Opportunity Costs for Families Providing Home and Community Base Dementia Care. Can We Have a Real Discussion about Policy?
Jang and Chen's report, “National Estimates of Incremental Absenteeism Costs Associated with Adult Children of Parents with Alzheimer's Disease and Related Dementia (ADRD),” provides important estimates for an understudied category of “opportunity costs” for work absenteeism among children providing home and commun ity based care (HCBC) for an ADRD parent verses those caring for a non-ADRD parent. (1) Using an elegantly designed econometric model and merged data from the 2015 through 2021 Medical Expenditure Panel Survey (MEPS), the investigators described sociodemographic characteristics of each HCBC caregive r gr...
Source: The American Journal of Geriatric Psychiatry - April 18, 2024 Category: Geriatrics Authors: Christopher C. Colenda Tags: Editorial Source Type: research
GSE264173 Insulin and leptin oscillations license food-entrained browning and metabolic flexibility [RNA-seq]
Contributor : P RajbhandariSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTimed-feeding leads to adipose browning, although the integrative mechanisms for the same remain unclear. Here we show that twice-a-nocturnal (TAN) feeding causes biphasic oscillations of circulating insulin and leptin, representing their entrainment by timed-feeding. Insulin and leptin surges lead to marked cellular, functional and metabolic remodeling of sWAT resulting in increased energy expenditure. Single-cell RNAseq analyses and flow cytometry reveal a role for insulin and leptin surges in ILC2 recruitme...
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Voluntary exercise fails to prevent metabolic dysfunction ‐associated steatotic liver disease progression in male rats fed a high‐fat high‐cholesterol diet
AbstractMetabolic dysfunction-associated steatotic liver disease (MASLD) is a major public health issue with a worldwide prevalence of 30% –32%. In animal models, voluntary exercise may be an alternative to forced physical activity, avoiding stress, potential injuries, and being logistically simpler. Here, we assessed voluntary exercise (Vex) in Sprague–Dawley rats fed a high-fat, high-cholesterol diet for 18 weeks to induce MASL D. We quantified workload (speed and distance) using exercise wheels and evaluated energy expenditure using calorimetric cages. MASLD progression was assessed using circulating and hepatic b...
Source: Physiological Reports - April 17, 2024 Category: Physiology Authors: Cl ément Besqueut‐Rougerie,
Vivien Chavanelle,
Arnaud Michaux,
Yolanda F. Otero,
Pascal Sirvent,
James A. King,
Gaël Ennequin Tags: ORIGINAL ARTICLE Source Type: research
Cancers, Vol. 16, Pages 1529: Drug Cost Avoidance Resulting from Participation in Clinical Trials: A 10-Year Retrospective Analysis of Cancer Patients with Solid Tumors
The objective of this single-center retrospective study was to describe the clinical characteristics of adult patients with solid tumors enrolled in cancer clinical trials over a 10-year period (2010–2019) and to assess drug cost avoidance (DCA) associated with sponsors’ contributions. The sponsors’ contribution to pharmaceutical expenditure was calculated according to the actual price (for each year) of pharmaceutical specialties that the Vall d’Hebron University Hospital (HUVH) would have had to bear in the absence of sponsorship. A total of 2930 clinical trials wer...
Source: Cancers - April 17, 2024 Category: Cancer & Oncology Authors: Maria-Josep Carreras Berta Renedo-Mir ó Carolina Valdivia Elena Tom ás-Guillén Anna Farriols Laura Ma ñós Jana Vidal Mar ía Alcalde Isabel De la Paz In és Jiménez-Lozano Maria-Eugenia Palacio-Lacambra Nuria Sabat é Enriqueta Felip Elena Garralda Tags: Article Source Type: research
Both religious and secular ethics to achieve both happiness and health: Panel data results based on a dynamic theoretical model
by Fabio Zagonari
This paper evaluates the direct and indirect impacts (and their interactions) of individual and social ethics from (primary, secondary, tertiary) education and religion (Buddhism, Christianity, Hinduism, Islam, Judaism) on health and happiness in alternative religious contexts (majority and minori ty religions) and for alternative education policies (gross enrolment and per-student expenditure). It also specifies the time lag for the short-run indirect impact (and its size) of happiness on health and the long-run equilibria of both happiness and health. The statistical results show that there is no relig...
Source: PLoS One - April 17, 2024 Category: Biomedical Science Authors: Fabio Zagonari Source Type: research
Endogenous Altruism and Impact of Child Labour Ban and Education Subsidy on Child Labour
AbstractThis paper builds an overlapping generations household economy model where child labour is present. Child schooling is determined by parental altruism. The degree of parental altruism is determined by the level of schooling of the parent. A more educated parent has a greater willingness to invest in the human capital formation of the child. These differences in the preferences of parents towards their offspring ’s schooling have significant effects on the long-run dynamics of schooling. The dynamics of schooling exhibit the possibility of the existence of a child labour trap. If the economy is trapped in an ineff...
Source: Child Indicators Research - April 17, 2024 Category: Child Development Source Type: research
Defining predictors of responsiveness to advanced therapies in Crohns disease and ulcerative colitis: protocol for the IBD-RESPONSE and nested CD-metaRESPONSE prospective, multicentre, observational cohort study in precision medicine
Introduction
Characterised by chronic inflammation of the gastrointestinal tract, inflammatory bowel disease (IBD) symptoms including diarrhoea, abdominal pain and fatigue can significantly impact patient’s quality of life. Therapeutic developments in the last 20 years have revolutionised treatment. However, clinical trials and real-world data show primary non-response rates up to 40%. A significant challenge is an inability to predict which treatment will benefit individual patients.
Current understanding of IBD pathogenesis implicates complex interactions between host genetics and the gut microbiome. Most cohorts s...
Source: BMJ Open - April 17, 2024 Category: General Medicine Authors: Wyatt, N. J., Watson, H., Anderson, C. A., Kennedy, N. A., Raine, T., Ahmad, T., Allerton, D., Bardgett, M., Clark, E., Clewes, D., Cotobal Martin, C., Doona, M., Doyle, J. A., Frith, K., Hancock, H. C., Hart, A. L., Hildreth, V., Irving, P. M., Iqbal, S. Tags: Open access, Gastroenterology and hepatology Source Type: research
Is alcohol and psychoactive medication use associated with excess hospital length-of-stay and admission frequency? A cross-sectional, observational study
Hospital length-of-stay and admission frequency are commonly used indicators of disease burden and health resource expenditures. However, the impact of psychoactive prescription medication use and harmful alco... (Source: BMC Emergency Medicine)
Source: BMC Emergency Medicine - April 16, 2024 Category: Emergency Medicine Authors: Danil Gamboa, Saranda Kabashi, Benedicte J ørgenrud, Anners Lerdal, Gudmund Nordby and Stig Tore Bogstrand Tags: Research Source Type: research
Orexinergic Receptor Antagonists as a New Therapeutic Target to Overcome Limitations of Current Pharmacological Treatment of Insomnia Disorder
This study reviews the benefits and risks of current pharmacological treatments for insomnia, with special reference to the orexinergic system as a novel therapeutic target for treatment. The prescription of GABAergic mechanism enhancers (benzodiazepine (BZD) and "Z drugs") has shown efficacy in short-term insomnia treatment (less than 4 weeks), however, concerns arise regarding their long-term effectiveness, unfavorable tolerability and safety profiles, including the potential for dependency. Drugs with antihistamine properties, including certain antidepressants and antipsychotics, exhibit short-term efficacy but have doc...
Source: Actas Espanolas de Psiquiatria - April 15, 2024 Category: Psychiatry Authors: Cecilio Álamo Jer ónimo Sáiz Ruiz Cristina Zaragoz á Arnáez Source Type: research
Orexinergic Receptor Antagonists as a New Therapeutic Target to Overcome Limitations of Current Pharmacological Treatment of Insomnia Disorder
This study reviews the benefits and risks of current pharmacological treatments for insomnia, with special reference to the orexinergic system as a novel therapeutic target for treatment. The prescription of GABAergic mechanism enhancers (benzodiazepine (BZD) and "Z drugs") has shown efficacy in short-term insomnia treatment (less than 4 weeks), however, concerns arise regarding their long-term effectiveness, unfavorable tolerability and safety profiles, including the potential for dependency. Drugs with antihistamine properties, including certain antidepressants and antipsychotics, exhibit short-term efficacy but have doc...
Source: Actas Espanolas de Psiquiatria - April 15, 2024 Category: Psychiatry Authors: Cecilio Álamo Jer ónimo Sáiz Ruiz Cristina Zaragoz á Arnáez Source Type: research
Orexinergic Receptor Antagonists as a New Therapeutic Target to Overcome Limitations of Current Pharmacological Treatment of Insomnia Disorder
This study reviews the benefits and risks of current pharmacological treatments for insomnia, with special reference to the orexinergic system as a novel therapeutic target for treatment. The prescription of GABAergic mechanism enhancers (benzodiazepine (BZD) and "Z drugs") has shown efficacy in short-term insomnia treatment (less than 4 weeks), however, concerns arise regarding their long-term effectiveness, unfavorable tolerability and safety profiles, including the potential for dependency. Drugs with antihistamine properties, including certain antidepressants and antipsychotics, exhibit short-term efficacy but have doc...
Source: Actas Espanolas de Psiquiatria - April 15, 2024 Category: Psychiatry Authors: Cecilio Álamo Jer ónimo Sáiz Ruiz Cristina Zaragoz á Arnáez Source Type: research
Orexinergic Receptor Antagonists as a New Therapeutic Target to Overcome Limitations of Current Pharmacological Treatment of Insomnia Disorder
This study reviews the benefits and risks of current pharmacological treatments for insomnia, with special reference to the orexinergic system as a novel therapeutic target for treatment. The prescription of GABAergic mechanism enhancers (benzodiazepine (BZD) and "Z drugs") has shown efficacy in short-term insomnia treatment (less than 4 weeks), however, concerns arise regarding their long-term effectiveness, unfavorable tolerability and safety profiles, including the potential for dependency. Drugs with antihistamine properties, including certain antidepressants and antipsychotics, exhibit short-term efficacy but have doc...
Source: Actas Espanolas de Psiquiatria - April 15, 2024 Category: Psychiatry Authors: Cecilio Álamo Jer ónimo Sáiz Ruiz Cristina Zaragoz á Arnáez Source Type: research
Orexinergic Receptor Antagonists as a New Therapeutic Target to Overcome Limitations of Current Pharmacological Treatment of Insomnia Disorder
This study reviews the benefits and risks of current pharmacological treatments for insomnia, with special reference to the orexinergic system as a novel therapeutic target for treatment. The prescription of GABAergic mechanism enhancers (benzodiazepine (BZD) and "Z drugs") has shown efficacy in short-term insomnia treatment (less than 4 weeks), however, concerns arise regarding their long-term effectiveness, unfavorable tolerability and safety profiles, including the potential for dependency. Drugs with antihistamine properties, including certain antidepressants and antipsychotics, exhibit short-term efficacy but have doc...
Source: Actas Espanolas de Psiquiatria - April 15, 2024 Category: Psychiatry Authors: Cecilio Álamo Jer ónimo Sáiz Ruiz Cristina Zaragoz á Arnáez Source Type: research
Orexinergic Receptor Antagonists as a New Therapeutic Target to Overcome Limitations of Current Pharmacological Treatment of Insomnia Disorder
This study reviews the benefits and risks of current pharmacological treatments for insomnia, with special reference to the orexinergic system as a novel therapeutic target for treatment. The prescription of GABAergic mechanism enhancers (benzodiazepine (BZD) and "Z drugs") has shown efficacy in short-term insomnia treatment (less than 4 weeks), however, concerns arise regarding their long-term effectiveness, unfavorable tolerability and safety profiles, including the potential for dependency. Drugs with antihistamine properties, including certain antidepressants and antipsychotics, exhibit short-term efficacy but have doc...
Source: Actas Espanolas de Psiquiatria - April 15, 2024 Category: Psychiatry Authors: Cecilio Álamo Jer ónimo Sáiz Ruiz Cristina Zaragoz á Arnáez Source Type: research
Orexinergic Receptor Antagonists as a New Therapeutic Target to Overcome Limitations of Current Pharmacological Treatment of Insomnia Disorder
This study reviews the benefits and risks of current pharmacological treatments for insomnia, with special reference to the orexinergic system as a novel therapeutic target for treatment. The prescription of GABAergic mechanism enhancers (benzodiazepine (BZD) and "Z drugs") has shown efficacy in short-term insomnia treatment (less than 4 weeks), however, concerns arise regarding their long-term effectiveness, unfavorable tolerability and safety profiles, including the potential for dependency. Drugs with antihistamine properties, including certain antidepressants and antipsychotics, exhibit short-term efficacy but have doc...
Source: Actas Espanolas de Psiquiatria - April 15, 2024 Category: Psychiatry Authors: Cecilio Álamo Jer ónimo Sáiz Ruiz Cristina Zaragoz á Arnáez Source Type: research
