Treated versus self-reported prevalence of chronic pain and costs of patients' health services utilization: a population-based study of health administrative databases
DISCUSSION: Our findings suggest that the economic burden of CP is considerable and that many people with self-reported CP do not use the public healthcare services. This can be multifactorial, including lack of availability and accessibility of publicly funded services, people's lack of awareness of available services, lower utilization due to COVID-19 pandemic, and reliance on self-management, private services, and alternative treatments. Further studies are warranted to inform future policies and health system initiatives aiming to reduce the burden of CP and improve lives of people living with it.PMID:38545500 | PMC:PM...
Source: Pain Physician - March 28, 2024 Category: Anesthesiology Authors: Nguyen Xuan Thanh Elena Lopatina Lori S Montgomery Magali Robert Robert L Tanguay Tracy Wasylak Source Type: research
Trends in household out-of-pocket health expenditures and their underlying determinants: explaining variations within African regional economic communities from countries panel data
The persistently high out-of-pocket health spending (OOPHE) in Africa raise significant concern about the prospect of reaching SDG health targets and UHC. The study examines the convergence hypothesis of OOPHE... (Source: Globalization and Health)
Source: Globalization and Health - March 28, 2024 Category: International Medicine & Public Health Authors: Nicholas Ngepah and Ariane Ephemia Ndzignat Mouteyica Tags: Research Source Type: research
Telemental Health Services Usage and Association with Health Care Utilization and Expenditures Among Vulnerable Medicare Beneficiaries in 2019: A Comparative Study Using Propensity Score Matching
Telemedicine and e-Health, Ahead of Print. (Source: Telemedicine and e-Health)
Source: Telemedicine and e-Health - March 28, 2024 Category: Information Technology Authors: Yunxi Zhang Maria T. Pe ña Lincy S. Lal Yueh-Yun Lin Richard L. Summers Saurabh Chandra John Michael Swint Source Type: research
< em > Astragalus membranaceus < /em > Polysaccharide Regulates Small Intestinal Microbes and Activates IL-22 Signal Pathway to Promote Intestinal Stem Cell Regeneration in Aging Mice
In this study, we investigated the effects of Astragalus membranaceus polysaccharide (APS) and Astragalus membranaceus ethanol extract (AEE) on age-related intestinal dysfunction and gut microbiota dysbiosis in naturally aging mice. The energy expenditure and physical activity of 23-month-old C57BL6/J mice were recorded using a metabolic cage system. Pathological changes in the intestine were evaluated using Alcian blue staining. The protein levels of leucine-rich repeats containing G protein-coupled receptor 5 (Lgr5) and Stat3 in the small intestine were determined using immunohistochemistry. The intestinal cell migration...
Source: The American Journal of Chinese Medicine - March 27, 2024 Category: Complementary Medicine Authors: Jia-Ting Yin Ming-Ruo Zhang Shu Zhang Shu-Hui Yang Jian-Ping Li Yun Liu Jin-Ao Duan Jian-Ming Guo Source Type: research
Genetic Signatures for Distinguishing Chemo-Sensitive from Chemo-Resistant Responders in Prostate Cancer Patients
This study delves into the expression of drug resistance-associated genes, ABCB1 and CYP1B1, in cancer cells. Employing bioinformatics, we explored the molecular pathways and cascades linked to drug resistance following upregulation of these genes. Samples were obtained from archived prostate cancer patient specimens through pre-treatment biopsies of two categories: good vs. poor responders, with cDNAs synthesized from isolated RNAs subjected to qPCR analysis. The results revealed increased ABCB1 and CYP1B1 expression in tumor samples of the poor responders. Gene enrichment and network analysis associated ABCB1 with ABC tr...
Source: Cancer Control - March 27, 2024 Category: Cancer & Oncology Authors: Lemohang Gumenku Mamello Sekhoacha Beynon Abrahams Samson Mashele Aubrey Shoko Ochuko L Erukainure Source Type: research
Effects of Follicle Stimulating Hormone on Energy Balance and Tissue Metabolic Health After Loss of Ovarian Function
Am J Physiol Endocrinol Metab. 2024 Mar 27. doi: 10.1152/ajpendo.00400.2023. Online ahead of print.ABSTRACTLoss of ovarian function imparts increased susceptibility to obesity and metabolic disease. These effects are largely attributed to decreased estradiol (E2), but the role of increased follicle stimulating hormone (FSH) in modulating energy balance has not been fully investigated. Previous work that blocked FSH binding to its receptor in mice suggested this hormone may play a part in modulating body weight and energy expenditure after ovariectomy. We used an alternate approach to isolate the individual and combined con...
Source: Am J Physiol Endocri... - March 27, 2024 Category: Endocrinology Authors: Andrew E Libby Claudia Solt Matthew Jackman Vanessa Sherk Rebecca M Foright Ginger C Johnson Thi-Tina Nguyen Matthew Breit Nicholas Hulett Michael Rudolph Paul A Roberson Elizabeth Wellberg Purevsuren Jambal Rebecca L Scalzo Janine Higgins T Rajendra Kuma Source Type: research
Health anxiety: Another epidemic to prepare for
Rev Med Interne. 2024 Mar 26:S0248-8663(24)00082-1. doi: 10.1016/j.revmed.2024.03.002. Online ahead of print.ABSTRACTHealth anxiety (HA) is a frequent problem (up to 20% of consultants in the context of secondary care) responsible for decreased well-being, disability, somatic and psychiatric complications, which contributes to high healthcare expenditures at the population level. It is likely, if not definitely established, that the prevalence of ACS is increasing, and this can partly be explained by the growing medicalization of society in general, the appetite of Media for health issues, and the uncontrolled use of the I...
Source: Revue de Medecine Interne - March 27, 2024 Category: Internal Medicine Authors: P Cath ébras É Kohout A Savall J Goutte Source Type: research
Genetic Signatures for Distinguishing Chemo-Sensitive from Chemo-Resistant Responders in Prostate Cancer Patients
This study delves into the expression of drug resistance-associated genes, ABCB1 and CYP1B1, in cancer cells. Employing bioinformatics, we explored the molecular pathways and cascades linked to drug resistance following upregulation of these genes. Samples were obtained from archived prostate cancer patient specimens through pre-treatment biopsies of two categories: good vs. poor responders, with cDNAs synthesized from isolated RNAs subjected to qPCR analysis. The results revealed increased ABCB1 and CYP1B1 expression in tumor samples of the poor responders. Gene enrichment and network analysis associated ABCB1 with ABC tr...
Source: Genomics Proteomics ... - March 27, 2024 Category: Genetics & Stem Cells Authors: Lemohang Gumenku Mamello Sekhoacha Beynon Abrahams Samson Mashele Aubrey Shoko Ochuko L Erukainure Source Type: research
Genetic Signatures for Distinguishing Chemo-Sensitive from Chemo-Resistant Responders in Prostate Cancer Patients
This study delves into the expression of drug resistance-associated genes, ABCB1 and CYP1B1, in cancer cells. Employing bioinformatics, we explored the molecular pathways and cascades linked to drug resistance following upregulation of these genes. Samples were obtained from archived prostate cancer patient specimens through pre-treatment biopsies of two categories: good vs. poor responders, with cDNAs synthesized from isolated RNAs subjected to qPCR analysis. The results revealed increased ABCB1 and CYP1B1 expression in tumor samples of the poor responders. Gene enrichment and network analysis associated ABCB1 with ABC tr...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Lemohang Gumenku Mamello Sekhoacha Beynon Abrahams Samson Mashele Aubrey Shoko Ochuko L Erukainure Source Type: research
Effects of Follicle Stimulating Hormone on Energy Balance and Tissue Metabolic Health After Loss of Ovarian Function
Am J Physiol Endocrinol Metab. 2024 Mar 27. doi: 10.1152/ajpendo.00400.2023. Online ahead of print.ABSTRACTLoss of ovarian function imparts increased susceptibility to obesity and metabolic disease. These effects are largely attributed to decreased estradiol (E2), but the role of increased follicle stimulating hormone (FSH) in modulating energy balance has not been fully investigated. Previous work that blocked FSH binding to its receptor in mice suggested this hormone may play a part in modulating body weight and energy expenditure after ovariectomy. We used an alternate approach to isolate the individual and combined con...
Source: American Journal of Physiology. Endocrinology and Metabolism - March 27, 2024 Category: Physiology Authors: Andrew E Libby Claudia Solt Matthew Jackman Vanessa Sherk Rebecca M Foright Ginger C Johnson Thi-Tina Nguyen Matthew Breit Nicholas Hulett Michael Rudolph Paul A Roberson Elizabeth Wellberg Purevsuren Jambal Rebecca L Scalzo Janine Higgins T Rajendra Kuma Source Type: research
< em > Astragalus membranaceus < /em > Polysaccharide Regulates Small Intestinal Microbes and Activates IL-22 Signal Pathway to Promote Intestinal Stem Cell Regeneration in Aging Mice
In this study, we investigated the effects of Astragalus membranaceus polysaccharide (APS) and Astragalus membranaceus ethanol extract (AEE) on age-related intestinal dysfunction and gut microbiota dysbiosis in naturally aging mice. The energy expenditure and physical activity of 23-month-old C57BL6/J mice were recorded using a metabolic cage system. Pathological changes in the intestine were evaluated using Alcian blue staining. The protein levels of leucine-rich repeats containing G protein-coupled receptor 5 (Lgr5) and Stat3 in the small intestine were determined using immunohistochemistry. The intestinal cell migration...
Source: The American Journal of Chinese Medicine - March 27, 2024 Category: Complementary Medicine Authors: Jia-Ting Yin Ming-Ruo Zhang Shu Zhang Shu-Hui Yang Jian-Ping Li Yun Liu Jin-Ao Duan Jian-Ming Guo Source Type: research
Effects of Follicle Stimulating Hormone on Energy Balance and Tissue Metabolic Health After Loss of Ovarian Function
Am J Physiol Endocrinol Metab. 2024 Mar 27. doi: 10.1152/ajpendo.00400.2023. Online ahead of print.ABSTRACTLoss of ovarian function imparts increased susceptibility to obesity and metabolic disease. These effects are largely attributed to decreased estradiol (E2), but the role of increased follicle stimulating hormone (FSH) in modulating energy balance has not been fully investigated. Previous work that blocked FSH binding to its receptor in mice suggested this hormone may play a part in modulating body weight and energy expenditure after ovariectomy. We used an alternate approach to isolate the individual and combined con...
Source: Am J Physiol Endocri... - March 27, 2024 Category: Endocrinology Authors: Andrew E Libby Claudia Solt Matthew Jackman Vanessa Sherk Rebecca M Foright Ginger C Johnson Thi-Tina Nguyen Matthew Breit Nicholas Hulett Michael Rudolph Paul A Roberson Elizabeth Wellberg Purevsuren Jambal Rebecca L Scalzo Janine Higgins T Rajendra Kuma Source Type: research
Health anxiety: Another epidemic to prepare for
Rev Med Interne. 2024 Mar 26:S0248-8663(24)00082-1. doi: 10.1016/j.revmed.2024.03.002. Online ahead of print.ABSTRACTHealth anxiety (HA) is a frequent problem (up to 20% of consultants in the context of secondary care) responsible for decreased well-being, disability, somatic and psychiatric complications, which contributes to high healthcare expenditures at the population level. It is likely, if not definitely established, that the prevalence of ACS is increasing, and this can partly be explained by the growing medicalization of society in general, the appetite of Media for health issues, and the uncontrolled use of the I...
Source: Revue de Medecine Interne - March 27, 2024 Category: Internal Medicine Authors: P Cath ébras É Kohout A Savall J Goutte Source Type: research
Genetic Signatures for Distinguishing Chemo-Sensitive from Chemo-Resistant Responders in Prostate Cancer Patients
This study delves into the expression of drug resistance-associated genes, ABCB1 and CYP1B1, in cancer cells. Employing bioinformatics, we explored the molecular pathways and cascades linked to drug resistance following upregulation of these genes. Samples were obtained from archived prostate cancer patient specimens through pre-treatment biopsies of two categories: good vs. poor responders, with cDNAs synthesized from isolated RNAs subjected to qPCR analysis. The results revealed increased ABCB1 and CYP1B1 expression in tumor samples of the poor responders. Gene enrichment and network analysis associated ABCB1 with ABC tr...
Source: Genomics Proteomics ... - March 27, 2024 Category: Genetics & Stem Cells Authors: Lemohang Gumenku Mamello Sekhoacha Beynon Abrahams Samson Mashele Aubrey Shoko Ochuko L Erukainure Source Type: research
Genetic Signatures for Distinguishing Chemo-Sensitive from Chemo-Resistant Responders in Prostate Cancer Patients
This study delves into the expression of drug resistance-associated genes, ABCB1 and CYP1B1, in cancer cells. Employing bioinformatics, we explored the molecular pathways and cascades linked to drug resistance following upregulation of these genes. Samples were obtained from archived prostate cancer patient specimens through pre-treatment biopsies of two categories: good vs. poor responders, with cDNAs synthesized from isolated RNAs subjected to qPCR analysis. The results revealed increased ABCB1 and CYP1B1 expression in tumor samples of the poor responders. Gene enrichment and network analysis associated ABCB1 with ABC tr...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Lemohang Gumenku Mamello Sekhoacha Beynon Abrahams Samson Mashele Aubrey Shoko Ochuko L Erukainure Source Type: research
