Orexinergic Receptor Antagonists as a New Therapeutic Target to Overcome Limitations of Current Pharmacological Treatment of Insomnia Disorder
This study reviews the benefits and risks of current pharmacological treatments for insomnia, with special reference to the orexinergic system as a novel therapeutic target for treatment. The prescription of GABAergic mechanism enhancers (benzodiazepine (BZD) and "Z drugs") has shown efficacy in short-term insomnia treatment (less than 4 weeks), however, concerns arise regarding their long-term effectiveness, unfavorable tolerability and safety profiles, including the potential for dependency. Drugs with antihistamine properties, including certain antidepressants and antipsychotics, exhibit short-term efficacy but have doc...
Source: Actas Espanolas de Psiquiatria - April 15, 2024 Category: Psychiatry Authors: Cecilio Álamo Jer ónimo Sáiz Ruiz Cristina Zaragoz á Arnáez Source Type: research
Orexinergic Receptor Antagonists as a New Therapeutic Target to Overcome Limitations of Current Pharmacological Treatment of Insomnia Disorder
This study reviews the benefits and risks of current pharmacological treatments for insomnia, with special reference to the orexinergic system as a novel therapeutic target for treatment. The prescription of GABAergic mechanism enhancers (benzodiazepine (BZD) and "Z drugs") has shown efficacy in short-term insomnia treatment (less than 4 weeks), however, concerns arise regarding their long-term effectiveness, unfavorable tolerability and safety profiles, including the potential for dependency. Drugs with antihistamine properties, including certain antidepressants and antipsychotics, exhibit short-term efficacy but have doc...
Source: Actas Espanolas de Psiquiatria - April 15, 2024 Category: Psychiatry Authors: Cecilio Álamo Jer ónimo Sáiz Ruiz Cristina Zaragoz á Arnáez Source Type: research
Orexinergic Receptor Antagonists as a New Therapeutic Target to Overcome Limitations of Current Pharmacological Treatment of Insomnia Disorder
This study reviews the benefits and risks of current pharmacological treatments for insomnia, with special reference to the orexinergic system as a novel therapeutic target for treatment. The prescription of GABAergic mechanism enhancers (benzodiazepine (BZD) and "Z drugs") has shown efficacy in short-term insomnia treatment (less than 4 weeks), however, concerns arise regarding their long-term effectiveness, unfavorable tolerability and safety profiles, including the potential for dependency. Drugs with antihistamine properties, including certain antidepressants and antipsychotics, exhibit short-term efficacy but have doc...
Source: Actas Espanolas de Psiquiatria - April 15, 2024 Category: Psychiatry Authors: Cecilio Álamo Jer ónimo Sáiz Ruiz Cristina Zaragoz á Arnáez Source Type: research
Orexinergic Receptor Antagonists as a New Therapeutic Target to Overcome Limitations of Current Pharmacological Treatment of Insomnia Disorder
This study reviews the benefits and risks of current pharmacological treatments for insomnia, with special reference to the orexinergic system as a novel therapeutic target for treatment. The prescription of GABAergic mechanism enhancers (benzodiazepine (BZD) and "Z drugs") has shown efficacy in short-term insomnia treatment (less than 4 weeks), however, concerns arise regarding their long-term effectiveness, unfavorable tolerability and safety profiles, including the potential for dependency. Drugs with antihistamine properties, including certain antidepressants and antipsychotics, exhibit short-term efficacy but have doc...
Source: Actas Espanolas de Psiquiatria - April 15, 2024 Category: Psychiatry Authors: Cecilio Álamo Jer ónimo Sáiz Ruiz Cristina Zaragoz á Arnáez Source Type: research
Sensors, Vol. 24, Pages 2520: Energy Expenditure Prediction from Accelerometry Data Using Long Short-Term Memory Recurrent Neural Networks
In this study, we investigated the energy expenditure prediction from acceleration measured at the subjects’ hip, wrist, thigh, and back using recurrent neural networks utilizing temporal elements of the data. The acceleration was measured in children (N = 33) performing a standardized activity protocol in their natural environment. The energy expenditure was modelled using Multiple Linear Regression (MLR), stacked long short-term memory (LSTM) networks, and combined convolutional neural networks (CNN) and LSTM. The correlation and mean absolute percentage error (MAPE) were 0.76 and 19.9% for the MLR, 0.882 a...
Source: Sensors - April 14, 2024 Category: Biotechnology Authors: Martin Vib æk Abdolrahman Peimankar Uffe Kock Wiil Daniel Arvidsson Jan Christian Br ønd Tags: Article Source Type: research
The intersection of frailty and metabolism
Cell Metab. 2024 Apr 5:S1550-4131(24)00091-3. doi: 10.1016/j.cmet.2024.03.012. Online ahead of print.ABSTRACTOn average, aging is associated with unfavorable changes in cellular metabolism, which are the processes involved in the storage and expenditure of energy. However, metabolic dysregulation may not occur to the same extent in all older individuals as people age at different rates. Those who are aging rapidly are at increased risk of adverse health outcomes and are said to be "frail." Here, we explore the links between frailty and metabolism, including metabolic contributors and consequences of frailty. We examine how...
Source: Cell Metabolism - April 13, 2024 Category: Cytology Authors: Manish Mishra Judy Wu Alice E Kane Susan E Howlett Source Type: research
The intersection of frailty and metabolism
Cell Metab. 2024 Apr 5:S1550-4131(24)00091-3. doi: 10.1016/j.cmet.2024.03.012. Online ahead of print.ABSTRACTOn average, aging is associated with unfavorable changes in cellular metabolism, which are the processes involved in the storage and expenditure of energy. However, metabolic dysregulation may not occur to the same extent in all older individuals as people age at different rates. Those who are aging rapidly are at increased risk of adverse health outcomes and are said to be "frail." Here, we explore the links between frailty and metabolism, including metabolic contributors and consequences of frailty. We examine how...
Source: Cell Metabolism - April 13, 2024 Category: Cytology Authors: Manish Mishra Judy Wu Alice E Kane Susan E Howlett Source Type: research
The intersection of frailty and metabolism
Cell Metab. 2024 Apr 5:S1550-4131(24)00091-3. doi: 10.1016/j.cmet.2024.03.012. Online ahead of print.ABSTRACTOn average, aging is associated with unfavorable changes in cellular metabolism, which are the processes involved in the storage and expenditure of energy. However, metabolic dysregulation may not occur to the same extent in all older individuals as people age at different rates. Those who are aging rapidly are at increased risk of adverse health outcomes and are said to be "frail." Here, we explore the links between frailty and metabolism, including metabolic contributors and consequences of frailty. We examine how...
Source: Cell Metabolism - April 13, 2024 Category: Cytology Authors: Manish Mishra Judy Wu Alice E Kane Susan E Howlett Source Type: research
The intersection of frailty and metabolism
Cell Metab. 2024 Apr 5:S1550-4131(24)00091-3. doi: 10.1016/j.cmet.2024.03.012. Online ahead of print.ABSTRACTOn average, aging is associated with unfavorable changes in cellular metabolism, which are the processes involved in the storage and expenditure of energy. However, metabolic dysregulation may not occur to the same extent in all older individuals as people age at different rates. Those who are aging rapidly are at increased risk of adverse health outcomes and are said to be "frail." Here, we explore the links between frailty and metabolism, including metabolic contributors and consequences of frailty. We examine how...
Source: Cell Metabolism - April 13, 2024 Category: Cytology Authors: Manish Mishra Judy Wu Alice E Kane Susan E Howlett Source Type: research
Effort-cost decision-making associated with negative symptoms in schizophrenia and bipolar disorder
Behav Brain Res. 2024 Apr 10:114996. doi: 10.1016/j.bbr.2024.114996. Online ahead of print.ABSTRACTMotivational deficits and reduced goal-directed behavior for external rewards have long been considered an important features of negative symptoms in patients with schizophrenia (SCZ). Negative symptoms have also a high prevalence in bipolar disorder (BP). We used a transdiagnostic approach in order to examine association between negative symptoms and effort allocation for monetary rewards. 41 patients with SCZ and 34 patients with BP were enrolled in the study along with 41 healthy controls (HC). Effort-Expenditure for Rewar...
Source: Behavioural Brain Research - April 12, 2024 Category: Neurology Authors: Serhan Is ıklı Asl ıhan Bilge Bektaş Şule Temel Murat Atabay Bilgesu Deniz Arkal ı Ba şak Bağcı Adem Bayrakc ı Miriam Sebold Nabi Zorlu Source Type: research
Effort-cost decision-making associated with negative symptoms in schizophrenia and bipolar disorder
Behav Brain Res. 2024 Apr 10:114996. doi: 10.1016/j.bbr.2024.114996. Online ahead of print.ABSTRACTMotivational deficits and reduced goal-directed behavior for external rewards have long been considered an important features of negative symptoms in patients with schizophrenia (SCZ). Negative symptoms have also a high prevalence in bipolar disorder (BP). We used a transdiagnostic approach in order to examine association between negative symptoms and effort allocation for monetary rewards. 41 patients with SCZ and 34 patients with BP were enrolled in the study along with 41 healthy controls (HC). Effort-Expenditure for Rewar...
Source: Brain Research - April 12, 2024 Category: Neurology Authors: Serhan Is ıklı Asl ıhan Bilge Bektaş Şule Temel Murat Atabay Bilgesu Deniz Arkal ı Ba şak Bağcı Adem Bayrakc ı Miriam Sebold Nabi Zorlu Source Type: research
Transcriptomic profiling analysis of the effect of palmitic acid on 3D spheroids of β-like cells derived from induced pluripotent stem cells
Gene. 2024 Apr 10:148441. doi: 10.1016/j.gene.2024.148441. Online ahead of print.ABSTRACTType 2 diabetes (T2D) is posing a serious public health concern with a considerable impact on human life and health expenditures worldwide. The disease develops when insulin plasma level is insufficient for coping insulin resistance, caused by the decline of pancreatic β-cell function and mass. In β-cells, the lipotoxicity exerted by saturated free fatty acids in particular palmitate (PA), which is chronically elevated in T2D, plays a major role in β-cell dysfunction and mass. However, there is a lack of human relevant in vitro mode...
Source: Gene - April 12, 2024 Category: Genetics & Stem Cells Authors: Lisa Morisseau Fumiya Tokito Mathilde Lucas St éphane Poulain Soo Hyeon Kim Val érie Plaisance Val érie Pawlowski C écile Legallais Rachid Jellali Yasuyuki Sakai Amar Abderrahmani Eric Leclerc Source Type: research
Transcriptomic profiling analysis of the effect of palmitic acid on 3D spheroids of β-like cells derived from induced pluripotent stem cells
Gene. 2024 Apr 10;917:148441. doi: 10.1016/j.gene.2024.148441. Online ahead of print.ABSTRACTType 2 diabetes (T2D) is posing a serious public health concern with a considerable impact on human life and health expenditures worldwide. The disease develops when insulin plasma level is insufficient for coping insulin resistance, caused by the decline of pancreatic β-cell function and mass. In β-cells, the lipotoxicity exerted by saturated free fatty acids in particular palmitate (PA), which is chronically elevated in T2D, plays a major role in β-cell dysfunction and mass. However, there is a lack of human relevant in vitro ...
Source: Gene - April 12, 2024 Category: Genetics & Stem Cells Authors: Lisa Morisseau Fumiya Tokito Mathilde Lucas St éphane Poulain Soo Hyeon Kim Val érie Plaisance Val érie Pawlowski C écile Legallais Rachid Jellali Yasuyuki Sakai Amar Abderrahmani Eric Leclerc Source Type: research
Utilisation, expenditure, and treatment patterns associated with calcitonin gene-related peptide monoclonal antibodies (CGRP mAbs) reimbursed subject to a managed access protocol in Ireland.
This study presents data on utilisation, expenditure and treatment patterns with CGRP mAbs available under a managed access protocol in Ireland, to a cohort of treatment refractory patients (failed three or more previous treatments) with chronic migraine. (Source: Value in Health)
Source: Value in Health - April 12, 2024 Category: International Medicine & Public Health Authors: Amelia Smith, Karen Finnigan, Sarah Clarke, Michael Barry, Claire Gorry Source Type: research
Cancers, Vol. 16, Pages 1489: Availability and Access to Orphan Drugs for Rare Cancers in Bulgaria: Analysis of Delays and Public Expenditures
This study aimed to explore the availability and access to orphan drugs for rare cancers in Bulgaria for the period of 2020–2023. We cross-compared data from both the European Union and national public sources to evaluate the number of available and accessible orphan drugs for rare cancers, the delay from market authorization to reimbursement, the dynamics of public expenditures, and regional disparities in access across the country. We juxtaposed the main characteristics of oncological and non-oncological orphan drugs as well. Only 15 out of 50 oncological orphan drugs that were authorized by the European Me...
Source: Cancers - April 12, 2024 Category: Cancer & Oncology Authors: Kostadin Kostadinov Ivelina Popova-Sotirova Yuliyana Marinova Nina Musurlieva Georgi Iskrov Rumen Stefanov Tags: Article Source Type: research
