Is Propolis a Potential Anti-Obesogenic Agent for Obesity?
AbstractPurpose of ReviewPropolis is a bee product that has been used for thousands of years. The chemical composition and biological activity of propolis, which has been investigated in the twentieth century, may vary according to location. Propolis polyphenols can induce thermogenesis in brown and beige fat tissue via the uncoupled protein-1 and creatinine kinase metabolic pathways. This review provides a comprehensive investigation of the structural and biological properties of propolis and provides insights into their promising potential strategies in body weight management.Recent FindingsBy raising overall energy expe...
Source: Current Nutrition Reports - March 4, 2024 Category: Nutrition Source Type: research
Public expenditure on health care and the incidence of non-communicable diseases (NDCs) in China from 2008 to 2018
Non-communicable diseases (NCDs) are the leading cause of morbidity and mortality globally. WHO estimates state that approximately 41 million people die from NCDs each year, and NCDs account for 74 % of the global deaths [1]. Previously often assumed to be diseases mainly associated with wealthier countries, NCDs are in reality a very important and growing challenge in many low and middle-income countries (LMICs) [2]. The poor, vulnerable and those from socially disadvantaged groups are oft en most likely to be affected by NCDs. (Source: Maturitas)
Source: Maturitas - March 4, 2024 Category: Primary Care Authors: Zhixin Feng, Xiaoting Liu, Wei Yang, David R. Phillips Tags: Original article Source Type: research
Public expenditure on health care and the incidence of non-communicable diseases (NCDs) in China from 2008 to 2018
Non-communicable diseases (NCDs) are the leading cause of morbidity and mortality globally. WHO estimates state that approximately 41 million people die from NCDs each year, and NCDs account for 74 % of the global deaths [1]. Previously often assumed to be diseases mainly associated with wealthier countries, NCDs are in reality a very important and growing challenge in many low and middle-income countries (LMICs) [2]. The poor, vulnerable and those from socially disadvantaged groups are ofte n most likely to be affected by NCDs. (Source: Maturitas)
Source: Maturitas - March 4, 2024 Category: Primary Care Authors: Zhixin Feng, Xiaoting Liu, Wei Yang, David R. Phillips Tags: Original article Source Type: research
Technological innovation, militarization, and environmental change: evidence from BRICS economies
This article incorporates technological innovation, militarization, and environmental change into a unified analytical framework to assess the potential impact of technological progress and defense military expenditure on the environment in BRICS countries. Based on CSD tests, unit root tests, and cointegration tests, this study constructs a CS-ARDL model to examine the long-term and short-term relationships among various variables from 1990 to 2021. The results show that technological innovation, military expenditure, and economic growth can significantly increase ecological footprint in the long run, while in the short t...
Source: Environmental Science and Pollution Research International - March 2, 2024 Category: Environmental Health Authors: Huaijia Zhu Shiwei Chang Bo Chen Source Type: research
P21-activated kinase-1 signaling is required to preserve adipose tissue homeostasis and cardiac function
In this study, we explored the effects of PAK1 deletion on energy balance, adipose tissue homeostasis, and cardiac function utilizing a whole-body PAK1 knockout (PAK1-/-) mouse model. Our findings revealed that body weight differences between PAK1-/- and WT mice emerged at 9 weeks of age, with further increases observed at 12 weeks. Furthermore, PAK1-/- mice displayed increased fat mass and decreased lean mass at 12 weeks, indicating a shift towards adiposity. In conjunction with the increased body weight, PAK1-/- mice had increased food intake and reduced energy expenditure. At a mechanistic level, PAK1 deletion boosted t...
Source: Molecular and Cellular Biochemistry - March 2, 2024 Category: Biochemistry Authors: Marcos Munoz Christopher Solis Maximilian McCann Jooman Park Koreena Rafael-Clyke Shamim A K Chowdhury Yuwei Jiang Paola C Rosas Source Type: research
P21-activated kinase-1 signaling is required to preserve adipose tissue homeostasis and cardiac function
In this study, we explored the effects of PAK1 deletion on energy balance, adipose tissue homeostasis, and cardiac function utilizing a whole-body PAK1 knockout (PAK1-/-) mouse model. Our findings revealed that body weight differences between PAK1-/- and WT mice emerged at 9 weeks of age, with further increases observed at 12 weeks. Furthermore, PAK1-/- mice displayed increased fat mass and decreased lean mass at 12 weeks, indicating a shift towards adiposity. In conjunction with the increased body weight, PAK1-/- mice had increased food intake and reduced energy expenditure. At a mechanistic level, PAK1 deletion boosted t...
Source: Molecular and Cellular Biochemistry - March 2, 2024 Category: Biochemistry Authors: Marcos Munoz Christopher Solis Maximilian McCann Jooman Park Koreena Rafael-Clyke Shamim A K Chowdhury Yuwei Jiang Paola C Rosas Source Type: research
Technological innovation, militarization, and environmental change: evidence from BRICS economies
This article incorporates technological innovation, militarization, and environmental change into a unified analytical framework to assess the potential impact of technological progress and defense military expenditure on the environment in BRICS countries. Based on CSD tests, unit root tests, and cointegration tests, this study constructs a CS-ARDL model to examine the long-term and short-term relationships among various variables from 1990 to 2021. The results show that technological innovation, military expenditure, and economic growth can significantly increase ecological footprint in the long run, while in the short t...
Source: Environmental Science and Pollution Research International - March 2, 2024 Category: Environmental Health Authors: Huaijia Zhu Shiwei Chang Bo Chen Source Type: research
P21-activated kinase-1 signaling is required to preserve adipose tissue homeostasis and cardiac function
In this study, we explored the effects of PAK1 deletion on energy balance, adipose tissue homeostasis, and cardiac function utilizing a whole-body PAK1 knockout (PAK1-/-) mouse model. Our findings revealed that body weight differences between PAK1-/- and WT mice emerged at 9 weeks of age, with further increases observed at 12 weeks. Furthermore, PAK1-/- mice displayed increased fat mass and decreased lean mass at 12 weeks, indicating a shift towards adiposity. In conjunction with the increased body weight, PAK1-/- mice had increased food intake and reduced energy expenditure. At a mechanistic level, PAK1 deletion boosted t...
Source: Molecular and Cellular Biochemistry - March 2, 2024 Category: Biochemistry Authors: Marcos Munoz Christopher Solis Maximilian McCann Jooman Park Koreena Rafael-Clyke Shamim A K Chowdhury Yuwei Jiang Paola C Rosas Source Type: research
3D bioprinted photo crosslinkable GelMA/methylcellulose hydrogel mimicking native corneal model with enhanced in vitro cytocompatibility and sustained keratocyte phenotype for stromal regeneration
Int J Biol Macromol. 2024 Feb 28:130472. doi: 10.1016/j.ijbiomac.2024.130472. Online ahead of print.ABSTRACTCorneal transplantation serves as the standard clinical therapy for serious corneal disorders. However, rejection of grafts, significant expenditures, and most crucially, the global donor shortage, may affect the outcome. Recently, 3D bioprinting using biodegradable polymeric materials has become a suitable method for creating tissue replicas with identical architecture. One such most renowned material is GelMA, for its scaffold's three-dimensional structure, biocompatibility, robust mechanics, and favourable optical...
Source: International Journal of Biological Macromolecules - March 1, 2024 Category: Biochemistry Authors: Renuka Vijayaraghavan Sravanthi Loganathan Ravi Babu Valapa Source Type: research
3D bioprinted photo crosslinkable GelMA/methylcellulose hydrogel mimicking native corneal model with enhanced in vitro cytocompatibility and sustained keratocyte phenotype for stromal regeneration
Int J Biol Macromol. 2024 Feb 28:130472. doi: 10.1016/j.ijbiomac.2024.130472. Online ahead of print.ABSTRACTCorneal transplantation serves as the standard clinical therapy for serious corneal disorders. However, rejection of grafts, significant expenditures, and most crucially, the global donor shortage, may affect the outcome. Recently, 3D bioprinting using biodegradable polymeric materials has become a suitable method for creating tissue replicas with identical architecture. One such most renowned material is GelMA, for its scaffold's three-dimensional structure, biocompatibility, robust mechanics, and favourable optical...
Source: Cell Research - March 1, 2024 Category: Cytology Authors: Renuka Vijayaraghavan Sravanthi Loganathan Ravi Babu Valapa Source Type: research
12-week Dolutegravir treatment marginally reduces energy expenditure but does not increase body weight or alter vascular function in a murine model of Human Immunodeficiency Virus infection
Vascul Pharmacol. 2024 Feb 28:107288. doi: 10.1016/j.vph.2024.107288. Online ahead of print.ABSTRACTCombination antiretroviral therapy (cART) has markedly increased life expectancy in people with HIV (PWH) but has also resulted in an increased prevalence of cardiometabolic disorders, whose etiopathology remains ill-defined. Notably, the respective contribution of cART and HIV-derived proteins to obesity and vascular alterations remain poorly understood. Therefore, we investigated the individual and combined effects of HIV-proteins and of the integrase strand transfer inhibitor Dolutegravir (DTG) on body composition and vas...
Source: Vascular Pharmacology - March 1, 2024 Category: Drugs & Pharmacology Authors: Taylor C Kress Priscilla Ajala Coleton R Jordan James Mintz Rodger MacArthur Simone Kennard Galina Antonova Eric J Belin de Chantem èle Source Type: research
12-week Dolutegravir treatment marginally reduces energy expenditure but does not increase body weight or alter vascular function in a murine model of Human Immunodeficiency Virus infection
Vascul Pharmacol. 2024 Feb 28:107288. doi: 10.1016/j.vph.2024.107288. Online ahead of print.ABSTRACTCombination antiretroviral therapy (cART) has markedly increased life expectancy in people with HIV (PWH) but has also resulted in an increased prevalence of cardiometabolic disorders, whose etiopathology remains ill-defined. Notably, the respective contribution of cART and HIV-derived proteins to obesity and vascular alterations remain poorly understood. Therefore, we investigated the individual and combined effects of HIV-proteins and of the integrase strand transfer inhibitor Dolutegravir (DTG) on body composition and vas...
Source: Vascular Pharmacology - March 1, 2024 Category: Drugs & Pharmacology Authors: Taylor C Kress Priscilla Ajala Coleton R Jordan James Mintz Rodger MacArthur Simone Kennard Galina Antonova Eric J Belin de Chantem èle Source Type: research
End-of-life expenditure on health care for the older population: a scoping review
The existing evidence shows that the pattern of health expenditure differs considerably between people at the end-of-life and people in other periods of their lives. The awareness of these differences, combine... (Source: Health Economics Review)
Source: Health Economics Review - March 1, 2024 Category: Health Management Authors: Ewa Kocot, Azzurra Ferrero, Shibu Shrestha and Katarzyna Dubas-Jak óbczyk Tags: Review Source Type: research
One-Year Medication Treatment Patterns, Healthcare Resource Utilization, and Expenditures for Medicaid Patients with Schizophrenia Starting Oral Atypical Antipsychotic Medication
AbstractOral atypical antipsychotic (OAAP) medications are the most commonly prescribed treatment for the management of schizophrenia symptoms. This retrospective study, using Medicaid claims data (2016 –2020), followed patients for 12 months after initiating OAAP therapy. Study outcomes included OAAP adherence, switching, augmentation, healthcare resource utilization (HRU), and expenditures. All-cause and schizophrenia-related HRU and expenditures were compared between adherent and nonadherent cohorts. Among 13,007 included patients (39.1 ± 12.8 years of age, 57.0% male, 36.1% Black, 31.8% White, 9.7% Hispanic), ...
Source: Administration and Policy in Mental Health and Mental Health Services Research - March 1, 2024 Category: Psychiatry Source Type: research
Graduate Prospects Explain Undergraduate Program Standing in University League Sports Science Tables
Adv Physiol Educ. 2024 Feb 29. doi: 10.1152/advan.00126.2023. Online ahead of print.ABSTRACTUK university undergraduate programs are compared by independent subject-specific rankings (Complete, Guardian, Times), based upon data from National Student Survey, Higher Education Statistics Agency, Universities and Colleges Admissions Service, Research Excellence Framework, and the universities. The sports and exercise science program at University of Glasgow, has steadily risen to currently rank as the top UK program. This investigation aimed to identify the underlying factors that explain this. Therefore, we obtained underlyin...
Source: Adv Physiol Educ - February 29, 2024 Category: Universities & Medical Training Authors: Ole J Kemi Victoria Penpraze Nairn Scobie Niall G MacFarlane Source Type: research
