid Darroudi Mobina Sadat Ahmadi Solimani Sajad Yaghoobi Samaneh Dolatabadi Ahmad Ghasemi Amir Abbas Momtazi-Borojeni Source Type: research
Combining deep learning and droplet microfluidics for rapid and label-free antimicrobial susceptibility testing of colistin
Biosens Bioelectron. 2024 Apr 16;257:116301. doi: 10.1016/j.bios.2024.116301. Online ahead of print.ABSTRACTEfficient tools for rapid antibiotic susceptibility testing (AST) are crucial for appropriate use of antibiotics, especially colistin, which is now often considered a last resort therapy with extremely drug resistant Gram-negative bacteria. Here, we developed a rapid, easy and miniaturized colistin susceptibility assay based on microfluidics, which allows for culture and high-throughput analysis of bacterial samples. Specifically, a simple microfluidic platform that can easily be operated was designed to encapsulate ...
Source: Biosensors and Bioelectronics - April 25, 2024 Category: Biotechnology Authors: Justine Riti Guillaume Sutra Thierry Naas Herv é Volland St éphanie Simon Karla Perez-Toralla Source Type: research
A dual-channel electrochemical biosensor enables concurrent detection of pathogens and antibiotic resistance
Biosens Bioelectron. 2024 Apr 20;257:116314. doi: 10.1016/j.bios.2024.116314. Online ahead of print.ABSTRACTDiarrheagenic E. coli infections, commonly treated with β-lactam antibiotics, contribute to antibiotic resistance - a pressing public health concern. Rapid monitoring of pathogen antibiotic resistance is vital to combat antimicrobial spread. Current bacterial diagnosis methods identify pathogens or determine antibiotic resistance separately, necessitating multiple assays. There is an urgent need for tools that simultaneously identify infectious agents and their antibiotic resistance at the point of care (POC). We de...
Source: Biosensors and Bioelectronics - April 25, 2024 Category: Biotechnology Authors: Dharanivasan Gunasekaran Irina Rostovsky David Taussig Talya Bar-Am Yariv Wine Neta Sal-Man Sefi Vernick Source Type: research
