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Genetic Signatures for Distinguishing Chemo-Sensitive from Chemo-Resistant Responders in Prostate Cancer Patients
This study delves into the expression of drug resistance-associated genes, ABCB1 and CYP1B1, in cancer cells. Employing bioinformatics, we explored the molecular pathways and cascades linked to drug resistance following upregulation of these genes. Samples were obtained from archived prostate cancer patient specimens through pre-treatment biopsies of two categories: good vs. poor responders, with cDNAs synthesized from isolated RNAs subjected to qPCR analysis. The results revealed increased ABCB1 and CYP1B1 expression in tumor samples of the poor responders. Gene enrichment and network analysis associated ABCB1 with ABC tr...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Lemohang Gumenku Mamello Sekhoacha Beynon Abrahams Samson Mashele Aubrey Shoko Ochuko L Erukainure Source Type: research

Quest for a More Accurate Diagnosis of Cellulitis
For most physicians, cellulitis is one of the classic “I know it when I see it” diseases, in which a diagnosis is rendered, antibiotics initiated, and the patient is quickly out of sight and out of mind. Unfortunately, being common and being simple are not the same, and more than one-third of patients suspected to have cellulitis are incorrectly di agnosed. The cumulative burden of misdiagnosis results in unnecessary antibiotic use, hospitalizations, and tremendous health care expenditures. (Source: JAMA Dermatology)
Source: JAMA Dermatology - March 27, 2024 Category: Dermatology Source Type: research

Pulling the trigger: Noncoding RNAs in white adipose tissue browning
AbstractWhite adipose tissue (WAT) serves as the primary site for energy storage and endocrine regulation in mammals, while brown adipose tissue (BAT) is specialized for thermogenesis and energy expenditure. The conversion of white adipocytes to brown-like fat cells, known as browning, has emerged as a promising therapeutic strategy for reversing obesity and its associated co-morbidities. Noncoding RNAs (ncRNAs) are a class of transcripts that do not encode proteins but exert regulatory functions on gene expression at various levels. Recent studies have shed light on the involvement of ncRNAs in adipose tissue development,...
Source: Reviews in Endocrine and Metabolic Disorders - March 26, 2024 Category: Endocrinology Source Type: research

Effect of Ketogenic Diet on Obesity and Other Metabolic Disorders: Narrative Review
Diabetes Metab Syndr Obes. 2024 Mar 21;17:1391-1401. doi: 10.2147/DMSO.S447659. eCollection 2024.ABSTRACTObesity is defined as an abnormal or excessive accumulation of fat that increases the burden of different chronic diseases in the population. It has reached epidemic proportions and is a major risk factor for a variety of diseases, including hypertension, cardiovascular disease, type 2 diabetes, dyslipidaemia, atherosclerosis, and some malignancies. Weight gain is a result of excessive energy intake compared to energy expenditure (energy loss from metabolism and physical exercise). A ketogenic diet has a more useful eff...
Source: Atherosclerosis - March 26, 2024 Category: Cardiology Authors: Temesgen Baylie Tiget Ayelgn Markeshaw Tiruneh Kibur Hunie Tesfa Source Type: research

Evaluating Health Expenditure Trends and Disease Burden in India: A Cost per DALY Approach
(Source: ClinicoEconomics and Outcomes Research)
Source: ClinicoEconomics and Outcomes Research - March 26, 2024 Category: Health Management Tags: ClinicoEconomics and Outcomes Research Source Type: research

What Is the True Impact of Periprosthetic Joint Infection Diagnosis on Mortality?
Mortality is a quality indicator that may affect expenditures. Revisions for periprosthetic joint infection (PJI) are, on average, more expensive and exhibit higher morbidity than aseptic-revisions, though reimbursement is similar. Therefore, we sought to determine: (1) impact on mortality rates of revision total hip (THA) and/or knee (TKA) arthroplasty performed for PJI diagnosis (septic) versus aseptic-revisions, at any point in time, and (2) mortality predictors among PJI patients. (Source: The Journal of Arthroplasty)
Source: The Journal of Arthroplasty - March 26, 2024 Category: Orthopaedics Authors: Jesus M. Villa, Katherine Rajschmir, Shu Lin, Carlos A. Higuera-Rueda Tags: 2023 AAHKS Proceedings Source Type: research

Triglyceride-glucose index predicts type 2 diabetes mellitus more effectively than oral glucose tolerance test-derived insulin sensitivity and secretion markers
Owing to the recent increase in the prevalence of type 2 diabetes mellitus (T2DM) and prediabetes, a rapid rise in the socio-economic burden has been observed. According to the International Diabetes Federation, the global prevalence of diabetes among adults aged 20 –79 years was estimated to be 10.5 % (536.6 million people) in 2021, and the prevalence is projected to increase to approximately 12.2 % (783.2 million) in 2045 [1]. Additionally, global health expenditures related to diabetes are estimated to have reached 966 billion dollars in 2021, and th ey are predicted to rise to 1,054 billion USD by the year 2045...
Source: Diabetes Research and Clinical Practice - March 26, 2024 Category: Endocrinology Authors: Min Jin Lee, Ji Hyun Bae, Ah Reum Khang, Dongwon Yi, Mi Sook Yun, Yang Ho Kang Source Type: research