Cutting back on low-value healthcare practices supports sustainable kidney care
July 2023 marked the hottest month on record, underscoring the urgent need for action on climate change. The imperative to reduce carbon emissions extends to all sectors including healthcare, with it being responsible for 5.5% of global emissions. In decarbonising healthcare, while much attention has focused on greening healthcare infrastructure and procurement, less attention has focused on reducing emissions through demand-side management. An important key element of this is reducing low-value care, given that approximately 20% of global healthcare expenditure is considered low-value. (Source: Kidney International)
Source: Kidney International - March 18, 2024 Category: Urology & Nephrology Authors: Scott McAlister, Valerie A. Luyckx, Andrea K. Viecelli Tags: mini review Source Type: research
Cutting back on low-value health care practices supports sustainable kidney care
July 2023 marked the hottest month on record, underscoring the urgent need for action on climate change. The imperative to reduce carbon emissions extends to all sectors, including health care, with it being responsible for 5.5% of global emissions. In decarbonizing health care, although much attention has focused on greening health care infrastructure and procurement, less attention has focused on reducing emissions through demand-side management. An important key element of this is reducing low-value care, given that ≈20% of global health care expenditure is considered low value. (Source: Kidney International)
Source: Kidney International - March 18, 2024 Category: Urology & Nephrology Authors: Scott McAlister, Valerie A. Luyckx, Andrea K. Viecelli Tags: Mini Review Source Type: research
Irisin delays the onset of type 1 diabetes in NOD mice by enhancing intestinal barrier
This study investigates whether irisin could delay T1D onset by enhancing the colon intestinal barrier. Impaired colon intestinal barriers were observed in newly diagnosed T1D patients and non-obese diabetic (NOD) mice, worsening with age and accompanied by islet inflammation. Using an LPS-induced colonic inflammation model, a dose-dependent impact of LPS on colon cells irisin expression, secretion, and barrier function was revealed. Exogenous irisin demonstrated remarkable effects, mitigating islet insulitis, enhancing energy expenditure, and alleviating autoimmune symptoms by reducing colon intestinal permeability. Singl...
Source: International Journal of Biological Macromolecules - March 17, 2024 Category: Biochemistry Authors: Yujing Sun Yilin Wang Ziang Lin Fuhua Zhang Yan Zhang Tongxin Ren LiNa Wang Qincheng Qiao Mengyang Shen Juncheng Wang Youchen Song Yu Sun Peng Lin Source Type: research
Irisin delays the onset of type 1 diabetes in NOD mice by enhancing intestinal barrier
This study investigates whether irisin could delay T1D onset by enhancing the colon intestinal barrier. Impaired colon intestinal barriers were observed in newly diagnosed T1D patients and non-obese diabetic (NOD) mice, worsening with age and accompanied by islet inflammation. Using an LPS-induced colonic inflammation model, a dose-dependent impact of LPS on colon cells irisin expression, secretion, and barrier function was revealed. Exogenous irisin demonstrated remarkable effects, mitigating islet insulitis, enhancing energy expenditure, and alleviating autoimmune symptoms by reducing colon intestinal permeability. Singl...
Source: International Journal of Biological Macromolecules - March 17, 2024 Category: Biochemistry Authors: Yujing Sun Yilin Wang Ziang Lin Fuhua Zhang Yan Zhang Tongxin Ren LiNa Wang Qincheng Qiao Mengyang Shen Juncheng Wang Youchen Song Yu Sun Peng Lin Source Type: research
Integrating climate resilience with sports, exercise, and public health expenditures on sustainable environment: Evidence from coastal regions of China
Environ Res. 2024 Mar 14:118616. doi: 10.1016/j.envres.2024.118616. Online ahead of print.ABSTRACTThe adoption of environmentally-friendly habits has become more crucial in the present period as a means to mitigate the rate of environmental degradation and its detrimental consequences. The augmentation of sports, exercise and physical activities has been associated with favourable health outcomes, in addition to the ability to mitigate carbon emissions resulting from vehicular transportation. Consequently, the objective of this study is to examine the influence of sports, exercise, and physical activities, along with publi...
Source: Environmental Research - March 16, 2024 Category: Environmental Health Authors: Bo Li Source Type: research
Integrating climate resilience with sports, exercise, and public health expenditures on sustainable environment: Evidence from coastal regions of China
Environ Res. 2024 Mar 14:118616. doi: 10.1016/j.envres.2024.118616. Online ahead of print.ABSTRACTThe adoption of environmentally-friendly habits has become more crucial in the present period as a means to mitigate the rate of environmental degradation and its detrimental consequences. The augmentation of sports, exercise and physical activities has been associated with favourable health outcomes, in addition to the ability to mitigate carbon emissions resulting from vehicular transportation. Consequently, the objective of this study is to examine the influence of sports, exercise, and physical activities, along with publi...
Source: Environmental Research - March 16, 2024 Category: Environmental Health Authors: Bo Li Source Type: research
Budget impact analyses for treatment of heart failure. A systematic review
This study aims to systemically review the budget impact analysis of heart failure treatments on health care expenditure worldwide. Scientific databases such as PubMed, Web of Science, Scopus, and Google Scholar were searched for budget impact analysis and heart failure treatments, over January 2001 to August 2023. The quality assessment of the selected studies was evaluated through ISPOR practice guideline. Nineteen studies were included in this systematic review. Based on ISPOR recommendations, most studies were performed on a 1-year time horizon and used a government (public health) or health system perspective. Data...
Source: Heart Failure Reviews - March 16, 2024 Category: Cardiology Source Type: research
The economic effect of financial compensation in China ’s healthcare system: comprehensive insights regarding supply and demand factors
We aim to analyse the effects of government subsidies on residents ’ health and healthcare expenditure from the perspectives of supply and demand. (Source: Health Economics Review)
Source: Health Economics Review - March 16, 2024 Category: Health Management Authors: Yi Guo, Xuezhi Hong, Dongmei Li, Qiannan An, Wenwen Fan, Minghe Yang and Luyang Xiao Tags: Research Source Type: research
Governing principles of transcriptional logic out of equilibrium
Biophys J. 2024 Mar 14:S0006-3495(24)00185-1. doi: 10.1016/j.bpj.2024.03.020. Online ahead of print.ABSTRACTTo survive, adapt, and develop, cells respond to external and internal stimuli, by tightly regulating transcription. Transcriptional regulation involves the combinatorial binding of a repertoire of transcription factors (TFs) to DNA, which often results in switch-like binary outputs, akin to Boolean logic gates. Recent experimental studies have demonstrated that in eukaryotes, transcription factor binding to DNA often involves energy expenditure, thereby driving the system out of equilibrium. The governing principles...
Source: Biophysical Journal - March 15, 2024 Category: Physics Authors: Smruti Dixit Teije C Middelkoop Sandeep Choubey Source Type: research
SEA 2024 Standards for Global Control of Vascular Risk
Clin Investig Arterioscler. 2024 Mar 14:S0214-9168(24)00017-2. doi: 10.1016/j.arteri.2024.02.001. Online ahead of print.ABSTRACTOne of the objectives of the Spanish Society of Arteriosclerosis is to contribute to the knowledge, prevention and treatment of vascular diseases, which are the leading cause of death in Spain and entail a high degree of disability and health expenditure. Atherosclerosis is a multifactorial disease and its prevention requires a global approach that takes into account the associated risk factors. This document summarises the current evidence and includes recommendations for patients with establishe...
Source: Atherosclerosis - March 15, 2024 Category: Cardiology Authors: Jos é María Mostaza Xavier Pint ó Pedro Armario Luis Masana Jos é T Real Pedro Valdivielso Teresa Arrobas-Velilla Ram ón Baeza-Trinidad Pilar Calmarza Jes ús Cebollada Miguel Civera-Andr és Jos é I Cuende Melero Jos é L Díaz-Díaz Javier Esp íl Source Type: research
Novel mechanisms involved in leptin sensitization in obesity
Biochem Pharmacol. 2024 Mar 13:116129. doi: 10.1016/j.bcp.2024.116129. Online ahead of print.ABSTRACTLeptin is a hormone that is secreted by adipocytes in proportion to adipose tissue size, and that informs the brain about the energy status of the body. Leptin acts through its receptor LepRb, expressed mainly in the hypothalamus, and induces a negative energy balance by potent inhibition of feeding and activation of energy expenditure. These actions have led to huge expectations for the development of therapeutic targets for metabolic complications based on leptin-derived compounds. However, the majority of patients with o...
Source: Biochemical Pharmacology - March 15, 2024 Category: Drugs & Pharmacology Authors: Veronica Pena-Leon Raquel Perez-Lois Villalon Maria Eva Prida Diego Mu ñoz Moreno Johan Fern ø Mar Qui ñones Omar Al-Massadi Luisa M Seoane Source Type: research
Governing principles of transcriptional logic out of equilibrium
Biophys J. 2024 Mar 14:S0006-3495(24)00185-1. doi: 10.1016/j.bpj.2024.03.020. Online ahead of print.ABSTRACTTo survive, adapt, and develop, cells respond to external and internal stimuli, by tightly regulating transcription. Transcriptional regulation involves the combinatorial binding of a repertoire of transcription factors (TFs) to DNA, which often results in switch-like binary outputs, akin to Boolean logic gates. Recent experimental studies have demonstrated that in eukaryotes, transcription factor binding to DNA often involves energy expenditure, thereby driving the system out of equilibrium. The governing principles...
Source: Biophysical Journal - March 15, 2024 Category: Physics Authors: Smruti Dixit Teije C Middelkoop Sandeep Choubey Source Type: research
Impaired skeletal muscle regeneration in diabetes: From cellular and molecular mechanisms to novel treatments
We describe the role of myogenic and non-myogenic cell types on muscle regeneration in conditions with or without diabetes. Therapies for skeletal muscle regeneration and gaps in our knowledge are also discussed, while proposing future directions for the field.PMID:38490209 | DOI:10.1016/j.cmet.2024.02.014 (Source: Cell Metabolism)
Source: Cell Metabolism - March 15, 2024 Category: Cytology Authors: Ever Espino-Gonzalez Emilie Dalbram R émi Mounier Julien Gondin Jean Farup Niels Jessen Jonas T Treebak Source Type: research
SEA 2024 Standards for Global Control of Vascular Risk
Clin Investig Arterioscler. 2024 Mar 14:S0214-9168(24)00017-2. doi: 10.1016/j.arteri.2024.02.001. Online ahead of print.ABSTRACTOne of the objectives of the Spanish Society of Arteriosclerosis is to contribute to the knowledge, prevention and treatment of vascular diseases, which are the leading cause of death in Spain and entail a high degree of disability and health expenditure. Atherosclerosis is a multifactorial disease and its prevention requires a global approach that takes into account the associated risk factors. This document summarises the current evidence and includes recommendations for patients with establishe...
Source: Atherosclerosis - March 15, 2024 Category: Cardiology Authors: Jos é María Mostaza Xavier Pint ó Pedro Armario Luis Masana Jos é T Real Pedro Valdivielso Teresa Arrobas-Velilla Ram ón Baeza-Trinidad Pilar Calmarza Jes ús Cebollada Miguel Civera-Andr és Jos é I Cuende Melero Jos é L Díaz-Díaz Javier Esp íl Source Type: research
Novel mechanisms involved in leptin sensitization in obesity
Biochem Pharmacol. 2024 Mar 13:116129. doi: 10.1016/j.bcp.2024.116129. Online ahead of print.ABSTRACTLeptin is a hormone that is secreted by adipocytes in proportion to adipose tissue size, and that informs the brain about the energy status of the body. Leptin acts through its receptor LepRb, expressed mainly in the hypothalamus, and induces a negative energy balance by potent inhibition of feeding and activation of energy expenditure. These actions have led to huge expectations for the development of therapeutic targets for metabolic complications based on leptin-derived compounds. However, the majority of patients with o...
Source: Biochemical Pharmacology - March 15, 2024 Category: Drugs & Pharmacology Authors: Veronica Pena-Leon Raquel Perez-Lois Villalon Maria Eva Prida Diego Mu ñoz Moreno Johan Fern ø Mar Qui ñones Omar Al-Massadi Luisa M Seoane Source Type: research
