Age-related ciliopathy: Obesogenic shortening of melanocortin-4 receptor-bearing neuronal primary cilia
This study provides a crucial mechanism for age-related obesity, which increases the risk of metabolic syndrome.PMID:38452767 | DOI:10.1016/j.cmet.2024.02.010 (Source: Cell Metabolism)
Source: Cell Metabolism - March 7, 2024 Category: Cytology Authors: Manami Oya Yoshiki Miyasaka Yoshiko Nakamura Miyako Tanaka Takayoshi Suganami Tomoji Mashimo Kazuhiro Nakamura Source Type: research
Measuring household vulnerability to medical expenditure shock: method and its empirical application
AbstractTo investigate household vulnerability for inability to cope with medical expenditure shock, we propose a method of measuring household vulnerability to medical expenditure shock by allowing for the heteroscedasticity and dependence of medical expenditure shock and income shock. Using the data from China Health and Nutrition Survey, we estimate the vulnerability of Chinese households, and further investigate crucial characteristics associated with it by comparing the vulnerability levels among groups with different characteristics and an empirical regression with Shorrocks-Shapely decomposition of R squared. Our re...
Source: International Journal of Health Care Finance and Economics - March 7, 2024 Category: Health Management Source Type: research
Leagility in the healthcare research: a systematic review
Expenditure of healthcare services has been growing over the past decades. Lean and agile are two popular paradigms that could potentially contain cost and improve proficiency of the healthcare system. However... (Source: BMC Health Services Research)
Source: BMC Health Services Research - March 7, 2024 Category: General Medicine Authors: Xueying Li and Ana L úcia Martins Tags: Systematic Review Source Type: research
Proximity to rewards modulates parameters of effortful control exertion.
Journal of Experimental Psychology: General, Vol 153(5), May 2024, 1257-1267; doi:10.1037/xge0001561The now-classic goal-gradient hypothesis posits that organisms increase effort expenditure as a function of their proximity to a goal. Despite nearly a century having passed since its original formulation, goal-gradient-like behavior in human cognitive performance remains poorly understood: Are we more willing to engage in costly cognitive processing when we are near, versus far, from a goal state? Moreover, the computational mechanisms underpinning these potential goal-gradient effects—for example, whether goal proximity ...
Source: Journal of Experimental Psychology: General - March 7, 2024 Category: Psychiatry & Psychology Source Type: research
Low resting metabolic rate and increased hunger due to β-MSH and β-endorphin deletion in a canine model
We report on a common canine mutation in pro-opiomelanocortin (POMC), which prevents production of β-melanocyte-stimulating hormone (β-MSH) and β-endorphin but not α-MSH; humans, similar to dogs, produce α-MSH and β-MSH from the POMC propeptide, but rodents produce only α-MSH. We show that energy expenditure is markedly lower in affected dogs, which also have increased motivational salience in response to a food cue, indicating increased wanting or hunger. There was no difference in satiety at a modified ad libitum meal or in their hedonic response to food, nor disruption of adrenocorticotropic hormone (ACTH) or thy...
Source: Adv Data - March 6, 2024 Category: Epidemiology Authors: Marie T Dittmann Gabriella Lakatos Jodie F Wainwright Jacek Mokrosinski Eloise Cross I Sadaf Farooqi Natalie J Wallis Lewis G Halsey Rory Wilson Stephen O'Rahilly Giles S H Yeo Eleanor Raffan Source Type: research
Low resting metabolic rate and increased hunger due to β-MSH and β-endorphin deletion in a canine model
We report on a common canine mutation in pro-opiomelanocortin (POMC), which prevents production of β-melanocyte-stimulating hormone (β-MSH) and β-endorphin but not α-MSH; humans, similar to dogs, produce α-MSH and β-MSH from the POMC propeptide, but rodents produce only α-MSH. We show that energy expenditure is markedly lower in affected dogs, which also have increased motivational salience in response to a food cue, indicating increased wanting or hunger. There was no difference in satiety at a modified ad libitum meal or in their hedonic response to food, nor disruption of adrenocorticotropic hormone (ACTH) or thy...
Source: Adv Data - March 6, 2024 Category: Epidemiology Authors: Marie T Dittmann Gabriella Lakatos Jodie F Wainwright Jacek Mokrosinski Eloise Cross I Sadaf Farooqi Natalie J Wallis Lewis G Halsey Rory Wilson Stephen O'Rahilly Giles S H Yeo Eleanor Raffan Source Type: research
Sensors, Vol. 24, Pages 1700: Building Individual Player Performance Profiles According to Pre-Game Expectations and Goal Difference in Soccer
This study used GPS wearable sensors to track players’ energy expenditure in 5-min intervals, alongside recording the goal timings and the win and lose probabilities from betting sites. A mathematical model was developed that considers pre-game expectations (e.g., favorite, non-favorite), endurance, and goal difference (GD) dynamics on player effort. Particle Swarm and Nelder–Mead optimization methods were used to construct these models, both consistently converging to similar cost function values. The model outperformed baselines relying solely on mean and median power per GD. This improvement ...
Source: Sensors - March 6, 2024 Category: Biotechnology Authors: Arian Skoki Boris Ga šparović Stefan Ivi ć Jonatan Lerga Ivan Štajduhar Tags: Article Source Type: research
Catastrophic health expenditures: a disproportionate risk in uninsured ethnic minorities with diabetes
Chargemaster prices are the list prices that providers and health systems assign to each of their medical services in the US. These charges are often several factors of magnitude higher than those extended to ... (Source: Health Economics Review)
Source: Health Economics Review - March 6, 2024 Category: Health Management Authors: Sebastian Linde and Leonard E. Egede Tags: Research Source Type: research
Paediatric oncology in the Eastern Mediterranean region (EMR): the current state and challenges
Ecancermedicalscience. 2024 Feb 28;18:1677. doi: 10.3332/ecancer.2024.1677. eCollection 2024.ABSTRACTThe WHO Eastern Mediterranean region (EMR) is characterised by highly economically diverse countries, with healthcare systems in various phases of development. Childhood cancer care provision also ranges from that provided in centres able to deliver sophisticated therapy resulting in outcomes comparable to those seen in highly developed nations, to countries with no provision for care of children with cancer. At 10·1 per 100,000 children at risk, the age standardised incidence-rate for cancer in children below 14 years of ...
Source: Ecancermedicalscience - March 5, 2024 Category: Cancer & Oncology Authors: Arsalan Kabir Siddiqui Asim Fakhruddin Belgaumi Source Type: research
